Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patie...Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.展开更多
Objective:To observe the effect of moxa-stick moxibustion plus recombinant human granulocyte-colony stimulating factor(rhG-CSF)in preventing chemotherapy infection in gastric cancer and its effect on immune function.M...Objective:To observe the effect of moxa-stick moxibustion plus recombinant human granulocyte-colony stimulating factor(rhG-CSF)in preventing chemotherapy infection in gastric cancer and its effect on immune function.Methods:A total of 70 patients with gastric cancer treated by chemotherapy were randomly divided into an observation group and a control group,with 35 cases in each group.The control group was given rhG-CSF,and the observation group was given additional moxa-stick moxibustion on the basis of rhG-CSF.Both groups were treated for 2 chemotherapy cycles,totally 6 weeks.The number of patients with infection,the duration of infection and the duration of continuous use of antibiotics were observed.The leukocytes and granulocytes counts,the levels of tumor necrosis factor-a(TNF-a)and interferon-γ(IFN-γ)were measured before and after treatment,and the levels of CD4,CD8 and natural killer(NK)cells were analyzed.Results:The infection rate of the observation group was significantly lower than that of the control group(P<0.05),and the duration of infection and the duration of continuous use of antibiotics were also shorter(P<0.05).After treatment,the leukocytes and granulocytes counts in the two groups were higher than those before treatment(all P<0.05).After treatment,the levels of TNF-α and IFN-γ of the patients in the two groups were improved(all P<0.05),and there were significant differences between the observation group and the control group(P<0.05).After treatment,the numbers of CD4,CD8,and NK cells in the observation group increased significantly(all P<0.05);but the changes in the control group were not significant(P>0.05).Conclusion:Moxa-stick moxibustion plus rhG-CSF can significantly reduce the incidence and severity of chemotherapy infection in gastric cancer,increase the leukocytes and granulocytes counts,and regulate the levels of inflammatory factors,which may be related to the improvement of the immune function of the patients.展开更多
Objective:To observe the clinical efficacy of tendon-regulating and bon e-setting manipulation combined with en dura nee resistance exercises in treating female with chronic neck pain,and explore the mechanism.Methods...Objective:To observe the clinical efficacy of tendon-regulating and bon e-setting manipulation combined with en dura nee resistance exercises in treating female with chronic neck pain,and explore the mechanism.Methods:A total of 57 female patients with chronic neck pain who met the inclusion criteria were randomly divided into a manipulation group(29 cases)and a medium-frequency electrotherapy group(28 cases).Patients in both groups received the same endura nee exercise therapy,while those in the man ipulation group received additi onalten don-regulating and bone-setting manipulation,and those in the medium-frequency electrotherapy group received additional medium-frequency electrotherapy.Both groups were treated for 5 weeks.Before and after treatment,the neck function of patients was evaluated by visual analog scale(VAS),Analgesy-Meter,Northwick Park questionnaire(NPQ),root mean square(RMS)and median frequency(MF)of surface electromyography of sternocleidomastoid muscle and posterior cervical extensor muscle,and the patients were followed up at a month after treatment.Results:All patients completed the treatment and were followed up.Compared with the same group before treatmerrt,the VAS scores of both groups decreased,the tenderness values increased,the RMS and MF values increased,and the NPQ scores decreased after treatment(all P<0.05).The improvement of manipulation group was more notable than that of medium-frequency electrotherapy group(all P<0.05).At one-month follow-up,the VAS and NPQ scores of the manipulation group were lower than those before and after treatment,and the VAS and NPQ scores of the mediumfreq ue ncy electrotherapy group were only lower than those before treatment;the two scores of the manipulation group were lower than those of the medium-frequency electrotherapy group(both P<0.05).Conclusion:Tendon-regulating and bone-setti ng man ipulati on combi ned with endurance resista nee exe rcises can relieve neck pain and cervical dysfunction in female patients with chronic neck pain.The efficacy of this method is more durable and better than that of medium-frequency electrotherapy combined with enduranee exercises.展开更多
文摘目的:研究中药石香膏对于糖尿病大鼠慢性难愈合创面的晚期糖基化终末产物受体(RAGE)/转录因子-κBp65(NF-κBp65)/内皮型一氧化氮合酶(e NOS) mRNA表达的影响。方法:将50只SD级清洁大鼠按随机数字表法分为正常组、正常对照组、难愈合组、贝复济组、石香膏组5组,每组每时间点(7 d/14 d) 5只。造模成功后,贝复济组创面外用贝复济溶液,石香膏组创面外敷石香膏。第7/14天取大鼠背部创面肉芽组织标本,荧光定量PCR法检测RAGE/NF-κBp65/e NOS mRNA表达水平。结果:干预7 d后,与难愈合组比较,贝复济组和石香膏组中RAGE/NF-κBp65 mRNA相对表达量降低,e NOS mRNA相对表达量升高,差异有统计学意义。与贝复济组比较,石香膏组中RAGE/NF-κBp65 mRNA相对表达量降低,e NOS mRNA升高,差异有统计学意义。干预14 d后,与贝复济组比较,石香膏组RAGE/NF-κBp65 mRNA相对表达量降低,差异有统计学意义。结论:石香膏可抑制糖尿病大鼠慢性难愈合创面中RAGE/NF-κBp65 mRNA表达,促进e NOS mRNA的表达,对于创面修复具有显著作用。
文摘Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.
文摘Objective:To observe the effect of moxa-stick moxibustion plus recombinant human granulocyte-colony stimulating factor(rhG-CSF)in preventing chemotherapy infection in gastric cancer and its effect on immune function.Methods:A total of 70 patients with gastric cancer treated by chemotherapy were randomly divided into an observation group and a control group,with 35 cases in each group.The control group was given rhG-CSF,and the observation group was given additional moxa-stick moxibustion on the basis of rhG-CSF.Both groups were treated for 2 chemotherapy cycles,totally 6 weeks.The number of patients with infection,the duration of infection and the duration of continuous use of antibiotics were observed.The leukocytes and granulocytes counts,the levels of tumor necrosis factor-a(TNF-a)and interferon-γ(IFN-γ)were measured before and after treatment,and the levels of CD4,CD8 and natural killer(NK)cells were analyzed.Results:The infection rate of the observation group was significantly lower than that of the control group(P<0.05),and the duration of infection and the duration of continuous use of antibiotics were also shorter(P<0.05).After treatment,the leukocytes and granulocytes counts in the two groups were higher than those before treatment(all P<0.05).After treatment,the levels of TNF-α and IFN-γ of the patients in the two groups were improved(all P<0.05),and there were significant differences between the observation group and the control group(P<0.05).After treatment,the numbers of CD4,CD8,and NK cells in the observation group increased significantly(all P<0.05);but the changes in the control group were not significant(P>0.05).Conclusion:Moxa-stick moxibustion plus rhG-CSF can significantly reduce the incidence and severity of chemotherapy infection in gastric cancer,increase the leukocytes and granulocytes counts,and regulate the levels of inflammatory factors,which may be related to the improvement of the immune function of the patients.
文摘Objective:To observe the clinical efficacy of tendon-regulating and bon e-setting manipulation combined with en dura nee resistance exercises in treating female with chronic neck pain,and explore the mechanism.Methods:A total of 57 female patients with chronic neck pain who met the inclusion criteria were randomly divided into a manipulation group(29 cases)and a medium-frequency electrotherapy group(28 cases).Patients in both groups received the same endura nee exercise therapy,while those in the man ipulation group received additi onalten don-regulating and bone-setting manipulation,and those in the medium-frequency electrotherapy group received additional medium-frequency electrotherapy.Both groups were treated for 5 weeks.Before and after treatment,the neck function of patients was evaluated by visual analog scale(VAS),Analgesy-Meter,Northwick Park questionnaire(NPQ),root mean square(RMS)and median frequency(MF)of surface electromyography of sternocleidomastoid muscle and posterior cervical extensor muscle,and the patients were followed up at a month after treatment.Results:All patients completed the treatment and were followed up.Compared with the same group before treatmerrt,the VAS scores of both groups decreased,the tenderness values increased,the RMS and MF values increased,and the NPQ scores decreased after treatment(all P<0.05).The improvement of manipulation group was more notable than that of medium-frequency electrotherapy group(all P<0.05).At one-month follow-up,the VAS and NPQ scores of the manipulation group were lower than those before and after treatment,and the VAS and NPQ scores of the mediumfreq ue ncy electrotherapy group were only lower than those before treatment;the two scores of the manipulation group were lower than those of the medium-frequency electrotherapy group(both P<0.05).Conclusion:Tendon-regulating and bone-setti ng man ipulati on combi ned with endurance resista nee exe rcises can relieve neck pain and cervical dysfunction in female patients with chronic neck pain.The efficacy of this method is more durable and better than that of medium-frequency electrotherapy combined with enduranee exercises.
