CHRT:Clustering-Based Hybrid Re-Routing System for Traffic Congestion Avoidance

Re-routing system has become an important technology to improve traffic efficiency.The traditional re-routing schemes do not consider the dynamic characteristics of urban traffic,making the planned routes unable to cope with the changing traf-fic conditions.Based on real-time traffic information,it is challenging to dynamically re-route connected vehicles to alleviate traffic congestion.Moreover,how to obtain global traffic information while reducing communication costs and improving travel efficiency poses a challenge to the re-routing system.To deal with these challenges,this paper proposes CHRT,a clustering-based hybrid re-routing system for traffic congestion avoidance.CHRT develops a multi-layer hybrid architecture.The central server accesses the global view of traffic,and the distributed part is composed of vehicles divided into clusters to reduce latency and communication overhead.Then,a clustering-based priority mechanism is proposed,which sets priorities for clusters based on realtime traffic information to avoid secondary congestion.Furthermore,to plan the optimal routes for vehicles while alleviating global traffic congestion,this paper presents a multi-metric re-routing algorithm.Through extensive simulations based on the SUMO traffic simulator,CHRT reduces vehicle traveling time,fuel consumption,and CO2 emissions compared to other systems.In addition,CHRT globally alleviates traffic congestion and improves traffic efficiency.

An SDN/NFV Based Framework for Management and Deployment of Service Based 5G Core Network

The traffic explosion and the rising of diverse requirements lead to many challenges for traditional mobile network architecture on flexibility, scalability, and deployability. To meet new requirements in the 5 G era, service based architecture is introduced into mobile networks. The monolithic network elements(e.g., MME, PGW, etc.) are split into smaller network functions to provide customized services. However, the management and deployment of network functions in service based 5 G core network are still big challenges. In this paper, we propose a novel management architecture for 5 G service based core network based on NFV and SDN. Combined with SDN, NFV and edge computing, the proposed framework can provide distributed and on-demand deployment of network functions, service guaranteed network slicing, flexible orchestration of network functions and optimal workload allocation. Simulations are conducted to show that the proposed framework and algorithm are effective in terms of reducing network operating cost.

Mobile-Edge Computing Framework with Data Compression for Wireless Network in Energy Internet

Under the situations of energy dilemma, energy Internet has become one of the most important technologies in international academic and industrial areas. However, massive small data from users, which are too scattered and unsuitable for compression, can easily exhaust computational resources and lower random access possibility, thereby reducing system performance. Moreover, electric substations are sensitive to transmission latency of user data, such as controlling information. However, the traditional energy Internet usually could not meet requirements. Integrating mobile-edge computing makes energy Internet convenient for data acquisition,processing, management, and accessing. In this paper, we propose a novel framework for energy Internet to improve random access possibility and reduce transmission latency. This framework utilizes the local area network to collect data from users and makes conducting data compression for energy Internet possible. Simulation results show that this architecture can enhance random access possibility by a large margin and reduce transmission latency without extra energy consumption overhead.

Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma

Sulforaphane(SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN inducing autophagy in cancers are still obscure, especially in esophageal squamous cell carcinoma(ESCC), one of malignancies with high incidence in North China. Here, we mainly explored the potential function of autophagy upon SFN treatment in ESCC and molecular mechanism. We demonstrated that SFN could inhibit cell proliferation and induce apoptosis by activating caspase pathway. Moreover, we found activation of NRF2 pathway by SFN was responsible for the induction of autophagy and also a disadvantage element to the anti-tumor effects of SFN on ESCC, indicating that SFN might induce protective autophagy in ESCC. We, therefore,investigated effects of autophagy inhibition on sensitivity of ESCC cells to SFN and found that chloroquine(CQ) could neutralize the activation of SFN on NRF2 and enhance the activation of SFN on caspase pathway, thus improved the anti-tumor efficiency of SFN on ESCC in vitro and in vivo. Our study provides a preclinical rationale for development of SFN and its analogs to the future treatment of ESCC.

RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma

Dysregulation of mTORCl/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types;however,the mechanism of mTORC2 in tumorigenesis is still obscure.Here,we mainly explored the potential role of mTORC2 in esophageal squamous cell carcinoma(ESCC)and its effects on the sensitivity of cells to mTOR inhibitors.We demonstrated that RICTOR,the key factor of mTORC2,and p-AKT(Ser473)were excessively activated in ESCC and their overexpression is related to lymph node metastasis and the tumor-node-metastasis(TNM)phase of ESCC patients.Furthermore,we found that mTORCl/mTORC2 inhibitor PP242 exhibited more efficacious anti-proliferative effect on ESCC cells than mTORC1 inhibitor RAD001 due to RAD001-triggered feedback activation of AKT signal.Another,we demonstrated that down-regulating expression of RICTOR in ECa109 and EC9706 cells inhibited proliferation and migration as well as induced cell cycle arrest and apoptosis.Noteworthy,knocking-down stably RICTOR significantly suppresses RAD001-induced feedback activation of AKT/PRAS40 signaling,and enhances inhibition efficacy of PP242 on the phosphorylation of AKT and PRAS40,thus potentiates the antitumor effect of RAD001 and PP242 both in vitro and in vivo.Our findings highlight that selective targeting mTORC2 could be a promising therapeutic strategy for future treatment of ESCC.

Experimental Study of Hygrothermal and Ultraviolet Aging on the Flexural Performance of Epoxy Polymer Mortar

This paper studies the effects of hygrothermal environment at different temperatures and ultraviolet(UV)radiation on the bending properties of epoxy polymer mortar(EPM).The microstructure changes of EPM during aging were studied by scanning electron microscopy,and the bending properties of EPM were predicted by the Arrhenius law.The results showed that the bending properties of EPM were greatly affected by the temperature in the hygrothermal aging,but not evidently affected by ultraviolet radiation in UV aging.The prediction of Arrhenius model shows that the EPM will steadily retain 92.8%,89.1%and 79.4%of the original flexural strength after long-term hygrothermal aging at 40∘C,60∘C and 80∘C,respectively.