Objective:To evaluate the effect of the case management model on patients operated for pancreatic cancer.Methods:90 pancreatic cancer surgery patients admitted to the hospital between January 2022 and June 2023 were s...Objective:To evaluate the effect of the case management model on patients operated for pancreatic cancer.Methods:90 pancreatic cancer surgery patients admitted to the hospital between January 2022 and June 2023 were selected and grouped by randomized numerical table.For 45 cases in the observation group,case management mode was adopted,and for 45 cases in the intervention group,conventional nursing care was chosen to compare the indexes of gastrointestinal function recovery.Results:The recovery time of all gastrointestinal functions of the observation group was shorter than that of the intervention group;after nursing,the psychological state score of the observation group was lower than that of the intervention group,the self-efficacy score was higher than that of the intervention group and the rate of complications was lower than that of the intervention group(P<0.05).Conclusion:The case management model can promote the recovery of gastrointestinal function in patients with pancreatic cancer surgery and its nursing feasibility is high.展开更多
Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(...Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(aged 19-90 years;male 72,female 56).The sera were analyzed for HbA_(1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C).According to the HbA_(1e) level,the patients were divided into three groups,group A(HbA_(?)<7%,n=31),group B(7%<HbA_(1c)<10%,n=48),and group C(HbA_(1c)>10%,n=49).The correlation of HbA_(1c)with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA(1c),LDL-C had a significantly increasing trend(P<0.05);whereas TC went up with the increased HbA(1c),without any significant differences between three groups.There was no significant correlation between HbA_(1c) and TG or HDL-C. With the increased level of HbA_(1c),TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups(P<0.05).The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.展开更多
Alfalfa(Medicago sativa L.) is one of the most extensively grown leguminous forage worldwide.Environmental saline-alkali stress significantly influences the growth,development,and yield of alfalfa,posing a threat to i...Alfalfa(Medicago sativa L.) is one of the most extensively grown leguminous forage worldwide.Environmental saline-alkali stress significantly influences the growth,development,and yield of alfalfa,posing a threat to its agricultural production.However,little is known about the potential mechanisms by which alfalfa responds to saline-alkali stress.Here,we investigated these mechanisms by cloning a saline-alkali-induced flavonol synthase gene(Ms FLS13) from alfalfa,which was previously reported to be significantly upregulated under saline-alkali stress,and examining its function in the saline-alkali response.Overexpression of Ms FLS13 in alfalfa promoted plant tolerance to saline-alkali stress by enhancing flavonol accumulation,antioxidant capacity,osmotic balance,and photosynthetic efficiency.Conversely,Ms FLS13 inhibition using RNA interference reduced flavonol synthase activity and inhibited hairy root growth under saline-alkali stress.Yeast one-hybrid and dual-luciferase reporter assays indicated that the R2R3-MYB Ms MYB12 transcription factor activates Ms FLS13 expression by binding to the MBS motif in the Ms FLS13 promoter.Further analysis revealed that abscisic acid mediates the salinealkali stress response partially by inducing Ms MYB12 and Ms FLS13 expression,which consequently increases flavonol levels and maintains antioxidant homeostasis in alfalfa.Collectively,our findings highlight the crucial role of Ms FLS13 in alfalfa in response to saline-alkali stress and provide a novel genetic resource for creating saline-alkali-resistant alfalfa through genetic engineering.展开更多
For making rational and scientific land-use planning,an inventory indicator of land productivity subject to biophysical limitations and human disturbance is required.This study introduces agricultural land productivit...For making rational and scientific land-use planning,an inventory indicator of land productivity subject to biophysical limitations and human disturbance is required.This study introduces agricultural land productivity(ALP)as the dynamic indicator to measure land productivity,involving factors that affect agricultural production,such as characteristics of climate,soil,and terrain.As a case study of this dynamic indicator,ALP was estimated at county level and aggregated into provincial level in the whole of China.The result shows that ALP increased during 2000-2010 in China,and the ratios of ALP to the actual grain yield were 65.40%and 66.38%in the years 2000 and 2005,respectively.The ALP is an effective dynamic indicator to estimate the land productivity and to represent the basic conditions about the supply of water,energy,nutrients,and the physical basis for plant growth,as well as the local input.ALP estimation could provide supporting information for policy-making about land production planning and land-use management.展开更多
Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the...Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding.展开更多
Black phosphorus(BP),especially for BP nanosheets,with unique layered structure among two dimensional(2D)materials has attracted much attention due to its outstanding physical properties,such as ultra-high mobility,in...Black phosphorus(BP),especially for BP nanosheets,with unique layered structure among two dimensional(2D)materials has attracted much attention due to its outstanding physical properties,such as ultra-high mobility,in-plane anisotropic properties.However,the small horizontal-size of reported BP limits its applications in the integrated circuit or some functional devices.In this work,a solvothermalassisted liquid-phase exfoliation technique is firstly employed for preparing large size and high-quality BP nanosheets.In the high-polar acetonitrile solvent,solvothermal treatment weakens the Van der Waals forces of block BP.Together with the subsequently ultrasonic processing,effective exfoliation of large size and high-quality BP nanosheets are realized.The TEM,AFM and Raman results indicate that the prepared BP nanosheets are high quality with an average thickness of about 2 nm,and the horizontalsize is up to 10μm.This facile and effective method for exfoliated BP nanosheets provides a promising strategy for the exfoliation of other 2D materials.展开更多
Nodulation Receptor Kinase(NORK) functions as a co-receptor of Nod factor receptors to mediate rhizobial symbiosis in legumes, but its direct phosphorylation substrates that positively mediate root nodulation remain t...Nodulation Receptor Kinase(NORK) functions as a co-receptor of Nod factor receptors to mediate rhizobial symbiosis in legumes, but its direct phosphorylation substrates that positively mediate root nodulation remain to be fully identified.Here, we identified a GmNORK-Interacting Small Protein(GmNISP1) that functions as a phosphorylation target of GmNORK to promote soybean nodulation. GmNORKα directly interacted with and phosphorylated GmNISP1. Transcription of GmNISP1 was strongly induced after rhizobial infection in soybean roots and nodules. GmNISP1 encodes a peptide containing 90 amino acids with a “DY” consensus motif at its N-terminus.GmNISP1 protein was detected to be present in the apoplastic space. Phosphorylation of GmNISP1 by GmNORKα could enhance its secretion into the apoplast. Pretreatment with either purified GmNISP1 or phosphorylation-mimic GmNISP1~(12D) on the roots could significantly increase nodule numbers compared with the treatment with phosphorylation-inactive GmNISP1~(12A).The data suggested a model that soybean GmNORK phosphorylates GmNISP1 to promote its secretion into the apoplast, which might function as a potential peptide hormone to promote root nodulation.展开更多
The nanolaminated materials generally exhibit poor plasticity due to the fast onset of shear instability.Engineering interface structure is an eff ective approach for enhancing plasticity via postponing or suppressing...The nanolaminated materials generally exhibit poor plasticity due to the fast onset of shear instability.Engineering interface structure is an eff ective approach for enhancing plasticity via postponing or suppressing the shear instability.Here,we introduce 4 nm thick CuNb 3D amorphous interface layers and Nb 3D crystalline interface layers in Cu nanolaminated materials,respectively.In situ micro-pillar compression tests show that samples with crystalline interface layers exhibit shear instability,while the samples with amorphous interface layers display uniform deformation.Since the plastic deformation of the singlecrystal crystalline interface layer is anisotropic,except for well-aligned slip systems,dislocations on other slip systems have a poor ability to transmit the 3D crystalline interface layer,leading to localized dislocations pileups and shear instability.In contrast,the amorphous interface layer which is plastically isotropic accommodates dislocations from arbitrary slip systems of the matrix,which can alleviate the stress concentrations at the interface,and thus suppresses the shear instability.展开更多
In this study,an inverse-problem method was applied to estimate the solid concentration in a solid-liquid two-phase flow.An algebraic slip mixture model was introduced to solve the forward problem of solid-liquid conv...In this study,an inverse-problem method was applied to estimate the solid concentration in a solid-liquid two-phase flow.An algebraic slip mixture model was introduced to solve the forward problem of solid-liquid convective heat transfer.The time-average conservation equations of mass,momentum,energy,as well as the volume fraction equation were computed in a computational fluid dynamics(CFD)simulation.The solid concentration in the CFD model was controlled using an external program that included the inversion iteration,and an optimal estimation was performed via experimental measurements.Experiments using a fly-ash-water mixture and sand-water mixture with different solid concentrations in a horizontal pipeline were conducted to verify the accuracy of the inverse-problem method.The estimated results were rectified using a method based on the relationship between the estimated results and estimation error;consequently,the accuracy of the corrected inversion results improved significantly.After a verification through experiments,the inverse-problem method was concluded to be feasible for predicting the solid concentration,as the estimation error of the corrected results was within 7%for all experimental samples for a solid concentration of less than 50%.The inverse-problem method is expected to provide accurate predictions of the solid concentration in solid-liquid two-phase flow systems.展开更多
The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a se...The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a set of programs to facilitate the study of interactions between a circularly polarized laser and atomic hydrogen.These programs included only contribution from the bound states of the hydrogen atom.However,as the laser intensity increases,contribution from continuum states to the excitation and ionization processes becomes larger and can no longer be neglected.Furthermore,because the original code is not able to add this contribution directly due to its many disadvantages,a major upgrade of the code is required before including the contribution from continuum states in future.In this paper,first we deduce some important formulas for contribution of continuum states and present modifications and tests for the upgraded code in detail.Second we show some comparisons among new results,old results from the original codes and the available experimental data.Overall the new result agrees with experimental data well.Last we present our calculation of above-threshold ionization(ATI)rate and compare it with a pertubative calculation.The comparison shows that our nonperturbative calculation can also produce ATI peak suppression.展开更多
Objective To establish an effective prognostic nomogram for patients with gastric cancer after radical gastrectomy.Methods In the present study,we retrospectively analyzed the records of 1635 patients with gastric can...Objective To establish an effective prognostic nomogram for patients with gastric cancer after radical gastrectomy.Methods In the present study,we retrospectively analyzed the records of 1635 patients with gastric cancer treated at Changhai Hospital from January 2014 to December 2019.Final independent prognostic factors of overall survival to build a nomogram were screened using univariate and multivariate analyses.The predictive accuracy and discriminating ability of the nomogram were determined using the concordance index(C-index)and calibration curves.The results were validated using bootstrap resampling of 701 patients.The survival curves for low-,middle-,and high-risk patients were used to evaluate the accuracy of the nomogram.Results Multivariate analysis of the primary cohort revealed independent factors for survival as follows:age,sex,body mass index(BMI),depth of tumor invasion(T),lymph node metastasis(N),perineural invasion(PNI),tumor deposits,Alpha fetoprotein(AFP),and lactate dehydrogenase(LDH).Combining these predictors in the nomogram achieved powerful prognostic ability in the training and test sets.The C-index of the training set was 0.772(95%CI,0.748 to 0.796)compared with the C-index values of the AJCC 8^(th)(0.718),T(0.683),N(0.726)and that of the testing set(0.726[95%CI,0.684 to 0.767]),which were significant higher than the C-index values of the TNM system.The calibration curve for probability of survival showed good consistency between predictions made using nomogram compared with actual observations.The survival curves showed significant differences between-high,middle-,and low-risk groups.Conclusion We constructed a more accurate and comprehensive nomogram to predict the prognosis of gastric cancer after surgery,which may serve as a potential tool to guide personalized treatment.展开更多
文摘Objective:To evaluate the effect of the case management model on patients operated for pancreatic cancer.Methods:90 pancreatic cancer surgery patients admitted to the hospital between January 2022 and June 2023 were selected and grouped by randomized numerical table.For 45 cases in the observation group,case management mode was adopted,and for 45 cases in the intervention group,conventional nursing care was chosen to compare the indexes of gastrointestinal function recovery.Results:The recovery time of all gastrointestinal functions of the observation group was shorter than that of the intervention group;after nursing,the psychological state score of the observation group was lower than that of the intervention group,the self-efficacy score was higher than that of the intervention group and the rate of complications was lower than that of the intervention group(P<0.05).Conclusion:The case management model can promote the recovery of gastrointestinal function in patients with pancreatic cancer surgery and its nursing feasibility is high.
文摘Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(aged 19-90 years;male 72,female 56).The sera were analyzed for HbA_(1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C).According to the HbA_(1e) level,the patients were divided into three groups,group A(HbA_(?)<7%,n=31),group B(7%<HbA_(1c)<10%,n=48),and group C(HbA_(1c)>10%,n=49).The correlation of HbA_(1c)with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA(1c),LDL-C had a significantly increasing trend(P<0.05);whereas TC went up with the increased HbA(1c),without any significant differences between three groups.There was no significant correlation between HbA_(1c) and TG or HDL-C. With the increased level of HbA_(1c),TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups(P<0.05).The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.
基金supported by the National Natural Science Foundation of China (U21A20182, 31972507)the Science and Technology Major Project of Heilongjiang Province (2021ZXJ03B05)the Graduate Innovation Fund of Harbin Normal University (HSDBSCX2021-106)。
文摘Alfalfa(Medicago sativa L.) is one of the most extensively grown leguminous forage worldwide.Environmental saline-alkali stress significantly influences the growth,development,and yield of alfalfa,posing a threat to its agricultural production.However,little is known about the potential mechanisms by which alfalfa responds to saline-alkali stress.Here,we investigated these mechanisms by cloning a saline-alkali-induced flavonol synthase gene(Ms FLS13) from alfalfa,which was previously reported to be significantly upregulated under saline-alkali stress,and examining its function in the saline-alkali response.Overexpression of Ms FLS13 in alfalfa promoted plant tolerance to saline-alkali stress by enhancing flavonol accumulation,antioxidant capacity,osmotic balance,and photosynthetic efficiency.Conversely,Ms FLS13 inhibition using RNA interference reduced flavonol synthase activity and inhibited hairy root growth under saline-alkali stress.Yeast one-hybrid and dual-luciferase reporter assays indicated that the R2R3-MYB Ms MYB12 transcription factor activates Ms FLS13 expression by binding to the MBS motif in the Ms FLS13 promoter.Further analysis revealed that abscisic acid mediates the salinealkali stress response partially by inducing Ms MYB12 and Ms FLS13 expression,which consequently increases flavonol levels and maintains antioxidant homeostasis in alfalfa.Collectively,our findings highlight the crucial role of Ms FLS13 in alfalfa in response to saline-alkali stress and provide a novel genetic resource for creating saline-alkali-resistant alfalfa through genetic engineering.
基金financially supported by the Key Project of the Chinese Academy of Sciences[grant number KZZD-EW-08]the consulting project"Strategy Study on the Ecological Function and Food Security Maintenance of Grassland in China"of the Chinese Academy of Engineeringsupported by the "Strategy and Policies on Environment and Development in Western China" project of "China Council for International Cooperation on Environment and Development(CCICED)."
文摘For making rational and scientific land-use planning,an inventory indicator of land productivity subject to biophysical limitations and human disturbance is required.This study introduces agricultural land productivity(ALP)as the dynamic indicator to measure land productivity,involving factors that affect agricultural production,such as characteristics of climate,soil,and terrain.As a case study of this dynamic indicator,ALP was estimated at county level and aggregated into provincial level in the whole of China.The result shows that ALP increased during 2000-2010 in China,and the ratios of ALP to the actual grain yield were 65.40%and 66.38%in the years 2000 and 2005,respectively.The ALP is an effective dynamic indicator to estimate the land productivity and to represent the basic conditions about the supply of water,energy,nutrients,and the physical basis for plant growth,as well as the local input.ALP estimation could provide supporting information for policy-making about land production planning and land-use management.
基金supported by the National Key R&D Program of China(2021YFD1201601,2016YFD0100201,2020YFE0202300)the National Natural Science Foundation of China(32072091)+2 种基金the Platform of National Crop Germplasm Resources of China(2016-004,2017-004,2018-004,2019-04,2020-05)the Crop Germplasm Resources Protection(2016NWB036-05,2017NWB036-05,2018NWB03605,2019NWB036-05)the Agricultural Science and Technology Innovation Program(ASTIP)of Chinese Academy of Agricultural Sciences(CAASZDRW202109)。
文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding.
基金This work was supported by the National Natural Science Foundation of China(51702203,51772182,21471093)the Program for Key Science&Technology Innovation Team of Shaanxi Province(2012KCT-21),the 111 Project(B14041)the Fundamental Research Funds for the Central Universities(GK201501007).
文摘Black phosphorus(BP),especially for BP nanosheets,with unique layered structure among two dimensional(2D)materials has attracted much attention due to its outstanding physical properties,such as ultra-high mobility,in-plane anisotropic properties.However,the small horizontal-size of reported BP limits its applications in the integrated circuit or some functional devices.In this work,a solvothermalassisted liquid-phase exfoliation technique is firstly employed for preparing large size and high-quality BP nanosheets.In the high-polar acetonitrile solvent,solvothermal treatment weakens the Van der Waals forces of block BP.Together with the subsequently ultrasonic processing,effective exfoliation of large size and high-quality BP nanosheets are realized.The TEM,AFM and Raman results indicate that the prepared BP nanosheets are high quality with an average thickness of about 2 nm,and the horizontalsize is up to 10μm.This facile and effective method for exfoliated BP nanosheets provides a promising strategy for the exfoliation of other 2D materials.
基金supported by the National Natural Science Foundation of China (32090063 to Y.C.)the National Key R&D Program of China (2016YFD0100702 to Y.C.)+1 种基金the Natural Science Foundation of Hubei Province (2020CFA008 to Y.C.)a Fundamental Research Fund for the Central Universities (2662022SKYJ002 to Y.C.)。
文摘Nodulation Receptor Kinase(NORK) functions as a co-receptor of Nod factor receptors to mediate rhizobial symbiosis in legumes, but its direct phosphorylation substrates that positively mediate root nodulation remain to be fully identified.Here, we identified a GmNORK-Interacting Small Protein(GmNISP1) that functions as a phosphorylation target of GmNORK to promote soybean nodulation. GmNORKα directly interacted with and phosphorylated GmNISP1. Transcription of GmNISP1 was strongly induced after rhizobial infection in soybean roots and nodules. GmNISP1 encodes a peptide containing 90 amino acids with a “DY” consensus motif at its N-terminus.GmNISP1 protein was detected to be present in the apoplastic space. Phosphorylation of GmNISP1 by GmNORKα could enhance its secretion into the apoplast. Pretreatment with either purified GmNISP1 or phosphorylation-mimic GmNISP1~(12D) on the roots could significantly increase nodule numbers compared with the treatment with phosphorylation-inactive GmNISP1~(12A).The data suggested a model that soybean GmNORK phosphorylates GmNISP1 to promote its secretion into the apoplast, which might function as a potential peptide hormone to promote root nodulation.
基金financially supported by the National Natural Science Foundation of China(Nos.51771201,52071124)the Key Project of Natural Science Foundation of Hebei(No.E2021202135)+2 种基金the Key Project of Natural Science Foundation of Tianjin(No.20JCZDJC00440)the Central Funds Guiding the Local Science and Technology Development of Hebei Province(No.226Z1001G and 226Z1012G)the Open Research Fund from the State Key Laboratory of Rolling and Automation,Northeastern University,Grant No.:2020RALKFKT002。
文摘The nanolaminated materials generally exhibit poor plasticity due to the fast onset of shear instability.Engineering interface structure is an eff ective approach for enhancing plasticity via postponing or suppressing the shear instability.Here,we introduce 4 nm thick CuNb 3D amorphous interface layers and Nb 3D crystalline interface layers in Cu nanolaminated materials,respectively.In situ micro-pillar compression tests show that samples with crystalline interface layers exhibit shear instability,while the samples with amorphous interface layers display uniform deformation.Since the plastic deformation of the singlecrystal crystalline interface layer is anisotropic,except for well-aligned slip systems,dislocations on other slip systems have a poor ability to transmit the 3D crystalline interface layer,leading to localized dislocations pileups and shear instability.In contrast,the amorphous interface layer which is plastically isotropic accommodates dislocations from arbitrary slip systems of the matrix,which can alleviate the stress concentrations at the interface,and thus suppresses the shear instability.
基金This study was financially supported by the National Natural Science Foundation of China(No.51679225)National Natural Sci ence Science Foundation of China(No.51706214),and China Scholarship Council.
文摘In this study,an inverse-problem method was applied to estimate the solid concentration in a solid-liquid two-phase flow.An algebraic slip mixture model was introduced to solve the forward problem of solid-liquid convective heat transfer.The time-average conservation equations of mass,momentum,energy,as well as the volume fraction equation were computed in a computational fluid dynamics(CFD)simulation.The solid concentration in the CFD model was controlled using an external program that included the inversion iteration,and an optimal estimation was performed via experimental measurements.Experiments using a fly-ash-water mixture and sand-water mixture with different solid concentrations in a horizontal pipeline were conducted to verify the accuracy of the inverse-problem method.The estimated results were rectified using a method based on the relationship between the estimated results and estimation error;consequently,the accuracy of the corrected inversion results improved significantly.After a verification through experiments,the inverse-problem method was concluded to be feasible for predicting the solid concentration,as the estimation error of the corrected results was within 7%for all experimental samples for a solid concentration of less than 50%.The inverse-problem method is expected to provide accurate predictions of the solid concentration in solid-liquid two-phase flow systems.
基金This work is supported by One Hundred Talents Project of Chinese Academy of Sciences(2006)(26010701)by Knowledge Innovation Project of Chinese Academy of Sciences(KJCX2-SW-N13)by the National Natural Science Foundation of China(10675156).
文摘The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a set of programs to facilitate the study of interactions between a circularly polarized laser and atomic hydrogen.These programs included only contribution from the bound states of the hydrogen atom.However,as the laser intensity increases,contribution from continuum states to the excitation and ionization processes becomes larger and can no longer be neglected.Furthermore,because the original code is not able to add this contribution directly due to its many disadvantages,a major upgrade of the code is required before including the contribution from continuum states in future.In this paper,first we deduce some important formulas for contribution of continuum states and present modifications and tests for the upgraded code in detail.Second we show some comparisons among new results,old results from the original codes and the available experimental data.Overall the new result agrees with experimental data well.Last we present our calculation of above-threshold ionization(ATI)rate and compare it with a pertubative calculation.The comparison shows that our nonperturbative calculation can also produce ATI peak suppression.
基金The Science and Technology Commission of Shanghai Municipality(21Y11913100)Shanghai Municipal Health Commission(20204Y0416)funded this research.
文摘Objective To establish an effective prognostic nomogram for patients with gastric cancer after radical gastrectomy.Methods In the present study,we retrospectively analyzed the records of 1635 patients with gastric cancer treated at Changhai Hospital from January 2014 to December 2019.Final independent prognostic factors of overall survival to build a nomogram were screened using univariate and multivariate analyses.The predictive accuracy and discriminating ability of the nomogram were determined using the concordance index(C-index)and calibration curves.The results were validated using bootstrap resampling of 701 patients.The survival curves for low-,middle-,and high-risk patients were used to evaluate the accuracy of the nomogram.Results Multivariate analysis of the primary cohort revealed independent factors for survival as follows:age,sex,body mass index(BMI),depth of tumor invasion(T),lymph node metastasis(N),perineural invasion(PNI),tumor deposits,Alpha fetoprotein(AFP),and lactate dehydrogenase(LDH).Combining these predictors in the nomogram achieved powerful prognostic ability in the training and test sets.The C-index of the training set was 0.772(95%CI,0.748 to 0.796)compared with the C-index values of the AJCC 8^(th)(0.718),T(0.683),N(0.726)and that of the testing set(0.726[95%CI,0.684 to 0.767]),which were significant higher than the C-index values of the TNM system.The calibration curve for probability of survival showed good consistency between predictions made using nomogram compared with actual observations.The survival curves showed significant differences between-high,middle-,and low-risk groups.Conclusion We constructed a more accurate and comprehensive nomogram to predict the prognosis of gastric cancer after surgery,which may serve as a potential tool to guide personalized treatment.