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Reduced-order method for nuclear reactor primary circuit calculation
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作者 Ze-Long Zhao Ya-Hui Wang +2 位作者 zhe-xian liu Hong-Hang Chi Yu Ma 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第11期28-45,共18页
Accurate real-time simulations of nuclear reactor circuit systems are particularly important for system safety analysis and design.To effectively improve computational efficiency without reducing accuracy,this study e... Accurate real-time simulations of nuclear reactor circuit systems are particularly important for system safety analysis and design.To effectively improve computational efficiency without reducing accuracy,this study establishes a thermal-hydraulics reduced-order model(ROM)for nuclear reactor circuit systems.The full-order circuit system calculation model is first established and verified and then used to calculate the thermal-hydraulic properties of the circuit system under different states as snapshots.The proper orthogonal decomposition method is used to extract the basis functions from snapshots,and the ROM is constructed using the least-squares method,effectively reducing the difficulty in constructing the ROM.A comparison between the full-order simulation and ROM prediction results of the AP1000 circuit system shows that the proposed ROM can improve computational efficiency by 1500 times while achieving a maximum relative error of 0.223%.This research develops a new direction and perspective for the digital twin modeling of nuclear reactor system circuits. 展开更多
关键词 Reactor system model Primary circuit Reduced-order Proper orthogonal decomposition Least-squares method
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Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma 被引量:3
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作者 Ji-Bin Li zhe-xian liu +6 位作者 Rui Zhang Si-Ping Ma Tao Lin Yan-Xi Li Shi-Hua Yang Wan-Chuan Zhang Yong-Peng Wang 《World Journal of Gastroenterology》 SCIE CAS 2019年第22期2776-2787,共12页
BACKGROUND Aberrant expression of stanniocalcin 2 (STC2) is implicated in colon adenocarcinoma (COAD). A previous study identified that STC2 functions as a tumor promoter to drive development of some cancers, but the ... BACKGROUND Aberrant expression of stanniocalcin 2 (STC2) is implicated in colon adenocarcinoma (COAD). A previous study identified that STC2 functions as a tumor promoter to drive development of some cancers, but the role of its overexpression in the development of COAD remains unclear. AIM To evaluate the regulation mechanism of STC2 overexpression in COAD. METHODS The expression of STC2 in COAD was assessed by TCGA COAD database and GEO (GSE50760). Methylation level of the STC2 promoter was evaluated with beta value in UALCAN platform, and the correlation between STC2 expression and survival rate was investigated with TCGA COAD. Transcription binding site prediction was conducted by TRANSFAC and LASAGNA, and a luciferase reporter system was used to identify STC2 promoter activity in several cell lines, including HEK293T, NCM460, HT29, SW480, and HCT116. Western blotting was performed to evaluate the role of Sp1 on the expression of STC2. RESULTS The central finding of this work is that STC2 is overexpressed in COAD tissues and positively correlated with poor prognosis. Importantly, the binding site of the transcription factor Sp1 is widely located in the promoter region of STC2. A luciferase reporter system was successfully constructed to analyze the transcription activity of STC2, and knocking down the expression of Sp1 significantly inhibited the transcription activity of STC2. Furthermore, inhibition of Sp1 remarkably decreased protein levels of STC2. CONCLUSION Our data provide evidence that the transcription factor Sp1 is essential for the overexpression of STC2 in COAD through activation of promoter activity. Taken together, our finding provides new insights into the mechanism of oncogenic function of COAD by STC2. 展开更多
关键词 Transcription factor SP1 STANNIOCALCIN 2 OVEREXPRESSION Promoter activity COLON ADENOCARCINOMA
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