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Experimental investigation on shear strength deterioration at the interface between different rock types under cyclic loading
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作者 Qiong Wu Zhiqi Liu +6 位作者 Huiming Tang Liangqing Wang Xiaoxue Huo zhen cui Shiyu Li Bo Zhang Zhiwei Lin 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期3063-3079,共17页
The shear strength deterioration of bedding planes between different rock types induced by cyclic loading is vital to reasonably evaluate the stability of soft and hard interbedded bedding rock slopes under earthquake... The shear strength deterioration of bedding planes between different rock types induced by cyclic loading is vital to reasonably evaluate the stability of soft and hard interbedded bedding rock slopes under earthquake;however,rare work has been devoted to this subject due to lack of attention.In this study,experimental investigations on shear strength weakening of discontinuities with different joint wall material(DDJM)under cyclic loading were conducted by taking the interface between siltstone and mudstone in the Shaba slope of Yunnan Province,China as research objects.A total of 99 pairs of similar material samples of DDJM(81 pairs)and discontinuities with identical joint wall material(DIJM)(18 pairs)were fabricated by inserting plates,engraved with typical surface morphology obtained by performing three-dimensional laser scanning on natural DDJMs sampled from field,into mold boxes.Cyclic shear tests were conducted on these samples to study their shear strength changes with the cyclic number considering the effects of normal stress,joint surface morphology,shear displacement amplitude and shear rate.The results indicate that the shear stress vs.shear displacement curves under each shear cycle and the peak shear strength vs.cyclic number curves of the studied DDJMs are between those of DIJMs with siltstone and mudstone,while closer to those of DIJMs with mudstone.The peak shear strengths of DDJMs exhibit an initial rapid decline followed by a gradual decrease with the cyclic number and the decrease rate varies from 6%to 55.9%for samples with varied surface morphology under different testing conditions.The normal stress,joint surface morphology,shear displacement amplitude and shear rate collectively influence the shear strength deterioration of DDJM under cyclic shear loading,with the degree of influence being greater for larger normal stress,rougher surface morphology,larger shear displacement amplitude and faster shear rate. 展开更多
关键词 Discontinuities with different joint wall material(DDJM) Discontinuities with identical joint wall material(DIJM) Cyclic shear test Shear strength deterioration Joint surface morphology Shear displacement amplitude Shear rate Normal stress
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Aseismic performances of constrained damping lining structures made of rubber-sand-concrete
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作者 Xiancheng Mei Qian Sheng +4 位作者 Jian Chen zhen cui Jianhe Li Chuanqi Li Daniel Dias 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第5期1522-1537,共16页
Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering structures.In this study,a constrained damping structure for underground tunnel lining,using ... Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering structures.In this study,a constrained damping structure for underground tunnel lining,using a rubber-sand-concrete(RSC)as the aseismic material,is proposed.The aseismic performances of constrained damping structure were investigated by a series of hammer impact tests.The damping layer thickness and shape effects on the aseismic performance such as effective duration and acceleration amplitude of time-domain analysis,composite loss factor and damping ratio of the transfer function analysis,and total vibration level of octave spectrum analysis were discussed.The hammer impact tests revealed that the relationship between the aseismic performance and damping layer thickness was not linear,and that the hollow damping layer had a better aseismic performance than the flat damping layer one.The aseismic performances of constrained damping structure under different seismicity magnitudes and geological conditions were investigated.The effects of the peak ground acceleration(PGA)and tunnel overburden depth on the aseismic performances such as the maximum principal stress and equivalent plastic strain(PEEQ)were discussed.The numerical results show the constrained damping structure proposed in this paper has a good aseismic performance,with PGA in the range(0.2-1.2)g and tunnel overburden depth in the range of 0-300 m. 展开更多
关键词 Constrained damping structure Aseismic performance Hammer impact tests Damping layer Peak ground acceleration Overburden depth
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Simulation of transport mechanism of radium isotopes in aquifer on the southern coast of Laizhou Bay
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作者 Yancheng Wang Guangquan Chen +7 位作者 Hongjun Yu Xingyong Xu Yinqiao Zou Wenqing Zhao Weitao Han Wenzhe Lyu zhen cui Runtian Ding 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第8期40-48,共9页
Naturally occurring radium(^(223)Ra,^(224)Ra,^(226)Ra,and^(228)Ra)isotopes have been widely applied as geochemical tracers in marine environments,especially when estimating the submarine groundwater discharge(SGD).In ... Naturally occurring radium(^(223)Ra,^(224)Ra,^(226)Ra,and^(228)Ra)isotopes have been widely applied as geochemical tracers in marine environments,especially when estimating the submarine groundwater discharge(SGD).In this sense,the influencing factors and transport mechanism of radium isotope activity in aquifers can be key information for SGD estimation.This work evaluates the adsorption/desorption behavior of^(224)Ra and^(226)Ra in the solid-liquid phase through a leaching experiment and analysis of field data.The results suggested that radium isotope activity was positively correlated with salinity and grain size,in the case of abundant sediments.Through ion analysis,we found that the ions(Na^(+),Ca^(2+),Mg^(2+),and Ba^(2+))exchanged with radium isotopes in the process of transport.A 1-D reactive transport model was established to simulate the transport process of radium isotope in aquifers.The model successfully simulated the variation of radium isotope desorption activity with salinity and was subsequently verified in the field.This study contributes to the understanding of the geochemical behavior of radium isotopes in aquifers and provides guidance for selecting a suitable groundwater endmember in SGD estimation. 展开更多
关键词 RADIUM adsorption/desorption behavior leaching experiment reactive transport model coastal aquifer Laizhou Bay
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Variational Gridded Graph Convolution Network for Node Classification 被引量:3
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作者 Xiaobin Hong Tong Zhang +1 位作者 zhen cui Jian Yang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第10期1697-1708,共12页
The existing graph convolution methods usually suffer high computational burdens,large memory requirements,and intractable batch-processing.In this paper,we propose a high-efficient variational gridded graph convoluti... The existing graph convolution methods usually suffer high computational burdens,large memory requirements,and intractable batch-processing.In this paper,we propose a high-efficient variational gridded graph convolution network(VG-GCN)to encode non-regular graph data,which overcomes all these aforementioned problems.To capture graph topology structures efficiently,in the proposed framework,we propose a hierarchically-coarsened random walk(hcr-walk)by taking advantage of the classic random walk and node/edge encapsulation.The hcr-walk greatly mitigates the problem of exponentially explosive sampling times which occur in the classic version,while preserving graph structures well.To efficiently encode local hcr-walk around one reference node,we project hcrwalk into an ordered space to form image-like grid data,which favors those conventional convolution networks.Instead of the direct 2-D convolution filtering,a variational convolution block(VCB)is designed to model the distribution of the randomsampling hcr-walk inspired by the well-formulated variational inference.We experimentally validate the efficiency and effectiveness of our proposed VG-GCN,which has high computation speed,and the comparable or even better performance when compared with baseline GCNs. 展开更多
关键词 Graph coarsening GRIDDING node classification random walk variational convolution
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Mechanical characteristics of composite honeycomb sandwichstructures under oblique impact
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作者 Yuechen Duan zhen cui +3 位作者 Xin Xie Ying Tie Ting Zou Tingting Wang 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2022年第5期359-370,共12页
Carbon fiber reinforced polymer(CFRP)and CFRP-based composite honeycomb sandwich structures are particularly sensitive to impact.The mechanical characteristics of composite honeycomb sandwich structures under oblique ... Carbon fiber reinforced polymer(CFRP)and CFRP-based composite honeycomb sandwich structures are particularly sensitive to impact.The mechanical characteristics of composite honeycomb sandwich structures under oblique impact are studied by numerical simulation and experiment.The oblique impact model is established,and the reliability of the model is verified by the oblique impact test.To further analyze the influence of structural parameters on energy absorption under oblique impact,the influence of impact angle,face sheet thickness and wall thickness of the honeycomb is numerically studied.The results show that the impact angle has an important effect on energy distribution.The structural parameters also have an effect on the peak contact force,contact time,and energy absorption,and the effect is different from normal impact due to the presence of frictional dissipation energy.Compared with normal impact,the debonding of oblique impact will be reduced,but the buckling range of the honeycomb core will be expanded. 展开更多
关键词 Composite sandwich structures HONEYCOMB Oblique impact Mechanical characteristics Energy absorption
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Fish Behavior Analysis Based on Computer Vision: A Survey
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作者 Yizhi Zhou Hong Yu +2 位作者 Junfeng Wu zhen cui Fangyan Zhang 《国际计算机前沿大会会议论文集》 2019年第2期139-141,共3页
Fish behavior refers to various movements of fish. Fish behavior is closely related to the ecology of fish, physiological changes of fish, aquaculture and so on. Related applications will be expanded if fish behavior ... Fish behavior refers to various movements of fish. Fish behavior is closely related to the ecology of fish, physiological changes of fish, aquaculture and so on. Related applications will be expanded if fish behavior is analyzed properly. Traditional analysis of fish behavior mainly relies on the observation of human eyes. With the deepening and extension of application and the rapid development of computer technology, computer vision technology is increasingly used to analyze fish behaviors. This paper summarized the research status, research progress and main problems of fish behavior analysis by using computer vision and made forecast about future research. 展开更多
关键词 FISH behaviour ANALYSIS COMPUTER VISION FISH BEHAVIORS monitoring
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Underwater Image Saliency Detection Based on Improved Histogram Equalization
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作者 zhen cui Junfeng Wu +2 位作者 Hong Yu Yizhi Zhou Liang Liang 《国际计算机前沿大会会议论文集》 2019年第2期163-165,共3页
In order to solve the problem of unsatisfactory detection effect of underwater visual saliency map, an image saliency detection algorithm based on improved histogram equalization is proposed. Underwater images are oft... In order to solve the problem of unsatisfactory detection effect of underwater visual saliency map, an image saliency detection algorithm based on improved histogram equalization is proposed. Underwater images are often not clear enough because the refraction of light underwater causes insufficient image resolution. Therefore, in order to solve the existing problems of traditional histogram equalization algorithm, an improved histogram equalization method is proposed to enhance the quality of images, which makes the saliency regions smoother and clearer. In this paper, the simulation experiments were conducted on UIEBD dataset and DLOU_underwater dataset. The experimental results show the effectiveness, robustness and accuracy of the proposed algorithm. 展开更多
关键词 UNDERWATER IMAGE HISTOGRAM EQUALIZATION SALIENCY EXTRACTION
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A DNA micro-complex containing polyaptamer for exosome separation and wound healing
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作者 Jingwen Zhao Jianpu Tang +3 位作者 zhen cui Limin Liu Dayong Yang Chi Yao 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第9期257-261,共5页
Exosomes(EXOs)have showed great potential in regenerative medicine.The separation of EXOs from complex biological media is essential for the down-stream applications.Herein,we report a deoxyribonucleic acid(DNA)-based... Exosomes(EXOs)have showed great potential in regenerative medicine.The separation of EXOs from complex biological media is essential for the down-stream applications.Herein,we report a deoxyribonucleic acid(DNA)-based micro-complex(DMC)containing polyaptamers,which realized the specific separation of EXOs from cell culture media and the significant promotion of wound healing.The synthesis of DMCs was based on a biomineralization process via rolling circle amplification(RCA)under the catalysis of phi29 DNA polymerase.To endow DMCs with the ability to capture EXOs,the DNA template of RCA was integrated with complementary sequence of aptamer that specifically recognized the CD63 proteins on EXOs.The obtained DMCs contained polyaptamers that can specifically capture the EXOs in cell culture media.The EXOs-capturing DMCs were collected by centrifugation,achieving the separation of EXOs.Mesenchymal stem cell(MSC)-derived EXOs(MSC-EXOs)were separated by this DMC-based strategy,and the separated MSC-EXOs significantly enhanced the migration ability of cells.In particular,the significant therapeutic efficacy of the DMCs with MSC-EXOs was verified in full-thickness wound excision mouse models,in which the wounds completely healed in 10 days.We envision that this DMC-based separation strategy can be a promising route to promote the development of EXOs in biomedicine. 展开更多
关键词 DNA nanotechnology DNA materials APTAMER EXOSOMES Wound healing
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Experimental study on the effect of flexible joints of a deep-buried tunnel across an active fault under high in-situ stress conditions
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作者 Jiawei Zhang zhen cui +2 位作者 Qian Sheng Wanhua Zhao Liang Song 《Underground Space》 SCIE EI CSCD 2024年第6期189-207,共19页
During dislocation,a tunnel crossing the active fault will be damaged to varying degrees due to its permanent stratum displacement.Most previous studies did not consider the influence of the tunnel’s deep burial and ... During dislocation,a tunnel crossing the active fault will be damaged to varying degrees due to its permanent stratum displacement.Most previous studies did not consider the influence of the tunnel’s deep burial and the high in-situ stress,so the results were not entirely practical.In this paper,the necessity of solving the anti-dislocation problem of deep-buried tunnels is systemically discussed.Through the model test of tunnels across active faults,the differences in failures between deep-buried tunnels and shallow-buried tunnels were compared,and the dislocation test of deep-buried segmental tunnels was carried out to analyze the external stress change,lining strain,and failure mode of tunnels.The results are as follows.(1)The overall deformation of deep-buried and shallow-buried tunnels is both Sshaped.The failure mode of deep-buried tunnels is primarily characterized by shear and tensile failure,resulting in significant compressive deformation and a larger damaged area.In contrast,shallow-buried tunnels mainly experience shear failure,with the tunnel being sheared apart at the fault crossing,leading to more severe damage.(2)After the segmental structure design of the deep-buried tunnel,the‘‘S”deformation pattern is transformed into a‘‘ladder”pattern,and the strain of the tunnel and the peak stress of the external rock mass are reduced;therefore,damages are significantly mitigated.(3)Through the analysis of the distribution of cracks in the tunnel lining,it is found that the tunnel without a segmental structure design has suffered from penetrating failure and that cracks affect the entire lining.The cracks in a flexible segmental tunnel affect about 66.6%of the entire length of the tunnel,and cracks in a tunnel with a short segmental tunnel only affect about 33.3%of the entire length of the tunnel.Therefore,a deep-buried tunnel with a short segmental tunnel can yield a better anti-dislocation effect.(4)By comparing the shallow-buried segmental tunnel in previous studies,it is concluded that the shallow-buried segmental tunnel will also suffer from deformation outside the fault zone,while the damages to the deep-buried segmental tunnel are concentrated in the fault zone,so the anti-dislocation protection measures of the deep-buried tunnel shall be provided mainly in the fault zone.The results of the above study can provide theoretical reference and technical support for the design and reinforcement measures of the tunnel crossing active fault under high in-situ stress conditions. 展开更多
关键词 Tunnel project Crossing active fault High in-situ stress Segmental structure design Flexible joint
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IDDoR:a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways 被引量:1
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作者 Yu Chen zhen cui +2 位作者 Zhixi Chen Ying Jiang Zhiyong Mao 《Protein & Cell》 SCIE CSCD 2023年第5期369-375,共7页
Dear Editor,Two distinct pathways,non-homologous end joining(NHEJ)and homologous recombination(HR)repair,have evolved to repair DNA double-strand breaks(DSBs),the most deleterious type of DNA damage.Impaired NHEJ and ... Dear Editor,Two distinct pathways,non-homologous end joining(NHEJ)and homologous recombination(HR)repair,have evolved to repair DNA double-strand breaks(DSBs),the most deleterious type of DNA damage.Impaired NHEJ and HR are often associated with a high incidence of tumorigenesis and the early onset of aging.A number of methods and tools have been developed to help elucidate the regulatory mechanisms of the two repair pathways in the past.In vitro biochemical assays employ 32P-labeled broken DNA fragments and cell extracts to evaluate DSB repair capacity.At DSB sites,several DSB repair factors form foci,which can be visualized through immunofluorescence and microscopy.Among them,phosphorylated H2AX at the Ser139 residue is often considered a DSB marker,and its formation and removal at different time points post the induction of DSBs can be used to reflect the repair capacity and genomic instability.In addition,by quantifying the kinetics of the recruitment of specific NHEJ and HR factors such as 53BP1,DNA-PKcs,MRE11,RPA2,and RAD51,one would be able to make judgments on whether NHEJ,HR,or both pathways is/are affected and sometimes at which steps DSB repair pathways are regulated.An alternative approach for kinetic analysis is to quantify the microirradiation-induced recruitment of repair factors.Moreover,comet assays are also utilized to measure DNA damage-induced genomic stability at the single-cell level.However,with these assays,it is still difficult to measure NHEJ and HR efficiency in a relatively less time-consuming and more quantitative manner. 展开更多
关键词 double REPAIR SIMULTANEOUS
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Comparing T-and B-cell responses to COVID-19 vaccines across varied immune backgrounds
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作者 zhen cui Wenxin Luo +13 位作者 Ruihong Chen Yalun Li Zhoufeng Wang Yong Liu Shuo Liu LeiLei Feng Zijing Jia Ruixin Cheng Jun Tang Weijin Huang Yanjun Zhang Huawen Liu Xiangxi Wang Weimin Li 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第6期3029-3038,共10页
The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide.A recent analysis of immune responses in people who received inactivated vaccines has revealed that ind... The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide.A recent analysis of immune responses in people who received inactivated vaccines has revealed that individuals with no prior infection have limited resistance to Omicron and its sub-lineages,while those with previous infections exhibit a significant amount of neutralizing antibodies and memory B cells.However,specific T-cell responses remain largely unaffected by the mutations,indicating that T-cell-mediated cellular immunity can still provide protection.Moreover,the administration of a third dose of vaccine has resulted in a marked increase in the spectrum and duration of neutralizing antibodies and memory B cells in vivo,which has enhanced resistance to emerging variants such as BA.2.75 and BA.2.12.1.These results highlight the need to consider booster immunization for previously infected individuals and the development of novel vaccination strategies.The rapid spread of adapted variants of the SARS-CoV-2 virus presents a significant challenge to global health.The findings from this study underscore the importance of tailoring vaccination strategies based on individual immune backgrounds and the potential need for booster shots to combat emerging variants.Continued research and development are crucial to discovering new immunization strategies that will effectively protect public health against the evolving virus. 展开更多
关键词 vaccines IMMUNITY adapted
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D DT Theorem over square-free numbers in short interval 被引量:2
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作者 Bin FENG zhen cui 《Frontiers of Mathematics in China》 SCIE CSCD 2017年第2期367-375,共9页
We study the Cesaro means related to the divisor function. We show that the DDT Theorem holds over square-free numbers in short interval, which generalizes some results established by Deshouillers-Dress-Tenenbaum and ... We study the Cesaro means related to the divisor function. We show that the DDT Theorem holds over square-free numbers in short interval, which generalizes some results established by Deshouillers-Dress-Tenenbaum and by Cui-Wu. 展开更多
关键词 Selberg-Delang method arcsine law square-free number
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The Selberg-Delange method in short intervals with some applications 被引量:1
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作者 zhen cui Guangshi Lü Jie Wu 《Science China Mathematics》 SCIE CSCD 2019年第3期447-468,共22页
In this paper, we establish a quite general mean value result of arithmetic functions over short intervals with the Selberg-Delange method and give some applications. In particular, we generalize Selberg's result ... In this paper, we establish a quite general mean value result of arithmetic functions over short intervals with the Selberg-Delange method and give some applications. In particular, we generalize Selberg's result on the distribution of integers with a given number of prime factors and Deshouillers-Dress-Tenenbaum's arcsin law on divisors to the short interval case. 展开更多
关键词 ASYMPTOTIC results on ARITHMETIC FUNCTIONS Selberg-Delange METHOD ARITHMETIC FUNCTIONS distribution of INTEGERS
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Fish Density Estimation with Multi-Scale Context Enhanced Convolutional Neural Network 被引量:2
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作者 Yizhi Zhou Hong Yu +3 位作者 Junfeng Wu zhen cui Hongshuai Pang Fangyan Zhang 《Journal of Communications and Information Networks》 CSCD 2019年第3期80-88,共9页
With the development of fishery industry,accurate estimation of the number of fish in aquaculture waters is of great importance to fish behavior analysis,bait feeding and fishery resource investigation.In this paper,w... With the development of fishery industry,accurate estimation of the number of fish in aquaculture waters is of great importance to fish behavior analysis,bait feeding and fishery resource investigation.In this paper,we propose a method for fish density estimation based on the multi-scale context enhanced convolutional network,which could map a fish school image taken at any angle to a density map,and calculate the number of fish in the image finally.In order to eliminate the influence of camera perspective effect and image resolution on density estimation,multi-scale filters are utilized in a convolutional neural network to process fish image in parallel.And then,the context enhancement module is merged in the network structure to help the network understand the global context information of the image.Finally,different feature maps are merged together to construct the density map of fish school images,and finally get the number of fish in the image.In order to make the effectiveness of our method valid,we test the proposed method on DlouDataset.The results show that the proposed method has lower mean square error and mean absolute error,which is helpful to improve the accuracy of the fish counting in dense fish school images. 展开更多
关键词 fish counting density estimation neural network context enhancement module
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A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters 被引量:1
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作者 Xiao-Feng Li zhen cui +17 位作者 Hang Fan Qi Chen Lei Cao Hong-Ying Qiu Na-Na Zhang Yan-Peng Xu Rong-Rong Zhang Chao Zhou Qing Ye Yong-Qiang Deng Yan Guo Si Qin Kaiyue Fan Lei Wang Zijing Jia Yujun cui Xiangxi Wang Cheng-Feng Qin 《The Innovation》 2022年第2期126-135,共10页
The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being us... The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being used to generate safe and effective COVID-19 vaccines.Here,we generated a live-attenuated candidate vaccine strain by serial passaging of a SARSCoV-2 clinical isolate in Vero cells. 展开更多
关键词 VACCINE ATTENUATED INFECTION
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On Sums of Sparse Prime Subsets
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作者 zhen cui Hong Ze LI Bo Qing XUE 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2013年第8期1535-1542,共8页
For arbitrary c00, if A is a subset of the primes less than x with cardinality δx(logx)-1, δ≥(logx)-c0, then there exists a positive constant c such that the cardinality of A+A is larger than cδx(loglogx)-1.
关键词 Density SUBSETS subsets of the primes circle method sifted numbers
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Fusing magnitude and phase features with multiple face models for robust face recognition 被引量:1
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作者 Yan LI Shiguang SHAN +2 位作者 Ruiping WANG zhen cui Xilin CHEN 《Frontiers of Computer Science》 SCIE EI CSCD 2018年第6期1173-1191,共19页
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超长单链DNA与茶多酚超分子组装构筑多功能水凝胶
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作者 唐建普 崔臻 +2 位作者 欧俊含 姚池 仰大勇 《高分子学报》 SCIE CAS CSCD 北大核心 2022年第10期1261-1270,共10页
为开发新的DNA组装模式、整合杂化功能模块、丰富DNA水凝胶的合成方法和功能,利用双滚环扩增策略合成了超长DNA链,通过茶多酚(TP)与DNA链间的超分子组装,构建了TP-DNA杂化水凝胶.优化了水凝胶组分,通过扫描电子显微镜、流变测试等对水... 为开发新的DNA组装模式、整合杂化功能模块、丰富DNA水凝胶的合成方法和功能,利用双滚环扩增策略合成了超长DNA链,通过茶多酚(TP)与DNA链间的超分子组装,构建了TP-DNA杂化水凝胶.优化了水凝胶组分,通过扫描电子显微镜、流变测试等对水凝胶进行表征,以此研究TP的引入对DNA水凝胶性能的影响.研究结果表明,TP的引入不仅可以调节DNA水凝胶受核酸酶降解的速率,还赋予水凝胶抑菌、促进伤口愈合的特性,在大鼠伤口模型中显著地促进伤口愈合. 展开更多
关键词 DNA水凝胶 茶多酚 抗菌 抗降解
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Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants
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作者 Xiaorui Xing Lei Wang +7 位作者 zhen cui Wangjun Fu Tao zheng Lili Qin Pingju Ge Aidong Qian Nan Wang Shuai Yuan 《Virologica Sinica》 SCIE CAS CSCD 2022年第6期938-941,共4页
Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane sur... Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein. 展开更多
关键词 ACE2 al. ACUTE
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The role of caveolae in endothelial dysfunction
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作者 Jinlong He zhen cui Yi Zhu 《Medical Review》 2021年第1期78-91,共14页
Caveolae,the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells,play critical roles in regulating various cellular processes,including cholesterol homeostasis,nitric oxide p... Caveolae,the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells,play critical roles in regulating various cellular processes,including cholesterol homeostasis,nitric oxide production,and signal transduction.Endothelial caveolae serve as a membrane platform for compartmentalization,modulation,and integration of signal events associated with endothelial nitric oxide synthase,ATP synthaseβ,and integrins,which are involved in the regulation of endothelial dysfunction and related cardiovascular diseases,such as atherosclerosis and hypertension.Furthermore,these dynamic microdomains on cell membrane are modulated by various extracellular stimuli,including cholesterol and flow shear stress.In this brief review,we summarize the critical roles of caveolae in the orchestration of endothelial function based on recent findings as well as our work over the past two decades. 展开更多
关键词 ATHEROSCLEROSIS CAVEOLAE CAVEOLIN-1 endothelial cell INTEGRIN shear stress.
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