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Magmatic-tectonic response of the South China Craton to the Paleo-Pacific subduction during the Triassic:a new viewpoint based on Well NK-1
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作者 Chan WANG Hao LIU +7 位作者 Gang LI zhen sun Tingting GONG Li MIAO Xiaowei ZHU Yunying ZHANG Weihai XU Wen YAN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期58-89,共32页
The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic transformation.To ... The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic transformation.To reveal the essence of western Paleo-Pacific subduction during the Triassic period,Well NK-1 in this block was selected for petrographic study,and published research data from other cooperative teams were compared.A double-cycle pattern of basic to neutral magmatic volcanism was established,and 36 lithological rhythmic layers and representative cryptoexplosive breccia facies and welded tuff bands were identified.Combined with a reanalysis of published geochronological data,geochemical elements,and isotope geochemistry,we found that the rock assemblages could be divided into an intermediate-acid dacite(DA)series(SiO_(2)>65%)and basaltic(BA)series(Co<40μg/g),which was formed during the early Late Triassic((218.6±3.2)–(217.9±3.5)Ma).BA exhibits obvious calc-alkaline island-arc magmatic properties:(^(87)Sr/^(86)Sr)_i ratio ranging 0.70377–0.71118(average:0.70645),^(147)Sm/^(144)Nd ratio ranging 0.119–0.193(average:0.168),and chondrite-normalized rare earth element(REE)curves being flat,while DA exhibits remarkable characteristics of subducted island-arc andesitic magma:(^(87)Sr/^(86)Sr)_i ratio(0.70939–0.71129;average:0.71035),εNd(t)value(-6.2–-4.8;average:-5.6)andε_(Hf)(t)value(-2.9–-1.7,average:-2.2)show obvious crust-mantle mixing characteristics.BA and DA reveal typical characteristics of island-arc magma systems and typeⅡenriched mantle(EM-Ⅱ)magma.BA magma was likely resulted from the process whereby the continental crust frontal accretionary wedge was driven by the Paleo-Pacific slab subduction into the deep and began to melt,resulting in a large amount of melt(fluid)joined the asthenosphere on the side of the continental margin.In contrast,DA magma was likely resulted from the process whereby the plate front was forced to bend with increasing subduction distance,which triggered the upwelling of the asthenosphere near the continent and subsequently led to the partial melting of the lithospheric mantle and lower crust due to continuous underplating.The lithospheric thinning environment in the study area at the end of Triassic created suitable conditions for the separation between the NB and SCC,which provided an opportunity for the formation of the early intracontinental rift during the later expansion of the South China Sea(SCS). 展开更多
关键词 Paleo-Pacific tectonic domain tectonic evolution rift volcanic rock Nansha Block South China Craton
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Sensitivity of Marine Controllable Source Electromagnetic Soundings for Identifying Plume Migration in Offshore CO_(2) Storage
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作者 Ning Qiu Chunwu Pan +3 位作者 Yongheng Zhang Bin Liu zhen sun Pengchun Li 《哈尔滨工程大学学报(英文版)》 CSCD 2024年第3期656-673,共18页
Offshore carbon dioxide(CO_(2)) storage is an effective method for reducing greenhouse gas emissions. However, when using traditional seismic wave methods to monitor the migration of sequestration CO_(2) plumes, the c... Offshore carbon dioxide(CO_(2)) storage is an effective method for reducing greenhouse gas emissions. However, when using traditional seismic wave methods to monitor the migration of sequestration CO_(2) plumes, the characteristics of wave velocity changes tend to become insignificant beyond a certain limit. In contrast, the controllable source electromagnetic method(CSEM) remains highly sensitive to resistivity changes. By simulating different CO_(2) plume migration conditions, we established the relevant models and calculated the corresponding electric field response characteristic curves, allowing us to analyze the CSEM's ability to monitor CO_(2) plumes. We considered potential scenarios for the migration and diffusion of offshore CO_(2) storage, including various burial depths, vertical extension diffusion, lateral extension diffusion,multiple combinations of lateral intervals, and electric field components. We also obtained differences in resistivity inversion imaging obtained by CSEM to evaluate its feasibility in monitoring and to analyze all the electric field(Ex, Ey, and Ez) response characteristics. CSEM has great potential in monitoring CO_(2) plume migration in offshore saltwater reservoirs due to its high sensitivity and accuracy. Furthermore, changes in electromagnetic field response reflect the transport status of CO_(2) plumes, providing an important basis for monitoring and evaluating CO_(2)transport behavior during storage processes. 展开更多
关键词 Offshore carbon dioxide storage Geophysics Resistivity inversion Monitoring Plume migration Marine controllable source electromagnetic method
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Fuel recycling feedback control via real-time boron powder injection in EAST with full metal wall
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作者 Zhe WANG zhen sun +9 位作者 Guizhong ZUO Kai WU Yao HUANG Wei XU Ming HUANG Zhitai ZHOU Yanhong GUAN Haotian QIU Rajesh MAINGI Jiansheng HU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第12期41-48,共8页
A feedback control of fuel recycling via real-time boron powder injection,addressing the issue of continuously increasing recycling in long-pulse plasma discharges,has been successfully developed and implemented on EA... A feedback control of fuel recycling via real-time boron powder injection,addressing the issue of continuously increasing recycling in long-pulse plasma discharges,has been successfully developed and implemented on EAST tokamak.The feedback control system includes four main parts:the impurity powder dropper(IPD),a diagnostic system measuring fuel recycling level represented by D_(α)emission,a plasma control system(PCS)implementing the Proportional Integral Derivative(PID)algorithm,and a signal converter connecting the IPD and PCS.Based on this control system,both active control and feedback control experiments have recently been performed on EAST with a full metal wall.The experimental results show that the fuel recycling can be gradually reduced to lower level as PCS control voltage increases.In the feedback control experiments,it is also observed that the D_(α)emission is reduced to the level below the target D_(α)value by adjusting boron injection flow rate,indicating successful implementation of the fuel recycling feedback control on EAST.This technique provides a new method for fuel recycling control of long pulse and high parameter plasma operations in future fusion devices. 展开更多
关键词 fuel recycling feedback control boron powder EAST
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Spatial distribution and inventory of natural gas hydrate in the Qiongdongnan Basin,northern South China Sea 被引量:1
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作者 Zhongxian ZHAO Ning QIU +4 位作者 zhen sun Wen YAN Genyuan LONG Pengchun LI Haiteng ZHUO 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期729-739,共11页
Natural gas hydrate is a potential clean energy source and is related to submarine geohazard,climate change,and global carbon cycle.Multidisciplinary investigations have revealed the occurrence of hydrate in the Qiong... Natural gas hydrate is a potential clean energy source and is related to submarine geohazard,climate change,and global carbon cycle.Multidisciplinary investigations have revealed the occurrence of hydrate in the Qiongdongnan Basin,northern South China Sea.However,the spatial distribution,controlling factors,and favorable areas are not well defined.Here we use the available high-resolution seismic lines,well logging,and heat flow data to explore the issues by calculating the thickness of gas hydrate stability zone(GHSZ)and estimating the inventory.Results show that the GHSZ thickness ranges between mostly~200 and 400 m at water depths>500 m.The gas hydrate inventory is~6.5×109-t carbon over an area of~6×104 km2.Three areas including the lower uplift to the south of the Lingshui sub-basin,the Songnan and Baodao sub-basins,and the Changchang sub-basin have a thick GHSZ of~250-310 m,250-330 m,and 350-400 m,respectively,where water depths are~1000-1600 m,1000-2000 m,and2400-3000 m,respectively.In these deep waters,bottom water temperatures vary slightly from~4 to 2℃.However,heat flow increases significantly with water depth and reaches the highest value of~80-100 mW/m2 in the deepest water area of Changchang sub-basin.High heat flow tends to reduce GHSZ thickness,but the thickest GHSZ still occurs in the Changchang sub-basin,highlighting the role of water depth in controlling GHSZ.The lower uplift to the south of the Lingshui sub-basin has high deposition rate(~270-830 m/Ma in 1.8-0 Ma);the thick Cenozoic sediment,rich biogenic and thermogenic gas supplies,and excellent transport systems(faults,diapirs,and gas chimneys)enables it a promising area of hydrate accumulation,from which hydrate-related bottom simulating reflectors,gas chimneys,and active cold seeps were widely revealed. 展开更多
关键词 gas hydrate stability zone gas hydrate inventory Qiongdongnan Basin South China Sea
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CD137 signaling aggravates myocardial ischemia-reperfusion injury by inhibiting mitophagy mediated NLRP3 inflammasome activation 被引量:1
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作者 Guang-Yao ZANG Qing YIN +5 位作者 Chen SHAO zhen sun Li-Li ZHANG Yao XU Li-Hua LI Zhong-Qun WANG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2023年第3期223-237,共15页
BACKGROUND The inflammatory response caused by the NLRP3 is closely related to the formation of myocardial ischemiareperfusion injury.Costimulatory receptor CD137 and its ligand play a crucial role in regulating the i... BACKGROUND The inflammatory response caused by the NLRP3 is closely related to the formation of myocardial ischemiareperfusion injury.Costimulatory receptor CD137 and its ligand play a crucial role in regulating the inflammatory immune response in atherosclerosis,which is the fundamental cause of cardiovascular diseases.However,the roles of CD137 signaling in the process of myocardial ischaemia-reperfusion(IR)injury remain unknown.METHODS Genetic ablation was used to determine the functional significance of CD137 in myocardial IR injury.Expression of CD137 was examined by Western-blot,quantitative real-time polymerase chain reaction,and immunohistochemistry in a murine IR model by coronary artery ligation.Even’s blue-TTC staining and echocardiography to evaluate the severity of myocardial IR injury.Furthermore,HL-1 cardiomyocytes treated with agonist-CD137 recombinant protein were used to explore the underlying mechanism in CD137 signaling-induced NLRP3 inflammasome activation in response to hypoxia/reoxygenation or LPS/ATP.RESULTS We demonstrated that CD137 knockout significantly improved cardiac function,accompanied by a markedly reduced NLRP3-mediated inflammatory response and IA/AAR which were reversed by mitophagy inhibitor Mdivi-1.Activating CD137 signaling significantly inhibited mitophagy and provoked NLRP3-mediated inflammatory response in H/R-injured or LPS-primed and ATP-stimulated HL-1 cardiomyocytes,the effects of which could be abolished by either anti-CD137 or mitophagy activator FCCP.Besides,mitochondrial ROS was augmented by activating CD137 signaling through the suppression of mitophagy.CONCLUSIONS Our results reveal that activating CD137 signaling aggravates myocardial IR injury by upregulating NLRP3 inflammasome activation via suppressing mitophagy and promoting mtROS generation. 展开更多
关键词 CD137 NLRP3 INHIBITING
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Nε-(carboxymethyl)lysine promotes lipid uptake of macrophage via cluster of differentiation 36 and receptor for advanced glycation end products 被引量:1
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作者 Zhong-Qun Wang Hai-Peng Yao zhen sun 《World Journal of Diabetes》 SCIE 2023年第3期222-233,共12页
BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell ... BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell formation,and thereby accelerate atherosclerosis.The receptor for AGEs(RAGE)and cluster of differentiation 36(CD36)were the receptors of CML.However,it is still unknown whether RAGE and CD36 play key roles in CML-promoted lipid uptake.AIM Our study aimed to explore the role of RAGE and CD36 in CML-induced macrophage lipid uptake.METHODS In this study,we examined the effect of CML on lipid uptake by Raw264.7 macrophages.After adding 10 mmol/L CML,the lipid accumulation in macrophages was confirmed by oil red O staining.Expression changes of CD36 and RAGE were detected with immunoblotting and quantitative real-time polymerase chain reaction.The interaction between CML with CD36 and RAGE was verified by immunoprecipitation.We synthesized a novel N-succinimidyl-4-18Ffluorobenzoate-CML radioactive probe.Radioactive receptor-ligand binding assays were performed to test the binding affinity between CML with CD36 and RAGE.The effects of blocking CD36 or RAGE on CML-promoting lipid uptake were also detected.RESULTS The study revealed that CML significantly promoted lipid uptake by macrophages.Immunoprecipitation and radioactive receptor-ligand binding assays indicated that CML could specifically bind to both CD36 and RAGE.CML had a higher affinity for CD36 than RAGE.ARG82,ASN71,and THR70 were the potential interacting amino acids that CD36 binds to CML Anti-CD36 and anti-RAGE could block the uptake of CML by macrophages.The lipid uptake promotion effect of CML was significantly attenuated after blocking CD36 or RAGE.CONCLUSION Our results suggest that the binding of CML with CD36 and RAGE promotes macrophage lipid uptake. 展开更多
关键词 Nε-(carboxymethyl)lysine Cluster of differentiation 36 Receptor for advanced glycation end products Lipid uptake MACROPHAGE
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Precise Positioning Method for Seafloor Geodetic Stations Based on the Temporal Variation of Sound Speed Structure 被引量:1
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作者 Shuang ZHAO zhenjie WANG +3 位作者 Zhixi NIE Kaifei HE Huimin LIU zhen sun 《Journal of Geodesy and Geoinformation Science》 CSCD 2023年第2期81-92,共12页
At present,GNSS-Acoustic(GNSS-A)combined technology is widely used in positioning for seafloor geodetic stations.Based on Sound Velocity Profiles(SVPs)data,the equal gradient acoustic ray-tracing method is applied in ... At present,GNSS-Acoustic(GNSS-A)combined technology is widely used in positioning for seafloor geodetic stations.Based on Sound Velocity Profiles(SVPs)data,the equal gradient acoustic ray-tracing method is applied in high-precision position inversion.However,because of the discreteness of the SVPs used in the forementioned method,it ignores the continuous variation of sound velocity structure in time domain,which worsens the positioning accuracy.In this study,the time-domain variation of Sound Speed Structure(SSS)has been considered,and the cubic B-spline function is applied to characterize the perturbed sound velocity.Based on the ray-tracing theory,an inversion model of“stepwise iteration&progressive corrections”for both positioning and sound speed information is proposed,which conducts the gradual correction of seafloor geodetic station coordinates and disturbed sound velocity.The practical data was used to test the effectiveness of our method.The results show that the Root Mean Square(RMS)errors of the residual values of the traditional methods without sound velocity correction,based on quadratic polynomial correction and based on cubic B-spline function correction are 1.43 ms,0.44 ms and 0.21 ms,respectively.The inversion model with sound velocity correction can effectively eliminate the systematic error caused by the change of SSS,and significantly improve the positioning accuracy of the seafloor geodetic stations. 展开更多
关键词 GNSS-Acoustic sound speed structure temporal variation seafloor positioning
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Formation of the Zengmu and Beikang Basins,and West Baram Line in the southwestern South China Sea margin
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作者 Bing HAN Zhongxian ZHAO +7 位作者 Xiaofang WANG zhen sun Fucheng LI Benduo ZHU Yongjian YAO Liqiang LIU Tianyue PENG Genyuan LONG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期592-611,共20页
The Zengmu and Beikang basins,separated by the West Baram Line(WBL)in the southwestern South China Sea margin,display distinct geological and geophysical features.However,the nature of the basins and the WBL are debat... The Zengmu and Beikang basins,separated by the West Baram Line(WBL)in the southwestern South China Sea margin,display distinct geological and geophysical features.However,the nature of the basins and the WBL are debated.Here we explore this issue by conducting the stratigraphic and structural interpretation,faults and subsidence analysis,and lithospheric finite extension modelling using seismic data.Results show that the WBL is a trans-extensional fault zone comprising normal faults and flower structures mainly active in the Late Eocene to Early Miocene.The Zengmu Basin,to the southwest of the WBL,shows an overall synformal geometry,thick folded strata in the Late Eocene to Late Miocene(40.4-5.2 Ma),and pretty small normal faults at the basin edge,which imply that the Zengmu Basin is a foreland basin under the Luconia and Borneo collision in the Sarawak since the Eocene.Furthermore,the basin exhibits two stages of subsidence(fast in 40.4-30 Ma and slow in 30-0 Ma);but the amount of observed subsidence and heat flow are both greater than that predicted by crustal thinning.The Beikang Basin,to the NE of the WBL,consists of the syn-rift faulted sub-basins(45-16.4 Ma)and the post-rift less deformed sequences(16.4-0 Ma).The heat flow(~60 mW/m2)is also consistent with that predicted based on crustal thinning,inferring that it is a rifted basin.However,the basin shows three stages of subsidence(fast in 45-30 Ma,uplift in 30-16.4 Ma,and fast in 16.4-0 Ma).In the uplift stage,the strata were partly folded in the Late Oligocene and partly eroded in the Early Miocene,which is probably caused by the flexural bulging in response to the paleo-South China Sea subduction and the subsequent Dangerous Grounds and Borneo collision in the Sabah to the east of the WBL. 展开更多
关键词 tectonic subsidence foreland basin West Baram Line Zengmu Basin Beikang Basin South China Sea
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Geological environment in the South China Sea
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作者 Danling TANG zhen sun Guangjun SUI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期403-408,共6页
The South China Sea(SCS),situated in southern China,at the junction of the Pacific Plate,the Eurasian Plate,and the Indian Ocean Plate,is a northeast-southwest trending semi-enclosed sea.It spans an area of approximat... The South China Sea(SCS),situated in southern China,at the junction of the Pacific Plate,the Eurasian Plate,and the Indian Ocean Plate,is a northeast-southwest trending semi-enclosed sea.It spans an area of approximately 3.5 million square kilometers and has an average water depth of about 1200 m,its deepest point reaching 5559 m.In 2021,a scientific expedition(called as U1 voyage)in the South China Sea was organized by the Innovation Research Team of Guangdong Special Key Program from March to April,this marks the first comprehensive scientific research voyage to the southern Uboundary corridor.Consisting of a total of 30 papers,this special issue is to share a portion of the research findings from this scientific expedition U1 voyage,covering six aspects:1)characteristics of the marine ecosystem in the SCS and its response to marine dynamic processes;2)multi-scale marine dynamic processes,sea-air interactions,and forecasting techniques in the SCS;3)geomorphology and geological structure;4)sedimentary processes and resource potential in the SCS;5)geostrategy,rights and interests maintenance and strategic countermeasures in the SCS;6)marine scientific instruments.By integrating the scientific research with the study of history,jurisprudence and international strategies,this issue presents new insights into the formation history and scope evolution of the SCS,and it also seeks to establish a new scientific framework based on the marine governance and development of the SCS. 展开更多
关键词 South China Sea U-boundary geological science U 1 voyage ecological environment ocean remote sensing
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The sedimentary record of the Sanshui Basin:Implication to the Late Cretaceous tectonic evolution in the northern margin of South China Sea
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作者 Zhe ZHANG Nianqiao FANG zhen sun 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期532-549,共18页
Whether the South China continental margin had shifted from active subduction to passive extension in the Late Cretaceous remains controversial.Located in the northernmost of the South China Sea continental margin,San... Whether the South China continental margin had shifted from active subduction to passive extension in the Late Cretaceous remains controversial.Located in the northernmost of the South China Sea continental margin,Sanshui Basin developed continuous stratigraphy from Lower Cretaceous to Eocene and provides precious outcrops to study the regional tectonic evolution during the Cretaceous.Therefore,we conducted field observations,petrology,clay mineralogy,geochemistry,and detrital zircon chronology analyses of sedimentary rocks from the Upper Cretaceous Sanshui Formation in Sanshui Basin.Results suggest that the Sanshui Basin is characterized as an intermoutane basin with multiple provenances,strong hydrodynamic environment,and proximal accumulation in the Late Cretaceous.An angular unconformity at the boundary between the Lower and Upper Cretaceous was observed in the basin.The sedimentary facies of the northern basin changed from lacustrine sedimentary environment in the Early Cretaceous to alluvial facies in the Late Cretaceous.The zircon U-Pb ages of granitic gravelly sandstone from Sanshui Formation prominently range from 100 Ma to 300 Ma,which is close to the deposition age of Sanshui Formation.The major and trace elements of the Late Cretaceous sedimentary samples show characteristics of active continental margin,and are different from the Paleogene rifting sequences.Hence,we propose that the northern South China Sea margin underwent an intense tectonic uplift at the turn of the Early and Late Cretaceous(around 100 Ma).Afterward,the northern South China Sea margin entered a wide extension stage in the Late Cretaceous(~100 to~80 Ma).This extensional phase is related to the back-arc extension in the active continental margin environment,which is different from the later passive rifting in the Cenozoic.The transition from active subduction to passive extension in the northern South China Sea may occur between the late Late Cretaceous and the Paleogene. 展开更多
关键词 continental margin South China Sea Sanshui Basin Late Cretaceous tectonic transition
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Low-noise,low-power-consumption seafloor vector magnetometer
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作者 Xiaochen LI Xianhu LUO +3 位作者 Ming DENG Ning QIU zhen sun Kai CHEN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期804-815,共12页
The seafloor vector magnetometer is an effective tool for marine geomagnetic surveys and seafloor magnetotelluric(MT)detection.However,the noise,power consumption,cost,and volume characteristics of existing seafloor v... The seafloor vector magnetometer is an effective tool for marine geomagnetic surveys and seafloor magnetotelluric(MT)detection.However,the noise,power consumption,cost,and volume characteristics of existing seafloor vector magnetometers are insufficient for practical use.Therefore,a low-noise,low-power-consumption seafloor vector magnetometer that can be used for data acquisition of deep-ocean geomagnetic vector components is developed and presented.A seafloor vector magnetometer mainly consists of a fluxgate sensor,data acquisition module,acoustic release module,glass sphere,frame,burn-wire release,and anchor.A new low-noise data acquisition module and a fluxgate sensor greatly reduce power consumption.Furthermore,compact size is achieved by integrating an acoustic telemetry module and replacing the acoustic release with an external burn-wire release.The new design and magnetometer characteristics reduce the volume of the instrument and the cost of hardware considerably,thereby improving the integrity and deployment efficiency of the equipment.Theoretically,it can operate for 90 days underwater at a maximum depth of 6000 m.The seafloor vector magnetometer was tested in the South China Sea and the Philippine Sea and obtained high-quality geomagnetic data.The deep-water environment facilitates magnetic field data measurements,and the magnetometer has an approximate noise level of 10 pT/rt(Hz)@1 Hz,a peak-to-peak value error of 0.2 nT,and approximate power consumption of 200 mW.The fluxgate sensor can measure the magnetic field in the lower frequency band and realize geomagnetic field measurements over prolonged periods. 展开更多
关键词 seafloor vector magnetometer low noise low power consumption
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Conversion immunotherapy for deficient mismatch repair locally unresectable colon cancer:A case report
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作者 zhen sun He Liu +1 位作者 Guan-Nan Zhang Yi Xiao 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第12期2237-2241,共5页
BACKGROUND Owing to the special features of biologics,deficient mismatch repair(dMMR)in patients with colon cancer has achieved little treatment efficacy from chemoradiotherapy.Immunotherapy has shown promising result... BACKGROUND Owing to the special features of biologics,deficient mismatch repair(dMMR)in patients with colon cancer has achieved little treatment efficacy from chemoradiotherapy.Immunotherapy has shown promising results for the treatment of colon cancer.The high response rate observed suggests a great option for patients presenting with unresectable tumors,as it allows for better oncological resection.Here,we aimed to highlight the significant effects of immunotherapy on dMMR in colon cancer.CASE SUMMARY A 54-year-old man diagnosed with locally unresectable dMMR colon cancer received preoperative immunotherapy(three cycles of pembrolizumab)and achieved a pathological complete response after surgery.CONCLUSION Immunotherapy can be used as a conversion treatment for locally unresectable colon cancer with dMMR. 展开更多
关键词 Colon cancer IMMUNOTHERAPY Pathological complete response Case report
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婴幼儿腹腔镜手术中二氧化碳气腹对米库氯铵作用时间的影响 被引量:2
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作者 孙震 陈丽娟 +1 位作者 吕晶 王琦 《中国现代医学杂志》 CAS 2019年第4期100-103,共4页
目的探讨小儿腹腔镜手术二氧化碳CO_2气腹对米库氯铵作用时间的影响。方法选取全身麻醉气管插管下行择期腹股沟疝修补术的61例患儿,随机分为腹腔镜组(31例)和开腹组(30例)。静脉给予丙泊酚2.5 mg/kg、芬太尼2μg/kg及米库氯铵0.2 mg/kg... 目的探讨小儿腹腔镜手术二氧化碳CO_2气腹对米库氯铵作用时间的影响。方法选取全身麻醉气管插管下行择期腹股沟疝修补术的61例患儿,随机分为腹腔镜组(31例)和开腹组(30例)。静脉给予丙泊酚2.5 mg/kg、芬太尼2μg/kg及米库氯铵0.2 mg/kg进行麻醉诱导,术中吸入50%一氧化二氮N2O+50%氧气O_2+七氟醚维持麻醉,麻醉深度维持在1.2~1.4 MAC。使用肌松监测仪记录4个成串刺激(TOF);分别记录T_1完全消失时间(Ta)(即肌松药完全起效时间);T_1消失至T_1恢复到对照值25%的时间(Tb)(即肌松药有效作用时间)。检测手术前后24 h血浆胆碱酯酶(CHE)、谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)浓度。结果两组米库氯铵Ta、Tb比较,差异无统计学意义(P>0.05);两组术前、术后24 h的CHE、ALT、AST及TBIL浓度比较,差异无统计学意义(P>0.05)。结论婴幼儿CO_2气腹米库氯铵的完全起效时间和有效作用时间无影响。 展开更多
关键词 气腹 人工 婴儿 米库氯铵/苄异喹啉类 反应时间
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Inhibition of Osteoarthritis in Rats by Electroporation with Interleukin-1 Receptor Antagonist
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作者 zhen sun Heyong Yin +11 位作者 Xiaoming Yu Xun sun Bo Xiao Yichi Xu Zhiguo Yuan Haoye Meng Jiang Peng Changlong Yu Yu Wang Quanyi Guo Aiyuan Wang Shibi Lu 《Journal of Biomedical Science and Engineering》 2016年第7期323-336,共14页
Gene therapy constitutes a promising strategy for the treatment of osteoarthritis (OA). We assessed the use of electroporation (EP) of non-viral gene vectors, and compared its efficacy with that of adeno-associated vi... Gene therapy constitutes a promising strategy for the treatment of osteoarthritis (OA). We assessed the use of electroporation (EP) of non-viral gene vectors, and compared its efficacy with that of adeno-associated virus (AAV) vectors. EP- and AAV-mediated delivery of human interleukin-1 receptor antagonist (hIL-1Ra) was localized performed in the joints of rats following induction of OA. mRNA levels for hIL-1Ra, IL-1β, TNF-α, MMP-13 and ADAMTS-4 in the cartilage and synovial tissues were analyzed. Structural analyses of the subchondral bone at the medial femoral condyle were performed by Micro-CT after treatment. Knee joint specimens were staining with hematoxylin and eosin and Saffron O. Induction of hIL-1Ra by both EP and AAV inhibited inflammatory-induced sub-chondral bone reconstruction, and effectively suppressed IL-1β activity, as evidenced by decreased expression of MMP-13 and ADAMTS-4. Histological analyses revealed significant protection of cartilage, proteoglycan by EP and AAV. hIL-1Ra expression was similar in both the EP and AAV groups. Notably, this gene is not easier degraded transduced by EP compared with AAV. Taken together, these results show that EP offers transfection efficiency comparable to that of AAV, with the potential for longer gene expression, making EP a promising candidate for efficient non-viral delivery of OA gene therapy. 展开更多
关键词 ELECTROPORATION Interleukin-1 Receptor Antagonist Adeno-Associated Virus Gene Therapy OSTEOARTHRITIS CARTILAGE SYNOVIUM
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Advances in neovascularization after diabetic ischemia 被引量:6
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作者 Yue Cai Guang-Yao Zang +5 位作者 Yan Huang zhen sun Li-Li Zhang Yong-Jiang Qian Wei Yuan Zhong-Qun Wang 《World Journal of Diabetes》 SCIE 2022年第11期926-939,共14页
With the high incidence of diabetes around the world,ischemic complications cause a serious influence on people’s production and living.Neovascularization plays a significant role in its development.Therefore,neovasc... With the high incidence of diabetes around the world,ischemic complications cause a serious influence on people’s production and living.Neovascularization plays a significant role in its development.Therefore,neovascularization after diabetic ischemia has aroused attention and has become a hot spot in recent years.Neovascularization is divided into angiogenesis represented by atherosclerosis and arteriogenesis characterized by coronary collateral circulation.When mononuclear macrophages successively migrate to the ischemia anoxic zone after ischemia or hypoxia,they induce the secretion of cytokines,such as vascular endothelial growth factor and hypoxia-inducible factor,activate signaling pathways such as classic Wnt and phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt)pathways,trigger oxidative stress response,activate endothelial progenitor cells or enter the glycolysis or lactic acid process and promote the formation of new blood vessels,remodeling them into mature blood vessels and restoring blood supply.However,the hypoglycemic condition has different impacts on neovascularization.Consequently,this review aimed to introduce the mechanisms of neovascularization after diabetic ischemia,increase our understanding of diabetic ischemic complications and their therapies and provide more treatment options for clinical practice and effectively relieve patients’pain.It is believed that in the near future,neovascularization will bring more benefits and hope to patients with diabetes. 展开更多
关键词 Diabetes mellitus Angiogenesis ARTERIOGENESIS ISCHEMIA HYPOXIA
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Improved Evaluation of BBR and Collisional Frequency Shifts of NIM-Sr2 with 7.2×10^(-18)Total Uncertainty 被引量:4
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作者 Bing-Kun Lu zhen sun +7 位作者 Tao Yang Yi-Ge Lin Qiang Wang Ye Li Fei Meng Bai-Ke Lin Tian-Chu Li Zhan-Jun Fang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第8期22-27,共6页
NIM-Sr2 optical lattice clock has been developed on the Changping campus of National Institute of Metrology(NIM).Considering the limitations in NIM-Sr1,several improved parts have been designed including a differentia... NIM-Sr2 optical lattice clock has been developed on the Changping campus of National Institute of Metrology(NIM).Considering the limitations in NIM-Sr1,several improved parts have been designed including a differential pumping stage in the vacuum system,a permanent magnet Zeeman slower,water-cooled anti-Helmholtz coils,an extended viewport for Zeeman slower,etc.A clock laser with a short-time stability better than 3×10^(-16)is realized based on a self-designed 30-cm-long ultra-low expansion cavity.The systematic frequency shift has been evaluated to an uncertainty of 7.2×10^(-18),with the uncertainty of BBR shift and the collisional frequency shift being an order of magnitude lower than the last evaluation of NIM-Sr1. 展开更多
关键词 PUMPING SLOWER SHIFT
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大数据分析在城镇燃气企业生产运营中的应用研究 被引量:2
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作者 孙震 《城市燃气》 2022年第5期1-8,共8页
针对现有燃气企业信息化建设背景,梳理燃气企业业务现状、信息化现状、数据现状,指出大数据分析技术在燃气企业中应用的可能性。根据燃气生产经营的特点,探讨燃气企业大数据分析体系架构。结合燃气企业业务需求,探讨大数据分析在燃气企... 针对现有燃气企业信息化建设背景,梳理燃气企业业务现状、信息化现状、数据现状,指出大数据分析技术在燃气企业中应用的可能性。根据燃气生产经营的特点,探讨燃气企业大数据分析体系架构。结合燃气企业业务需求,探讨大数据分析在燃气企业中的应用场景。最终通过效益分析,说明大数据分析技术在燃气企业的应用效果。即应用大数据分析技术,可显著降低供销差,有效减少三方施工事故发生率,为燃气企业带来直接经济效益。 展开更多
关键词 城镇燃气 信息化 大数据 数据分析 供销差
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Line identification of extreme ultraviolet (EUV) spectra from low-Z impurity ions in EAST tokamak plasmas 被引量:1
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作者 Lei LI Ling ZHANG +15 位作者 Zong XU Shigeru MORITA Yunxin CHENG Fengling ZHANG Wenmin ZHANG Yanmin DUAN Qing ZANG Shouxin WANG Shuyu DAI Guizhong ZUO zhen sun Liang WANG Xiaobin DING Jinping QIAN Haiqing LIU Liqun HU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第7期15-30,共16页
Extreme ultraviolet(EUV) spectra emitted from low-Z impurity ions in the wavelength range of10–500Å were observed in Experimental Advanced Superconducting Tokamak(EAST)discharges. Several spectral lines from K-a... Extreme ultraviolet(EUV) spectra emitted from low-Z impurity ions in the wavelength range of10–500Å were observed in Experimental Advanced Superconducting Tokamak(EAST)discharges. Several spectral lines from K-and L-shell partially ionized ions were successfully observed with sufficient spectral intensities and resolutions for helium, lithium, boron, carbon,oxygen, neon, silicon and argon using two fast-time-response EUV spectrometers of which the spectral intensities are absolutely calibrated based on the intensity comparison method between visible and EUV bremsstrahlung continua. The wavelength is carefully calibrated using wellknown spectra. The lithium, boron and silicon are individually introduced for the wall coating of the EAST vacuum vessel to suppress mainly the hydrogen and oxygen influxes from the vacuum wall, while the carbon and oxygen intrinsically exist in the plasma. The helium is frequently used as the working gas as well as the deuterium. The neon and argon are also often used for the radiation cooling of edge plasma to reduce the heat flux onto the divertor plate. The measured spectra were analyzed mainly based on the database of National Institute of Standards and Technology. As a result, spectral lines of He Ⅱ, Li Ⅱ–Ⅲ, B Ⅳ–Ⅴ, C Ⅲ–Ⅵ, O Ⅲ–Ⅷ, Ne Ⅱ–Ⅹ,Si Ⅴ–Ⅻ, and Ar Ⅹ–XVI are identified in EAST plasmas of which the central electron temperature and chord-averaged electron density range in Te0=0.6–2.8 keV and ne=(0.5–6.0)×1019 m-3, respectively. The wavelengths and transitions of EUV lines identified here are summarized and listed in a table for each impurity species as the database for EUV spectroscopy using fusion plasmas. 展开更多
关键词 line identification EUV spectroscopy EUV spectra impurity line emissions tokamak plasmas
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A 3D basin modeling study of the factors controlling gas hydrate accumulation in the Shenhu Area of the South China Sea 被引量:1
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作者 Zhi-yuan Xie Jian-gong Wei +2 位作者 Jin-yun zheng zhen sun Kun Zhang 《China Geology》 2022年第2期218-233,共16页
Great advancement has been made on natural gas hydrates exploration and test production in the northern South China Sea.However,there remains a lot of key questions yet to be resolved,particularly about the mechanisms... Great advancement has been made on natural gas hydrates exploration and test production in the northern South China Sea.However,there remains a lot of key questions yet to be resolved,particularly about the mechanisms and the controls of gas hydrates enrichment.Numerical simulaution would play signficant role in addressing these questions.This study focused on the gas hydrate exploration in the Shenhu Area,Northern South China Sea.Based on the newly obtained borehole and multichannel reflection seismic data,the authors conducted an integrated 3D basin modeling study on gas hydrate.The results indicate that the Shenhu Area has favorable conditions for gas hydrate accumulation,such as temperature,pressure,hydrocarbon source,and tectonic setting.Gas hydrates are most concentrated in the Late Miocene strata,particularly in the structual highs between the Baiyun Sag and the Liwan Sag,and area to the south of it.It also proved the existence of overpressure in the main sag of source rocks,which was subject to compaction disequilibrium and hydrocarbon generation.It also shown that the regional fault activity is not conducive to gas hydrate accumulation due to excess gas seepage.The authors conjecture that fault activity may slightly weaken overpressure for the positive effect of hydrocarbon expulsion and areas lacking regional fault activity have better potential. 展开更多
关键词 3D basin modeling Gas hydrates Fault reactivation OVERPRESSURE Gas seepage Heat flow NGHs exploration trial engineering Oil and gas exploration engineering Shenhu Area South China Sea
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Evidence of vapor shielding effect on heat flux loaded on flowing liquid lithium limiter in EAST 被引量:1
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作者 Chenglong LI Guizhong ZUO +13 位作者 R MANIGI K TRITZ D ANDRUCZYK Bin ZHANG Ruirong LIANG D OLIVER zhen sun Wei XU Xiancai MENG Ming HUANG Zhongliang TANG Binfu GAO Ning YAN Jiansheng HU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第9期45-51,共7页
A lithium(Li)vapour layer was formed around a flowing liquid Li limiter to shield against the plasma incident power and reduce limiter heat flux in the EAST tokamak.The results revealed that after a plasma operation o... A lithium(Li)vapour layer was formed around a flowing liquid Li limiter to shield against the plasma incident power and reduce limiter heat flux in the EAST tokamak.The results revealed that after a plasma operation of a few seconds,the layer became clear,which indicated a strong Li emission with a decrease in the limiter surface temperature.This emission resulted in a dense vapour around the limiter,and Li ions moved along the magnetic fleld to form a green shielding layer on the limiter.The plasma heat flux loaded on the limiter,measured by the probe installed on the limiter,was approximately 52%lower than that detected by a fast-reciprocating probe at the same radial position without the limiter in EAST.Additionally,approximately 42%of the parallel heat flux was dissipated directly with the enhanced Li radiation in the discharge with the liquid metal infused trenches(LIMIT)limiter.This observation revealed that the Li vapour layer exhibited an excellent shielding effect to liquid Li on plasma heat flux,which is a possible beneflt of liquid-plasma-facing components in future fusion devices. 展开更多
关键词 liquid Li limiter Li vapor shielding heat flux EAST
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