The southern Ordos Basin has excellent petroleum exploration prospects.However,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are unclea...The southern Ordos Basin has excellent petroleum exploration prospects.However,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are unclear.In this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution history.In the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern area.The paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source rocks.The vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation stage.The Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation stage.The southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and thinning.This event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and accumulation.The southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic belt.The southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the north.The strongest overprinting occurred in the southwestern part of the basin.The large-scale uplift,denudation and faulting led to oil and gas loss from reservoirs.The petroleum generation,accumulation and preservation in the southern Ordos Basin were affected by deep lithospheric structures and the tectono-thermal evolution.This work provides a novel tectono-thermal perspective on the petroleum generation,accumulation and preservation condition of the southern Ordos Basin.展开更多
Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenva...Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of uHCC.Methods: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) months.Median OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher AEs.Conclusions: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.展开更多
Visible-infrared Cross-modality Person Re-identification(VI-ReID)is a critical technology in smart public facilities such as cities,campuses and libraries.It aims to match pedestrians in visible light and infrared ima...Visible-infrared Cross-modality Person Re-identification(VI-ReID)is a critical technology in smart public facilities such as cities,campuses and libraries.It aims to match pedestrians in visible light and infrared images for video surveillance,which poses a challenge in exploring cross-modal shared information accurately and efficiently.Therefore,multi-granularity feature learning methods have been applied in VI-ReID to extract potential multi-granularity semantic information related to pedestrian body structure attributes.However,existing research mainly uses traditional dual-stream fusion networks and overlooks the core of cross-modal learning networks,the fusion module.This paper introduces a novel network called the Augmented Deep Multi-Granularity Pose-Aware Feature Fusion Network(ADMPFF-Net),incorporating the Multi-Granularity Pose-Aware Feature Fusion(MPFF)module to generate discriminative representations.MPFF efficiently explores and learns global and local features with multi-level semantic information by inserting disentangling and duplicating blocks into the fusion module of the backbone network.ADMPFF-Net also provides a new perspective for designing multi-granularity learning networks.By incorporating the multi-granularity feature disentanglement(mGFD)and posture information segmentation(pIS)strategies,it extracts more representative features concerning body structure information.The Local Information Enhancement(LIE)module augments high-performance features in VI-ReID,and the multi-granularity joint loss supervises model training for objective feature learning.Experimental results on two public datasets show that ADMPFF-Net efficiently constructs pedestrian feature representations and enhances the accuracy of VI-ReID.展开更多
We consider maps on positive definite cones of von Neumann algebras preserving unitarily invariant norms of the spectral geometric means. The main results concern Jordan *-isomorphisms between <em>C</em>*-...We consider maps on positive definite cones of von Neumann algebras preserving unitarily invariant norms of the spectral geometric means. The main results concern Jordan *-isomorphisms between <em>C</em>*-algebras, and show that they are characterized by the preservation of unitarily invariant norms of those operations.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.42102164,42241204,41630312and 42272174)the Petro China Changqing Oilfield Company Science and Technology Major Project(ZDZX 2021-01)。
文摘The southern Ordos Basin has excellent petroleum exploration prospects.However,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are unclear.In this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution history.In the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern area.The paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source rocks.The vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation stage.The Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation stage.The southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and thinning.This event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and accumulation.The southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic belt.The southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the north.The strongest overprinting occurred in the southwestern part of the basin.The large-scale uplift,denudation and faulting led to oil and gas loss from reservoirs.The petroleum generation,accumulation and preservation in the southern Ordos Basin were affected by deep lithospheric structures and the tectono-thermal evolution.This work provides a novel tectono-thermal perspective on the petroleum generation,accumulation and preservation condition of the southern Ordos Basin.
基金financially supported by the Science and Technology Plan Project of Guangzhou (No. 202102010171)National Natural Science Foundation Cultivation Project of the Third Affiliated Hospital of Sun Yat-sen University (No. 2020GZRPYMS11)+2 种基金Natural Science Foundation of Guangdong Province (No. 2018A030313641)Natural Science Foundation of Guangdong Province (No. 2016A030313848)Science and Technology Plan Project of Guangzhou (No. 201704020175)。
文摘Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of uHCC.Methods: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) months.Median OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher AEs.Conclusions: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.
基金supported in part by the National Natural Science Foundation of China under Grant 62177029,62307025in part by the Startup Foundation for Introducing Talent of Nanjing University of Posts and Communications under Grant NY221041in part by the General Project of The Natural Science Foundation of Jiangsu Higher Education Institution of China 22KJB520025,23KJD580.
文摘Visible-infrared Cross-modality Person Re-identification(VI-ReID)is a critical technology in smart public facilities such as cities,campuses and libraries.It aims to match pedestrians in visible light and infrared images for video surveillance,which poses a challenge in exploring cross-modal shared information accurately and efficiently.Therefore,multi-granularity feature learning methods have been applied in VI-ReID to extract potential multi-granularity semantic information related to pedestrian body structure attributes.However,existing research mainly uses traditional dual-stream fusion networks and overlooks the core of cross-modal learning networks,the fusion module.This paper introduces a novel network called the Augmented Deep Multi-Granularity Pose-Aware Feature Fusion Network(ADMPFF-Net),incorporating the Multi-Granularity Pose-Aware Feature Fusion(MPFF)module to generate discriminative representations.MPFF efficiently explores and learns global and local features with multi-level semantic information by inserting disentangling and duplicating blocks into the fusion module of the backbone network.ADMPFF-Net also provides a new perspective for designing multi-granularity learning networks.By incorporating the multi-granularity feature disentanglement(mGFD)and posture information segmentation(pIS)strategies,it extracts more representative features concerning body structure information.The Local Information Enhancement(LIE)module augments high-performance features in VI-ReID,and the multi-granularity joint loss supervises model training for objective feature learning.Experimental results on two public datasets show that ADMPFF-Net efficiently constructs pedestrian feature representations and enhances the accuracy of VI-ReID.
文摘We consider maps on positive definite cones of von Neumann algebras preserving unitarily invariant norms of the spectral geometric means. The main results concern Jordan *-isomorphisms between <em>C</em>*-algebras, and show that they are characterized by the preservation of unitarily invariant norms of those operations.
