Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region ...Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.展开更多
目的对近20年有关青蒿挥发油的化学成分、生物活性以及应用领域的研究进行了全面、系统的综述,为充分利用青蒿挥发油提供参考。方法在Web of Science、Scifinder、PubMed、中国知网和万方等数据库,对2001—2023年的相关文献进行检索,以...目的对近20年有关青蒿挥发油的化学成分、生物活性以及应用领域的研究进行了全面、系统的综述,为充分利用青蒿挥发油提供参考。方法在Web of Science、Scifinder、PubMed、中国知网和万方等数据库,对2001—2023年的相关文献进行检索,以青蒿挥发油、提取方法、活性、应用等为关键词进行检索,对化合物的种类、活性等进行归纳总结。结果青蒿挥发油的化学成分主要包括倍半萜类、醇类、醛类、酸类、酚类、酯类、酮类,其具有抗炎、抑菌、抗寄生虫、抗病毒、抗肿瘤等生物活性。结论青蒿挥发油呈多样性的生物活性,其中抗菌作用较为显著,可以作为化妆品的祛屑成分,其作用机制还需进一步深入研究。展开更多
The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing ...The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains illdefined.We present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument measurements.Variations in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to 2021.We further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.展开更多
BACKGROUND Perception is frequently impaired in patients with Alzheimer’s disease(AD).Several patients exhibit visual or haptic hallucinations.CASE SUMMARY A 71-year-old Chinese man presented with visual and haptic h...BACKGROUND Perception is frequently impaired in patients with Alzheimer’s disease(AD).Several patients exhibit visual or haptic hallucinations.CASE SUMMARY A 71-year-old Chinese man presented with visual and haptic hallucinations he had been experiencing for 2 weeks.The clinical manifestations were the feeling of insects crawling and biting the limbs and geison.He looked for the insects while itching and scratching,which led to skin breakage on the limbs.He was treated with topical and anti-allergic drugs in several dermatology departments without any significant improvement.After admission,the patient was administered risperidone(0.5 mg)and duloxetine(2 mg/day).One week later,the dose of risperidone was increased to 2 mg/day,and that of duloxetine was increased to 60 mg/day.After 2 weeks of treatment,the patient’s sensation of insects crawling and biting disappeared,and his mood stabilized.CONCLUSION This patient manifested psychiatric behavioral symptoms caused by AD brain atrophy.It was important to re-evaluate the patient’s cognitive-psychological status when the patient repeatedly went to the hospital for treatment.Follow-up attention to cognitive function and the consideration of perceptual deficits as early manifestations of AD should be considered.展开更多
【目的】大断面隧道开挖易对上部建筑物的稳定性带来安全隐患,为实现对地表建筑物风险等级的准确预测,构建大断面隧道下穿建筑物风险评估模型。【方法】基于静态贝叶斯网络,建立包含地质、隧道、建筑物结构、隧道与建筑物位置关系4个一...【目的】大断面隧道开挖易对上部建筑物的稳定性带来安全隐患,为实现对地表建筑物风险等级的准确预测,构建大断面隧道下穿建筑物风险评估模型。【方法】基于静态贝叶斯网络,建立包含地质、隧道、建筑物结构、隧道与建筑物位置关系4个一级指标及14个二级指标的风险评估模型,通过风险状态划分、专家语言模糊化处理得到先验风险概率值,并通过运用变异系数和弧间距算法得到影响地表建筑物的关键风险因素及其影响强度。进一步建立动态贝叶斯网络模型,运用Genie软件中的“Noisymax node”“Strength of influence”等模块,结合白塔山隧道下穿百花亭工程案例中现场监测数据,更新模型推理结果,进而计算整个施工过程中的地表建筑物风险变化趋势。【结果】土体因素是最为关键的风险因素,隧道直径及洞顶沉降速率、周边收敛速率、洞顶累计沉降和周边累计收敛等隧道因素次之,接下来为地下水和不良地质,且地下水、不良地质和施工管理为影响强度最大的风险因素。从动态贝叶斯网络中得到的风险变化趋势数据与施工现场监测数据相比,误差仅为5.0%。【结论】本文提出的大断面隧道下穿建筑物风险评估方法,能够定量分析关键风险因素及其影响强度,结合工程监测数据,可以实现地表建筑物风险的动态预测,为类似工程提供一定理论和实践指导。展开更多
文摘Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.
文摘目的对近20年有关青蒿挥发油的化学成分、生物活性以及应用领域的研究进行了全面、系统的综述,为充分利用青蒿挥发油提供参考。方法在Web of Science、Scifinder、PubMed、中国知网和万方等数据库,对2001—2023年的相关文献进行检索,以青蒿挥发油、提取方法、活性、应用等为关键词进行检索,对化合物的种类、活性等进行归纳总结。结果青蒿挥发油的化学成分主要包括倍半萜类、醇类、醛类、酸类、酚类、酯类、酮类,其具有抗炎、抑菌、抗寄生虫、抗病毒、抗肿瘤等生物活性。结论青蒿挥发油呈多样性的生物活性,其中抗菌作用较为显著,可以作为化妆品的祛屑成分,其作用机制还需进一步深入研究。
基金the National Natural Science Foundation of China(Grants No.42041006,41790443 and 41927806).
文摘The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains illdefined.We present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument measurements.Variations in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to 2021.We further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.
文摘BACKGROUND Perception is frequently impaired in patients with Alzheimer’s disease(AD).Several patients exhibit visual or haptic hallucinations.CASE SUMMARY A 71-year-old Chinese man presented with visual and haptic hallucinations he had been experiencing for 2 weeks.The clinical manifestations were the feeling of insects crawling and biting the limbs and geison.He looked for the insects while itching and scratching,which led to skin breakage on the limbs.He was treated with topical and anti-allergic drugs in several dermatology departments without any significant improvement.After admission,the patient was administered risperidone(0.5 mg)and duloxetine(2 mg/day).One week later,the dose of risperidone was increased to 2 mg/day,and that of duloxetine was increased to 60 mg/day.After 2 weeks of treatment,the patient’s sensation of insects crawling and biting disappeared,and his mood stabilized.CONCLUSION This patient manifested psychiatric behavioral symptoms caused by AD brain atrophy.It was important to re-evaluate the patient’s cognitive-psychological status when the patient repeatedly went to the hospital for treatment.Follow-up attention to cognitive function and the consideration of perceptual deficits as early manifestations of AD should be considered.
文摘【目的】大断面隧道开挖易对上部建筑物的稳定性带来安全隐患,为实现对地表建筑物风险等级的准确预测,构建大断面隧道下穿建筑物风险评估模型。【方法】基于静态贝叶斯网络,建立包含地质、隧道、建筑物结构、隧道与建筑物位置关系4个一级指标及14个二级指标的风险评估模型,通过风险状态划分、专家语言模糊化处理得到先验风险概率值,并通过运用变异系数和弧间距算法得到影响地表建筑物的关键风险因素及其影响强度。进一步建立动态贝叶斯网络模型,运用Genie软件中的“Noisymax node”“Strength of influence”等模块,结合白塔山隧道下穿百花亭工程案例中现场监测数据,更新模型推理结果,进而计算整个施工过程中的地表建筑物风险变化趋势。【结果】土体因素是最为关键的风险因素,隧道直径及洞顶沉降速率、周边收敛速率、洞顶累计沉降和周边累计收敛等隧道因素次之,接下来为地下水和不良地质,且地下水、不良地质和施工管理为影响强度最大的风险因素。从动态贝叶斯网络中得到的风险变化趋势数据与施工现场监测数据相比,误差仅为5.0%。【结论】本文提出的大断面隧道下穿建筑物风险评估方法,能够定量分析关键风险因素及其影响强度,结合工程监测数据,可以实现地表建筑物风险的动态预测,为类似工程提供一定理论和实践指导。
