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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire
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作者 Fei Weng Guijun Bi +5 位作者 Youxiang Chew Shang Sui Chaolin Tan zhenglin du Jinlong Su Fern Lan Ng 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期154-168,共15页
The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully ci... The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),respectively.With the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire deposits.Microstructure characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α phases.The mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and discussed.The mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat treatment.No fracture occurred within the interfacial area,further suggesting the robust interface.The findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition. 展开更多
关键词 laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior
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GSA-Human:人类遗传资源数据管理的公共系统 被引量:10
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作者 张思思 陈旭 +16 位作者 陈婷婷 朱军伟 唐碧霞 王安可 董丽莉 张哲文 孙艳玲 俞彩霞 翟爽 孙玉彬 陈焕新 杜政霖 肖景发 章张 鲍一明 王彦青 赵文明 《遗传》 CAS CSCD 北大核心 2021年第10期988-993,共6页
GSA-Human是人类遗传资源数据汇交、存储、管理与共享的数据库系统,可提供人类遗传资源数据的上传、下载、浏览、检索等公共服务,并有效支撑了国家重点研发计划科技项目数据的汇交与管理工作。系统具有符合《中华人民共和国人类遗传资... GSA-Human是人类遗传资源数据汇交、存储、管理与共享的数据库系统,可提供人类遗传资源数据的上传、下载、浏览、检索等公共服务,并有效支撑了国家重点研发计划科技项目数据的汇交与管理工作。系统具有符合《中华人民共和国人类遗传资源管理条例》数据安全管理策略,提供公开访问和受控访问相结合的数据使用模式。公开访问数据允许用户自由下载与获取;受控访问数据采用申请-审核的模式,即需要通过数据管理委员会(Data Access Committee,DAC)的授权方可获得下载和使用权限。系统自上线以来,截至2021年7月,汇集数据总量已超5.27 PB。 展开更多
关键词 人类遗传资源数据管理系统 组学数据 数据汇交 数据共享
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Study of the intrinsic mechanisms of nickel additive for grain refinement and strength enhancement of laser aided additively manufactured Ti–6Al–4V 被引量:14
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作者 Shang Sui Youxiang Chew +3 位作者 Fei Weng Chaolin Tan zhenglin du Guijun Bi 《International Journal of Extreme Manufacturing》 SCIE EI CAS 2022年第3期132-148,共17页
It is well-known that grain refiners can tailor the microstructure and enhance the mechanical properties of titanium alloys fabricated by additive manufacturing(AM). However, the intrinsic mechanisms of Ni addition on... It is well-known that grain refiners can tailor the microstructure and enhance the mechanical properties of titanium alloys fabricated by additive manufacturing(AM). However, the intrinsic mechanisms of Ni addition on AM-built Ti–6Al–4V alloy is not well established. This limits its industrial applications. This work systematically investigated the influence of Ni additive on Ti–6Al–4V alloy fabricated by laser aided additive manufacturing(LAAM). The results showed that Ni addition yields three key effects on the microstructural evolution of LAAM-built Ti–6Al–4V alloy.(a) Ni additive remarkably refines the prior-β grains, which is due to the widened solidification range. As the Ni addition increased from 0 to 2.5 wt. %, the major-axis length and aspect ratio of the prior-β grains reduced from over 1500 μm and 7 to 97.7 μm and1.46, respectively.(b) Ni additive can discernibly induce the formation of globular α phase,which is attributed to the enhanced concentration gradient between the β and α phases. This is the driving force of globularization according to the termination mass transfer theory. The aspect ratio of the α laths decreased from 4.14 to 2.79 as the Ni addition increased from 0 to2.5 wt. %.(c) Ni as a well-known β-stabilizer and it can remarkably increase the volume fraction of β phase. Room-temperature tensile results demonstrated an increase in mechanical strength and an almost linearly decreasing elongation with increasing Ni addition. A modified mathematical model was used to quantitatively analyze the strengthening mechanism. It was evident from the results that the α lath phase and the solid solutes contribute the most to the overall yield strength of the LAAM-built Ti–6Al–4V–x Ni alloys in this work. Furthermore, the decrease in elongation with increasing Ni addition is due to the deterioration in deformability of the β phase caused by a large amount of solid-solution Ni atoms. These findings can accelerate the development of additively manufactured titanium alloys. 展开更多
关键词 Ni addition microstructure refinement laser aided additive manufacturing titanium alloys strengthening mechanism
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T2T-YAO: A Telomere-to-telomere Assembled Diploid Reference Genome for Han Chinese 被引量:4
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作者 Yukun He Yanan Chu +39 位作者 Shuming Guo Jiang Hu Ran Li Yali Zheng Xinqian Ma zhenglin du Lili Zhao Wenyi Yu Jianbo Xue Wenjie Bian Feifei Yang Xi Chen Pingan Zhang Rihan Wu Yifan Ma Changjun Shao Jing Chen Jian Wang Jiwei Li Jing Wu Xiaoyi Hu Qiuyue Long Mingzheng Jiang Hongli Ye Shixu Song Guangyao Li Yue Wei Yu Xu Yanliang Ma Yanwen Chen Keqiang Wang Jing Bao Wen Xi Fang Wang Wentao Ni Moqin Zhang Yan Yu Shengnan Li Yu Kang Zhancheng Gao 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2023年第6期1085-1100,共16页
Since its initial release in 2001,the human reference genome has undergone continuous improvement in quality,and the recently released telomere-to-telomere(T2T)version-T2T-CHM13—reaches its highest level of continuit... Since its initial release in 2001,the human reference genome has undergone continuous improvement in quality,and the recently released telomere-to-telomere(T2T)version-T2T-CHM13—reaches its highest level of continuity and accuracy after 20 years of effort by working on a simplified,nearly homozygous genome of a hydatidiform mole cell line.Here,to provide an authentic complete diploid human genome reference for the Han Chinese,the largest population in the world,we assembled the genome of a male Han Chinese individual,T2T-YAO,which includes T2T assemblies of all the 22+X+M and 22+Y chromosomes in both haploids.The quality of T2T-YAO is much better than those of all currently available diploid assemblies,and its haploid version,T2T-YAO-hp,generated by selecting the better assembly for each autosome,reaches the top quality of fewer than one error per 29.5 Mb,even higher than that of T2T-CHM13.Derived from an individual living in the aboriginal region of the Han population,T2T-YAO shows clear ancestry and potential genetic continuity from the ancient ancestors.Each haplotype of T2TYAO possesses330-Mb exclusive sequences,3100 unique genes,and tens of thousands of nucleotide and structural variations as compared with CHM13,highlighting the necessity of a population-stratified reference genome.The construction of T2T-YAO,an accurate and authentic representative of the Chinese population,would enable precise delineation of genomic variations and advance our understandings in the hereditability of diseases and phenotypes,especially within the context of the unique variations of the Chinese population. 展开更多
关键词 Referencegenome Telomere-to-telomere assembly Han Chinese Haplotype-resolved assembly DIPLOID
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C–H…S Hydrogen Bond Assisted Supramolecular Encapsulation of Fullerenes with Nanobelts
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作者 Jialin Xie Xia Li +2 位作者 zhenglin du Yandie Liu Kelong Zhu 《CCS Chemistry》 CSCD 2023年第4期958-970,共13页
Hydrogen-bonded capsules have been widely employed as supramolecular hosts for organic molecular guests.Encapsulation of fullerenes by capsules is relatively scarce,especially those that utilize sulfur atoms as hydrog... Hydrogen-bonded capsules have been widely employed as supramolecular hosts for organic molecular guests.Encapsulation of fullerenes by capsules is relatively scarce,especially those that utilize sulfur atoms as hydrogen-bond acceptors.Herein,we describe,in both solution and solid state,a bowl-shaped nanobelt[8]cyclophenoxathiin 1a and its tetra-methylated derivative 1b that can form C–H⋯S hydrogen-bonded capsules induced by complexation with suitable fullerenes.1a strongly encapsulates C60,C70,or 6,6-phenyl-C61-butyric acid methyl ester(PC61BM)to form a 2∶1 ternary complex featuring 16 equatorial(sp2)C–H⋯S hydrogen bonds.A pseudorotaxane structure was further obtained for the complex of 1a with PC61BM.Conversely,a 1∶1 inclusion complex was observed for binding C60 or PC61BM with 1b indicating the reduced tendency to form capsules by introducing methyl groups into the belt.Surprisingly,the capsule-like structure was retained for the 1:2 complex of C70 with 1b as observed by the presence of multiple(sp3)C–H⋯S hydrogen bonds.The strong binding affinity and tailorable complexation mode enable further applications of nanobelts in fullerene chemistry. 展开更多
关键词 supramolecular capsule FULLERENE hydrogen bond NANOBELT host-guest chemistry
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Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome 被引量:9
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作者 zhenglin du Liang Ma +27 位作者 Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2019年第3期229-247,共19页
To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy... To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. 展开更多
关键词 De novo assembly Reference GENOME Variation map PHENOTYPE association Large POPULATION
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The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR 被引量:14
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作者 Shuhui Song Lina Ma +27 位作者 Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya duan Mochen Zhang Tong Jin Chengmin Shi zhenglin du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2020年第6期749-759,共11页
On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS... On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. 展开更多
关键词 2019nCoVR SARS-CoV-2 DATABASE Genomic variation HAPLOTYPE
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Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France 被引量:1
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作者 Qi Liu zhenglin du +3 位作者 Sihui Zhu Wenming Zhao Hua Chen Yongbiao Xue 《Biosafety and Health》 CSCD 2021年第6期307-311,共5页
By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007–2012 H1N1 flu seasons in France,we identified 22 samples with SARS-CoV sequences.In three of them,the SARS gen... By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007–2012 H1N1 flu seasons in France,we identified 22 samples with SARS-CoV sequences.In three of them,the SARS genome sequences could be fully assembled out of each.These sequences are highly similar(99.99%and 99.70%)to the artificially constructed recombinant SARS-CoV(SARSr-CoV)strains generated by the J.Craig Venter Institute in the USA.Moreover,samples from different flu seasons have different SARS-CoV strains,and the divergence between these strains cannot be explained by natural evolution.Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serve as a genomic strategy for the research of the origins or spread of infectious diseases. 展开更多
关键词 METAGENOMICS SARS-CoV Influenza A virus Retrospective study
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