BACKGROUND During the perioperative period, the characteristic therapy of traditional Chinese medicine is effective in improving postoperative rehabilitation. In large-scale hospitals practicing traditional Chinese me...BACKGROUND During the perioperative period, the characteristic therapy of traditional Chinese medicine is effective in improving postoperative rehabilitation. In large-scale hospitals practicing traditional Chinese medicine, there is accumulating experience related to the promotion of fast recovery in the perioperative period.AIM To evaluate the efficacy and safety of Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique.METHODS This prospective, multicenter, randomized, controlled study included two groups: Treatment group and control group. The patients in the treatment group and control group received Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique and routine treatment, respectively. Clinical observation regarding postoperative recovery of gastrointestinal function was performed, including the times to first passage of flatus, first defecation, and first normal bowel sounds. The comparison between groups was conducted through descriptive analysis, χ~2, t, F, and rank-sum tests.RESULTS There was a statistically significant difference in the time to postoperative first defecation between the treatment and control group(87.16 ± 32.09 vs 109.79 ±40.25 h, respectively;P < 0.05). Similarly, the time to initial recovery of bowel sounds in the treatment group was significantly shorter than that in the control group(61.17 ± 26.75 vs 79.19 ± 33.35 h, respectively;P < 0.05). However, there was no statistically significant difference in the time to initial exhaust between the treatment and control groups(51.54 ± 23.66 vs 62.24 ± 25.95 h, respectively;P >0.05). The hospitalization expenses for the two groups of patients were 62283.45 ±12413.90 and 62059.42 ± 11350.51 yuan, respectively. Although the cost of hospitalization was decreased in the control group, the difference was not statistically significant(P > 0.05). This clinical trial was safe without reports of any adverse reaction or event.CONCLUSION The rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes the recovery of postoperative gastrointestinal function and is significantly better than standard approach for patients after colorectal surgery.展开更多
AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal motility.METHODS Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antr...AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal motility.METHODS Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP(n = 30) or placebo(n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay.RESULTS Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5(13.0-26.7) vs 16.9(12.3-23.9), P < 0.05], jejunal contractions [18.3(15.3-25.0) vs 15.4(11.7-23.9), P < 0.01], and the motility index of duodenal contractions [522.0(146.0-139.0) vs 281.0(76.5-1006.0), P < 0.01] in phase Ⅱ of the migratory motor complex(MMC), which subsequently initiated the MMC cycle [74.0(30.0-118.0) vs 116.5(24.0-219.0), P < 0.05], shortened the duration of phase I of the MMC [42.0(0.0-90.0) vs 111.5(42.0-171.0), P < 0.01], and lengthened the duration of phase Ⅱ of the MMC [120(21-240) vs 58(16-170), P < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8(14.0-30.0) vs 18.0(13.0-28.5), P < 0.05], the motility index of duodenal contractions [236.0(115.0-306.0) vs 195.0(109.0-310.0), P < 0.05], and jejunal contractions [214.0(95.0-403.0) vs 178.0(55.0-304.0), P < 0.01] in phase Ⅲ of the MMC. Oral administration of XBP greatly increased plasma motilin(57.69 ± 9.03 vs 49.38 ± 8.63, P < 0.01) and ghrelin(279.20 ± 104.31 vs 238.73 ± 115.59, P < 0.01) concentrations compared to concentrations after oral administration of the placebo.CONCLUSION XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.展开更多
Neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease and amyotrophic lateral sclerosis,are a group of incurable neurological disorders,characterized by the chronic progr...Neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease and amyotrophic lateral sclerosis,are a group of incurable neurological disorders,characterized by the chronic progressive loss of different neuronal subtypes.However,despite its increasing prevalence among the everincreasing aging population,little progress has been made in the coincident immense efforts towards development of therapeutic agents.Research interest has recently turned towards stem cells including stem cells-derived exosomes,neurotrophic factors,and their combination as potential therapeutic agents in neurodegenerative diseases.In this review,we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases,with an emphasis on the combination therapy.展开更多
A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evalua...A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evaluated simultaneously when the doping amount of zinc was10%.Moreover,Zn‐doped(10%)g‐C3N4synthesized by an impregnation method showed superior active ability to form the Z‐scheme with BiVO4than by in‐situ synthesis.X‐ray diffraction,UV‐Vis spectroscopy,scanning electron microscopy,and X‐ray photoelectron spectroscopy were used to characterize the samples.It was determined that more Zn?N bonds could be formed on the surface of g‐C3N4by impregnation,which could facilitate charge transfer.展开更多
In this study,a ZnxCd1-xS solid solution was successfully synthesized using a hydrothermal method.MoS2 serving as a co-catalyst for hydrogen evolution was also prepared through a one-pot hydrothermal method.The struct...In this study,a ZnxCd1-xS solid solution was successfully synthesized using a hydrothermal method.MoS2 serving as a co-catalyst for hydrogen evolution was also prepared through a one-pot hydrothermal method.The structures,morphology,chemical states,and optical properties were characterized using powder X-ray diffraction,scanning electron microscopy,high-angle annular dark field-scanning transmission electron microscopy,elemental mapping,X-ray photoelectron spectroscopy,and UV-Vis diffuse reflection spectroscopy.Visible-light-driven photocatalytic experiments were conducted to simultaneously achieve hydrogen production and amoxicillin antibiotic wastewater degradation.The results indicated 8%MoS2/ZnxCd1-xS achieves the best photocatalytic performance.The ZnxCd1-xS samples illustrated a superior performance to that of CdS,which can be attributed to a thermodynamic improvement.Based on the results of PL and TRPL analyses,the enhancement of the hydrogen production mechanisms can be ascribed to the prolonged separation process of the photocarriers.Furthermore,the degradation results were analyzed using the HPLC method and the possible degradation pathways were determined through the HPLC-MS techniques.展开更多
Step-scheme(S-scheme)heterojunctions in photocatalysts can provide novel and practical insight on promoting photogenerated carrier separation.The latter is critical in controlling the overall efficiency in one-step ph...Step-scheme(S-scheme)heterojunctions in photocatalysts can provide novel and practical insight on promoting photogenerated carrier separation.The latter is critical in controlling the overall efficiency in one-step photoexcitation systems.In this study,a nanosized BiVO4/Bi0.6Y0.4VO4 solid solution was prepared by a coprecipitation method following with hydrothermal or calcination processes.The S-scheme heterojunction was fabricated by in-situ pressure-induced transformations of bismuth vanadate from the tetragonal zircon phase to the monoclinic scheelite phase,which led to the formation of BiVO4 nanoparticles with a diameter of approximately 5 nm on the surface of BiVO_(4)/Bi_(0.6)Y_(0.4)VO_(4)/Bi_(0.6)Y_(0.4)VO_(4) with S-scheme heterojunctions showed significantly enhanced photocatalytic overall water splitting activity compared with using bare BiVO_(4)/Bi_(0.6)Y_(0.4)VO_(4).Characterization of the carrier dynamics demonstrated that a superior carrier separation through S-type heterojunctions might have caused the enhanced overall water splitting(OWS)activity.Surface photovoltage spectra and the results of selective photodeposition experiments indicated that the photogenerated holes mainly migrated to the BiVO4 nanoparticles in the heterojunction.This confirmed that the charge transfer route corresponds to an S-scheme rather than a type-II heterojunction mechanism under light illumination.This study presents a facile and efficient strategy to construct S-scheme heterojunctions through a pressure-induced phase transition.The results demonstrated that S-scheme junctions composed of different crystalline phases can boost the carrier separation capacity and eventually improve the photocatalytic OWS activity.展开更多
BACKGROUND Interdigestive migrating motor complexes(MMC)produce periodic contractions in the gastrointestinal tract,but the exact mechanism of action still remains unclear.Intramuscular interstitial cells of Cajal(ICC...BACKGROUND Interdigestive migrating motor complexes(MMC)produce periodic contractions in the gastrointestinal tract,but the exact mechanism of action still remains unclear.Intramuscular interstitial cells of Cajal(ICC-IM)participate in gastrointestinal hormone and neuromodulation,but the correlation between ICCIM and MMC is also unclear.We found that xiangbinfang granules(XBF)mediated the phase III contraction of MMC.Here,the effects of XBF on gastric antrum motility in W/Wv mice and the effects of ICC-IM on gastric antrum MMC are reported.AIM To observe the effects of ICC-IM on gastric antrum motility and to establish the mechanism of XBF in promoting gastric antrum motility.METHODS The density of c-kit-positive ICC myenteric plexus(ICC-MP)and ICC-IM in the antral muscularis of W/Wv and wild-type(WT)mice was examined by confocal microscopy.The effects of XBF on gastric antrum slow waves in W/Wv and WT mice were recorded by intracellular amplification recording.Micro-strain-gauge force transducers were implanted into the gastric antrum to monitor the MMC and the effect of XBF on gastric antrum motility in conscious W/Wv and WT mice.RESULTS In the gastric antrum of W/Wv mice,c-kit immunoreactivity was significantly reduced,and no ICC-IM network was observed.Spontaneous rhythmic slow waves also appeared in the antrum of W/Wv mice,but the amplitude of the antrum slow wave decreased significantly in W/Wv mice(22.62±2.23 mV vs 2.92±0.52 mV,P<0.0001).MMCs were found in 7 of the 8 WT mice but no complete MMC cycle was found in W/Wv mice.The contractile frequency and amplitude index of the gastric antrum were significantly increased in conscious WT compared to W/Wv mice(frequency,3.53±0.18 cpm vs 1.28±0.12 cpm;amplitude index,23014.26±1798.65 mV·20 min vs 3782.16±407.13 mV·20 min;P<0.0001).XBF depolarized smooth muscle cells of the gastric antrum in WT and W/Wv mice in a dose-dependent manner.Similarly,the gastric antrum motility in WT mice was significantly increased after treatment with XBF 5 mg(P<0.05).Atropine(0.1 mg/kg)blocked the enhancement of XBF in WT and W/Wv mice completely,while tetrodotoxin(0.05 mg/kg)partially inhibited the enhancement by XBF.CONCLUSION ICC-IM participates in the regulation of gastric antrum MMC in mice.XBF induces MMC III-like contractions that enhance gastric antrum motility via ICCIM in mice.展开更多
A long-/long-wave dual-color detector with N-M-π-B-π-M-N structure was developed based on a type-Ⅱ InAs/GaSb superlattice. The saturated responsivity was achieved under low bias voltage for both channels. The devic...A long-/long-wave dual-color detector with N-M-π-B-π-M-N structure was developed based on a type-Ⅱ InAs/GaSb superlattice. The saturated responsivity was achieved under low bias voltage for both channels. The device could be operated as a single detector for sequential detection and showed high quantum efficiencies. The peak quantum efficiencies of long-wavelength infrared band-1(blue channel) and long-wavelength infrared band-2(red channel) were 44% at 6.3 μm under 20 mV and 57% at 9.1 μm under-60 mV, respectively. The optical performance for each channel was achieved using a 2 μm thickness absorber. Due to the high QE, the specific detectivities of the blue and red channels reached5.0×10^(11) cm·Hz^(1/2)/W at 6.8 μm and 3.1×10^(11) cm·Hz1^(1/2)/W at 9.1 μm, respectively, at 77 K.展开更多
Aluminum nitride （AIN） nanowires, serrated nanoribbons, and nanoribbons were selectively obtained through a simple chloride assisted chemical vapor deposition process. The morphologies of the products could be contr...Aluminum nitride （AIN） nanowires, serrated nanoribbons, and nanoribbons were selectively obtained through a simple chloride assisted chemical vapor deposition process. The morphologies of the products could be controlled by adjusting the deposition position and the flux of the reactant gas. The morphologies and structures of the AIN products were investigated in detail. The formation mechanism of the as-prepared different morphologies of AIN one-dimensional （ID） nanostructures was discussed on the basis of the experimental results.展开更多
Co-catalysts play a critical role in enhancing the efficiency of inorganic semiconductor photocatalysts;however,synthetic approaches to tailoring cocatalyst properties are rarely the focus of research efforts.A photom...Co-catalysts play a critical role in enhancing the efficiency of inorganic semiconductor photocatalysts;however,synthetic approaches to tailoring cocatalyst properties are rarely the focus of research efforts.A photomediated route to control the dispersion and oxidation state of a platinum(Pt)cocatalyst through defect generation in the P25 titania photocatalyst substrate is reported.Titania photoirradiation in the presence of methanol induces longlived surface defects which subsequently promote the photodeposition of highly dispersed(2.2±0.8 nm)and heavily reduced Pt nanoparticles on exposure to H2 PtCl6.The optimal methanol concentration of 20 vol%produces the highest density of metallic Pt nanoparticles.Photocatalytic activity for water splitting and associated hydrogen(H2)production under UV irradiation mirrors the methanol concentration employed during the P25 photoirradiation pretreatment and resulting Pt loading resulting in a common mass-normalized H2 productivity of 3800±130 mmol gpt-1 h-1.Photomediated surface defects(arising in the presence of a methanol hole scavenger)provide electron traps that regulate subsequent photodeposition of a Pt co-catalyst over P25,offering a facile route to tune photocatalytic efficiency.展开更多
The reconstruction during oxygen evolution reaction (OER) significantly affects the electronic and local geometry structure of metal sites in electrocatalyst.Compared with well-investigated cobalt-based materials,the ...The reconstruction during oxygen evolution reaction (OER) significantly affects the electronic and local geometry structure of metal sites in electrocatalyst.Compared with well-investigated cobalt-based materials,the reconstruction of rocksalt CoO with purely Co^(2+) in octahedral (Oh) coordination has not been revealed in detail.Herein,monolayer Co O supported on reduced graphene oxide (r GO) was synthesized via a one-pot hydrothermal strategy with calcinating in Ar atmosphere.The structure evolution of twodimension (2D) Co O/r GO during OER was revealed by in situ X-ray absorption spectroscopy (XAS).The transition from Co O toward Co3O_(4) already occurred at open circuit potential,further enhanced at 1.23 V (vs.RHE).The Co Ox(OH)ywas determined as the active phase at 1.53 V,displaying a tetrahedral Co coordination defective spinel Co_(3)O_(4) with the Co-O shell that featured the (oxy)hydroxide,not the standard Co OOH.After OER,the irreversible transition from CoO to Co_(3)O_(4) was observed.In contrast,in situ Raman spectra revealed a reversible amorphization process on Co_(3)O_(4)/r GO under operation conditions.Furthermore,this study indicated that the reconstruction behavior could be more effectively revealed by XAS using 2D materials.展开更多
Developing low-cost and high-efficient noble-metal-free cocatalysts has been a challenge to achieve economic hydrogen production.In this work,molybdenum oxides(MoO3-x)were in situ loaded on polymer carbon nitride(PCN)...Developing low-cost and high-efficient noble-metal-free cocatalysts has been a challenge to achieve economic hydrogen production.In this work,molybdenum oxides(MoO3-x)were in situ loaded on polymer carbon nitride(PCN)via a simple one-pot impregnation-calcination approach.Different from post-impregnation method,intimate coupling interface between high-dispersed ultra-small MoO3-xnanocrystal and PCN was successfully formed during the in situ growth process.The MoO3-x-PCN-X(X=1,2,3,4)photocatalyst without noble platinum(Pt)finally exhibited enhanced photocatalytic hydrogen performance under visible light irradiation(λ>420 nm),with the highest hydrogen evolution rate of 15.6μmol/h,which was more than 3 times that of bulk PCN.Detailed structure-performance revealed that such improvement in visible-light hydrogen production activity originated from the intimate interfacial interaction between high-dispersed ultra-small MoO3-xnanocrystal and polymer carbon nitride as well as efficient charge carriers transfer brought by Schottky junction formed.展开更多
Aluminum nitride （AlN） nanobelts were successfully synthesized in high yield through a chloride assisted vapor-solid process. X-ray diffraction, transmission electron microscopy, and selected area electronic diffrac...Aluminum nitride （AlN） nanobelts were successfully synthesized in high yield through a chloride assisted vapor-solid process. X-ray diffraction, transmission electron microscopy, and selected area electronic diffraction demonstrate that the as-prepared nanobelts are pure, structurally uniform and single crystalline, and can be indexed to hexagonal wurtzite structure. The micro observations show that there exist no defects in the obtained nanobelts. The growth direction of the nanobelts is along [0001]. The frequency spectra of the relative dielectric constant and of the dielectric loss were measured in the frequency range of 50 Hz to 5 MHz. Analysis of these spectra indicates that the interface in samples has great influence on the dielectric behavior of samples. As compared with AlN micropowders, AlN nanobelts have much higher relative dielectric constant, especially at low frequencies at room temperature.展开更多
Non-thermal plasma(NTP)catalysis is considered one of the most promising technologies to address a wide range of energy and environmental needs,such as carbon dioxide(CO_(2))conversion,NH3 synthesis,and volatile organ...Non-thermal plasma(NTP)catalysis is considered one of the most promising technologies to address a wide range of energy and environmental needs,such as carbon dioxide(CO_(2))conversion,NH3 synthesis,and volatile organic compounds(VOCs)removal.A systematic approach to optimizing NTP systems benefits from understanding VOCs'fundamental NTP destruction behavior and analyzing the correlations between molecular structures and conversion and selectivity.Herein,the mechanical performance of the toluene destruction in NTP is examined and compared with benzene bearing a similar molecular structure.Different experimental and theoretical techniques are applied,including synchrotron vacuum ultraviolet photoionization mass spectrometry(SVUV-PIMS),thermochemistry,and quantum chemistry.Comparatively,toluene is more readily destroyed under the same NTP conditions than benzene.More intriguingly,the distribution of the decomposition species is significantly different.The theoretical calculations reveal that the abundant methyl radicals generated in toluene decomposition mainly lead to the various species distribution.These radicals promote some reactions,such as the decomposition of o-benzoquinone,one of the key intermediates,thus leading to new reaction pathways and products different from benzene.Finally,the critical mechanistic steps of toluene decomposition under the present non-thermal plasma conditions are established,which include the interactions between toluene and electrons or reactive radicals,the cleavage of the aromatic ring,and the various reaction pathways involving of methyl radicals.This study presents an effective approach to elucidate the distinct fundamental reaction mechanisms arising from subtle structural differences,offering new insights into the underlying plasma chemistry crucial for advancing various promising environmental and energy applications of non-thermal plasma systems.展开更多
Non-thermal plasma(NTP)has been demonstrated as one of the promising technologies that can degrade volatile organic compounds(VOCs)under ambient condition.However,one of the key challenges of VOCs degradation in NTP i...Non-thermal plasma(NTP)has been demonstrated as one of the promising technologies that can degrade volatile organic compounds(VOCs)under ambient condition.However,one of the key challenges of VOCs degradation in NTP is its relatively low mineralization rate,which needs to be addressed by introducing catalysts.Therefore,the design and optimization of catalysts have become the focus of NTP coupling catalysis research.In thiswork,a series of two-dimensional nanosheet Co-Ni metal oxides were synthesized by microwave method and investigated for the catalytic oxidation of benzene in an NTP-catalysis coupling system.Among them,Co_(2)Ni_(1)O_(x)achieves 60%carbon dioxide(CO_(2))selectivity(SCO_(2))when the benzene removal efficiency(REbenzene)reaches more than 99%,which is a significant enhancement compared with the CO_(2)selectivity obtained without any catalysts(38%)under the same input power.More intriguingly,this SCO_(2)is also significantly higher than that of single metal oxides,NiO or Co_(3)O_(4),which is only around 40%.Such improved performance of this binary metal oxide catalyst is uniquely attributed to the synergistic effects of Co and Ni in Co_(2)Ni_(1)O_(x)catalyst.The introduction of Co_(2)Ni_(1)O_(x)was found to promote the generation of acrolein significantly,one of the key intermediates found in NTP alone system reported previously,suggest the benzene ring open reaction is promoted.Compared with monometallic oxides NiO and Co_(3)O_(4),Co_(2)Ni_(1)O_(x)also shows higher active oxygen proportion,better oxygenmobility,and stronger low-temperature redox capability.The above factors result in the improved catalytic performance of Co_(2)Ni_(1)O_(x)in the NTP coupling removal of benzene.展开更多
Plasma-coupled catalysis is a promising volatile organic co mpounds(VOCs) removal technology because of its interactional principles of plasma decomposition and catalytic oxidation.However,the problem of harmful by-pr...Plasma-coupled catalysis is a promising volatile organic co mpounds(VOCs) removal technology because of its interactional principles of plasma decomposition and catalytic oxidation.However,the problem of harmful by-products is still in trouble.A series of rare earth doped RE-NiO_(x)(RE=Ce,Y,La) composite oxides were synthesized by metal organic frameworks(MOFs)-derived method for coupled plasma oxidation of benzene and by-product ozone removal.Compared with plasma alone,the 1%La-NiO_(x)catalyst shows the best enhancement of 50% for benzene conversion with complete removal of a maximum of 800 ppm ozone.The energy consumption for 90% benzene removal efficiency(η90%) is also reduced from 3600 to 1200 J/L.Characterization re sults of RE-NiO_(x) catalysts indicate that the doping of La causes interaction and synergistic effect between La and Ni,and the surface oxygen and lattice oxygen with defects play crucial roles in benzene oxidation and ozone decomposition,respectively.In addition,the decomposition mechanism of benzene and ozone under plasma is proposed.Plasma is responsible for the indiscriminate bond breaking in benzene and oxygen to form a variety of organic intermediates and ozone,while the La-NiO_(x) catalyst selectively oxidizes the intermediates to CO_(x)/H2O and decomposes the ozone into oxygen.展开更多
基金Supported by Guangdong Provincial Department of Science and Technology,No.2014A020212278。
文摘BACKGROUND During the perioperative period, the characteristic therapy of traditional Chinese medicine is effective in improving postoperative rehabilitation. In large-scale hospitals practicing traditional Chinese medicine, there is accumulating experience related to the promotion of fast recovery in the perioperative period.AIM To evaluate the efficacy and safety of Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique.METHODS This prospective, multicenter, randomized, controlled study included two groups: Treatment group and control group. The patients in the treatment group and control group received Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique and routine treatment, respectively. Clinical observation regarding postoperative recovery of gastrointestinal function was performed, including the times to first passage of flatus, first defecation, and first normal bowel sounds. The comparison between groups was conducted through descriptive analysis, χ~2, t, F, and rank-sum tests.RESULTS There was a statistically significant difference in the time to postoperative first defecation between the treatment and control group(87.16 ± 32.09 vs 109.79 ±40.25 h, respectively;P < 0.05). Similarly, the time to initial recovery of bowel sounds in the treatment group was significantly shorter than that in the control group(61.17 ± 26.75 vs 79.19 ± 33.35 h, respectively;P < 0.05). However, there was no statistically significant difference in the time to initial exhaust between the treatment and control groups(51.54 ± 23.66 vs 62.24 ± 25.95 h, respectively;P >0.05). The hospitalization expenses for the two groups of patients were 62283.45 ±12413.90 and 62059.42 ± 11350.51 yuan, respectively. Although the cost of hospitalization was decreased in the control group, the difference was not statistically significant(P > 0.05). This clinical trial was safe without reports of any adverse reaction or event.CONCLUSION The rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes the recovery of postoperative gastrointestinal function and is significantly better than standard approach for patients after colorectal surgery.
基金Supported by Guangdong Provincial Department of Science and Technology,No.[2013]173
文摘AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal motility.METHODS Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP(n = 30) or placebo(n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay.RESULTS Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5(13.0-26.7) vs 16.9(12.3-23.9), P < 0.05], jejunal contractions [18.3(15.3-25.0) vs 15.4(11.7-23.9), P < 0.01], and the motility index of duodenal contractions [522.0(146.0-139.0) vs 281.0(76.5-1006.0), P < 0.01] in phase Ⅱ of the migratory motor complex(MMC), which subsequently initiated the MMC cycle [74.0(30.0-118.0) vs 116.5(24.0-219.0), P < 0.05], shortened the duration of phase I of the MMC [42.0(0.0-90.0) vs 111.5(42.0-171.0), P < 0.01], and lengthened the duration of phase Ⅱ of the MMC [120(21-240) vs 58(16-170), P < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8(14.0-30.0) vs 18.0(13.0-28.5), P < 0.05], the motility index of duodenal contractions [236.0(115.0-306.0) vs 195.0(109.0-310.0), P < 0.05], and jejunal contractions [214.0(95.0-403.0) vs 178.0(55.0-304.0), P < 0.01] in phase Ⅲ of the MMC. Oral administration of XBP greatly increased plasma motilin(57.69 ± 9.03 vs 49.38 ± 8.63, P < 0.01) and ghrelin(279.20 ± 104.31 vs 238.73 ± 115.59, P < 0.01) concentrations compared to concentrations after oral administration of the placebo.CONCLUSION XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.
基金Supported by the Social Development Project of Jiangsu Science and Technology Department,No.BE2015721。
文摘Neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease and amyotrophic lateral sclerosis,are a group of incurable neurological disorders,characterized by the chronic progressive loss of different neuronal subtypes.However,despite its increasing prevalence among the everincreasing aging population,little progress has been made in the coincident immense efforts towards development of therapeutic agents.Research interest has recently turned towards stem cells including stem cells-derived exosomes,neurotrophic factors,and their combination as potential therapeutic agents in neurodegenerative diseases.In this review,we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases,with an emphasis on the combination therapy.
基金supported by the National Natural Science Foundation of China (21773153)~~
文摘A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evaluated simultaneously when the doping amount of zinc was10%.Moreover,Zn‐doped(10%)g‐C3N4synthesized by an impregnation method showed superior active ability to form the Z‐scheme with BiVO4than by in‐situ synthesis.X‐ray diffraction,UV‐Vis spectroscopy,scanning electron microscopy,and X‐ray photoelectron spectroscopy were used to characterize the samples.It was determined that more Zn?N bonds could be formed on the surface of g‐C3N4by impregnation,which could facilitate charge transfer.
基金the National Natural Science Foundation of China (21773153)the National Key Basic Research and Development Program (2018YFB1502001) for the financial supportthe Funding support from Centre of Hydrogen Science, Shanghai Jiao Tong University, China~~
文摘In this study,a ZnxCd1-xS solid solution was successfully synthesized using a hydrothermal method.MoS2 serving as a co-catalyst for hydrogen evolution was also prepared through a one-pot hydrothermal method.The structures,morphology,chemical states,and optical properties were characterized using powder X-ray diffraction,scanning electron microscopy,high-angle annular dark field-scanning transmission electron microscopy,elemental mapping,X-ray photoelectron spectroscopy,and UV-Vis diffuse reflection spectroscopy.Visible-light-driven photocatalytic experiments were conducted to simultaneously achieve hydrogen production and amoxicillin antibiotic wastewater degradation.The results indicated 8%MoS2/ZnxCd1-xS achieves the best photocatalytic performance.The ZnxCd1-xS samples illustrated a superior performance to that of CdS,which can be attributed to a thermodynamic improvement.Based on the results of PL and TRPL analyses,the enhancement of the hydrogen production mechanisms can be ascribed to the prolonged separation process of the photocarriers.Furthermore,the degradation results were analyzed using the HPLC method and the possible degradation pathways were determined through the HPLC-MS techniques.
文摘Step-scheme(S-scheme)heterojunctions in photocatalysts can provide novel and practical insight on promoting photogenerated carrier separation.The latter is critical in controlling the overall efficiency in one-step photoexcitation systems.In this study,a nanosized BiVO4/Bi0.6Y0.4VO4 solid solution was prepared by a coprecipitation method following with hydrothermal or calcination processes.The S-scheme heterojunction was fabricated by in-situ pressure-induced transformations of bismuth vanadate from the tetragonal zircon phase to the monoclinic scheelite phase,which led to the formation of BiVO4 nanoparticles with a diameter of approximately 5 nm on the surface of BiVO_(4)/Bi_(0.6)Y_(0.4)VO_(4)/Bi_(0.6)Y_(0.4)VO_(4) with S-scheme heterojunctions showed significantly enhanced photocatalytic overall water splitting activity compared with using bare BiVO_(4)/Bi_(0.6)Y_(0.4)VO_(4).Characterization of the carrier dynamics demonstrated that a superior carrier separation through S-type heterojunctions might have caused the enhanced overall water splitting(OWS)activity.Surface photovoltage spectra and the results of selective photodeposition experiments indicated that the photogenerated holes mainly migrated to the BiVO4 nanoparticles in the heterojunction.This confirmed that the charge transfer route corresponds to an S-scheme rather than a type-II heterojunction mechanism under light illumination.This study presents a facile and efficient strategy to construct S-scheme heterojunctions through a pressure-induced phase transition.The results demonstrated that S-scheme junctions composed of different crystalline phases can boost the carrier separation capacity and eventually improve the photocatalytic OWS activity.
文摘BACKGROUND Interdigestive migrating motor complexes(MMC)produce periodic contractions in the gastrointestinal tract,but the exact mechanism of action still remains unclear.Intramuscular interstitial cells of Cajal(ICC-IM)participate in gastrointestinal hormone and neuromodulation,but the correlation between ICCIM and MMC is also unclear.We found that xiangbinfang granules(XBF)mediated the phase III contraction of MMC.Here,the effects of XBF on gastric antrum motility in W/Wv mice and the effects of ICC-IM on gastric antrum MMC are reported.AIM To observe the effects of ICC-IM on gastric antrum motility and to establish the mechanism of XBF in promoting gastric antrum motility.METHODS The density of c-kit-positive ICC myenteric plexus(ICC-MP)and ICC-IM in the antral muscularis of W/Wv and wild-type(WT)mice was examined by confocal microscopy.The effects of XBF on gastric antrum slow waves in W/Wv and WT mice were recorded by intracellular amplification recording.Micro-strain-gauge force transducers were implanted into the gastric antrum to monitor the MMC and the effect of XBF on gastric antrum motility in conscious W/Wv and WT mice.RESULTS In the gastric antrum of W/Wv mice,c-kit immunoreactivity was significantly reduced,and no ICC-IM network was observed.Spontaneous rhythmic slow waves also appeared in the antrum of W/Wv mice,but the amplitude of the antrum slow wave decreased significantly in W/Wv mice(22.62±2.23 mV vs 2.92±0.52 mV,P<0.0001).MMCs were found in 7 of the 8 WT mice but no complete MMC cycle was found in W/Wv mice.The contractile frequency and amplitude index of the gastric antrum were significantly increased in conscious WT compared to W/Wv mice(frequency,3.53±0.18 cpm vs 1.28±0.12 cpm;amplitude index,23014.26±1798.65 mV·20 min vs 3782.16±407.13 mV·20 min;P<0.0001).XBF depolarized smooth muscle cells of the gastric antrum in WT and W/Wv mice in a dose-dependent manner.Similarly,the gastric antrum motility in WT mice was significantly increased after treatment with XBF 5 mg(P<0.05).Atropine(0.1 mg/kg)blocked the enhancement of XBF in WT and W/Wv mice completely,while tetrodotoxin(0.05 mg/kg)partially inhibited the enhancement by XBF.CONCLUSION ICC-IM participates in the regulation of gastric antrum MMC in mice.XBF induces MMC III-like contractions that enhance gastric antrum motility via ICCIM in mice.
基金supported by the National Key Technology R&D Program of China(Grant Nos.2018YFA0209104 and 2016YFB0402403)
文摘A long-/long-wave dual-color detector with N-M-π-B-π-M-N structure was developed based on a type-Ⅱ InAs/GaSb superlattice. The saturated responsivity was achieved under low bias voltage for both channels. The device could be operated as a single detector for sequential detection and showed high quantum efficiencies. The peak quantum efficiencies of long-wavelength infrared band-1(blue channel) and long-wavelength infrared band-2(red channel) were 44% at 6.3 μm under 20 mV and 57% at 9.1 μm under-60 mV, respectively. The optical performance for each channel was achieved using a 2 μm thickness absorber. Due to the high QE, the specific detectivities of the blue and red channels reached5.0×10^(11) cm·Hz^(1/2)/W at 6.8 μm and 3.1×10^(11) cm·Hz1^(1/2)/W at 9.1 μm, respectively, at 77 K.
基金the National Natural Science Foundation of China under grant Nos.10674138 and 20571022.
文摘Aluminum nitride （AIN） nanowires, serrated nanoribbons, and nanoribbons were selectively obtained through a simple chloride assisted chemical vapor deposition process. The morphologies of the products could be controlled by adjusting the deposition position and the flux of the reactant gas. The morphologies and structures of the AIN products were investigated in detail. The formation mechanism of the as-prepared different morphologies of AIN one-dimensional （ID） nanostructures was discussed on the basis of the experimental results.
基金supported by the financial support from National Science Foundation of China(21872093)funding support from Center of Hydrogen Science,Shanghai Jiao Tong University,China
文摘Co-catalysts play a critical role in enhancing the efficiency of inorganic semiconductor photocatalysts;however,synthetic approaches to tailoring cocatalyst properties are rarely the focus of research efforts.A photomediated route to control the dispersion and oxidation state of a platinum(Pt)cocatalyst through defect generation in the P25 titania photocatalyst substrate is reported.Titania photoirradiation in the presence of methanol induces longlived surface defects which subsequently promote the photodeposition of highly dispersed(2.2±0.8 nm)and heavily reduced Pt nanoparticles on exposure to H2 PtCl6.The optimal methanol concentration of 20 vol%produces the highest density of metallic Pt nanoparticles.Photocatalytic activity for water splitting and associated hydrogen(H2)production under UV irradiation mirrors the methanol concentration employed during the P25 photoirradiation pretreatment and resulting Pt loading resulting in a common mass-normalized H2 productivity of 3800±130 mmol gpt-1 h-1.Photomediated surface defects(arising in the presence of a methanol hole scavenger)provide electron traps that regulate subsequent photodeposition of a Pt co-catalyst over P25,offering a facile route to tune photocatalytic efficiency.
基金supported by the National Natural Science Foundation of China(21872093)the National Key Research and Development Program of China(2018YFB1502001)funding support from the Center of Hydrogen Science,Shanghai Jiao Tong University,China。
文摘The reconstruction during oxygen evolution reaction (OER) significantly affects the electronic and local geometry structure of metal sites in electrocatalyst.Compared with well-investigated cobalt-based materials,the reconstruction of rocksalt CoO with purely Co^(2+) in octahedral (Oh) coordination has not been revealed in detail.Herein,monolayer Co O supported on reduced graphene oxide (r GO) was synthesized via a one-pot hydrothermal strategy with calcinating in Ar atmosphere.The structure evolution of twodimension (2D) Co O/r GO during OER was revealed by in situ X-ray absorption spectroscopy (XAS).The transition from Co O toward Co3O_(4) already occurred at open circuit potential,further enhanced at 1.23 V (vs.RHE).The Co Ox(OH)ywas determined as the active phase at 1.53 V,displaying a tetrahedral Co coordination defective spinel Co_(3)O_(4) with the Co-O shell that featured the (oxy)hydroxide,not the standard Co OOH.After OER,the irreversible transition from CoO to Co_(3)O_(4) was observed.In contrast,in situ Raman spectra revealed a reversible amorphization process on Co_(3)O_(4)/r GO under operation conditions.Furthermore,this study indicated that the reconstruction behavior could be more effectively revealed by XAS using 2D materials.
基金the National Natural Science Foundation of China(No.21872093)the National Key Research and Development Program of China(No.2018YFB1502001)the Center of Hydrogen Science of Shanghai Jiao Tong University。
文摘Developing low-cost and high-efficient noble-metal-free cocatalysts has been a challenge to achieve economic hydrogen production.In this work,molybdenum oxides(MoO3-x)were in situ loaded on polymer carbon nitride(PCN)via a simple one-pot impregnation-calcination approach.Different from post-impregnation method,intimate coupling interface between high-dispersed ultra-small MoO3-xnanocrystal and PCN was successfully formed during the in situ growth process.The MoO3-x-PCN-X(X=1,2,3,4)photocatalyst without noble platinum(Pt)finally exhibited enhanced photocatalytic hydrogen performance under visible light irradiation(λ>420 nm),with the highest hydrogen evolution rate of 15.6μmol/h,which was more than 3 times that of bulk PCN.Detailed structure-performance revealed that such improvement in visible-light hydrogen production activity originated from the intimate interfacial interaction between high-dispersed ultra-small MoO3-xnanocrystal and polymer carbon nitride as well as efficient charge carriers transfer brought by Schottky junction formed.
基金ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China （No.10674138 and No.20571022）. The authors express their appreciations to Professor Q. F. Fang, Dr. X. P. Wang, and Mr. Z. J. Cheng for the technical support and helpful discussions in the dielectric measurements.
文摘Aluminum nitride （AlN） nanobelts were successfully synthesized in high yield through a chloride assisted vapor-solid process. X-ray diffraction, transmission electron microscopy, and selected area electronic diffraction demonstrate that the as-prepared nanobelts are pure, structurally uniform and single crystalline, and can be indexed to hexagonal wurtzite structure. The micro observations show that there exist no defects in the obtained nanobelts. The growth direction of the nanobelts is along [0001]. The frequency spectra of the relative dielectric constant and of the dielectric loss were measured in the frequency range of 50 Hz to 5 MHz. Analysis of these spectra indicates that the interface in samples has great influence on the dielectric behavior of samples. As compared with AlN micropowders, AlN nanobelts have much higher relative dielectric constant, especially at low frequencies at room temperature.
基金supported by the National Natural Science Foundation of China(U1832155)National Key Research and Development Program of China(2017YFE0127500)。
文摘Non-thermal plasma(NTP)catalysis is considered one of the most promising technologies to address a wide range of energy and environmental needs,such as carbon dioxide(CO_(2))conversion,NH3 synthesis,and volatile organic compounds(VOCs)removal.A systematic approach to optimizing NTP systems benefits from understanding VOCs'fundamental NTP destruction behavior and analyzing the correlations between molecular structures and conversion and selectivity.Herein,the mechanical performance of the toluene destruction in NTP is examined and compared with benzene bearing a similar molecular structure.Different experimental and theoretical techniques are applied,including synchrotron vacuum ultraviolet photoionization mass spectrometry(SVUV-PIMS),thermochemistry,and quantum chemistry.Comparatively,toluene is more readily destroyed under the same NTP conditions than benzene.More intriguingly,the distribution of the decomposition species is significantly different.The theoretical calculations reveal that the abundant methyl radicals generated in toluene decomposition mainly lead to the various species distribution.These radicals promote some reactions,such as the decomposition of o-benzoquinone,one of the key intermediates,thus leading to new reaction pathways and products different from benzene.Finally,the critical mechanistic steps of toluene decomposition under the present non-thermal plasma conditions are established,which include the interactions between toluene and electrons or reactive radicals,the cleavage of the aromatic ring,and the various reaction pathways involving of methyl radicals.This study presents an effective approach to elucidate the distinct fundamental reaction mechanisms arising from subtle structural differences,offering new insights into the underlying plasma chemistry crucial for advancing various promising environmental and energy applications of non-thermal plasma systems.
基金supported by the National Key Research and Development Program of China(No.2017YFE0127500)National Natural Science Foundation of China(No.U1832155).
文摘Non-thermal plasma(NTP)has been demonstrated as one of the promising technologies that can degrade volatile organic compounds(VOCs)under ambient condition.However,one of the key challenges of VOCs degradation in NTP is its relatively low mineralization rate,which needs to be addressed by introducing catalysts.Therefore,the design and optimization of catalysts have become the focus of NTP coupling catalysis research.In thiswork,a series of two-dimensional nanosheet Co-Ni metal oxides were synthesized by microwave method and investigated for the catalytic oxidation of benzene in an NTP-catalysis coupling system.Among them,Co_(2)Ni_(1)O_(x)achieves 60%carbon dioxide(CO_(2))selectivity(SCO_(2))when the benzene removal efficiency(REbenzene)reaches more than 99%,which is a significant enhancement compared with the CO_(2)selectivity obtained without any catalysts(38%)under the same input power.More intriguingly,this SCO_(2)is also significantly higher than that of single metal oxides,NiO or Co_(3)O_(4),which is only around 40%.Such improved performance of this binary metal oxide catalyst is uniquely attributed to the synergistic effects of Co and Ni in Co_(2)Ni_(1)O_(x)catalyst.The introduction of Co_(2)Ni_(1)O_(x)was found to promote the generation of acrolein significantly,one of the key intermediates found in NTP alone system reported previously,suggest the benzene ring open reaction is promoted.Compared with monometallic oxides NiO and Co_(3)O_(4),Co_(2)Ni_(1)O_(x)also shows higher active oxygen proportion,better oxygenmobility,and stronger low-temperature redox capability.The above factors result in the improved catalytic performance of Co_(2)Ni_(1)O_(x)in the NTP coupling removal of benzene.
基金Project supported by the National Natural Science Foundation of China(22176123,U1832155)the National Key Research&Development Plan(2017YFC0211804).
文摘Plasma-coupled catalysis is a promising volatile organic co mpounds(VOCs) removal technology because of its interactional principles of plasma decomposition and catalytic oxidation.However,the problem of harmful by-products is still in trouble.A series of rare earth doped RE-NiO_(x)(RE=Ce,Y,La) composite oxides were synthesized by metal organic frameworks(MOFs)-derived method for coupled plasma oxidation of benzene and by-product ozone removal.Compared with plasma alone,the 1%La-NiO_(x)catalyst shows the best enhancement of 50% for benzene conversion with complete removal of a maximum of 800 ppm ozone.The energy consumption for 90% benzene removal efficiency(η90%) is also reduced from 3600 to 1200 J/L.Characterization re sults of RE-NiO_(x) catalysts indicate that the doping of La causes interaction and synergistic effect between La and Ni,and the surface oxygen and lattice oxygen with defects play crucial roles in benzene oxidation and ozone decomposition,respectively.In addition,the decomposition mechanism of benzene and ozone under plasma is proposed.Plasma is responsible for the indiscriminate bond breaking in benzene and oxygen to form a variety of organic intermediates and ozone,while the La-NiO_(x) catalyst selectively oxidizes the intermediates to CO_(x)/H2O and decomposes the ozone into oxygen.
