A personalized electronic textile for ultrasensitive pressure sensing enabled by biocompatible MXene/ PEDOT:PSS composite

Flexible,breathable,and highly sensitive pressure sensors have increasingly become a focal point of interest due to their pivotal role in healthcare monitoring,advanced electronic skin applications,and disease diagnosis.However,traditional methods,involving elastomer film-based substrates or encapsulation techniques,often fall short due to mechanical mismatches,discomfort,lack of breathability,and limitations in sensing abilities.Consequently,there is a pressing need,yet it remains a significant challenge to create pressure sensors that are not only highly breathable,flexible,and comfortable but also sensitive,durable,and biocompatible.Herein,we present a biocompatible and breathable fabric-based pressure sensor,using nonwoven fabrics as both the sensing electrode(coated with MXene/poly(3,4-ethylenedioxythiophene):polystyrene sulfonate[PEDOT:PSS])and the interdigitated electrode(printed with MXene pattern)via a scalable spray-coating and screen-coating technique.The resultant device exhibits commendable air permeability,biocompatibility,and pressure sensing performance,including a remarkable sensitivity(754.5 kPa^(−1)),rapid response/recovery time(180/110 ms),and robust cycling stability.Furthermore,the integration of PEDOT:PSS plays a crucial role in protecting the MXene nanosheets from oxidation,significantly enhancing the device's long-term durability.These outstanding features make this sensor highly suitable for applications in fullrange human activities detection and disease diagnosis.Our study underscores the promising future of flexible pressure sensors in the realm of intelligent wearable electronics,setting a new benchmark for the industry.

Two-step growth of β-Ga_(2)O_(3) on c-plane sapphire using MOCVD for solar-blind photodetector

In this work,a two-step metal organic chemical vapor deposition(MOCVD)method was applied for growingβ-Ga_(2)O_(3) film on c-plane sapphire.Optimized buffer layer growth temperature(T_(B))was found at 700℃ and theβ-Ga_(2)O_(3) film with full width at half maximum(FWHM)of 0.66°was achieved.A metal−semiconductor−metal(MSM)solar-blind photodetector(PD)was fabricated based on theβ-Ga_(2)O_(3) film.Ultrahigh responsivity of 1422 A/W@254 nm and photo-to-dark current ratio(PDCR)of 10^(6) at 10 V bias were obtained.The detectivity of 2.5×10^(15) Jones proved that the photodetector has outstanding performance in detecting weak signals.Moreover,the photodetector exhibited superior wavelength selectivity with rejection ratio(R_(250 nm)/R_(400 nm))of 105.These results indicate that the two-step method is a promising approach for preparation of high-qualityβ-Ga_(2)O_(3)films for high-performance solar-blind photodetectors.

Experimental study of solid-liquid origami composite structures with improved impact resistance

In this paper,a liquid-solid origami composite design is proposed for the improvement of impact resistance.Employing this design strategy,Kresling origami composite structures with different fillings were designed and fabricated,namely air,water,and shear thickening fluid(STF).Quasi-static compression and drop-weight impact experiments were carried out to compare and reveal the static and dynamic mechanical behavior of these structures.The results from drop-weight impact experiments demonstrated that the solid-liquid Kresling origami composite structures exhibited superior yield strength and reduced peak force when compared to their empty counterparts.Notably,the Kresling origami structures filled with STF exhibited significantly heightened yield strength and reduced peak force.For example,at an impact velocity of 3 m/s,the yield strength of single-layer STF-filled Kresling origami structures increased by 772.7%and the peak force decreased by 68.6%.This liquid-solid origami composite design holds the potential to advance the application of origami structures in critical areas such as aerospace,intelligent protection and other important fields.The demonstrated improvements in impact resistance underscore the practical viability of this approach in enhancing structural performance for a range of applications.

微胶囊相变材料对聚氨酯注浆材料固化放热行为的影响

聚氨酯注浆材料在固化时由于芯部热量的聚集会发生热解甚至阴燃,造成材料性能劣化和使用安全性隐患。文中通过将相变蓄热微胶囊引入聚氨酯注浆材料中实现对材料固化放热行为的可控调节。通过界面聚合制备了一系列以聚氨酯为壳、石蜡为芯的微胶囊相变材料(MEPCMs),并与多元醇、催化剂共混后与多异氰酸酯反应制备聚氨酯注浆材料。使用激光粒度仪、差示扫描量热仪、热重分析仪和红外热像仪对所合成的MEPCMs的粒径与热行为进行了表征,并使用旋转黏度计、万能试验机等测试了聚氨酯注浆材料A组分的浆液黏度、固结体的力学性能与固化行为。结果表明,与未改性的聚氨酯注浆材料相比,加入MEPCMs可使固化最高反应温度显著降低,固化时间明显延长,固化放热速率降低。随着MEPCMs含量的增加,A组分浆液黏度增加,固结体强度下降。当MEPCMs质量分数为15%时,A组分浆液黏度为551.9 m Pa·s,固化最高反应温度为98.7℃,固化时间为235 s,固结体压缩及拉伸强度分别为44.9 MPa和14.7 MPa。所制备的相变材料改性的聚氨酯注浆材料在保持良好的浆液可注性、固结体强度及热稳定性的同时,实现了对固化放热行为的调控。

Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of cancers worldwide,ranking fifth among men and seventh among women,resulting in more than 7 million deaths annually.With the development of medical tech-nology,the 5-year survival rate of HCC patients can be increased to 70%.How-ever,HCC patients are often at increased risk of cardiovascular disease(CVD)death due to exposure to potentially cardiotoxic treatments compared with non-HCC patients.Moreover,CVD and cancer have become major disease burdens worldwide.Thus,further research is needed to lessen the risk of CVD death in HCC patient survivors.METHODS This study was conducted on the basis of the Surveillance,Epidemiology,and End Results database and included HCC patients with a diagnosis period from 2010 to 2015.The independent risk factors were identified using the Fine-Gray model.A nomograph was constructed to predict the CVM in HCC patients.The nomograph performance was measured using Harrell’s concordance index(C-index),calibration curve,receiver operating characteristic(ROC)curve,and area under the ROC curve(AUC)value.Moreover,the net benefit was estimated via decision curve analysis(DCA).RESULTS The study included 21545 HCC patients,of whom 619 died of CVD.Age(<60)[1.981(1.573-2.496),P<0.001],marital status(married)[unmarried:1.370(1.076-1.745),P=0.011],alpha fetoprotein(normal)[0.778(0.640-0.946),P=0.012],tumor size(≤2 cm)[(2,5]cm:1.420(1.060-1.903),P=0.019;>5 cm:2.090(1.543-2.830),P<0.001],surgery(no)[0.376(0.297-0.476),P<0.001],and chemotherapy(none/unknown)[0.578(0.472-0.709),P<0.001]were independent risk factors for CVD death in HCC patients.The discrimination and calibration of the nomograph were better.The C-index values for the training and validation sets were 0.736 and 0.665,respectively.The AUC values of the ROC curves at 2,4,and 6 years were 0.702,0.725,0.740 in the training set and 0.697,0.710,0.744 in the validation set,respectively.The calibration curves showed that the predicted probab-ilities of the CVM prediction model in the training set vs the validation set were largely consistent with the actual probabilities.DCA demonstrated that the prediction model has a high net benefit.CONCLUSION Risk factors for CVD death in HCC patients were investigated for the first time.The nomograph served as an important reference tool for relevant clinical management decisions.

Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were enrolled.Based on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up treatment.Patients were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 genotype.We aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity.The cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were calculated.Results CLR was observed in 44.4%of the overall population.Significant differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P<0.05).At the 12-month follow-up,13 patients(1.9%)died and 96 patients(14.2%)experienced MACCEs.Patients with CLR(9.6%vs.11.7%vs.22.1%,P<0.05)or poor metabolizer(10.7%vs.16.4%vs.22.6%,P=0.026)experienced a higher rate of MACCEs.A MACCEs risk score between zero and two was calculated.The highest incidence of MACCEs significantly increased with the 2-positive results,and the area under the curve(AUC)was 0.712(95%CI:0.650-0.774,P<0.05).There was no significant difference between the group with a score of one and the occurrence of MACCEs(P>0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene polymorphism.CYP2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

Identification of yellowhorn(Xanthoceras sorbifolium)WRKY transcription factor family and analysis of abiotic stress response model

WRKY transcription factors are widely distributed in higher plants and play important roles in many biological processes,including stress resistance.The recently published genome sequence of yellowhorn,an oil tree with robust resistance to cold,drought,heat,salt and alkali,provides an excellent opportunity to identify and characterize the entire yellowhorn WRKY protein family and a basis for the study of abiotic stress resistance of WRKY gene family in forest species.In the present comprehensive analysis of WRKY transcription factors in yellowhorn,65 WRKY genes were identified and defined based on their location on the chromosome.According to their structure and phylogenetic relationships,XsWRKY genes clustered into WRKY groupsⅠ-Ⅲ.Segmental duplication events played a significant role in the expansion of WRKY gene family.Furthermore,transcriptomic data and real-time quantitative PCR analysis showed that expression of XsWRKY genes responding to salt and drought stresses and a hormone treatment.We also determined structures of the encoded proteins,c is-elements of the promoter region,and expression patterns.These results provide a foundation for the study of the biological function of WRKY transcription factors in yellowhorn.

无金属、卤素、硫等杂元素的聚甲基丙烯酸甲酯纳米微球的合成

聚合物纳米微球可用于多孔催化剂的制备,但是来源于乳化剂、引发剂等的硫、卤素、碱金属等容易导致催化剂中毒。因此,文中以十二烷基二甲基氧化胺为乳化剂,过氧化氢/抗坏血酸氧化还原体系为引发剂,通过甲基丙烯酸甲酯乳液聚合,合成了仅含碳、氢、氧、氮4种元素的聚甲基丙烯酸甲酯纳米微球。研究了聚合工艺、引发剂用量与配比、乳化剂用量及单体浓度对单体转化率和微球粒径的影响。结果表明,搅拌速率、温度、引发剂配比及乳化剂用量对单体转化率的影响较大;微球粒径受聚合工艺、引发剂用量及配比的影响较小,微球粒径主要受乳化剂用量和单体浓度控制。

75 GHz germanium waveguide photodetector with 64 Gbps data rates utilizing an inductive-gain-peaking technique

High-performance germanium(Ge)waveguide photodetectors are designed and fabricated utilizing the inductivegain-peaking technique.With the appropriate integrated inductors,the 3-dB bandwidth of photodetectors is significantly improved owing to the inductive-gain-peaking effect without any compromises to the dark current and optical responsivity.Measured 3-dB bandwidth up to 75 GHz is realized and clear open eye diagrams at 64 Gbps are observed.In this work,the relationship between the frequency response and large signal transmission characteristics on the integrated inductors of Ge waveguide photodetectors is investigated,which indicates the high-speed performance of photodetectors using the inductive-gainpeaking technique.

高镍三元/硅氧碳软包电池在不同温度下的日历老化机制

由于电动汽车在大多数时间处于非工作状态,因此电池搁置期间的日历老化会对电池的寿命产生显著影响。高温加速实验是快速评价电池日历寿命的常用方法,为了获得可靠的高温加速老化实验结果,需要对不同温度条件下的电池衰减机理进行研究。以高镍三元/硅氧碳软包电池为研究对象,基于无损的电化学微分曲线分析和电池拆解验证,研究不同搁置温度对高镍/硅氧碳电池日历老化性能及老化机制的影响。结果表明:随着搁置温度的升高,电池老化速度逐渐加快,表现为容量加速衰减和直流内阻大幅增加。无损分析结果表明:活性锂损失和正极活性物质损失是电池日历老化的主要影响因素,随着温度升高,电池的活性锂损失程度和正极活性物质损失程度都有所增加,负极老化情况基本保持不变;进一步结合拆解验证结果表明:55℃下的高温搁置加速了正极材料性能的衰退,高温下正极NCM811材料颗粒出现内部裂纹和粉化,不宜作为电池搁置期间加速老化实验的加速因子。

F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global incidence.Unfortunately,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive and therapeutic measures.AIM To explore the molecular mechanism of NAFLD.METHODS Whole genome sequencing(WGS)analysis was performed on liver tissues from patients with NAFLD(n=6)and patients with normal metabolic conditions(n=6)to identify the target genes.A NAFLD C57BL6/J mouse model induced by 16 wk of high-fat diet feeding and a hepatocyte-specific F-box only protein 2(FBXO2)overexpression mouse model were used for in vivo studies.Plasmid transfection,co-immunoprecipitation-based mass spectrometry assays,and ubiquitination in HepG2 cells and HEK293T cells were used for in vitro studies.RESULTS A total of 30982 genes were detected in WGS analysis,with 649 up-regulated and 178 down-regulated.Expression of FBXO2,an E3 ligase,was upregulated in the liver tissues of patients with NAFLD.Hepatocyte-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in mice.Overexpression of FBXO2 aggravated odium oleate(OA)-induced lipid accumulation in HepG2 cells,resulting in an abnormal expression of genes related to lipid metabolism,such as fatty acid synthase,peroxisome proliferator-activated receptor alpha,and so on.In contrast,knocking down FBXO2 in HepG2 cells significantly alleviated the OA-induced lipid accumulation and aberrant expression of lipid metabolism genes.The hydroxyl CoA dehydrogenase alpha subunit(HADHA),a protein involved in oxidative stress,was a target of FBXO2-mediated ubiquitination.FBXO2 directly bound to HADHA and facilitated its proteasomal degradation in HepG2 and HEK293T cells.Supplementation with HADHA alleviated lipid accumulation caused by FBXO2 overexpression in HepG2 cells.CONCLUSION FBXO2 exacerbates lipid accumulation by targeting HADHA and is a potential therapeutic target for NAFLD。

Temperature influences of the recoil characteristics for aluminum honeycomb buffer in the tether-net launcher

Fluctuations in outer space's temperature would affect the spacecraft's regular operation.This paper aims to study the temperature influences of the aluminum honeycomb buffer in the tether-net launcher.Firstly,a buffer structure was designed to attenuate the pyroshock generated by the pyrotechnic device.Secondly,the mechanical properties of aluminum honeycomb at different temperatures were obtained through quasi-static compression experiments.Then,the internal ballistic responses of the launcher were gained by the closed bomb tests and the equivalent classical interior ballistic model.Finally,the recoil performance of the launcher with aluminum honeycomb buffer at different temperatures was studied.It is revealed that the aluminum honeycomb crushing force gradually decreases with the temperature increases.The peak pressure,burning rate coefficient and velocity increase while the peak time decreases with the temperature increase for the interior ballistics.For the launcher recoil responses,the average launch recoil decreases if the aluminum honeycomb doesn't enter the dense stage.The impact acceleration,projectile velocity and displacement increase as the temperature increase.The paper spotlights the temperature's influence on the recoil characteristics of the aluminum honeycomb buffer,which provides a new idea for buffering technology of pyrotechnic devices in a complex space environment.

Causal associations of brain structure with bone mineral density:a large-scale genetic correlation study

In this study,we aimed to investigate the causal associations of brain structure with bone mineral density(BMD).Based on the genome-wide association study(GWAS)summary statistics of 1325 brain imaging-derived phenotypes(BIDPs)of brain structure from the UK Biobank and GWAS summary datasets of 5 BMD locations,including the total body,femoral neck,lumbar spine,forearm,and heel from the GEFOS Consortium,linkage disequilibrium score regression(LDSC)was conducted to determine the genetic correlations,and Mendelian randomization(MR)was then performed to explore the causal relationship between the BIDPs and BMD.Several sensitivity analyses were performed to verify the strength and stability of the present MR outcomes.To increase confidence in our findings,we also performed confirmatory MR between BIDPs and osteoporosis.LDSC revealed that 1.93%of BIDPs,with a false discovery rate(FDR)<0.01,were genetically correlated with BMD.Additionally,we observed that 1.31%of BIDPs exhibited a significant causal relationship with BMD(FDR<0.01)through MR.Both the LDSC and MR results demonstrated that the BIDPs“Volume of normalized brain,”“Volume of gray matter in Left Inferior Frontal Gyrus,pars opercularis,”“Volume of Estimated Total Intra Cranial”and“Volume-ratio of brain segmentation/estimated total intracranial”had strong associations with BMD.Interestingly,our results showed that more left BIDPs were causally associated with BMD,especially within and around the left frontal region.In conclusion,a part of the brain structure causally influences BMD,which may provide important perspectives for the prevention of osteoporosis and offer valuable insights for further research on the brain-bone axis.

Combination of a reaction cell and an ultra-high vacuum system for the in situ preparation and characterization of a model catalyst

An in-depth understanding of the structure-activity relationship between the surface structure,chemical composition,adsorption and desorption of molecules,and their reaction activity and selectivity is necessary for the rational design of high-performance catalysts.Herein,we present a method for studying catalytic mechanisms using a combination of in situ reaction cells and surface science techniques.The proposed system consists of four parts:preparation chamber,temperatureprogrammed desorption(TPD)chamber,quick load-lock chamber,and in situ reaction cell.The preparation chamber was equipped with setups based on the surface science techniques used for standard sample preparation and characterization,including an Ar+sputter gun,Auger electron spectrometer,and a low-energy electron diffractometer.After a well-defined model catalyst was prepared,the sample was transferred to a TPD chamber to investigate the adsorption and desorption of the probe molecule,or to the reaction cell,to measure the catalytic activity.A thermal desorption experiment for methanol on a clean Cu(111)surface was conducted to demonstrate the functionality of the preparation and TPD chambers.Moreover,the repeatability of the in situ reaction cell experiment was verified by CO_(2) hydrogenation on the Ni(110)surface.At a reaction pressure of 800 Torr at 673 K,turnover frequencies for the methanation reaction and reverse water-gas shift reaction were 0.15 and 7.55 Ni atom^(-1) s^(-1),respectively.

Detection of new candidate genes controlling seed weight by integrating gene coexpression analysis and QTL mapping in Brassica napus L.

Seed weight is a component of seed yield in rapeseed(Brassica napus L.).Although quantitative trait loci(QTL)for seed weight have been reported in rapeseed,only a few causal quantitative trait genes(QTGs)have been identified,resulting in a limitation in understanding of seed weight regulation.We constructed a gene coexpression network at the early seed developmental stage using transcripts of 20,408 genes in QTL intervals and 1017 rapeseed homologs of known genes from other species.Among the 10 modules in this gene coexpression network,modules 1 and 2 were core modules and contained genes involved in source–flow–sink processes such as synthesis and transportation of fatty acid and protein,and photosynthesis.A hub gene SERINE CARBOXYPEPTIDASE-LIKE 19(SCPL19)was identified by candidate gene association analysis in rapeseed and functionally investigated using Arabidopsis T-DNA mutant and overexpression lines.Our study demonstrates the power of gene coexpression analysis to prioritize candidate genes from large candidate QTG sets and enhances the understanding of molecular mechanism for seed weight at the early developmental stage in rapeseed.

Identification of a candidate QTG for seed number per silique by integrating QTL mapping and RNA-seq in Brassica napus L.

Seed number per silique(SNPS)is one of seed yield components in rapeseed,but its genetic mechanism remains elusive.Here a double haploid(DH)population derived from a hybrid between female 6Q006with 35–40 SNPS and male 6W26 with 10–15 SNPS was investigated for SNPS in the year 2017,2018,2019 and 2021,and genotyped with Brassica 60K Illumina Infinium SNP array.An overlapping major QTL(qSNPS.C09)explaining 51.50%of phenotypic variance on average was narrowed to a 0.90 Mb region from 44.87 Mb to 45.77 Mb on chromosome C09 by BSA-seq.Subsequently,two DEGs in this interval were detected between extreme individuals in DH and F_2populations by transcriptome sequencing at7 and 14 days after pollination siliques.Of which,BnaC09g45400D encoded an adenine phosphoribosyltransferase 5(APT5)has a 48-bp InDel variation in the promoter of two parents.Candidate gene association analysis showed that this InDel variation was associated with SNPS in a nature population of rapeseed,where 54 accessions carrying the same haplotype as parent 6Q006 had higher SNPS than103 accessions carrying the same haplotype as parent 6W26.Collectively,the findings are helpful for rapeseed molecular breeding of SNPS,and provide new insight into the genetic and molecular mechanism of SNPS in rapeseed.

Multi-point discharge model: study on corona discharge of double-ended needle in large space

Corona discharge, as a common means to obtain non-equilibrium plasma, can generally obtain high-concentration plasma by increasing discharge points to meet production needs. However,the existing numerical simulation models used to study multi-point corona discharge are all calculations of small-scale space models, which cannot obtain the distribution characteristics of plasma in large space. Based on our previous research, this paper proposes a hybrid model for studying the distribution of multi-point discharge plasma in large-scale spaces, which divides the computational domain and computes separately with the hydrodynamic model and the ion mobility model. The simulation results are verified by a needle–ball electrode device. Firstly, the electric field distribution and plasma distribution of the needle electrodes with single tip and double tips are compared and discussed. Secondly, the plasma distribution of the needle electrode with the double tip at different voltages is investigated. Both computational and experimental results indicate that the charged particle concentration and current of the needle electrode with double tips are both twice as high as those of the needle electrode with a single tip. This model can extend the computational area of the multi-point corona discharge finite element model to the sub-meter(25 cm) or meter level, which provides an effective means to study the plasma distribution generated by multiple discharge points in large-scale space.

Video Conference System in Mixed Reality Using a Hololens

The mixed reality conference system proposed in this paper is a robust,real-time video conference application software that makes up for the simple interaction and lack of immersion and realism of traditional video conference,which realizes the entire process of holographic video conference from client to cloud to the client.This paper mainly focuses on designing and implementing a video conference system based on AI segmentation technology and mixed reality.Several mixed reality conference system components are discussed,including data collection,data transmission,processing,and mixed reality presentation.The data layer is mainly used for data collection,integration,and video and audio codecs.The network layer uses Web-RTC to realize peer-to-peer data communication.The data processing layer is the core part of the system,mainly for human video matting and human-computer interaction,which is the key to realizing mixed reality conferences and improving the interactive experience.The presentation layer explicitly includes the login interface of the mixed reality conference system,the presentation of real-time matting of human subjects,and the presentation objects.With the mixed reality conference system,conference participants in different places can see each other in real-time in their mixed reality scene and share presentation content and 3D models based on mixed reality technology to have a more interactive and immersive experience.

A robust method for performance evaluation of the vapor cell for magnetometry

A robust performance evaluation method for vapor cells used in magnetometers is proposed in this work.The performance of the vapor cell determines the sensitivity of the magnetic measurement,which is the core parameter of a magnetometer.After establishing the relationship between intrinsic sensitivity and the total relaxation rate,the total relaxation rate of the vapor cell can be obtained to represent the intrinsic sensitivity of the magnetometer by fitting the parameters of the magnetic resonance experiments.The method for measurement of the total relaxation rate based on the magnetic resonance experiment proposed in this work is robust and insensitive to ambient noise.Experiments show that,compared with conventional sensitivity measurement,the total relaxation rate affected by magnetic noise below 0.9 n T,pump light frequency noise below 1.5 GHz,pump light power noise below 9%,probe light power noise below 3%and temperature fluctuation of 150±3℃deviates by less than 2%from the noise-free situation.This robust performance evaluation method for vapor cells is conducive to the construction of a multi-channel high-spatial-resolution cardio-encephalography system.

Diagnostic Value of TB-IGRA, PPD, TB-DNA-PCR and TB-Ab in Silicosis Complicated with Tuberculosis

Purpose: The purpose of this article is to investigate the clinical value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), PPD (Intradermal Terbuculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and TB-Ab (Tuberculosis-Antibody) in diagnosing silicosis complicated with pulmonary tuberculosis. Methods: 53 cases of suspected silicosis complicated with pulmonary tuberculosis were selected in the time span ranging from February 2017 to May 2019. TB-IGRA test, PPD test, TB-DNA-PCR and TB-Ab detection were performed. The sensitivity, specificity, positive predictive value and negative predictive value were calculated. Results: Silicosis and pulmonary tuberculosis were diagnosed in 11 cases, with an incidence of 20.75%. The positive rates of TB-IGRA, PPD, TB-DNA-PCR and TB-Ab were 66.04%, 30.19%, 5.67% and 26.42%, respectively. The sensitivity was 90.91%, 81.82%, 27.27% and 54.55% respectively. The specificity was 42.86%, 80.95%, 100% and 80.95% respectively. The positive predictive values were 28.57%, 50%, 100% and 42.86% respectively. The negative predictive values were 94.44%, 91.89%, 84% and 87.18%. The positive rate, sensitivity and negative predictive value of TB-IGRA were the highest, while the specificity of TB-DNA-PCR was the highest yet with low positive rate, sensitivity and positive predictive value. Conclusion: The positive rate and sensitivity of TB-IGRA were high, yet with poor specificity, so it was impossible to judge whether the cases belonged to active pulmonary tuberculosis. The combination of PPD and TB-DNA-PCR could improve the sensitivity, specificity and positive predictive value, and the diagnostic accuracy of active pulmonary tuberculosis, which showed satisfactory clinical value.