At present,approximately 20%of Hodgkin lymphomas(HL)are relapsed and refractory,and therapeutic methods including chemotherapy,radiotherapy,and even stem cell transplantation are unsatisfactory.Brentuximab vedotin,com...At present,approximately 20%of Hodgkin lymphomas(HL)are relapsed and refractory,and therapeutic methods including chemotherapy,radiotherapy,and even stem cell transplantation are unsatisfactory.Brentuximab vedotin,composed of CD30 antibody and a chemotherapeutic agent,is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface.In clinical trials,the response rate and complete remission rate of this drug were 73%and 40%,respectively,for relapsed and refractory HL.Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab.Before the treatment with brentuximab,the patient underwent chemotherapy,radiotherapy,and autologous stem cell transplantation.However,the disease continued to progress,affecting multiple organs and prompting symptoms such as persistent fever.After the treatment with brentuximab,the patient′s condition improved.Body temperature returned to normal after 4 days.Lung nodules were reduced in size and number after a single course of treatment,and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment,respectively.The entire treatment process progressed smoothly,though the patient experienced some symptoms due to chemotherapy,including peripheral neuritis of the limbs,irritating dry cough,and mild increase in aminotransferase.No serious adverse effects were observed.The current general condition of the patient is good;the continuous complete remission has amounted to 6 months.展开更多
We study the DeGroot model for continuous opinion dynamics under the influence of innovations. In the original model, individuals＇ opinions, after given their initial values, evolve merely according to the given lear...We study the DeGroot model for continuous opinion dynamics under the influence of innovations. In the original model, individuals＇ opinions, after given their initial values, evolve merely according to the given learning topology. The main contribution of this paper is that external innovation effects are introduced： each individual is given the opportunity to change her opinion to a randomly selected opinion according to a given distribution on the opinion space and then the external opinion is either adapted by the individual, or combined into her learning process. It turns out that all the classical results of the DeGroot model are violated in this new model. We prove that convergence can still be guaranteed in the expectation sense, regardless of the learning topology. We also study the steady distributions of opinions among the society and the time spent to reach a steady state by means of Monte-Carlo simulations.展开更多
文摘At present,approximately 20%of Hodgkin lymphomas(HL)are relapsed and refractory,and therapeutic methods including chemotherapy,radiotherapy,and even stem cell transplantation are unsatisfactory.Brentuximab vedotin,composed of CD30 antibody and a chemotherapeutic agent,is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface.In clinical trials,the response rate and complete remission rate of this drug were 73%and 40%,respectively,for relapsed and refractory HL.Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab.Before the treatment with brentuximab,the patient underwent chemotherapy,radiotherapy,and autologous stem cell transplantation.However,the disease continued to progress,affecting multiple organs and prompting symptoms such as persistent fever.After the treatment with brentuximab,the patient′s condition improved.Body temperature returned to normal after 4 days.Lung nodules were reduced in size and number after a single course of treatment,and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment,respectively.The entire treatment process progressed smoothly,though the patient experienced some symptoms due to chemotherapy,including peripheral neuritis of the limbs,irritating dry cough,and mild increase in aminotransferase.No serious adverse effects were observed.The current general condition of the patient is good;the continuous complete remission has amounted to 6 months.
基金Supported by the 973 Program(2010CB731405)National Natural Science Foundation of China(71101140,11471326)
文摘We study the DeGroot model for continuous opinion dynamics under the influence of innovations. In the original model, individuals＇ opinions, after given their initial values, evolve merely according to the given learning topology. The main contribution of this paper is that external innovation effects are introduced： each individual is given the opportunity to change her opinion to a randomly selected opinion according to a given distribution on the opinion space and then the external opinion is either adapted by the individual, or combined into her learning process. It turns out that all the classical results of the DeGroot model are violated in this new model. We prove that convergence can still be guaranteed in the expectation sense, regardless of the learning topology. We also study the steady distributions of opinions among the society and the time spent to reach a steady state by means of Monte-Carlo simulations.
