Segregated incompressible large eddy simulation and acoustic perturbation equations were used to obtain the flow field and sound field of 1:25 scale trains with three,six and eight coaches in a long tunnel,and the aer...Segregated incompressible large eddy simulation and acoustic perturbation equations were used to obtain the flow field and sound field of 1:25 scale trains with three,six and eight coaches in a long tunnel,and the aerodynamic results were verified by wind tunnel test with the same scale two-coach train model.Time-averaged drag coefficients of the head coach of three trains are similar,but at the tail coach of the multi-group trains it is much larger than that of the three-coach train.The eight-coach train presents the largest increment from the head coach to the tail coach in the standard deviation(STD)of aerodynamic force coefficients:0.0110 for drag coefficient(Cd),0.0198 for lift coefficient(Cl)and 0.0371 for side coef-ficient(Cs).Total sound pressure level at the bottom of multi-group trains presents a significant streamwise increase,which is different from the three-coach train.Tunnel walls affect the acoustic distribution at the bottom,only after the coach number reaches a certain value,and the streamwise increase in the sound pressure fluctuation of multi-group trains is strengthened by coach number.Fourier transform of the turbulent and sound pressures presents that coach number has little influence on the peak frequencies,but increases the sound pressure level values at the tail bogie cavities.Furthermore,different from the turbulent pressure,the first two sound pressure proper orthogonal decomposition(POD)modes in the bogie cavities contain 90%of the total energy,and the spatial distributions indicate that the acoustic distributions in the head and tail bogies are not related to coach number.展开更多
The technology of pantograph sinking in the cavity is generally adopted in the new generation of high-speed trains in China for aerodynamic noise reduction in this region. This study takes a high-speed train with a 4-...The technology of pantograph sinking in the cavity is generally adopted in the new generation of high-speed trains in China for aerodynamic noise reduction in this region. This study takes a high-speed train with a 4-car formation and a pantograph as the research object and compares the aerodynamic acoustic performance of two scale models, 1/8 and 1/1, using large eddy simulation and Ffowcs Williams–Hawkings integral equation. It is found that there is no direct scale similarity between their aeroacoustic performance. The 1/1 model airflow is separated at the leading edge of the panhead and reattached to the panhead, and its vortex shedding Strouhal number(St) is 0.17. However, the 1/8 model airflow is separated directly at the leading edge of the panhead, and its St is 0.13. The cavity's vortex shedding frequency is in agreement with that calculated by the Rooster empirical formula. The two scale models exhibit some similar characteristics in distribution of sound source energy, but the energy distribution of the 1/8 model is more concentrated in the middle and lower regions. The contribution rates of their middle and lower regions to the radiated noise in the two models are 27.3% and 87.2%, respectively. The peak frequencies of the radiated noise from the 1/1 model are 307 and 571 Hz. The 307 Hz is consistent with the frequency of panhead vortex shedding, and the 571 Hz is more likely to be the result of the superposition of various components. In contrast, the peak frequencies of the radiated noise from the 1/8 scale model are 280 and 1970 Hz. The 280 Hz comes from the shear layer oscillation between the cavity and the bottom frame, and the 1970 Hz is close to the frequency at which the panhead vortex sheds. This shows that the scaled model results need to be corrected before applying to the full-scale model.展开更多
Ceramic coatings play a keyrole in extending the service life of materials in aerospaceandenergy fields byprotectingmaterials from high temperature,oxidation,corrosion and thermal stress.Non-oxide and high entropy cer...Ceramic coatings play a keyrole in extending the service life of materials in aerospaceandenergy fields byprotectingmaterials from high temperature,oxidation,corrosion and thermal stress.Non-oxide and high entropy ceramics are new emerging coating materials which have been researched and developed in recent years.Compared with traditional oxide ceramics,non-oxide ceramics have better high temperature stability,oxidation resistance and erosion resistance.These characteristics make non-oxide ceramics perform well in extreme environments.It is particularly noteworthy that the non-oxide high entropy ceramic is a uniform solid solution composed of at least four or fiveatoms.Their unique structure and outstanding propertiesshow great potential application in the field of coating.In this paper,the researches aboutregulating microstructure,preparation technology and properties of nitride and its high entropy system,carbide and its high entropy system and boride and its high entropy system in coating field are summarized,and their future development and prospects are prospected.展开更多
Background:Pulmonary atresia(PA)is a group of heterogeneous complex congenital heart disease.Only one study modality might not get a correct diagnosis.This study aims to investigate the diagnostic power of dualsource ...Background:Pulmonary atresia(PA)is a group of heterogeneous complex congenital heart disease.Only one study modality might not get a correct diagnosis.This study aims to investigate the diagnostic power of dualsource computed tomography(DSCT)for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography(TTE).Materials and Methods:This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis.All associated malformations and clinical information,including treatments,were recorded and compared among the three groups.The diagnostic power of DSCT and TTE on all associated malformations were compared.The surgical index(McGoon ratio,pulmonary arterials index(PAI),and total neopulmonary arterial index)and radiation dose were calculated on the basis of DSCT.Results:Of the patients,32,30,and 17 were divided into the groups of PA with ventricular septal defect(VSD),PA with VSD and major aortopulmonary collateral arteries,and PA with other major malformations,respectively.Consequently,182,162,and 13 intracardiac,extracardiac,and other major malformations were diagnosed,respectively.Moreover,DSCT showed a better diagnostic performance in extracardiac deformities(154 vs.117,p<0.001),whereas TTE could diagnose intracardiac deformities better(159 vs.139,p=0.001).The McGoon ratio,PAI,and treatment methods were significantly different among the three groups(p=0.014,p=0.008,and p=0.018,respectively).Conclusion:More than one imaging modality should be used to make a correct diagnosis when clinically suspecting PA.DSCT is superior to TTE in diagnosing extracardiac deformities and could be used to roughly calculate surgical indices to optimize treatment strategy.展开更多
Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different ...Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different speed levels.Design/methodology/approach–Based on large eddy simulation(LES)method and Kirchhoff–Ffowcs Williams and Hawkings(K-FWH)equations,the characteristics of dipole and quadrupole sound sources of maglev trains at different speed levels were simulated and analyzed by constructing reasonable penetrable integral surface.Findings–The spatial disturbance resulting from the separation of the boundary layer in the streamlined area of the tail car is the source of aerodynamic sound of the maglev train.The dipole sources of the train are mainly distributed around the radio terminals of the head and tail cars of the maglev train,the bottom of the arms of the streamlined parts of the head and tail cars and the nose tip area of the streamlined part of the tail car,and the quadrupole sources are mainly distributed in the wake area.When the train runs at three speed levels of 400,500 and 600 km$h1,respectively,the radiated energy of quadrupole source is 62.4%,63.3%and 71.7%,respectively,which exceeds that of dipole sources.Originality/value–This study can help understand the aerodynamic noise characteristics generated by the high-speed maglev train and provide a reference for the optimization design of its aerodynamic shape.展开更多
In order to investigate how the aerodynamic drag and noise produced by the roof air conditioner of a high-speed train can be reduced,the related unsteady flow in the near-field was computed using the method of large e...In order to investigate how the aerodynamic drag and noise produced by the roof air conditioner of a high-speed train can be reduced,the related unsteady flow in the near-field was computed using the method of large eddy simulation.In this way,the aerodynamic source for noise generation has initially been determined.Then,the far-field aerodynamic noise has been computed in the framework of the Lighthill’s acoustics analogy theory.The propulsion height and flow-guide angle of the roof air conditioner were set as the design variables.According to the computational results,a lower propulsion height or flow-guide angle is beneficial in terms of aerodynamic drag and noise mitigation.However,compared to the design scheme with propulsion height of 0mm,the aerodynamic drag coefficient of the configuration with propulsion height of 190mm and flow-guide angle of 30°is slightly larger,while the aerodynamic noise is obviously reduced.Thus,from the viewpoint of the aerodynamic drag and noise,the design scheme with propulsion height of 190 mm and flow-guide angle of 30°is the optimal configuration in the range of conditions examined in the present work.展开更多
Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research fields.Since many structures in biological tissues exhibit strong nonlinear opt...Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research fields.Since many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical studies.Especially in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy techniques.In this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this filed.Our perspective of this field is also presented.展开更多
A huge amount of sensitive personal data is being collected by various online health monitoring applications.Although the data is anonymous,the personal trajectories(e.g.,the chronological access records of small cell...A huge amount of sensitive personal data is being collected by various online health monitoring applications.Although the data is anonymous,the personal trajectories(e.g.,the chronological access records of small cells)could become the anchor of linkage attacks to re-identify the users.Focusing on trajectory privacy in online health monitoring,we propose the User Trajectory Model(UTM),a generic trajectory re-identification risk predicting model to reveal the underlying relationship between trajectory uniqueness and aggregated data(e.g.,number of individuals covered by each small cell),and using the parameter combination of aggregated data to further mathematically derive the statistical characteristics of uniqueness(i.e.,the expectation and the variance).Eventually,exhaustive simulations validate the effectiveness of the UTM in privacy risk evaluation,confirm our theoretical deductions and present counter-intuitive insights.展开更多
We measured flow structures with stereoscopic particle image velocimetry(stereo-PIV) in the turbulent wakes of three parachute canopies, which had the same surface area, but different geometries. The tested parachute ...We measured flow structures with stereoscopic particle image velocimetry(stereo-PIV) in the turbulent wakes of three parachute canopies, which had the same surface area, but different geometries. The tested parachute canopies included ribbon canopy, 8-branches canopy, and cross canopy. The obtained results showed that the geometry of the parachute canopies had significant influences on the flow structures in the wakes of these three canopies. In addition, the variation of Reynolds number did not lead to a dramatic change in the distributions of velocity, vorticity,Reynolds stress, and turbulent kinetic energy.展开更多
Background:To evaluate the qualitative and quantitative differences between intracardiac and extracardiac vascular malformations in patients with a single atrium(SA),single ventricle(SV)and single atrium-single ventri...Background:To evaluate the qualitative and quantitative differences between intracardiac and extracardiac vascular malformations in patients with a single atrium(SA),single ventricle(SV)and single atrium-single ventricle(SA-SV)using dual-source CT(DSCT),and to compare the diagnostic performances of DSCT and transthoracic echocardiography(TTE).Methods:This retrospective study included 24 SA,75 SV and 24 SA-SV patients who underwent both DSCT and TTE before surgery.The diagnostic values of DSCT and TTE for intracardiac and extracardiac malformations were compared according to the surgical results.The diameters of the major artery and vein were measured and calculated based on DSCT and compared among the three groups.Results:The most common malformation was pulmonary artery disease in SA(50.0%)and SA-SV(45.8%)groups and patent ductus arteriosus(33.3%)in SV group.Although there was no statistical difference,arterial development was relatively poor in the SA group.All groups showed the trend of pulmonary artery stenosis(SA vs.SV vs.SA-SV:50.0%vs.30.7%vs.33.3%).There was a significant difference in mean pulmonary vein index among the groups(p=0.017).The diagnostic sensitivity of DSCT was superior to that of TTE for extracardiac malformations.Conclusions:The most common malformation in SA and SA-SV patients is pulmonary artery stenosis.SV patients are most likely to be complicated with patent ductus arteriosus.DSCT is more advantageous than TTE for diagnosing combined extracardiac malformations and can accurately measure the diameter of arteriovenous vessels.展开更多
Dioscorea bulbifera is a medicinal and edible plant of the Naxi nationality living in Lijiang area,and its tuber as a vegetable has the functions of clearing away heat and detoxification,and its bulbil has the functio...Dioscorea bulbifera is a medicinal and edible plant of the Naxi nationality living in Lijiang area,and its tuber as a vegetable has the functions of clearing away heat and detoxification,and its bulbil has the functions of clearing away heat and resolving phlegm,relieving cough and relieving asthma,dispersing the accumulation of evils and detoxification,etc.Related studies have shown that it mainly contains steroids,diterpene lactones,flavonoids,polyphenols,alkaloids and so on,and it can also fight cancer,inhibit bacteria,relieve pain,resist inflammation and so on.There is also related literature about hepatotoxicity after taking it.The key technique of traditional vegetable cultivation in Lijiang area is systematically summarized in this paper for reference in the future cultivation process.展开更多
Firstly,the paths and spatial distribution of hail in Zunhua City were analyzed,and then based on years of working experience in artificial operations,the mechanism of artificial hail-suppression operations in Zunhua ...Firstly,the paths and spatial distribution of hail in Zunhua City were analyzed,and then based on years of working experience in artificial operations,the mechanism of artificial hail-suppression operations in Zunhua was analyzed from the aspects of the occurrence law of hail,methods of artificial hail-suppression operations,and the layout of artificial operation sites in Zunhua City. Finally,the benefit of hail-suppression operations was analyzed based on the data of hail damage in the past five years. The results show that the layout of the built operation sites in Zunhua City is reasonable,and they effectively reduce the occurrence of hail damage and improve the disaster prevention and mitigation capacity of Zunhua City.展开更多
The simulation of the ground effect has always been a technical difficulty in wind tunnel tests of high-speed trains.In this paper,large eddy simulation and the curl acoustic integral equation were used to simulate th...The simulation of the ground effect has always been a technical difficulty in wind tunnel tests of high-speed trains.In this paper,large eddy simulation and the curl acoustic integral equation were used to simulate the flow-acoustic field results of high-speed trains under four ground simulation systems(GSSs):“moving ground+rotating wheel”,“stationary ground+rotating wheel”,“moving ground+stationary wheel”,and“stationary ground+stationary wheel”.By comparing the fluid-acoustic field results of the four GSSs,the influence laws of different GSSs on the flow field structure,aero-acoustic source,and far-field radiation noise characteristics were investigated,providing guidance for the acoustic wind tunnel testing of high-speed trains.The calculation results of the aerodynamic noise of a 350 km/h high-speed train show that the moving ground and rotating wheel affect mainly the aero-acoustic performance under the train bottom.The influence of the rotating wheel on the equivalent sound source power of the whole vehicle was not more than 5%,but that of the moving ground slip was more than 15%.The average influence of the rotating wheel on the sound pressure level radiated by the whole vehicle was 0.3 dBA,while that of the moving ground was 1.8 dBA.展开更多
The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic eff...The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.展开更多
Deformation-induced martensite transformation from metastable retained austenite is one of the most efficient strain-hardening mechanisms contributing to the enhancement of strength-ductility synergy in advanced high-...Deformation-induced martensite transformation from metastable retained austenite is one of the most efficient strain-hardening mechanisms contributing to the enhancement of strength-ductility synergy in advanced high-strength steels.However,the hard transformation product(often-martensite)and the H redistribution associated with phase transformation essentially decrease materials’resistance to hydrogen embrittlement.To solve this fundamental conflict,we introduce a new microstructure architecting strategy based on an accurately design of core–shell compositional distribution inside the austenite phase.We employed this approach in a typical medium Mn steel(8 wt.%Mn)with an ultrafine grained austenite-ferrite microstructure.We produced a high Mn content(15–16 wt.%)in the austenite shell region and a low Mn content(~12 wt.%)in the core region,through a thermodynamics-guided two-step austenite reversion treatment.During room-temperature deformation,the austenite core transforms continuously starting from a low strain,providing a high and persistent strain-hardening rate.The transformation of Mn-rich austenite shell,on the other hand,occurs only at the latest regime of the deformation,thus effectively inhibiting the nucleation of H-induced cracks at ferrite/deformation-induced martensite interfaces as well as suppressing their growth and percolation.This step-wise transformation,tailored directly targeted to protect the hydrogen-sensitive microstructure defects(interfaces),results in a significantly enhanced hydrogen embrittlement resistance without sacrificing the mechanical performance in hydrogen-free condition.The design of compositional core–shell structure is expected to be applicable to,at least,other multiphase advanced high-strength steels containing metastable austenite.展开更多
The influence of austenitizing temperature and austenite grain size on the crystallographic characteristics and mechanical properties of transformation products was investigated in a low-alloy steel.Annealing at a low...The influence of austenitizing temperature and austenite grain size on the crystallographic characteristics and mechanical properties of transformation products was investigated in a low-alloy steel.Annealing at a lower temperature after austenitization at 1050℃ can reduce the vacancy concentration and enhance the stability of austenite,thereby determining the martensite-start(Ms)temperature and density of twin-related V1/V2 variant pairs.V1/V2 variant pairs are predominately generated by autocatalytic nucleation,which can promote transformation by self-accommodation.Annealing at 800℃ after austenitization at 1050℃ generated the highest content of V1/V2 variant pairs,which contributed to high values of strength,Charpy impact energy,and elongation.In addition to refining the austenite grain size,niobium(Nb)microalloying increases the packet boundaries of the transformation products,mainly because the refined austenite grains provide more nucleation sites for the martensitic transformation.However,the density of block boundaries decreases after austenite refinement by Nb microalloying,owing to insufficient autocatalytic nucleation.展开更多
Innovation and entrepreneurship education is becoming one of the important goals of higher education in China.According to the requirements of the Ministry of Education to deepen the reform of innovation and entrepren...Innovation and entrepreneurship education is becoming one of the important goals of higher education in China.According to the requirements of the Ministry of Education to deepen the reform of innovation and entrepreneur-ship education in colleges and universities,we propose a core principle of“from basis to comprehensiveness,and then to innovation”to construct the software design and programming practice course in the information and communication engineering discipline.We have integrated specialized knowledge teaching with innovation and entrepreneurship training,implemented a series of experimental projects that integrate theory with practice,and explored mixed teaching methods and diversified examination methods.In this paper,details about software design and programming practice course construction are shown from aspects of teaching content,teaching methods,and examination methods.These course construction experiences will benefit teachers who engage in innovative practical courses in the information and communication engineering discipline.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 52072267)Shanghai Key Lab of Vehicle Aerodynamics and Vehicle Thermal Management Systems (Grant No. 23DZ2229029)
文摘Segregated incompressible large eddy simulation and acoustic perturbation equations were used to obtain the flow field and sound field of 1:25 scale trains with three,six and eight coaches in a long tunnel,and the aerodynamic results were verified by wind tunnel test with the same scale two-coach train model.Time-averaged drag coefficients of the head coach of three trains are similar,but at the tail coach of the multi-group trains it is much larger than that of the three-coach train.The eight-coach train presents the largest increment from the head coach to the tail coach in the standard deviation(STD)of aerodynamic force coefficients:0.0110 for drag coefficient(Cd),0.0198 for lift coefficient(Cl)and 0.0371 for side coef-ficient(Cs).Total sound pressure level at the bottom of multi-group trains presents a significant streamwise increase,which is different from the three-coach train.Tunnel walls affect the acoustic distribution at the bottom,only after the coach number reaches a certain value,and the streamwise increase in the sound pressure fluctuation of multi-group trains is strengthened by coach number.Fourier transform of the turbulent and sound pressures presents that coach number has little influence on the peak frequencies,but increases the sound pressure level values at the tail bogie cavities.Furthermore,different from the turbulent pressure,the first two sound pressure proper orthogonal decomposition(POD)modes in the bogie cavities contain 90%of the total energy,and the spatial distributions indicate that the acoustic distributions in the head and tail bogies are not related to coach number.
基金supported by the National Natural Science Foundation of China (No. 52272363)the Key Laboratory of Aerodynamic Noise Control (No. ANCL20200302),Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province。
文摘The technology of pantograph sinking in the cavity is generally adopted in the new generation of high-speed trains in China for aerodynamic noise reduction in this region. This study takes a high-speed train with a 4-car formation and a pantograph as the research object and compares the aerodynamic acoustic performance of two scale models, 1/8 and 1/1, using large eddy simulation and Ffowcs Williams–Hawkings integral equation. It is found that there is no direct scale similarity between their aeroacoustic performance. The 1/1 model airflow is separated at the leading edge of the panhead and reattached to the panhead, and its vortex shedding Strouhal number(St) is 0.17. However, the 1/8 model airflow is separated directly at the leading edge of the panhead, and its St is 0.13. The cavity's vortex shedding frequency is in agreement with that calculated by the Rooster empirical formula. The two scale models exhibit some similar characteristics in distribution of sound source energy, but the energy distribution of the 1/8 model is more concentrated in the middle and lower regions. The contribution rates of their middle and lower regions to the radiated noise in the two models are 27.3% and 87.2%, respectively. The peak frequencies of the radiated noise from the 1/1 model are 307 and 571 Hz. The 307 Hz is consistent with the frequency of panhead vortex shedding, and the 571 Hz is more likely to be the result of the superposition of various components. In contrast, the peak frequencies of the radiated noise from the 1/8 scale model are 280 and 1970 Hz. The 280 Hz comes from the shear layer oscillation between the cavity and the bottom frame, and the 1970 Hz is close to the frequency at which the panhead vortex sheds. This shows that the scaled model results need to be corrected before applying to the full-scale model.
文摘Ceramic coatings play a keyrole in extending the service life of materials in aerospaceandenergy fields byprotectingmaterials from high temperature,oxidation,corrosion and thermal stress.Non-oxide and high entropy ceramics are new emerging coating materials which have been researched and developed in recent years.Compared with traditional oxide ceramics,non-oxide ceramics have better high temperature stability,oxidation resistance and erosion resistance.These characteristics make non-oxide ceramics perform well in extreme environments.It is particularly noteworthy that the non-oxide high entropy ceramic is a uniform solid solution composed of at least four or fiveatoms.Their unique structure and outstanding propertiesshow great potential application in the field of coating.In this paper,the researches aboutregulating microstructure,preparation technology and properties of nitride and its high entropy system,carbide and its high entropy system and boride and its high entropy system in coating field are summarized,and their future development and prospects are prospected.
基金This study was approved by the Institutional Ethics Committee of West China Hospital,Sichuan University (Chengdu, Sichuan, ChinaNo. 14-163)+1 种基金This study has received funding by Sichuan Science and Technology Program(2020YJ0229)1⋅3⋅5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18013)。
文摘Background:Pulmonary atresia(PA)is a group of heterogeneous complex congenital heart disease.Only one study modality might not get a correct diagnosis.This study aims to investigate the diagnostic power of dualsource computed tomography(DSCT)for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography(TTE).Materials and Methods:This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis.All associated malformations and clinical information,including treatments,were recorded and compared among the three groups.The diagnostic power of DSCT and TTE on all associated malformations were compared.The surgical index(McGoon ratio,pulmonary arterials index(PAI),and total neopulmonary arterial index)and radiation dose were calculated on the basis of DSCT.Results:Of the patients,32,30,and 17 were divided into the groups of PA with ventricular septal defect(VSD),PA with VSD and major aortopulmonary collateral arteries,and PA with other major malformations,respectively.Consequently,182,162,and 13 intracardiac,extracardiac,and other major malformations were diagnosed,respectively.Moreover,DSCT showed a better diagnostic performance in extracardiac deformities(154 vs.117,p<0.001),whereas TTE could diagnose intracardiac deformities better(159 vs.139,p=0.001).The McGoon ratio,PAI,and treatment methods were significantly different among the three groups(p=0.014,p=0.008,and p=0.018,respectively).Conclusion:More than one imaging modality should be used to make a correct diagnosis when clinically suspecting PA.DSCT is superior to TTE in diagnosing extracardiac deformities and could be used to roughly calculate surgical indices to optimize treatment strategy.
基金The research was supported by the National Key Research and Development Program(Grant No.2020YFA0710903)the Financial Funding Project for Central Colleges and Universities(Grant No.202045014)the Science and Technology Research and Development Program of China State Railway Group Co.,Ltd.(Grant No.P2019J008).
文摘Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different speed levels.Design/methodology/approach–Based on large eddy simulation(LES)method and Kirchhoff–Ffowcs Williams and Hawkings(K-FWH)equations,the characteristics of dipole and quadrupole sound sources of maglev trains at different speed levels were simulated and analyzed by constructing reasonable penetrable integral surface.Findings–The spatial disturbance resulting from the separation of the boundary layer in the streamlined area of the tail car is the source of aerodynamic sound of the maglev train.The dipole sources of the train are mainly distributed around the radio terminals of the head and tail cars of the maglev train,the bottom of the arms of the streamlined parts of the head and tail cars and the nose tip area of the streamlined part of the tail car,and the quadrupole sources are mainly distributed in the wake area.When the train runs at three speed levels of 400,500 and 600 km$h1,respectively,the radiated energy of quadrupole source is 62.4%,63.3%and 71.7%,respectively,which exceeds that of dipole sources.Originality/value–This study can help understand the aerodynamic noise characteristics generated by the high-speed maglev train and provide a reference for the optimization design of its aerodynamic shape.
基金supported by the National Key R&D Program of China(No.2016YFB1200504-F)the National Natural Science Foundation of China(No.51705267)+1 种基金the China Postdoctoral Science Foundation(No.2018M630750)the China Railway R&D Program(No.2015J009-D).
文摘In order to investigate how the aerodynamic drag and noise produced by the roof air conditioner of a high-speed train can be reduced,the related unsteady flow in the near-field was computed using the method of large eddy simulation.In this way,the aerodynamic source for noise generation has initially been determined.Then,the far-field aerodynamic noise has been computed in the framework of the Lighthill’s acoustics analogy theory.The propulsion height and flow-guide angle of the roof air conditioner were set as the design variables.According to the computational results,a lower propulsion height or flow-guide angle is beneficial in terms of aerodynamic drag and noise mitigation.However,compared to the design scheme with propulsion height of 0mm,the aerodynamic drag coefficient of the configuration with propulsion height of 190mm and flow-guide angle of 30°is slightly larger,while the aerodynamic noise is obviously reduced.Thus,from the viewpoint of the aerodynamic drag and noise,the design scheme with propulsion height of 190 mm and flow-guide angle of 30°is the optimal configuration in the range of conditions examined in the present work.
基金the National Natural Science Foundation of China(61722508/61525503/61620106016/61835009/61935012/61961136005)(Key)Project of Department of Education of Guangdong Province(2016KCXTD007)Shenzhen Basic Research Project(JCYJ20180305124902165).
文摘Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research fields.Since many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical studies.Especially in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy techniques.In this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this filed.Our perspective of this field is also presented.
基金This work was supported in part by the National Natural Science Foundation of China under Grant 61871062and Grant 61771082the Natural Science Foundation of Chongqing of China under Grant cstc2013jcyjA40066+3 种基金the Program for Innovation Team Building at Institutions of Higher Education in Chongqing under Grant CXTDX201601020the Science and Technology Research Program of Chongqing Municipal Education Commission under Grant KJQN201801316the Key Industrial Technology Development Project of Chongqing of China Development and Reform Commission under Grant 2018148208the Innovation and Entrepreneurship Demonstration Team of Yingcai Program of Chongqing of China under Grant CQYC201903167.
文摘A huge amount of sensitive personal data is being collected by various online health monitoring applications.Although the data is anonymous,the personal trajectories(e.g.,the chronological access records of small cells)could become the anchor of linkage attacks to re-identify the users.Focusing on trajectory privacy in online health monitoring,we propose the User Trajectory Model(UTM),a generic trajectory re-identification risk predicting model to reveal the underlying relationship between trajectory uniqueness and aggregated data(e.g.,number of individuals covered by each small cell),and using the parameter combination of aggregated data to further mathematically derive the statistical characteristics of uniqueness(i.e.,the expectation and the variance).Eventually,exhaustive simulations validate the effectiveness of the UTM in privacy risk evaluation,confirm our theoretical deductions and present counter-intuitive insights.
基金supported by the Science and Technology Commission of Shanghai Municipality(Grant 15ZR1442700)the Fundamental Research Funds for the Central Universities
文摘We measured flow structures with stereoscopic particle image velocimetry(stereo-PIV) in the turbulent wakes of three parachute canopies, which had the same surface area, but different geometries. The tested parachute canopies included ribbon canopy, 8-branches canopy, and cross canopy. The obtained results showed that the geometry of the parachute canopies had significant influences on the flow structures in the wakes of these three canopies. In addition, the variation of Reynolds number did not lead to a dramatic change in the distributions of velocity, vorticity,Reynolds stress, and turbulent kinetic energy.
基金This work was supported by Sichuan Science and Technology Program[2020YJ0229]1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University[ZYGD18013].
文摘Background:To evaluate the qualitative and quantitative differences between intracardiac and extracardiac vascular malformations in patients with a single atrium(SA),single ventricle(SV)and single atrium-single ventricle(SA-SV)using dual-source CT(DSCT),and to compare the diagnostic performances of DSCT and transthoracic echocardiography(TTE).Methods:This retrospective study included 24 SA,75 SV and 24 SA-SV patients who underwent both DSCT and TTE before surgery.The diagnostic values of DSCT and TTE for intracardiac and extracardiac malformations were compared according to the surgical results.The diameters of the major artery and vein were measured and calculated based on DSCT and compared among the three groups.Results:The most common malformation was pulmonary artery disease in SA(50.0%)and SA-SV(45.8%)groups and patent ductus arteriosus(33.3%)in SV group.Although there was no statistical difference,arterial development was relatively poor in the SA group.All groups showed the trend of pulmonary artery stenosis(SA vs.SV vs.SA-SV:50.0%vs.30.7%vs.33.3%).There was a significant difference in mean pulmonary vein index among the groups(p=0.017).The diagnostic sensitivity of DSCT was superior to that of TTE for extracardiac malformations.Conclusions:The most common malformation in SA and SA-SV patients is pulmonary artery stenosis.SV patients are most likely to be complicated with patent ductus arteriosus.DSCT is more advantageous than TTE for diagnosing combined extracardiac malformations and can accurately measure the diameter of arteriovenous vessels.
基金Training Program for the Fourth Batch of Young and Middle-aged Academic and Technical Leaders in Lijiang CitySpecial Project of"100 Lijiang Agricultural Talents"in Lijiang CityReserve Talent Project for Young and Middle-aged Academic and Technical Leaders in Yunnan Province.
文摘Dioscorea bulbifera is a medicinal and edible plant of the Naxi nationality living in Lijiang area,and its tuber as a vegetable has the functions of clearing away heat and detoxification,and its bulbil has the functions of clearing away heat and resolving phlegm,relieving cough and relieving asthma,dispersing the accumulation of evils and detoxification,etc.Related studies have shown that it mainly contains steroids,diterpene lactones,flavonoids,polyphenols,alkaloids and so on,and it can also fight cancer,inhibit bacteria,relieve pain,resist inflammation and so on.There is also related literature about hepatotoxicity after taking it.The key technique of traditional vegetable cultivation in Lijiang area is systematically summarized in this paper for reference in the future cultivation process.
文摘Firstly,the paths and spatial distribution of hail in Zunhua City were analyzed,and then based on years of working experience in artificial operations,the mechanism of artificial hail-suppression operations in Zunhua was analyzed from the aspects of the occurrence law of hail,methods of artificial hail-suppression operations,and the layout of artificial operation sites in Zunhua City. Finally,the benefit of hail-suppression operations was analyzed based on the data of hail damage in the past five years. The results show that the layout of the built operation sites in Zunhua City is reasonable,and they effectively reduce the occurrence of hail damage and improve the disaster prevention and mitigation capacity of Zunhua City.
基金This work is supported by the National Natural Science Foundation of China(No.52272363)the Foundation of the Key Laboratory of Aerodynamic Noise Control(No.ANCL20200302),China.
文摘The simulation of the ground effect has always been a technical difficulty in wind tunnel tests of high-speed trains.In this paper,large eddy simulation and the curl acoustic integral equation were used to simulate the flow-acoustic field results of high-speed trains under four ground simulation systems(GSSs):“moving ground+rotating wheel”,“stationary ground+rotating wheel”,“moving ground+stationary wheel”,and“stationary ground+stationary wheel”.By comparing the fluid-acoustic field results of the four GSSs,the influence laws of different GSSs on the flow field structure,aero-acoustic source,and far-field radiation noise characteristics were investigated,providing guidance for the acoustic wind tunnel testing of high-speed trains.The calculation results of the aerodynamic noise of a 350 km/h high-speed train show that the moving ground and rotating wheel affect mainly the aero-acoustic performance under the train bottom.The influence of the rotating wheel on the equivalent sound source power of the whole vehicle was not more than 5%,but that of the moving ground slip was more than 15%.The average influence of the rotating wheel on the sound pressure level radiated by the whole vehicle was 0.3 dBA,while that of the moving ground was 1.8 dBA.
基金financially supported by the National Natural Science Foundation of China (No.61875131)Shenzhen Key Laboratory of Photonics and Biophotonics (No.ZDSYS20210623092006020)。
文摘The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.
基金H.Chen acknowledges financial support from the National Natural Science Foundation of China(Nos.51922054,U1860109 and U1808208)the National Key Research and Development Program of China(2022YFE0110800)+1 种基金Z.G.Yang acknowledges financial support from the National Natural Science Foundation of China(No.52171008)B.Sun acknowledgesfinancial support from the National Natural Science Foundation of China(No.52275147).
文摘Deformation-induced martensite transformation from metastable retained austenite is one of the most efficient strain-hardening mechanisms contributing to the enhancement of strength-ductility synergy in advanced high-strength steels.However,the hard transformation product(often-martensite)and the H redistribution associated with phase transformation essentially decrease materials’resistance to hydrogen embrittlement.To solve this fundamental conflict,we introduce a new microstructure architecting strategy based on an accurately design of core–shell compositional distribution inside the austenite phase.We employed this approach in a typical medium Mn steel(8 wt.%Mn)with an ultrafine grained austenite-ferrite microstructure.We produced a high Mn content(15–16 wt.%)in the austenite shell region and a low Mn content(~12 wt.%)in the core region,through a thermodynamics-guided two-step austenite reversion treatment.During room-temperature deformation,the austenite core transforms continuously starting from a low strain,providing a high and persistent strain-hardening rate.The transformation of Mn-rich austenite shell,on the other hand,occurs only at the latest regime of the deformation,thus effectively inhibiting the nucleation of H-induced cracks at ferrite/deformation-induced martensite interfaces as well as suppressing their growth and percolation.This step-wise transformation,tailored directly targeted to protect the hydrogen-sensitive microstructure defects(interfaces),results in a significantly enhanced hydrogen embrittlement resistance without sacrificing the mechanical performance in hydrogen-free condition.The design of compositional core–shell structure is expected to be applicable to,at least,other multiphase advanced high-strength steels containing metastable austenite.
基金financially supported by the National Key Research and Development Program of China(Grant No.2020YFB0311000)the Research Center for Iron based New Materials(School of Materials Science and Engineering,Tsinghua University&Masteel Co.Ltd.).
文摘The influence of austenitizing temperature and austenite grain size on the crystallographic characteristics and mechanical properties of transformation products was investigated in a low-alloy steel.Annealing at a lower temperature after austenitization at 1050℃ can reduce the vacancy concentration and enhance the stability of austenite,thereby determining the martensite-start(Ms)temperature and density of twin-related V1/V2 variant pairs.V1/V2 variant pairs are predominately generated by autocatalytic nucleation,which can promote transformation by self-accommodation.Annealing at 800℃ after austenitization at 1050℃ generated the highest content of V1/V2 variant pairs,which contributed to high values of strength,Charpy impact energy,and elongation.In addition to refining the austenite grain size,niobium(Nb)microalloying increases the packet boundaries of the transformation products,mainly because the refined austenite grains provide more nucleation sites for the martensitic transformation.However,the density of block boundaries decreases after austenite refinement by Nb microalloying,owing to insufficient autocatalytic nucleation.
基金This work is supported by the Teaching Reform Project of Harbin Engineering University under Grant JG2021B0806.
文摘Innovation and entrepreneurship education is becoming one of the important goals of higher education in China.According to the requirements of the Ministry of Education to deepen the reform of innovation and entrepreneur-ship education in colleges and universities,we propose a core principle of“from basis to comprehensiveness,and then to innovation”to construct the software design and programming practice course in the information and communication engineering discipline.We have integrated specialized knowledge teaching with innovation and entrepreneurship training,implemented a series of experimental projects that integrate theory with practice,and explored mixed teaching methods and diversified examination methods.In this paper,details about software design and programming practice course construction are shown from aspects of teaching content,teaching methods,and examination methods.These course construction experiences will benefit teachers who engage in innovative practical courses in the information and communication engineering discipline.