The advent of the age of Information shifts the environment we live in from off-line to on-line. The prospect of Collective Intelligence (CI) is promising. Based on this background, the aim of this paper is to discove...The advent of the age of Information shifts the environment we live in from off-line to on-line. The prospect of Collective Intelligence (CI) is promising. Based on this background, the aim of this paper is to discover the emergence mechanism and influence factors of CI in knowledge communities using the method of quantitative and qualitative analysis. On the basis of the previous research work, our model theorizes that the two dimensions of social network (i.e., interactive network structure and participant’s characteristics) affect two references of effectiveness (i.e. group knowledge production and participation of group decision). And this hypothetical model is validated with simulation data from “Zhihu” community. Our model has been useful since it offers some inspirations and directions to promote the level of CI in knowledge communities.展开更多
The removal of antibiotic pollutants remaining in the environmental media has been a big challenge nowadays.Herein,we report a facile and green approach to fabricate an eco-friendly composite membrane without addition...The removal of antibiotic pollutants remaining in the environmental media has been a big challenge nowadays.Herein,we report a facile and green approach to fabricate an eco-friendly composite membrane without addition of any toxic polymers or chemical cross-linking agents to effectively remove the tetracycline hydrochloride in Water.Firstly,the sulfated cellulose nanocrystalline(CNC) was obtained via hydrolysis of sulfuric acid by using microcrystalline cellulose(MCC) as raw material under ultrasonic condition.The as-prepared CNC has a nanowhisker dimension with 200.2 ± 110.2 nm in length,15.7 ± 9.3 nm in width,and 7.2 ± 3.1 nm in height.The obtained CNC is cellulose type I as determined by X-ray diffraction(XRD),while its crystallinity index(Crl) can reach 82.3%.Then,the composite membrane derived from the obtained CNC and commercial mixed cellulose ester(MCE)membrane was facilely prepared through vacuum dewatering process,which is applied to remove tetracycline hydrochloride(Th) in solution.The results showed that the removal efficiency of Th through the neat MCE was only28 ± 4%,while it could be improved to 58 ± 5% and 89 11%,respectively,by filtering through composite membranes with different contents of CNC deposition.Such effect is derived from the combine factors based on both steric hindrance(sieving) and electrostatic interaction(Donnan) effect of the composite membranes.The development of related CNC materials and composite fabrication processes is in favor of cost-effective and "green"polymer composites for the remediation of increasing antibiotic pollution and the purification of contaminated water nowadays.展开更多
Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in groundwater.Frequent monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a n...Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in groundwater.Frequent monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a necessity.We present a nanocomposite-based miniaturized electrode for the concurrent measurement of Pb2+and Cu^(2+)by exploiting the electroanalytical technique of square wave voltammetry.We also propose a facile in situ hydrothermal calcination method to directly grow binder-free mesoporous Ni O on a three-dimensional nickel foam,which is then electrochemically seeded with gold nanoparticles(Au NPs).The meticulous design of a low-barrier Ohmic contact between mesoporous Ni O and Au NPs facilitates target-mediated nanochannel-confined electron transfer within mesoporous Ni O.As a result,the heavy metals Pb2+(0.020 mg.L^(-1)detection limit;2.0–16.0 mg.L^(-1)detection range)and Cu^(2+)(0.013 mg.L^(-1)detection limit;0.4–12.8 mg.L^(-1)detection range)can be detected simultaneously with high precision.Furthermore,other heavy metal ions and common interfering ions found in groundwater showed negligible impacts on the electrode’s performance,and the recovery rate of groundwater samples varied between 96.3%±2.1%and 109.4%±0.6%.The compactness,flexible shape,low power consumption,and ability to remotely operate our electrode pave the way for onsite detection of heavy metals in groundwater,thereby demonstrating the potential to revolutionize the field of environmental monitoring.展开更多
Background:Highly expressed in various human cancers,circular RNA Protein Kinase C Iota(circPRKCI)has been reported to play an important role in cancer development and progression.Herein,we sought to reveal the progno...Background:Highly expressed in various human cancers,circular RNA Protein Kinase C Iota(circPRKCI)has been reported to play an important role in cancer development and progression.Herein,we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.Methods:We searched the Pubmed,Web of Science,and the Cochrane Library databases from inception until May 16,2021.The relationship between circPRKCI expression and cancer patients’survival,including overall survival(OS)and disease-free survival(DFS),was assessed by pooled hazard ratios(HR)with corresponding 95%confidence interval(CI).The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios(OR)with corresponding 95%CI.The data were analyzed by STATA software(version 12.0)or Review Manager(RevMan 5.3).Results:A total of 15 studies with 1109 patients were incorporated into our meta-analysis.The results demonstrated that high circPRKCI expression was significantly related to poor OS(HR=1.96,95%CI:1.61,2.39,P<0.001)when compared with low circPRKCI expression in diverse human cancers.However,elevated circPRKCI expression was not associated with DFS(HR=1.34,95%CI:0.93,1.95,P=0.121).Furthermore,the patient with a higher circPRKCI expression was prone to have a larger tumor size,advanced clinical stage,and lymph node metastasis,but it was not significantly correlated with age,gender,and distant metastasis.Conclusion:Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features,suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.展开更多
Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applicatio...Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.展开更多
Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach...Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.Resistance to GLS is quantitatively inherited in maize(Zea mays L.)and further sources of resistance remain to be analyzed.Here,we detected qRgls1.06,a major quantitative trait locus for GLS resistance in bin 1.06 that explained approximately 55%of the phenotype variance.Fine mapping over 2 consecutive years localized qRgls1.06 to a 2.38-Mb region.Homozygous qRgls1.06^(WGR/WGR) plants in DZ01 background displayed higher GLS resistance and 100-grain weight than DZ01 plants.The GLS responses of several susceptible elite inbred lines were improved by the introduction of qRgls1.06 by marker-assisted backcrossing.Our findings extend the understanding of the genetic basis of resistance to GLS and provide a set of resistant germplasm for genetic improvement of resistance to GLS in maize.展开更多
The present situation,problems and constraints of the circular agriculture development in Hebei Province are systematically analyzed,the subject modes suitable for the development of circular agriculture and the value...The present situation,problems and constraints of the circular agriculture development in Hebei Province are systematically analyzed,the subject modes suitable for the development of circular agriculture and the value-added potential are described,and finally some proposals are put forward.展开更多
Importance:Brain-computer interface(BCI)decodes and converts brain signals into machine instructions to interoperate with the external world.However,limited by the implantation risks of invasive BCIs and the operation...Importance:Brain-computer interface(BCI)decodes and converts brain signals into machine instructions to interoperate with the external world.However,limited by the implantation risks of invasive BCIs and the operational complexity of conventional noninvasive BCIs,applications of BCIs are mainly used in laboratory or clinical environments,which are not conducive to the daily use of BCI devices.With the increasing demand for intelligent medical care,the development of wearable BCI systems is necessary.Highlights:Based on the scalp-electroencephalogram(EEG),forehead-EEG,and ear-EEG,the state-of-the-art wearable BCI devices for disease management and patient assistance are reviewed.This paper focuses on the EEG acquisition equipment of the novel wearable BCI devices and summarizes the development direction of wearable EEG-based BCI devices.Conclusions:BCI devices play an essential role in the medical field.This review briefly summarizes novel wearable EEG-based BCIs applied in the medical field and the latest progress in related technologies,emphasizing its potential to help doctors,patients,and caregivers better understand and utilize BCI devices.展开更多
The substitution/adsorption structures of Co on an anatase TiO2 (001)-(1 × 4) surface are investigated using the DFT/local density approximation (LDA) method. Theoretical calculation shows that the Co ion p...The substitution/adsorption structures of Co on an anatase TiO2 (001)-(1 × 4) surface are investigated using the DFT/local density approximation (LDA) method. Theoretical calculation shows that the Co ion prefers to be adsorbed on the surface of anatase TiO2. The density of states (DOS) analysis finds that the Co 3d is located mainly in the energy gap region. The Co 3d partial density of states (PDOS) indicates that there is a substantial degree of hybridization between O 2s and Co 3d in valence band (VB) regions in the substitution models. The conclusion is that the mode of substitution is more active when the catalyst is a higher-energy surface.展开更多
Cervical cancer is one of the most common malignant gynecological tumors and has the second highest incidence of all malignancies in females.Chronic and persistent infection with High Risk Human Papillomavirus(HR-HPV)...Cervical cancer is one of the most common malignant gynecological tumors and has the second highest incidence of all malignancies in females.Chronic and persistent infection with High Risk Human Papillomavirus(HR-HPV)is the main cause of cervical cancer.There is a distinct lack of methodology by which to determine whether cervical epithelial dysplasia is cancerous following HPV infection.HPV L1 capsid protein is a major structural protein of human papillomavirus(HPV),and it is the main target of the local cellular immune response aiming to combat human papillomavirus after HPV infection within cervical cells.Greater understanding of HPV L1 capsid protein and its association with cervical cytology,histopathology,patient age and human papillomavirus viral load has the potential to contribute toward improved the diagnosis and management of cervical cancer,providing useful information for gynecological clinicians in the hope of improving patient treatment and quality of life.This article reviews the predictive utility of HPV L1 capsid protein for cervical lesions.展开更多
Cancer remains a significant global health concern,necessitating the development of innovative therapeutic strategies.This research paper aims to investigate the role of pyroptosis induction in cancer treatment.Pyropt...Cancer remains a significant global health concern,necessitating the development of innovative therapeutic strategies.This research paper aims to investigate the role of pyroptosis induction in cancer treatment.Pyroptosis,a form of programmed cell death characterized by the release of pro-inflammatory cytokines and the formation of plasma membrane pores,has gained significant attention as a potential target for cancer therapy.The objective of this study is to provide a comprehensive overview of the current understanding of pyroptosis and its role in cancer treatment.The paper discusses the concept of pyroptosis and its relationship with other forms of cell death,such as apoptosis and necroptosis.It explores the role of pyroptosis in immune activation and its potential for combination therapy.The study also reviews the use of natural,biological,chemical,and multifunctional composite materials for pyroptosis induction in cancer cells.The molecular mechanisms underlying pyroptosis induction by these materials are discussed,along with their advantages and challenges in cancer treatment.The findings of this study highlight the potential of pyroptosis induction as a novel therapeutic strategy in cancer treatment and provide insights into the different materials and mechanisms involved in pyroptosis induction.展开更多
Three new lignan glucosides, baicalensinosides A-C (1-3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemica...Three new lignan glucosides, baicalensinosides A-C (1-3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7'-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 mu mol/L, compounds 1-3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.展开更多
Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain lar...Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown.Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity.Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 inflammasome.Mechanistically,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the inflammasome.Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity.Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists.In authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity.These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics.展开更多
This paper presents a study on a novel instrumentation system for the measurement of temperature distribution of combustion flames. This system operates upon the three-color principle combining advanced optical sensin...This paper presents a study on a novel instrumentation system for the measurement of temperature distribution of combustion flames. This system operates upon the three-color principle combining advanced optical sensing and digital image processing techniques. It comprises an endoscope, a light splitter assembly, a CCD camera, a frame-grabber and associated software. This system was calibrated using a blackbody furnace as standard temperature source. The relationship between flame temperatures and grey-level of the images was established through image processing and function correlation. Experimental results obtained on a gas-fired combustion rig provide flame images and temperature distributions on three different wavelengths. Based on the flame temperature distribution the combustion conditions can be analyzed. Experimental results also reveal that this system is capable of online measurement of temperature distribution in a combustion zone. This system can potentially be applied to many areas such as power generation, metallurgy, chemical engineering. It is also a powerful tool for improving the control of combustion process. Keywords three-color method - flame monitor - temperature - imaging processing CLC number TK311展开更多
To address the resource-competing issue between high sensitivity and wide working range for a stand-alone sensor,development of capacitive sensors with an adjustable gap between two electrodes has been of growing inte...To address the resource-competing issue between high sensitivity and wide working range for a stand-alone sensor,development of capacitive sensors with an adjustable gap between two electrodes has been of growing interest.While several approaches have been developed to fabricate tunable capacitive sensors,it remains challenging to achieve,simultaneously,a broad range of tunable sensitivity and working range in a single device.In this work,a 3D capacitive sensor with a seesaw-like shape is designed and fabricated by the controlled compressive buckling assembly,which leverages the mechanically tunable configuration to achieve high-precision force sensing(resolution~5.22 nN)and unprecedented adjustment range(by~33 times)of sensitivity.The mechanical tests under different loading conditions demonstrate the stability and reliability of capacitive sensors.Incorporation of an asymmetric seesaw-like structure design in the capacitive sensor allows the acceleration measurement with a tunable sensitivity.These results suggest simple and low-cost routes to high-performance,tunable 3D capacitive sensors,with diverse potential applications in wearable electronics and biomedical devices.展开更多
Detection and analysis of volatile organic compounds (VOCs) as pollutants in the atmosphere and liquids are of great significance because of the detrimental effects of VOCs. A polymer-coated graphene micro-tube pipi...Detection and analysis of volatile organic compounds (VOCs) as pollutants in the atmosphere and liquids are of great significance because of the detrimental effects of VOCs. A polymer-coated graphene micro-tube piping (GMP) structure with a cross-linked and interconnected channel network was synthesized for liquid sensing. By virtue of their unique cross-linked and interconnected channel network configuration, polycrystalline conformation, and the support of a polymer layer, the resistivity of the 3D hollow micro-tubing GMPs was sensitive to strain, ensuring high sensitivity of the liquid sensor (R/Ro of -4 × 10^3% for pure acetone and R/Ro of -105% for 0.01 wt.% acetone solution). Due to the capillary force, the interfaces of the 3D structures can speed up the penetration of solvents into the polymer, thus promote distinct selectivity within seconds and significantly decrease the response time. Owing to their good selectivity, high sensitivity, rapid response and flexibility, and the ease of use of the sensors and the simplicity of the fabrication processes, the GMP/polymer composites should be a good candidate for liquid sensing.展开更多
Experimental data ofβ--decay half-lives of nuclei with atomic number between 20 and 190 are investigated.A systematic formula has been proposed to calculateβ^--decay half-lives of neutron-rich nuclei,with a particul...Experimental data ofβ--decay half-lives of nuclei with atomic number between 20 and 190 are investigated.A systematic formula has been proposed to calculateβ^--decay half-lives of neutron-rich nuclei,with a particular consideration on shell and pair effects,the decay energy Q as well as the nucleon numbers(Z,N).Although the formula has relatively few parameters,it reproduces the experimentalβ^--decay half-lives of neutron-rich nuclei very well.The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations.展开更多
The booklice genus,Liposcelis(Psocodea:Liposcelididae),owns some stored product pests and have economic importance.In this study,6 booklice specimens from Sri Lanka were collected and identified based on morphological...The booklice genus,Liposcelis(Psocodea:Liposcelididae),owns some stored product pests and have economic importance.In this study,6 booklice specimens from Sri Lanka were collected and identified based on morphological and molecular data.According to the morphological and phylogenetic analyses,the samples were identified as Liposcelis entomophila.The mitochondrial gene cytochrome c oxidase I(COI)and second internal transcribed spacer(ITS2)were sequenced for phylogenetic work.The phylogenetic trees show that the samples assemble with L.entomophila together and could be distinguished with other Liposcelis spp.apparently.The genus Liposcelis and the species L.entomophila are firstly reported in Sri Lanka.展开更多
Objective A vacuum sample chamber for SAXS measurement of solutions was developed to improve the signal-to-noise ratio of the instrument at Beijing Synchrotron Radiation Facility(BSRF).Methods We developed a vacuum sa...Objective A vacuum sample chamber for SAXS measurement of solutions was developed to improve the signal-to-noise ratio of the instrument at Beijing Synchrotron Radiation Facility(BSRF).Methods We developed a vacuum sample chamber which could be connected to the upstream and the downstream vacuum tubes by bellows.Horizontal and vertical linear slides were mounted in the vacuum chamber to adjust the sample position by 35 mm in the horizontal and vertical directions to align the sample in the light path.The liquid sample holder of the chamber was sealed with polyimide film by squeezing instead of gluing to avoid the potential influence of sealant on the solution.Results The chamber had been used for SAXS measurements of water and bovine serum albumin solution at BSRF.The results showed that the background scattering intensity in air was much higher than that in vacuum,especially in the smallangle area near the beamstop.When the q value is 0.142 nm−1,1.01 nm−1 and 1.25 nm−1,the background scattering intensity in air is 45,6.8 and 4.6 times of that in vacuum,respectively.And the background-subtracted scattering curves of bovine serum albumin solution(10 mg/ml)in air and vacuum differ in intensity by a factor of about 2.When the q value is 2 nm−1,the signal-to-noise ratios of scattering intensity of BSA in air and vacuum are 0.79 and 8.51,respectively.Conclusion We designed a simple vacuum sample chamber to be used on the SAXS instrument at 1W2A station of BSRF.The scattering of the background and protein solution in air and vacuum was tested and compared,and the signal-to-noise ratio was clearly improved.展开更多
文摘The advent of the age of Information shifts the environment we live in from off-line to on-line. The prospect of Collective Intelligence (CI) is promising. Based on this background, the aim of this paper is to discover the emergence mechanism and influence factors of CI in knowledge communities using the method of quantitative and qualitative analysis. On the basis of the previous research work, our model theorizes that the two dimensions of social network (i.e., interactive network structure and participant’s characteristics) affect two references of effectiveness (i.e. group knowledge production and participation of group decision). And this hypothetical model is validated with simulation data from “Zhihu” community. Our model has been useful since it offers some inspirations and directions to promote the level of CI in knowledge communities.
基金financially supported by the Tianjin Science and Technology Committee Major Project Program(18ZXJMTG00070)
文摘The removal of antibiotic pollutants remaining in the environmental media has been a big challenge nowadays.Herein,we report a facile and green approach to fabricate an eco-friendly composite membrane without addition of any toxic polymers or chemical cross-linking agents to effectively remove the tetracycline hydrochloride in Water.Firstly,the sulfated cellulose nanocrystalline(CNC) was obtained via hydrolysis of sulfuric acid by using microcrystalline cellulose(MCC) as raw material under ultrasonic condition.The as-prepared CNC has a nanowhisker dimension with 200.2 ± 110.2 nm in length,15.7 ± 9.3 nm in width,and 7.2 ± 3.1 nm in height.The obtained CNC is cellulose type I as determined by X-ray diffraction(XRD),while its crystallinity index(Crl) can reach 82.3%.Then,the composite membrane derived from the obtained CNC and commercial mixed cellulose ester(MCE)membrane was facilely prepared through vacuum dewatering process,which is applied to remove tetracycline hydrochloride(Th) in solution.The results showed that the removal efficiency of Th through the neat MCE was only28 ± 4%,while it could be improved to 58 ± 5% and 89 11%,respectively,by filtering through composite membranes with different contents of CNC deposition.Such effect is derived from the combine factors based on both steric hindrance(sieving) and electrostatic interaction(Donnan) effect of the composite membranes.The development of related CNC materials and composite fabrication processes is in favor of cost-effective and "green"polymer composites for the remediation of increasing antibiotic pollution and the purification of contaminated water nowadays.
基金supported by the National Key Research and Development Project of China(2019YFC1804802)。
文摘Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in groundwater.Frequent monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a necessity.We present a nanocomposite-based miniaturized electrode for the concurrent measurement of Pb2+and Cu^(2+)by exploiting the electroanalytical technique of square wave voltammetry.We also propose a facile in situ hydrothermal calcination method to directly grow binder-free mesoporous Ni O on a three-dimensional nickel foam,which is then electrochemically seeded with gold nanoparticles(Au NPs).The meticulous design of a low-barrier Ohmic contact between mesoporous Ni O and Au NPs facilitates target-mediated nanochannel-confined electron transfer within mesoporous Ni O.As a result,the heavy metals Pb2+(0.020 mg.L^(-1)detection limit;2.0–16.0 mg.L^(-1)detection range)and Cu^(2+)(0.013 mg.L^(-1)detection limit;0.4–12.8 mg.L^(-1)detection range)can be detected simultaneously with high precision.Furthermore,other heavy metal ions and common interfering ions found in groundwater showed negligible impacts on the electrode’s performance,and the recovery rate of groundwater samples varied between 96.3%±2.1%and 109.4%±0.6%.The compactness,flexible shape,low power consumption,and ability to remotely operate our electrode pave the way for onsite detection of heavy metals in groundwater,thereby demonstrating the potential to revolutionize the field of environmental monitoring.
基金supported by grants from the National Natural Science Foundation of China(Nos.81902745,82172500,82272664,and 82103228)Hunan Provincial Innovation Foundation for Post-graduate(No.CX20190160)China Postdoctoral Science Foundation(No.2021M693557)
文摘Background:Highly expressed in various human cancers,circular RNA Protein Kinase C Iota(circPRKCI)has been reported to play an important role in cancer development and progression.Herein,we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.Methods:We searched the Pubmed,Web of Science,and the Cochrane Library databases from inception until May 16,2021.The relationship between circPRKCI expression and cancer patients’survival,including overall survival(OS)and disease-free survival(DFS),was assessed by pooled hazard ratios(HR)with corresponding 95%confidence interval(CI).The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios(OR)with corresponding 95%CI.The data were analyzed by STATA software(version 12.0)or Review Manager(RevMan 5.3).Results:A total of 15 studies with 1109 patients were incorporated into our meta-analysis.The results demonstrated that high circPRKCI expression was significantly related to poor OS(HR=1.96,95%CI:1.61,2.39,P<0.001)when compared with low circPRKCI expression in diverse human cancers.However,elevated circPRKCI expression was not associated with DFS(HR=1.34,95%CI:0.93,1.95,P=0.121).Furthermore,the patient with a higher circPRKCI expression was prone to have a larger tumor size,advanced clinical stage,and lymph node metastasis,but it was not significantly correlated with age,gender,and distant metastasis.Conclusion:Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features,suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.
基金supported by the China Capital Health Research and Development of Special (No. 2018-14111)the National Natural Science Foundation of China (grant No. 62004007 and No. 82027805)the China Postdoctoral Science Foundation Grant (No. 2021M700258)
文摘Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.
基金This work was supported by the National Key Laboratory of Crop Genetic Improvement Self-Research Program(ZW18B0101)the China Scholarship Council(201908420122)+1 种基金the Teachers’Scientific Ability Cultivation Foundation of Hubei University of Arts and Science(PYSB20201001)the Xiangyang Youth Science and Technology Talent Development Plan.
文摘Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.Resistance to GLS is quantitatively inherited in maize(Zea mays L.)and further sources of resistance remain to be analyzed.Here,we detected qRgls1.06,a major quantitative trait locus for GLS resistance in bin 1.06 that explained approximately 55%of the phenotype variance.Fine mapping over 2 consecutive years localized qRgls1.06 to a 2.38-Mb region.Homozygous qRgls1.06^(WGR/WGR) plants in DZ01 background displayed higher GLS resistance and 100-grain weight than DZ01 plants.The GLS responses of several susceptible elite inbred lines were improved by the introduction of qRgls1.06 by marker-assisted backcrossing.Our findings extend the understanding of the genetic basis of resistance to GLS and provide a set of resistant germplasm for genetic improvement of resistance to GLS in maize.
基金Supported by the Youth Foundation of Hebei Academy of Agricultural and Forestry Sciences(08149402A)
文摘The present situation,problems and constraints of the circular agriculture development in Hebei Province are systematically analyzed,the subject modes suitable for the development of circular agriculture and the value-added potential are described,and finally some proposals are put forward.
基金the National Key Research and Development Program of China(nos.2022YFF1202301 and 2022YFF1502100)the National Natural Science Foundation of China(no.62004007)the China Postdoctoral Science Foundation(no.2021M700258).
文摘Importance:Brain-computer interface(BCI)decodes and converts brain signals into machine instructions to interoperate with the external world.However,limited by the implantation risks of invasive BCIs and the operational complexity of conventional noninvasive BCIs,applications of BCIs are mainly used in laboratory or clinical environments,which are not conducive to the daily use of BCI devices.With the increasing demand for intelligent medical care,the development of wearable BCI systems is necessary.Highlights:Based on the scalp-electroencephalogram(EEG),forehead-EEG,and ear-EEG,the state-of-the-art wearable BCI devices for disease management and patient assistance are reviewed.This paper focuses on the EEG acquisition equipment of the novel wearable BCI devices and summarizes the development direction of wearable EEG-based BCI devices.Conclusions:BCI devices play an essential role in the medical field.This review briefly summarizes novel wearable EEG-based BCIs applied in the medical field and the latest progress in related technologies,emphasizing its potential to help doctors,patients,and caregivers better understand and utilize BCI devices.
基金This work was supported by the National Natural Science Foundation of China (Grant No.20676087) the National Basic Research Program of China(Grant No 2005CB221204)
文摘The substitution/adsorption structures of Co on an anatase TiO2 (001)-(1 × 4) surface are investigated using the DFT/local density approximation (LDA) method. Theoretical calculation shows that the Co ion prefers to be adsorbed on the surface of anatase TiO2. The density of states (DOS) analysis finds that the Co 3d is located mainly in the energy gap region. The Co 3d partial density of states (PDOS) indicates that there is a substantial degree of hybridization between O 2s and Co 3d in valence band (VB) regions in the substitution models. The conclusion is that the mode of substitution is more active when the catalyst is a higher-energy surface.
文摘Cervical cancer is one of the most common malignant gynecological tumors and has the second highest incidence of all malignancies in females.Chronic and persistent infection with High Risk Human Papillomavirus(HR-HPV)is the main cause of cervical cancer.There is a distinct lack of methodology by which to determine whether cervical epithelial dysplasia is cancerous following HPV infection.HPV L1 capsid protein is a major structural protein of human papillomavirus(HPV),and it is the main target of the local cellular immune response aiming to combat human papillomavirus after HPV infection within cervical cells.Greater understanding of HPV L1 capsid protein and its association with cervical cytology,histopathology,patient age and human papillomavirus viral load has the potential to contribute toward improved the diagnosis and management of cervical cancer,providing useful information for gynecological clinicians in the hope of improving patient treatment and quality of life.This article reviews the predictive utility of HPV L1 capsid protein for cervical lesions.
文摘Cancer remains a significant global health concern,necessitating the development of innovative therapeutic strategies.This research paper aims to investigate the role of pyroptosis induction in cancer treatment.Pyroptosis,a form of programmed cell death characterized by the release of pro-inflammatory cytokines and the formation of plasma membrane pores,has gained significant attention as a potential target for cancer therapy.The objective of this study is to provide a comprehensive overview of the current understanding of pyroptosis and its role in cancer treatment.The paper discusses the concept of pyroptosis and its relationship with other forms of cell death,such as apoptosis and necroptosis.It explores the role of pyroptosis in immune activation and its potential for combination therapy.The study also reviews the use of natural,biological,chemical,and multifunctional composite materials for pyroptosis induction in cancer cells.The molecular mechanisms underlying pyroptosis induction by these materials are discussed,along with their advantages and challenges in cancer treatment.The findings of this study highlight the potential of pyroptosis induction as a novel therapeutic strategy in cancer treatment and provide insights into the different materials and mechanisms involved in pyroptosis induction.
基金supported by grants from National Natural Science Foundation of China(No.81361138020)
文摘Three new lignan glucosides, baicalensinosides A-C (1-3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7'-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 mu mol/L, compounds 1-3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
基金supported by the National Natural Science Foundation of China(82070285,81701861,and 81871527 to L.L.82000271 to P.G.81730009 to Y.Z.)the Shanghai Health Committee Research Foundation(20194Y0066 to L.L.)。
文摘Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown.Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity.Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 inflammasome.Mechanistically,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the inflammasome.Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity.Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists.In authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity.These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics.
文摘This paper presents a study on a novel instrumentation system for the measurement of temperature distribution of combustion flames. This system operates upon the three-color principle combining advanced optical sensing and digital image processing techniques. It comprises an endoscope, a light splitter assembly, a CCD camera, a frame-grabber and associated software. This system was calibrated using a blackbody furnace as standard temperature source. The relationship between flame temperatures and grey-level of the images was established through image processing and function correlation. Experimental results obtained on a gas-fired combustion rig provide flame images and temperature distributions on three different wavelengths. Based on the flame temperature distribution the combustion conditions can be analyzed. Experimental results also reveal that this system is capable of online measurement of temperature distribution in a combustion zone. This system can potentially be applied to many areas such as power generation, metallurgy, chemical engineering. It is also a powerful tool for improving the control of combustion process. Keywords three-color method - flame monitor - temperature - imaging processing CLC number TK311
基金support from the National Natural Science Foundation of China(Grant 12002189)the China Postdoctoral Science Foundation(Grant 2019M650649)+2 种基金Y.Z.acknowledges support from the National Natural Science Foundation of China(Grants 12050004 and 11921002)the Tsinghua National Laboratory for Information Science and Technology,the Henry Fok Education Foundation and the Institute for Guo Qiang,Tsinghua University(Grant 2019GQG1012)L.L.acknowledges support from National Natural Science Foundation of China(Grant 51675304).
文摘To address the resource-competing issue between high sensitivity and wide working range for a stand-alone sensor,development of capacitive sensors with an adjustable gap between two electrodes has been of growing interest.While several approaches have been developed to fabricate tunable capacitive sensors,it remains challenging to achieve,simultaneously,a broad range of tunable sensitivity and working range in a single device.In this work,a 3D capacitive sensor with a seesaw-like shape is designed and fabricated by the controlled compressive buckling assembly,which leverages the mechanically tunable configuration to achieve high-precision force sensing(resolution~5.22 nN)and unprecedented adjustment range(by~33 times)of sensitivity.The mechanical tests under different loading conditions demonstrate the stability and reliability of capacitive sensors.Incorporation of an asymmetric seesaw-like structure design in the capacitive sensor allows the acceleration measurement with a tunable sensitivity.These results suggest simple and low-cost routes to high-performance,tunable 3D capacitive sensors,with diverse potential applications in wearable electronics and biomedical devices.
基金Acknowledgements This work was supported by National Science Foundation of China (Nos. 51372133 and 91323304), Beijing Science and Technology Program (No. D141100000514001), and Beijing Natural Science Foundation (No. 2122027).
文摘Detection and analysis of volatile organic compounds (VOCs) as pollutants in the atmosphere and liquids are of great significance because of the detrimental effects of VOCs. A polymer-coated graphene micro-tube piping (GMP) structure with a cross-linked and interconnected channel network was synthesized for liquid sensing. By virtue of their unique cross-linked and interconnected channel network configuration, polycrystalline conformation, and the support of a polymer layer, the resistivity of the 3D hollow micro-tubing GMPs was sensitive to strain, ensuring high sensitivity of the liquid sensor (R/Ro of -4 × 10^3% for pure acetone and R/Ro of -105% for 0.01 wt.% acetone solution). Due to the capillary force, the interfaces of the 3D structures can speed up the penetration of solvents into the polymer, thus promote distinct selectivity within seconds and significantly decrease the response time. Owing to their good selectivity, high sensitivity, rapid response and flexibility, and the ease of use of the sensors and the simplicity of the fabrication processes, the GMP/polymer composites should be a good candidate for liquid sensing.
基金supported by the National Natural Science Foundation of China(Grant Nos.11490563 and 11375269)the National Basic Research Program of China(Grant No.2013CB834406)the National Key Research and Development Program of China(Grant No.2016YFA0400502)
文摘Experimental data ofβ--decay half-lives of nuclei with atomic number between 20 and 190 are investigated.A systematic formula has been proposed to calculateβ^--decay half-lives of neutron-rich nuclei,with a particular consideration on shell and pair effects,the decay energy Q as well as the nucleon numbers(Z,N).Although the formula has relatively few parameters,it reproduces the experimentalβ^--decay half-lives of neutron-rich nuclei very well.The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations.
基金supported by National Training Program of Innovation and Entrepreneurship for Undergraduates in China(201910019030)
文摘The booklice genus,Liposcelis(Psocodea:Liposcelididae),owns some stored product pests and have economic importance.In this study,6 booklice specimens from Sri Lanka were collected and identified based on morphological and molecular data.According to the morphological and phylogenetic analyses,the samples were identified as Liposcelis entomophila.The mitochondrial gene cytochrome c oxidase I(COI)and second internal transcribed spacer(ITS2)were sequenced for phylogenetic work.The phylogenetic trees show that the samples assemble with L.entomophila together and could be distinguished with other Liposcelis spp.apparently.The genus Liposcelis and the species L.entomophila are firstly reported in Sri Lanka.
基金National Key R&D Program of China(Grant No.2017YFA0403000the National Natural Science Foundation of China(Grant Nos.31600597,U1532105,21576005,21878006)the Foundation of State Key Laboratory of Coal Conversion(Grant No.J19-20-604).
文摘Objective A vacuum sample chamber for SAXS measurement of solutions was developed to improve the signal-to-noise ratio of the instrument at Beijing Synchrotron Radiation Facility(BSRF).Methods We developed a vacuum sample chamber which could be connected to the upstream and the downstream vacuum tubes by bellows.Horizontal and vertical linear slides were mounted in the vacuum chamber to adjust the sample position by 35 mm in the horizontal and vertical directions to align the sample in the light path.The liquid sample holder of the chamber was sealed with polyimide film by squeezing instead of gluing to avoid the potential influence of sealant on the solution.Results The chamber had been used for SAXS measurements of water and bovine serum albumin solution at BSRF.The results showed that the background scattering intensity in air was much higher than that in vacuum,especially in the smallangle area near the beamstop.When the q value is 0.142 nm−1,1.01 nm−1 and 1.25 nm−1,the background scattering intensity in air is 45,6.8 and 4.6 times of that in vacuum,respectively.And the background-subtracted scattering curves of bovine serum albumin solution(10 mg/ml)in air and vacuum differ in intensity by a factor of about 2.When the q value is 2 nm−1,the signal-to-noise ratios of scattering intensity of BSA in air and vacuum are 0.79 and 8.51,respectively.Conclusion We designed a simple vacuum sample chamber to be used on the SAXS instrument at 1W2A station of BSRF.The scattering of the background and protein solution in air and vacuum was tested and compared,and the signal-to-noise ratio was clearly improved.