人才培养和学科发展的支撑和保障:西北大学化学国家级实验教学示范中心建设的探索与实践

作为支撑人才培养和学科发展的重要基地,西北大学化学国家级实验教学示范中心通过构建起三层次的实验课程体系,配合以四阶段的实践教学环节,有效提升了学生的科研能力和创新思维;并且中心的大型科学仪器平台为化学及相关学科的研究提供先进的技术支持,加速了科研成果的产出,促进了学术交流与合作。同时,中心强化了实验室安全管理,为师生提供了可靠的研究与学习空间;此外,中心积极开展科普活动和对外交流,提升了公众的科学素养,展现了化学学科的社会价值。面向未来,中心将继续优化教学模式,提升科研服务水平,为培养高素质化学人才和推动化学学科的发展做出更大的贡献。

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

Flexible sensors based on hybrid materials

With the rapid development of mobile Internet and intelligent devices,flexible electronic technology has attracted wide attention driven by the huge demand of the market.As one type of flexible electronic devices,flexible sensors have attracted great interest because of their promising prospects in artificial intelligence,medical health,and environmental protection.In recent years,flexible sensors with high sensitivity,selectivity,good deformability,reliable stability,and portability are urgently needed to meet the developments of artificial skin,human-computer interaction,point of care diagnostics and wearable electronic devices.

Wavelength-selectivity polarization dependence of optical absorption and photoresponse in SnS nanosheets

The optical and optoelectronic characteristics of SnS nanosheets with strong anisotropic crystal structure are researched.Transmission electron microscopy and polarized Raman spectra are used to determine the crystal orientation of SnS nanosheets.The photodetector based on SnS nanosheets exhibits the carrier mobility of 37.75 cm^(2)/V·s,photoresponsivity of 310.5 A/W and external quantum efficiency of 8.56×10^(4)%at 450 nm.Optical absorption around the absorption edge presents obvious polarization sensitivity with the highest optical absorption dichroic ratio of 3.06 at 862 nm.Due to anisotropic optical absorption,the polarized photocurrent appears as the periodic change affected by the polarized direction of the incident light at 808 nm.Overall,SnS nanosheets show good potential in the future application of the polarized photodetectors for specific wavelength.

One-Pot Synthesis of 4-Aryl-NH-1,2,3-Triazoles through Three- Component Reaction of Aldehydes, Nitroalkanes and NaN3

A one-pot three-component reaction of aldehydes, nitroalkanes and NaN3 for the synthesis ofNH-1,2,3-triazoles has been developed. The reaction provides a safe, efficient and step-economic approach for the synthesis of various NH-1,2,3-triazoles in good to excellent yields.