Based on the data of annual average precipitation in Deyang area and its five stations (Mianzhu, Deyang, Zhongjiang, Shifang and Guanghan) from 1984 to 2013, the annual precipitation anomaly percentage was calculated,...Based on the data of annual average precipitation in Deyang area and its five stations (Mianzhu, Deyang, Zhongjiang, Shifang and Guanghan) from 1984 to 2013, the annual precipitation anomaly percentage was calculated, and then the flood and drought situation in Deyang area was graded to discuss the variation characteristics of droughts and floods in the past 30 years. The results show that the cycle of droughts and floods in Deyang was about 3-5 a. The precipitation anomaly percentage indicates that the climate in Deyang area of Sichuan tended to be dry slowly in the past 30 years, and Deyang gradually entered a dry and warm period.展开更多
Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques usi...Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques using Nd:YAG lasers operate only at tens of hertz. Here, we present the development of a high-repetition-rate TS instrument based on a high-speed, pulse-burst laser system to greatly increase the temporal resolution of measurements. Successful instrument prototype testing was carried out by collecting TS light from laboratory helium and argon plasmas at 10 kHz. Calibration of the instrument detection sensitivity using nitrogen/ oxygen rotational Raman scattering signal is also presented. Quantitative electron number densities and electron temperatures of the plasma were acquired at 10 kHz, for stable plasma discharges as, respectively,~0.9 eV and ~5.37×10^21 m^-3 for the argon plasma, and ~1 eV and ~6.5×10^21 m^-3 for the helium plasma.展开更多
As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed rail.The properties of magnetic fluorescent bifunctional composites,such as fluorescence...As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed rail.The properties of magnetic fluorescent bifunctional composites,such as fluorescence intensity and magnetic properties,have increasing demands in magnetic particle inspection.Rare earth compounds offer potential as novel materials for fluorescent magnetic bifunctional composites due to their excellent optical properties and extremely narrow emission spectra.In this work,the rare earth fluorescent material Y_(2)O_(2)S:Eu^(3+) was synthesized by solid-state reaction method.Fe_(3)O_(4)nanoparticles prepared by hydrothermal method were uniformly coated on the Y_(2)O_(2)S:Eu^(3+) particles through physical adsorption of surfactants.The obtained Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) exhibits dark red color under the ultraviolet light.In additio n,X-ray diffractio n,morphology,photoluminescence and hyste resis loop of Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) were investigated.The luminescence mechanism of Y_(2)O_(2)S:Eu^(3+) is described in detail Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) displays good paramagnetism and has a good controllability under a magnetic field.The magnetic particle inspection of Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) was performed using a 4-pole electromagnet and a test piece shim.The magnetic fluorescent bifunctional composite presented in this work can be applied for non-destructive testing.展开更多
In this communication, the crystal structure of Cr_4AlB_4, a new MAB phase compound(where M is a transition metal, A is Al or Si, B is boron) discovered in Cr-Al-B system is reported. This new MAB phase was synthesize...In this communication, the crystal structure of Cr_4AlB_4, a new MAB phase compound(where M is a transition metal, A is Al or Si, B is boron) discovered in Cr-Al-B system is reported. This new MAB phase was synthesized from a mixture of CrB and Al powders at 1000?C and its crystal structure was determined by a combination of X-ray diffraction, first-principles calculations and energy dispersive X-ray spectroscopy(EDS). Cr_4AlB_4 crystallizes in an orthorhombic structure with Immm space group. The lattice constants are a = 2.9343(6) ?, b = 18.8911(0) ?, c = 2.9733(7) ?, and the atomic positions are Cr1 at 4 g(0, 0.2936(5),0), Cr2 at 4 h(0.5, 0.5859(7), 0), Al at 2 b(0, 0.5, 0.5), B1 at 4 h(0, 0.3839(8), 0.5) and B2 at 4 g(0.5, 0.6646(2),0.5).展开更多
In this communication, the possibility for the preparation of two-dimensional MBene CrB from MAB phase Cr2AlB2 is demonstrated for the first time. Herein M is a transition metal, A is a group IIIAor IVA element and B ...In this communication, the possibility for the preparation of two-dimensional MBene CrB from MAB phase Cr2AlB2 is demonstrated for the first time. Herein M is a transition metal, A is a group IIIAor IVA element and B is boron; MAB phases are layered transition metal ternary borides, MBene is used to emphasize the loss of A group element from the parent MAB phases and to highlight the 2 D nature. The possible 2 D CrB nano sheets are prepared by selectively etching out Al layers from Cr2AlB-2 by immersing the Cr2AlB2 powders in dilute HCl solution at room temperature. The as-prepared 2 D CrB nano sheets are examined using X-ray diffraction and scanning electron microscopy and energy dispersive X-ray spectroscopy(EDS). In addition, different structure models are built to explain the observed phenomena.The discovery in this work opens a door to the synthesis of a large number of new 2 D MBenes from MAB phases.展开更多
Phase pure and well crystalline Cr2AlB2 powders are synthesized by heating the mixtures of CrB and Al powders at 900~℃.Cr2AlB2 exhibits nanolaminated morphology which transforms from flake-like crystallite to needle-...Phase pure and well crystalline Cr2AlB2 powders are synthesized by heating the mixtures of CrB and Al powders at 900~℃.Cr2AlB2 exhibits nanolaminated morphology which transforms from flake-like crystallite to needle-like grain with the increase of holding time.The morphology-structure relationships of Cr2AlB2 are delicately discussed.Meanwhile,as the precursor for fabrication of Cr2AlB2,high purity CrB powders are also prepared by high-temperature reaction of B and Cr elemental powders at 1800℃.CrB grains grow into regular plate-like morphology.Through Rietveld structure refinement,new sets of diffraction data are presented for both CrB and Cr2AlB2 and overlapped peak positions and intensities are revealed which make up for the deficiency of the existing data in ICDD PDF#32-0277(CrB)and ICDD PDF#72-1847(Cr2AlB2).Moreover,since MAB phases are precursors for preparing MBenes,2D-CrBnanosheets are successfully prepared by completely etching out Al atomic layers from Cr2AlB2.2D-CrB crystalizes in CrB structure with two-dimensional lamellar morphology.Simultaneously the formation mechanism of 2D-CrB is vividly depicted.A system of materials preparation from CrB to Cr2AlB2 and then to 2D-CrB is well established.展开更多
A novel equimolar high-entropy(HE)transition metal monoboride,(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B,was designed and prepared in powder and bulk form by high temperature elemental reaction method and spark plasm...A novel equimolar high-entropy(HE)transition metal monoboride,(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B,was designed and prepared in powder and bulk form by high temperature elemental reaction method and spark plasma sintering(SPS)method,respectively.XRD analysis shows that HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B possesses orthorhombic structure with Pnma space group.Through Rietveld refinement,the lattice parameters of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B are a=5.6675,b=2.9714,c=4.2209 and the theoretical density is 6.95 g/cm~3.The Vickers hardness and electrical conductivity of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B bulk with relative density of 90%is 12.3±0.5 GPa and 0.49±0.04×10~6 S/m,respectively.Due to high electrical conductivity,HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B bulk with 3.0 mm thickness displays superior EMI shielding performance in 18.0–26.5 GHz(K-band),and the average values of SET,SER,and SEAare 23.3 dB,13.9 dB,and 9.4 dB,respectively.The EMI shielding mechanism of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B mainly results from reflection.展开更多
In the present study,novel ester derivatives of CAPE were designed and synthesized as neuroprotective agents.The anti-inflammatory and antioxidant activities of these compounds were evaluated at the cellular level,whi...In the present study,novel ester derivatives of CAPE were designed and synthesized as neuroprotective agents.The anti-inflammatory and antioxidant activities of these compounds were evaluated at the cellular level,while the blood-brain barrier(BBB)permeability was predicted by parallel artificial membrane permeability assay(PAMPA).The results revealed that phenolic hydroxyl groups and double bonds in the structure of CAPE had important effects on neuroprotective activities.Accordingly,a preliminary structure-activity relationship was summarized in this paper.In addition,we observed a significant improvement on BBB permeability.These results provided important references for the structural modification and optimization of CAPE in the future.展开更多
An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prep...An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prepared using solid-phase peptide synthesis,and subsequently activated by acetylacet one(acac)without exoge nous thiol additives.Strained peptidyl thiolactones could be the possible reactive in termediates that drastically accelerate the reacti on rates at the sterically demandi ng proline and valine sites.This developed protocol allows for sequential peptide ligations in a one-pot manner,and expedites the assembly of mucin 1(MUC-1)variable number tandem repeat(VNTR)trimers in various glycosylated forms.展开更多
Aiming at the human–computer interaction control(HCIC)requirements of multi operators in collaborative virtual maintenance(CVM),real-time motion capture and simulation drive of multi operators with optical human moti...Aiming at the human–computer interaction control(HCIC)requirements of multi operators in collaborative virtual maintenance(CVM),real-time motion capture and simulation drive of multi operators with optical human motion capture system(HMCS)is proposed.The detailed realization process of real-time motion capture and data drive for virtual operators in CVM environment is presented to actualize the natural and online interactive operations.In order to ensure the cooperative and orderly interactions of virtual operators with the input operations of actual operators,collaborative HCIC model is established according to specific planning,allocating and decision-making of different maintenance tasks as well as the human–computer interaction features and collaborative maintenance operation features among multi maintenance trainees in CVM process.Finally,results of the experimental implementation validate the effectiveness and practicability of proposed methods,models,strategies and mechanisms.展开更多
Among the structurally diverse NNRTIs, pyridinone scaffolds demonstrate high potency against HIV-1 wild type and drug-resistant strains. During the optimization of our pyridinone compound 1(LAM-trans), we found that...Among the structurally diverse NNRTIs, pyridinone scaffolds demonstrate high potency against HIV-1 wild type and drug-resistant strains. During the optimization of our pyridinone compound 1(LAM-trans), we found that the introduction of the N atoms in the C-4 position could dramatically improve the water solubility(7b), whereas protonation of the piperidine N atom resulted in a decrease in its hydrophobic interaction with the binding pocket. In particular, protonation altered the orientation of the alicyclic rings in the hydrophobic pocket, thus impeding the formation of key halogen bond and eventually leading to a huge change in anti-HIV-1 RT activity. These results provided theoretical and experimental basis for the subsequent structural modification of pyridinone compounds.展开更多
Three series of novel anti-immunodeficiency virus 1 (HIV-1) dual (RT/1N) inhibitors were rationally designed by introducing a functioning diketo acid (DKA) into pyridin-2-one scaffold. To efficiently analyze inh...Three series of novel anti-immunodeficiency virus 1 (HIV-1) dual (RT/1N) inhibitors were rationally designed by introducing a functioning diketo acid (DKA) into pyridin-2-one scaffold. To efficiently analyze inhibitory activity, these compounds were screened against HIV-1 RT and IN respectively via surface plasmon resonance (SPR), and active compounds were subsequently evaluated by enzyme assay. It was noteworthy that compound A2 exhibited moderate activity against both HIV-1 RT and IN. This result provided information for further development of pyridinone analogues as potent dual HIV-1 inhibitors.展开更多
The modeling and simulation of sea clutter are important in detecting radar targets in sea backgrounds.Because the nonstationary property of sea clutter is ignored in traditional statistical models,a new method based ...The modeling and simulation of sea clutter are important in detecting radar targets in sea backgrounds.Because the nonstationary property of sea clutter is ignored in traditional statistical models,a new method based on measured sea clutter is proposed in this paper.First,we convert the measured sea clutter data under different sea conditions[xI,xQ]into real amplitude SM.Instantaneous phaseθis then extracted from the coherent radar’s baseband data.Second,we select a candidate statistic model and estimate its parameters based on SM by utilizing maximum likelihood estimation.Finally,we generate random series A using corresponding random data generator and then add instantaneous phaseθinto A,i.e.,y=Ae^(jθ),to obtain simulated sea clutter series.Through a comparison of simulated sea clutter and measured sea clutter data via histogram,the validity of the proposed method is proved.展开更多
This work develops a distributed environmental monitoring system for the combination of hydroponics and aquaculture based on the internet of things technology,which mainly includes the information perception layer,the...This work develops a distributed environmental monitoring system for the combination of hydroponics and aquaculture based on the internet of things technology,which mainly includes the information perception layer,the information transmission layer and the sys-tem architecture.The system has employed multiple sensors terminal to real-time acqui-sition,including air and water temperatures,dissolved oxygen etc.LoRa protocol is suitable for sending small data and the 4G was employed to collect data and send to the cloud plat-form.Java is used to develop background applications,to access cloud platforms and local data processing.Based on the collection and processing of environmental data and cloud service platform,the mobile application program client and remote login desktop have been developed.It has been implemented and tested in Tongzhou,Beijing for 3 months in 2020.The results showed the proposed monitoring system stability for overall operation and accuracy data transmission,which can support the actual hydroponics and aquacul-ture production management.After analysis of monitoring data collected from the devel-oped monitoring system,indoor air and water temperature have the obvious correlation with atmospheric pressure(0.7 and 0.9)and outdoor temperature(1.0 and 0.9),respectively.展开更多
As the effective capture region of optical motion capture system is limited by quantity,installation mode,resolution and focus of infrared cameras,the reflective markers on certain body parts(such as wrists,elbows,etc...As the effective capture region of optical motion capture system is limited by quantity,installation mode,resolution and focus of infrared cameras,the reflective markers on certain body parts(such as wrists,elbows,etc.)of multi-actual trainees may be obscured when they perform the collaborative interactive operation.To address this issue,motion data compensation method based on the additional feature information provided by the electromagnetic spatial position tracking equipment is proposed in this paper.The main working principle and detailed realization process of the proposed method are introduced step by step,and the practical implementation is presented to illustrate its validity and efficiency.The results show that the missing capture data and motion information of relevant obscured markers on arms can be retrieved with the proposed method,which can avoid the simulation motions of corresponding virtual operators being interrupted and deformed during the collaborative interactive operation process performed by multiactual trainees with optical human motion capture system in a limited capture range.展开更多
In order to provide a simple and efficient approach to perform the real-time interactive motion control of virtual human in virtual maintenance environment(VME),the motion control method of virtual human based on limi...In order to provide a simple and efficient approach to perform the real-time interactive motion control of virtual human in virtual maintenance environment(VME),the motion control method of virtual human based on limited input information is proposed.With the space position tracking system with only one sensor the action sequences and motion models of virtual human,the human motions and hand actions in VME are driven by the sensor data in stages and in real time through the transmission condition control in the process of maintenance operation.And the input data and information is processed based on the method of Kalman filtering and wavelet transforming to improve the control effects.An experimental VME is also established to validate the control efficiency,and the experiment results show that the space motion control of virtual human in VME can be performed based on limited information with proposed control strategy.展开更多
We proposed a novel Al Ga N/Ga N enhancement-mode(E-mode) high electron mobility transistor(HEMT) with a dual-gate structure and carried out the detailed numerical simulation of device operation using Silvaco Atla...We proposed a novel Al Ga N/Ga N enhancement-mode(E-mode) high electron mobility transistor(HEMT) with a dual-gate structure and carried out the detailed numerical simulation of device operation using Silvaco Atlas. The dual-gate device is based on a cascode connection of an E-mode and a D-mode gate. The simulation results show that electric field under the gate is decreased by more than 70% compared to that of the conventional E-mode MIS-HEMTs(from 2.83 MV/cm decreased to 0.83 MV/cm). Thus, with the discussion of ionized trap density, the proposed dual-gate structure can highly improve electric field-related reliability, such as, threshold voltage stability. In addition, compared with HEMT with field plate structure, the proposed structure exhibits a simplified fabrication process and a more effective suppression of high electric field.展开更多
文摘Based on the data of annual average precipitation in Deyang area and its five stations (Mianzhu, Deyang, Zhongjiang, Shifang and Guanghan) from 1984 to 2013, the annual precipitation anomaly percentage was calculated, and then the flood and drought situation in Deyang area was graded to discuss the variation characteristics of droughts and floods in the past 30 years. The results show that the cycle of droughts and floods in Deyang was about 3-5 a. The precipitation anomaly percentage indicates that the climate in Deyang area of Sichuan tended to be dry slowly in the past 30 years, and Deyang gradually entered a dry and warm period.
基金supported by the US Department of Energy’s STTR program under Grant No.DE-SC0018672(Program Manager:Dr Matthew Lanctot)
文摘Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques using Nd:YAG lasers operate only at tens of hertz. Here, we present the development of a high-repetition-rate TS instrument based on a high-speed, pulse-burst laser system to greatly increase the temporal resolution of measurements. Successful instrument prototype testing was carried out by collecting TS light from laboratory helium and argon plasmas at 10 kHz. Calibration of the instrument detection sensitivity using nitrogen/ oxygen rotational Raman scattering signal is also presented. Quantitative electron number densities and electron temperatures of the plasma were acquired at 10 kHz, for stable plasma discharges as, respectively,~0.9 eV and ~5.37×10^21 m^-3 for the argon plasma, and ~1 eV and ~6.5×10^21 m^-3 for the helium plasma.
基金supported by the National Natural Science Foundation of China (51927810)。
文摘As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed rail.The properties of magnetic fluorescent bifunctional composites,such as fluorescence intensity and magnetic properties,have increasing demands in magnetic particle inspection.Rare earth compounds offer potential as novel materials for fluorescent magnetic bifunctional composites due to their excellent optical properties and extremely narrow emission spectra.In this work,the rare earth fluorescent material Y_(2)O_(2)S:Eu^(3+) was synthesized by solid-state reaction method.Fe_(3)O_(4)nanoparticles prepared by hydrothermal method were uniformly coated on the Y_(2)O_(2)S:Eu^(3+) particles through physical adsorption of surfactants.The obtained Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) exhibits dark red color under the ultraviolet light.In additio n,X-ray diffractio n,morphology,photoluminescence and hyste resis loop of Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) were investigated.The luminescence mechanism of Y_(2)O_(2)S:Eu^(3+) is described in detail Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) displays good paramagnetism and has a good controllability under a magnetic field.The magnetic particle inspection of Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) was performed using a 4-pole electromagnet and a test piece shim.The magnetic fluorescent bifunctional composite presented in this work can be applied for non-destructive testing.
基金financial supports from the National Natural Science Foundation of China under grant No.51672064 and No.U1435206
文摘In this communication, the crystal structure of Cr_4AlB_4, a new MAB phase compound(where M is a transition metal, A is Al or Si, B is boron) discovered in Cr-Al-B system is reported. This new MAB phase was synthesized from a mixture of CrB and Al powders at 1000?C and its crystal structure was determined by a combination of X-ray diffraction, first-principles calculations and energy dispersive X-ray spectroscopy(EDS). Cr_4AlB_4 crystallizes in an orthorhombic structure with Immm space group. The lattice constants are a = 2.9343(6) ?, b = 18.8911(0) ?, c = 2.9733(7) ?, and the atomic positions are Cr1 at 4 g(0, 0.2936(5),0), Cr2 at 4 h(0.5, 0.5859(7), 0), Al at 2 b(0, 0.5, 0.5), B1 at 4 h(0, 0.3839(8), 0.5) and B2 at 4 g(0.5, 0.6646(2),0.5).
基金supports from the National Natural Science Foundation of China under grant No. 51672064 and No. U1435206the Beijing Municipal Science & Technology Commission under grant No. Z151100003315012 and No. D161100002416001
文摘In this communication, the possibility for the preparation of two-dimensional MBene CrB from MAB phase Cr2AlB2 is demonstrated for the first time. Herein M is a transition metal, A is a group IIIAor IVA element and B is boron; MAB phases are layered transition metal ternary borides, MBene is used to emphasize the loss of A group element from the parent MAB phases and to highlight the 2 D nature. The possible 2 D CrB nano sheets are prepared by selectively etching out Al layers from Cr2AlB-2 by immersing the Cr2AlB2 powders in dilute HCl solution at room temperature. The as-prepared 2 D CrB nano sheets are examined using X-ray diffraction and scanning electron microscopy and energy dispersive X-ray spectroscopy(EDS). In addition, different structure models are built to explain the observed phenomena.The discovery in this work opens a door to the synthesis of a large number of new 2 D MBenes from MAB phases.
基金financial supports from the National Natural Science Foundation of China under grant No. 51672064, No. U1435206 and No. 61271049
文摘Phase pure and well crystalline Cr2AlB2 powders are synthesized by heating the mixtures of CrB and Al powders at 900~℃.Cr2AlB2 exhibits nanolaminated morphology which transforms from flake-like crystallite to needle-like grain with the increase of holding time.The morphology-structure relationships of Cr2AlB2 are delicately discussed.Meanwhile,as the precursor for fabrication of Cr2AlB2,high purity CrB powders are also prepared by high-temperature reaction of B and Cr elemental powders at 1800℃.CrB grains grow into regular plate-like morphology.Through Rietveld structure refinement,new sets of diffraction data are presented for both CrB and Cr2AlB2 and overlapped peak positions and intensities are revealed which make up for the deficiency of the existing data in ICDD PDF#32-0277(CrB)and ICDD PDF#72-1847(Cr2AlB2).Moreover,since MAB phases are precursors for preparing MBenes,2D-CrBnanosheets are successfully prepared by completely etching out Al atomic layers from Cr2AlB2.2D-CrB crystalizes in CrB structure with two-dimensional lamellar morphology.Simultaneously the formation mechanism of 2D-CrB is vividly depicted.A system of materials preparation from CrB to Cr2AlB2 and then to 2D-CrB is well established.
基金financial supports from the National Natural Science Foundation of China under grant No.51672064,No.51972089,and No.51927810。
文摘A novel equimolar high-entropy(HE)transition metal monoboride,(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B,was designed and prepared in powder and bulk form by high temperature elemental reaction method and spark plasma sintering(SPS)method,respectively.XRD analysis shows that HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B possesses orthorhombic structure with Pnma space group.Through Rietveld refinement,the lattice parameters of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B are a=5.6675,b=2.9714,c=4.2209 and the theoretical density is 6.95 g/cm~3.The Vickers hardness and electrical conductivity of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B bulk with relative density of 90%is 12.3±0.5 GPa and 0.49±0.04×10~6 S/m,respectively.Due to high electrical conductivity,HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B bulk with 3.0 mm thickness displays superior EMI shielding performance in 18.0–26.5 GHz(K-band),and the average values of SET,SER,and SEAare 23.3 dB,13.9 dB,and 9.4 dB,respectively.The EMI shielding mechanism of HE(Cr_(0.2)Mn_(0.2)Fe_(0.2)Co_(0.2)Mo_(0.2))B mainly results from reflection.
文摘In the present study,novel ester derivatives of CAPE were designed and synthesized as neuroprotective agents.The anti-inflammatory and antioxidant activities of these compounds were evaluated at the cellular level,while the blood-brain barrier(BBB)permeability was predicted by parallel artificial membrane permeability assay(PAMPA).The results revealed that phenolic hydroxyl groups and double bonds in the structure of CAPE had important effects on neuroprotective activities.Accordingly,a preliminary structure-activity relationship was summarized in this paper.In addition,we observed a significant improvement on BBB permeability.These results provided important references for the structural modification and optimization of CAPE in the future.
基金The authors are grateful for financial support from the Beijing Natural Science Foundation(No.JQ18024)the National Natural Science Foundation of China(Nos.21822701,91953111,21672012)+1 种基金the Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910001001)State Key Laboratory of Natural and Biomimetic Drugs.
文摘An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prepared using solid-phase peptide synthesis,and subsequently activated by acetylacet one(acac)without exoge nous thiol additives.Strained peptidyl thiolactones could be the possible reactive in termediates that drastically accelerate the reacti on rates at the sterically demandi ng proline and valine sites.This developed protocol allows for sequential peptide ligations in a one-pot manner,and expedites the assembly of mucin 1(MUC-1)variable number tandem repeat(VNTR)trimers in various glycosylated forms.
文摘Aiming at the human–computer interaction control(HCIC)requirements of multi operators in collaborative virtual maintenance(CVM),real-time motion capture and simulation drive of multi operators with optical human motion capture system(HMCS)is proposed.The detailed realization process of real-time motion capture and data drive for virtual operators in CVM environment is presented to actualize the natural and online interactive operations.In order to ensure the cooperative and orderly interactions of virtual operators with the input operations of actual operators,collaborative HCIC model is established according to specific planning,allocating and decision-making of different maintenance tasks as well as the human–computer interaction features and collaborative maintenance operation features among multi maintenance trainees in CVM process.Finally,results of the experimental implementation validate the effectiveness and practicability of proposed methods,models,strategies and mechanisms.
基金The National Natural Science Foundation of China(Grant No.21172014,20972011 and 21042009)
文摘Among the structurally diverse NNRTIs, pyridinone scaffolds demonstrate high potency against HIV-1 wild type and drug-resistant strains. During the optimization of our pyridinone compound 1(LAM-trans), we found that the introduction of the N atoms in the C-4 position could dramatically improve the water solubility(7b), whereas protonation of the piperidine N atom resulted in a decrease in its hydrophobic interaction with the binding pocket. In particular, protonation altered the orientation of the alicyclic rings in the hydrophobic pocket, thus impeding the formation of key halogen bond and eventually leading to a huge change in anti-HIV-1 RT activity. These results provided theoretical and experimental basis for the subsequent structural modification of pyridinone compounds.
基金National Natural Science Foundation of China(Grant No.21172014,812111023 and 81172733)grants from the Ministry of Science and Technology of China(Grant No.200 9ZX09301-010)
文摘Three series of novel anti-immunodeficiency virus 1 (HIV-1) dual (RT/1N) inhibitors were rationally designed by introducing a functioning diketo acid (DKA) into pyridin-2-one scaffold. To efficiently analyze inhibitory activity, these compounds were screened against HIV-1 RT and IN respectively via surface plasmon resonance (SPR), and active compounds were subsequently evaluated by enzyme assay. It was noteworthy that compound A2 exhibited moderate activity against both HIV-1 RT and IN. This result provided information for further development of pyridinone analogues as potent dual HIV-1 inhibitors.
文摘The modeling and simulation of sea clutter are important in detecting radar targets in sea backgrounds.Because the nonstationary property of sea clutter is ignored in traditional statistical models,a new method based on measured sea clutter is proposed in this paper.First,we convert the measured sea clutter data under different sea conditions[xI,xQ]into real amplitude SM.Instantaneous phaseθis then extracted from the coherent radar’s baseband data.Second,we select a candidate statistic model and estimate its parameters based on SM by utilizing maximum likelihood estimation.Finally,we generate random series A using corresponding random data generator and then add instantaneous phaseθinto A,i.e.,y=Ae^(jθ),to obtain simulated sea clutter series.Through a comparison of simulated sea clutter and measured sea clutter data via histogram,the validity of the proposed method is proved.
基金This research was financially supported by Research on Industrialization of Real-time Measurement and Control Technology for Efficient Fish-vegetable Symbiosis System(Project No.:KJ2019CX099).
文摘This work develops a distributed environmental monitoring system for the combination of hydroponics and aquaculture based on the internet of things technology,which mainly includes the information perception layer,the information transmission layer and the sys-tem architecture.The system has employed multiple sensors terminal to real-time acqui-sition,including air and water temperatures,dissolved oxygen etc.LoRa protocol is suitable for sending small data and the 4G was employed to collect data and send to the cloud plat-form.Java is used to develop background applications,to access cloud platforms and local data processing.Based on the collection and processing of environmental data and cloud service platform,the mobile application program client and remote login desktop have been developed.It has been implemented and tested in Tongzhou,Beijing for 3 months in 2020.The results showed the proposed monitoring system stability for overall operation and accuracy data transmission,which can support the actual hydroponics and aquacul-ture production management.After analysis of monitoring data collected from the devel-oped monitoring system,indoor air and water temperature have the obvious correlation with atmospheric pressure(0.7 and 0.9)and outdoor temperature(1.0 and 0.9),respectively.
基金the project supported by the National Natural Science Foundation of China(Grant No.61702524)the Natural Science Foundation of Shaanxi Province(Grant No.2016JQ6052).
文摘As the effective capture region of optical motion capture system is limited by quantity,installation mode,resolution and focus of infrared cameras,the reflective markers on certain body parts(such as wrists,elbows,etc.)of multi-actual trainees may be obscured when they perform the collaborative interactive operation.To address this issue,motion data compensation method based on the additional feature information provided by the electromagnetic spatial position tracking equipment is proposed in this paper.The main working principle and detailed realization process of the proposed method are introduced step by step,and the practical implementation is presented to illustrate its validity and efficiency.The results show that the missing capture data and motion information of relevant obscured markers on arms can be retrieved with the proposed method,which can avoid the simulation motions of corresponding virtual operators being interrupted and deformed during the collaborative interactive operation process performed by multiactual trainees with optical human motion capture system in a limited capture range.
文摘In order to provide a simple and efficient approach to perform the real-time interactive motion control of virtual human in virtual maintenance environment(VME),the motion control method of virtual human based on limited input information is proposed.With the space position tracking system with only one sensor the action sequences and motion models of virtual human,the human motions and hand actions in VME are driven by the sensor data in stages and in real time through the transmission condition control in the process of maintenance operation.And the input data and information is processed based on the method of Kalman filtering and wavelet transforming to improve the control effects.An experimental VME is also established to validate the control efficiency,and the experiment results show that the space motion control of virtual human in VME can be performed based on limited information with proposed control strategy.
基金supported by the Key Technologies Support Program of Jiangsu Province(No.BE2013002-2)the National Key Scientific Instrument and Equipment Development Projects of China(No.2013YQ470767)
文摘We proposed a novel Al Ga N/Ga N enhancement-mode(E-mode) high electron mobility transistor(HEMT) with a dual-gate structure and carried out the detailed numerical simulation of device operation using Silvaco Atlas. The dual-gate device is based on a cascode connection of an E-mode and a D-mode gate. The simulation results show that electric field under the gate is decreased by more than 70% compared to that of the conventional E-mode MIS-HEMTs(from 2.83 MV/cm decreased to 0.83 MV/cm). Thus, with the discussion of ionized trap density, the proposed dual-gate structure can highly improve electric field-related reliability, such as, threshold voltage stability. In addition, compared with HEMT with field plate structure, the proposed structure exhibits a simplified fabrication process and a more effective suppression of high electric field.