For oil and gas pipeline monitoring applications, this paper proposed a dual-parameter fusion distributed fiber optic sensor system that enables distributed temperature and distributed vibration measurements in a sing...For oil and gas pipeline monitoring applications, this paper proposed a dual-parameter fusion distributed fiber optic sensor system that enables distributed temperature and distributed vibration measurements in a single fiber. Through the fiber-scattering spectrum time domain detection combined with coded pulse sequence and Raman scattering spectrum is obtained, which realizes high-resolution temperature measurement and wide-band vibrational wave measurement. The experimental results show that, on 10 km optical fiber measurement, temperature resolution up to 0.1?C and vibration response frequency range 20 Hz - 5 kHz. This sensing system achieves temperature and vibration dual-parameter measurements with fiber optics, greatly simplifying the system and facilitating installation and it can be widely used in oil and gas pipeline monitoring.展开更多
In this paper, an optical fiber sensor is designed by using optical Faraday effect. It is composed of fiber collimator, polarizer, magneto-optical crystal and mirror. Based on the magnetic flux leakage (MFL) theory, T...In this paper, an optical fiber sensor is designed by using optical Faraday effect. It is composed of fiber collimator, polarizer, magneto-optical crystal and mirror. Based on the magnetic flux leakage (MFL) theory, The optical fiber sensor was placed between two permanent magnets with the N-pole. Therefore, the optical fiber sensing system was built to detect the defective ferromagnetic objects. Theoretical and experimental studies shown that the system can identify a little defects, such as irons’ blind hole (diameter φ =?3mm , depth t = 4mm?), irons’ grooves (length l= 30mm , width?ω = 10mm ), hole (φ?=?3mm ) and crackle etc. The system has the characteristics of small size, high sensitivity, fast signal response and high resolution. In terms of the defective oil and gas pipelines detection, The optical fiber sensing system is used in non-destructive testing, which will be valuable and meaningful.展开更多
In the present study,we aimed to investigate the pharmacokinetics and dosage proportionality for a single,intravenous utilization of Pazufloxacin Mesilate Sodium Chloride,an injectable synthetic fluoroquinolone antiba...In the present study,we aimed to investigate the pharmacokinetics and dosage proportionality for a single,intravenous utilization of Pazufloxacin Mesilate Sodium Chloride,an injectable synthetic fluoroquinolone antibacterial agent,in healthy Chinese volunteers.In this open-labeled,three-dosage parallel study,subjects were randomized to receive a single dose of Pazufloxacin Mesilate at 150,300 or 600 mg(n=10,10 and 10,respectively)administered as a 30-min intravenous infusion.Blood and urine samples were serially collected from 0 to 24 h after drug administration.Moreover,the sample’s drug concentrations were analyzed via validated RP-HPLC method.Subjects receiving a single dose of Pazufloxacin Mesilate 150,300 or 600 mg were in accordance with the two compartment model.The Cmax for each dosage group was 2.37±0.89,4.27±0.74 and 10.74±4.06 mg·mL(–1),respectively;and the AUC0→∞was 3.24±1.2,5.89±1.51 and 13.32±2.35 mg·h·mL–1,respectively.In addition,Tmax for groups treated with 150,300 and 600 mg was 0.48±0.08,0.50±0.00 and 0.53±0.08 h,respectively.The correlation analysis for AUC0→∞,Cmax and dosage suggested that pazufolxacin mesilate displayed dose proportion at the dose ranging from 150 to 600 mg.The data suggested that all three different dosage regimens fit with the two compartment model.Meanwhile,it presented a linear correlation between AUC0→∞,Cmax and dosage over the range of 150–600 mg.展开更多
FeAlCuCrNiMo0.6Tix(x=0.2,0.6,0.8) high-entropy alloys were fabricated with flux-cored wire and surfaced on low-carbon steel by gas metal arc welding.The effect of Ti addition on the microstructures and properties of F...FeAlCuCrNiMo0.6Tix(x=0.2,0.6,0.8) high-entropy alloys were fabricated with flux-cored wire and surfaced on low-carbon steel by gas metal arc welding.The effect of Ti addition on the microstructures and properties of FeAlCuCrNiMo0.6Tix HEAs surfacing layer was systematically studied.The results show that FeAlCuCrNiMo0.6Tix HEAs surfacing layer exhibits a majority of BCC solid solution based on Fe-Cr phase and a small amount of MC phase.Microhardness and wear tests results show that the addition of Ti can significantly improve the microhardness and wear resistance of the surfacing layer.The microhardness of surfacing layer can reach up to 642 HV0.5,which is about 2.8 times that of the substrate.Meanwhile,the wear mass loss is minimum.Electrochemical corrosion test results show that the addition of Ti can improve the corrosion resistance of surfacing layer,which is better than 304 stainless steel substrate.With the increase in Ti,the corrosion resistance increases first and then decreases.When the Ti content is 0.6,the self-corrosion current density of polarization curve is the smallest,the capacitive impedance radius of electrochemical impedance spectroscopy is the largest,and the corrosion resistance effect is the best.展开更多
文摘For oil and gas pipeline monitoring applications, this paper proposed a dual-parameter fusion distributed fiber optic sensor system that enables distributed temperature and distributed vibration measurements in a single fiber. Through the fiber-scattering spectrum time domain detection combined with coded pulse sequence and Raman scattering spectrum is obtained, which realizes high-resolution temperature measurement and wide-band vibrational wave measurement. The experimental results show that, on 10 km optical fiber measurement, temperature resolution up to 0.1?C and vibration response frequency range 20 Hz - 5 kHz. This sensing system achieves temperature and vibration dual-parameter measurements with fiber optics, greatly simplifying the system and facilitating installation and it can be widely used in oil and gas pipeline monitoring.
文摘In this paper, an optical fiber sensor is designed by using optical Faraday effect. It is composed of fiber collimator, polarizer, magneto-optical crystal and mirror. Based on the magnetic flux leakage (MFL) theory, The optical fiber sensor was placed between two permanent magnets with the N-pole. Therefore, the optical fiber sensing system was built to detect the defective ferromagnetic objects. Theoretical and experimental studies shown that the system can identify a little defects, such as irons’ blind hole (diameter φ =?3mm , depth t = 4mm?), irons’ grooves (length l= 30mm , width?ω = 10mm ), hole (φ?=?3mm ) and crackle etc. The system has the characteristics of small size, high sensitivity, fast signal response and high resolution. In terms of the defective oil and gas pipelines detection, The optical fiber sensing system is used in non-destructive testing, which will be valuable and meaningful.
基金the support of Laboratory of National Institution of Drug Clinical Trial,Xiangya Hospital,Central South University
文摘In the present study,we aimed to investigate the pharmacokinetics and dosage proportionality for a single,intravenous utilization of Pazufloxacin Mesilate Sodium Chloride,an injectable synthetic fluoroquinolone antibacterial agent,in healthy Chinese volunteers.In this open-labeled,three-dosage parallel study,subjects were randomized to receive a single dose of Pazufloxacin Mesilate at 150,300 or 600 mg(n=10,10 and 10,respectively)administered as a 30-min intravenous infusion.Blood and urine samples were serially collected from 0 to 24 h after drug administration.Moreover,the sample’s drug concentrations were analyzed via validated RP-HPLC method.Subjects receiving a single dose of Pazufloxacin Mesilate 150,300 or 600 mg were in accordance with the two compartment model.The Cmax for each dosage group was 2.37±0.89,4.27±0.74 and 10.74±4.06 mg·mL(–1),respectively;and the AUC0→∞was 3.24±1.2,5.89±1.51 and 13.32±2.35 mg·h·mL–1,respectively.In addition,Tmax for groups treated with 150,300 and 600 mg was 0.48±0.08,0.50±0.00 and 0.53±0.08 h,respectively.The correlation analysis for AUC0→∞,Cmax and dosage suggested that pazufolxacin mesilate displayed dose proportion at the dose ranging from 150 to 600 mg.The data suggested that all three different dosage regimens fit with the two compartment model.Meanwhile,it presented a linear correlation between AUC0→∞,Cmax and dosage over the range of 150–600 mg.
基金financially supported by the National Key R&D Program of China (No. 2017YFB1103603)the Natural Science Foundation Program Key Projects of Liaoning Province (No. 20180510030)。
文摘FeAlCuCrNiMo0.6Tix(x=0.2,0.6,0.8) high-entropy alloys were fabricated with flux-cored wire and surfaced on low-carbon steel by gas metal arc welding.The effect of Ti addition on the microstructures and properties of FeAlCuCrNiMo0.6Tix HEAs surfacing layer was systematically studied.The results show that FeAlCuCrNiMo0.6Tix HEAs surfacing layer exhibits a majority of BCC solid solution based on Fe-Cr phase and a small amount of MC phase.Microhardness and wear tests results show that the addition of Ti can significantly improve the microhardness and wear resistance of the surfacing layer.The microhardness of surfacing layer can reach up to 642 HV0.5,which is about 2.8 times that of the substrate.Meanwhile,the wear mass loss is minimum.Electrochemical corrosion test results show that the addition of Ti can improve the corrosion resistance of surfacing layer,which is better than 304 stainless steel substrate.With the increase in Ti,the corrosion resistance increases first and then decreases.When the Ti content is 0.6,the self-corrosion current density of polarization curve is the smallest,the capacitive impedance radius of electrochemical impedance spectroscopy is the largest,and the corrosion resistance effect is the best.