Advances in the production technology of hydrogen peroxide

This article mainly summarizes various aspects of hydrogen peroxide(H2O2)production through the anthraquinone route,including hydrogenation catalysts,working solution,regeneration technique,hydrogenation reactors,and environmental protection.The advances and breakthrough of SINOPEC in the production of H2O2 through the anthraquinone route is presented in this review,highlighting recent innovative technology on these aspects developed independently.The technical prospect and scientific challenges associated with the direct synthesis method from hydrogen and oxygen are also briefly discussed.

High power tunable Raman fiber laser at 1.2μm waveband

Development of a high power fiber laser at special waveband,which is difficult to achieve by conventional rare-earth-doped fibers,is a significant challenge.One of the most common methods for achieving lasing at special wavelength is Raman conversion.Phosphorus-doped fiber(PDF),due to the phosphorus-related large frequency shift Raman peak at 40 THz,is a great choice for large frequency shift Raman conversion.Here,by adopting 150 m large mode area triple-clad PDF as Raman gain medium,and a novel wavelength-selective feedback mechanism to suppress the silica-related Raman emission,we build a high power cladding-pumped Raman fiber laser at 1.2μm waveband.A Raman signal with power up to 735.8 W at 1252.7 nm is obtained.To the best of our knowledge,this is the highest output power ever reported for fiber lasers at 1.2μm waveband.Moreover,by tuning the wavelength of the pump source,a tunable Raman output of more than 450 W over a wavelength range of 1240.6–1252.7 nm is demonstrated.This work proves PDF’s advantage in high power large frequency shift Raman conversion with a cladding pump scheme,thus providing a good solution for a high power laser source at special waveband.

5 kW-level single-mode fiber amplifier based on low-numerical-aperture fiber

A low-numerical-aperture(NA)concept enables large-mode-area fiber with better single-mode operation ability,which is beneficial for transverse mode instability and nonlinear effects suppression.In this contribution,we reported a high-power fiber amplifier based on a piece of self-developed large-mode-area low-NA fiber with a core NA of 0.049 and a core/inner cladding diameter of 25/400μm.The influence of the pump wavelength and fiber length on the power scaling potential of the fiber amplifier is systematically investigated.As a result,an output of 4.80 kW and a beam quality factor of~1.33 were finally obtained,which is the highest output power ever reported in a fiber amplifier exploiting the low-NA fiber.The results reveal that low-NA fibers have superiority in power scaling and beam quality maintenance at high power levels.

Brightness enhancement on random-distributed-feedback Raman fiber lasers pumped by multimode diodes

The power scaling on short wavelength(SW)fiber lasers operating around 1μm are in significant demand for applications in energy,environment and industry.The challenge for performance scalability of high-power SW lasers based on rare-earth-doped fiber primarily lies in the physical limitations,including reabsorption,amplified spontaneous emission and parasitic laser oscillation.Here,we demonstrate an all-fiberized,purely passive SW(1018 nm)randomdistributed-feedback Raman fiber laser(RRFL)to validate the capability of achieving high-power output at SWs based on multimode laser diodes(LDs)direct pumping.Directly pumped by multimode LDs,the high-brightness RRFL delivers over 656 W,with an electro-optical efficiency of 20%relative to the power.The slope efficiency is 94%.The beam quality M2factor is 2.9(which is~20 times that of the pump)at the maximum output signal power,achieving the highest brightness enhancement of 14.9 in RRFLs.To the best of our knowledge,this achievement also represents the highest power record of RRFLs utilizing multimode diodes for direct pumping.This work may not only provide a new insight into the realization of high-power,high-brightness RRFLs but also is a promising contender in the power scaling of SWs below 1μm.

2×3 kW bidirectional output fiber oscillator employing spindle-shaped ytterbium-doped fiber

A 2×3 kW-level bidirectional output fiber oscillator is realized by combining the specially designed spindle-shaped ytterbium-doped fiber,non-wavelength-stabilized 976-nm LDs,and grating bandwidth optimization to balance transverse mode instability and stimulated Raman scattering.The maximum output powers at both ends are 3265 and 2840 W,respectively,with a total efficiency of 73.2%.The M^(2) factors of the lasers at both ends are about 1.98 and 2.38,respectively.The beam profile at both ends shows that a bidirectional output annular beam fiber oscillator has been realized,which has great potential in practical applications.

High power cladding-pumped low quantum defect Raman fiber amplifier

Heat generated by the quantum defect(QD)in optically pumped lasers can result in detrimental effects such as mode instability,frequency noise,and even catastrophic damage.Previously,we demonstrated that boson-peakbased Raman fiber lasers have great potential in low QD laser generation.But their power scalability and heat load characteristics have yet to be investigated.Here,we demonstrate a boson-peak-based Raman fiber amplifier(RFA)with 815 W output power and a QD of 1.3%.The low heat generation characteristics of this low QD RFA are demonstrated.Both experimental and simulation results show that at this power level,the heat load of the low QD RFA is significantly lower than that of the conventional RFA with a QD of 4.8%.Thanks to its low heat generation characteristics,the proposed phosphosilicate-fiber-based low QD RFA provides an effective solution for the intractable thermal issue in optically pumped lasers,which is of significance in reducing the laser’s noise,improving the laser’s stability and safety,and solving the challenge of heat removing.

Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel

Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops.

Advances in the slurry reactor technology of the anthraquinone process for H2O2 production

This paper overviews the development of the anthraquinone auto-oxidation （AO） process for the pro- duction of hydrogen peroxide in China and abroad. The characteristics and differences between the fixed-bed and fiuidized-bed reactors for the AO process are presented. The detailed comparison indicates that the production of hydrogen peroxide with the fluidized-bed reactor has many advantages, such as lower operation cost and catalyst consumption, less anthraquinone degradation, higher catalyst utilization efficiency, and higher hydrogenation efficiency. The key characters of the production technology of hydrogen peroxide based on the fluidized-bed reactor developed by the Research Institute of Petroleum Proces- sing, Sinopec are also disclosed. It is apparent that substituting the fluidized-bed reactor for the fixed-bed reactor is a major direction of breakthrough for the production technology of hydrogen peroxide in China.

Functional Fibers and Functional Fiber‑Based Components for High‑Power Lasers

The success of high-power fiber lasers is fueled by maturation of active and passive fibers,combined with the availability of high-power fiber-based components.In this contribution,we first overview the enormous potential of rare-earth doped fibers in spectral coverage and recent developments of key fiber-based components employed in high-power laser systems.Subsequently,the emerging functional active and passive fibers in recent years,which exhibit tremendous advantages in balancing or mitigating parasitic nonlinearities hindering high-power transmission,are outlined from the perspectives of geo-metric and material engineering.Finally,novel functional applications of conventional fiber-based components for nonlinear suppression or spatial mode selection,and correspondingly,the high-power progress of function fiber-based components in power handling are introduced,which suggest more flexible controllability on high-power laser operations.

Transverse mode instability mitigation in a high-power confined-doped fiber amplifier with good beam quality through seed laser control

In this work,a confined-doped fiber with the core/inner-cladding diameter of 40/250μm and a relative doping ratio of 0.75 is fabricated through a modified chemical vapor deposition method combined with the chelate gas deposition technique,and subsequently applied in a tandem-pumped fiber amplifier for high-power operation and transverse mode instability(TMI)mitigation.Notably,the impacts of the seed laser power and mode purity are preliminarily investigated through comparative experiments.It is found that the TMI threshold could be significantly affected by the seed laser mode purity.The possible mechanism behind this phenomenon is proposed and revealed through comprehensive comparative experiments and theoretical analysis.Finally,a maximum output power of 7.49 kW is obtained with the beam quality factor of approximately 1.83,which is the highest output power ever reported in a forward tandem-pumped confined-doped fiber amplifier.This work could provide a good reference and practical solution to improve the TMI threshold and realize high-power high-brightness fiber lasers.

Cladding-pumped Raman fiber laser with 0.78%quantum defect enabled by phosphorus-doped fiber

The quantum defect(QD)is an important issue that demands prompt attention in high-power fiber lasers.A large QD may aggravate the thermal load in the laser,which would impact the frequency,amplitude noise and mode stability,and threaten the security of the high-power laser system.Here,we propose and demonstrate a cladding-pumped Raman fiber laser(RFL)with QD of less than 1%.Using the Raman gain of the boson peak in a phosphorus-doped fiber to enable the cladding pump,the QD is reduced to as low as 0.78%with a 23.7 W output power.To our knowledge,this is the lowest QD ever reported in a cladding-pumped RFL.Furthermore,the output power can be scaled to 47.7 W with a QD of 1.29%.This work not only offers a preliminary platform for the realization of high-power low-QD fiber lasers,but also proves the great potential of low-QD fiber lasers in power scaling.

Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma

Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas directly,mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways.IDH mutations mediate immune-cell infiltration and function by modulating immune-checkpoint gene expression and chemokine secretion.In addition,IDH mutation-derived D2-hydroxyglutarate can be absorbed by surrounding immune cells,also affecting their functioning.In this review,we summarize current knowledge about the effects of IDH mutations as well as other gene mutations on the immune microenvironment of gliomas.We also describe recent preclinical and clinical data related to IDH-mutant inhibitors for the treatment of gliomas.Finally,we discuss different types of immunotherapy and the immunotherapeutic potential of IDH mutations in gliomas.

Recent advances in fruit crop genomics

In recent years,dramatic progress has been made in the genomics of fruit crops.The publication of a dozen fruit crop genomes represents a milestone for both functional genomics and breeding programs in fruit crops.Rapid advances in high-throughput sequencing technology have revolutionized the manner and scale of genomics in fruit crops.Research on fruit crops is encompassing a wide range of biological questions which are unique and cannot be addressed in a model plant such as Arabidopsis.This review summarizes recent achievements of research on the genome,transcriptome,proteome,miRNAs and epigenome of fruit crops.

Spectrally U-shaped profile of beam propagation factor in all-solid photonic bandgap fiber

We found the beam quality factor M^(2)of the fundamental mode as a function of wavelength is U-shaped in the working photonic bandgap(PBG) of an all-solid PBG fiber(AS-PBGF) for the first time,to the best of our knowledge,and our simulation results also match well with the phenomenon.The normal band that is near the high-frequency edge of the third PBG integrates the lowest M^(2)and single-mode operation simultaneously,while the other two edge regions suffer from anomalous variation of M^(2)versus wavelength.The general applicability of this finding can be further extended to other PBGs and also other representative structures in the AS-PBGF field.

刑事检察指导性案例制度基本问题研究

刑事检察指导性案例与其他业务指导性案例有显著区别,是检察机关发布指导性案例最为集中、最具特色的业务领域。刑事检察指导性案例属于刑事司法的“准法源”,作为一种司法裁判规则的提供方式和集成典范,是司法解释的有益补充,可以有效保障刑事检察工作的完整性和统一性。刑事检察指导性案例主要有指引示范、保障司法公正和普法预防等功能。刑事检察指导性案例主要特征有整批次和专题化、发布频次较高、案例规模适中、实体和程序并重等。目前刑事检察指导性案例制度还存在一些现实困境,需在刑事检察指导性案例供给能力、司法治理能力、数字化能力等方面进一步加强、提升和强化。

Design and optimization methods towards a 10 kW high beam quality fiber laser based on the counter tandem pumping scheme

In this study,we investigated the influence of fiber parameters on stimulated Raman scattering(SRS)and identified a unique pattern of SRS evolution in the counter tandem pumping configuration.Our findings revealed that the SRS threshold in counter-pumping is predominantly determined by the length of the output delivery fiber rather than the gain fiber.By employing the counter tandem pumping scheme and optimizing the fiber parameters,a 10 kW fiber laser was achieved with beam quality M^(2)of 1.92.No mode instability or severe SRS limitation was observed.To our knowledge,this study achieved the highest beam quality in over 10 kW fiber lasers based on conventional double-clad Yb-doped fiber.