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田蓟苷调节AMPK/SIRT1/PGC1α信号通路对脑出血大鼠认知功能和神经元损伤的影响
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作者 罗聪 钟崛 +4 位作者 邓敏敏 肖潇 黄丹霞 范慧 王盼 《中西医结合心脑血管病杂志》 2024年第2期274-279,共6页
目的:探讨田蓟苷(TIL)对脑出血(ICH)大鼠认知功能、神经元损伤及腺苷酸激活蛋白激酶(AMPK)/沉默调节蛋白1(SIRT1)/过氧化物酶体增殖活化受体γ辅助活化因子1α(PGC1α)信号通路的影响。方法:采用Ⅳ型胶原酶注射法构建ICH大鼠模型,将造... 目的:探讨田蓟苷(TIL)对脑出血(ICH)大鼠认知功能、神经元损伤及腺苷酸激活蛋白激酶(AMPK)/沉默调节蛋白1(SIRT1)/过氧化物酶体增殖活化受体γ辅助活化因子1α(PGC1α)信号通路的影响。方法:采用Ⅳ型胶原酶注射法构建ICH大鼠模型,将造模成功的ICH大鼠随机分为模型组(ICH组)、TIL组(16 mg/kg)、AMPK抑制剂组(Compound C组,250μg/kg)、TIL+AMPK抑制剂组(TIL+Compound C组),另设假手术组(Sham组),每组12只。采用改良的Garcia JH法、Morris水迷宫实验和敞箱实验评价大鼠的神经功能和认知功能;苏木素-伊红(HE)和脱氧核糖核苷酸末端转移酶介导的缺口末端标记(TUNEL)法行脑组织病理学和神经元凋亡观察;蛋白质印迹法(Western Blot)检测AMPK/SIRT1/PGC1α通路蛋白表达。结果:与Sham组相比,ICH组大鼠脑组织出现细胞核皱缩、排列紊乱等损伤,神经功能评分、穿越平台次数、垂直活动得分和水平活动得分、磷酸化AMPK(p-AMPK)/AMPK、SIRT1、PGC1α蛋白水平均明显下降(P<0.05),找寻平台时间、神经元凋亡率、半胱氨酸蛋白酶-3(Caspase-3)、B淋巴细胞瘤-2(Bcl-2)蛋白表达水平均明显增加(P<0.05);与ICH组相比,TIL组大鼠脑组织损伤减轻,神经功能评分、穿越平台次数、垂直活动得分和水平活动得分、p-AMPK/AMPK、SIRT1、PGC1α蛋白水平均明显增加(P<0.05),找寻平台时间、神经元凋亡率、Caspase-3、Bcl-2蛋白表达水平均明显降低(P<0.05);而Compound C组大鼠以上指标呈现相反的趋势。且TIL对ICH大鼠脑组织及认知功能的保护作用均被AMPK抑制剂Compound C减弱(P<0.05)。结论:TIL可能通过激活AMPK/SIRT1/PGC1α通路,改善ICH大鼠认知功能,减轻神经元损伤。 展开更多
关键词 脑出血 田蓟苷 腺苷酸激活蛋白激酶/沉默调节蛋白1/过氧化物酶体增殖活化受体γ辅助活化因子1α通路 认知功能 神经元 实验研究
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重组人促红细胞生成素对脑出血大鼠脑组织损伤的影响 被引量:2
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作者 钟崛 张世强 +3 位作者 罗聪 徐剑 殷燕 周心宇 《中华老年心脑血管病杂志》 CAS 北大核心 2023年第3期307-311,共5页
目的探讨重组人促红细胞生成素(EPO)调控细胞因子信号传导抑制蛋白3(SOCS3)/信号传导与转录激活因子3(STAT3)对脑出血大鼠脑组织损伤的影响。方法将90只SD大鼠随机分为假手术(Sham)组、模型(Model)组、EPO组(5 U/g)、STAT3激活剂Colive... 目的探讨重组人促红细胞生成素(EPO)调控细胞因子信号传导抑制蛋白3(SOCS3)/信号传导与转录激活因子3(STAT3)对脑出血大鼠脑组织损伤的影响。方法将90只SD大鼠随机分为假手术(Sham)组、模型(Model)组、EPO组(5 U/g)、STAT3激活剂Colivelin组(Colivelin组,1 mg/kg SOCS3/STAT3通路激活剂Colivelin)、EPO+Colivelin组(5 U/g EPO+1 mg/kg Colivelin),每组18只,Sham组、Model组注射等量生理盐水,1次/d,持续2周。采用Longa 5级评分法评估神经功能损伤情况;伊文思蓝测定血脑屏障通透性;试剂盒检测血清白细胞介素(IL)6、IL-1β、TNF-α、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛水平;苏木精-伊红、TUNEL法检测脑组织病理学及细胞凋亡;Western blot检测SOCS3/STAT3通路及酪氨酸蛋白激酶2(JAK2)蛋白表达。结果与Sham组比较,Model组神经功能评分、SOD、GSH-PX及SOCS3/GAPDH蛋白水平显著降低(P<0.05),伊文思蓝含量、IL-1β、IL-6、TNF-α、丙二醛、细胞凋亡率、STAT3/GAPDH、JAK2/GAPDH显著升高(P<0.05)。EPO组神经功能评分显著高于Model组[(4.67±0.25)分vs(1.83±0.07)分,P<0.05],伊文思蓝含量显著低于Model组[(3.37±0.12)μg/g vs(12.23±2.02)μg/g,P<0.05];与Model组比较,EPO组SOD、GSH-PX、SOCS3/GAPDH蛋白水平显著升高(P<0.05),IL-1β、IL-6、TNF-α、丙二醛水平、细胞凋亡率及STAT3/GAPDH、JAK2/GAPDH比例显著降低(P<0.05)。与EPO组比较,EPO+Colivelin组神经功能评分、SOD、GSH-PX水平及SOCS3/GAPDH蛋白水平显著降低(P<0.05),伊文思蓝含量、IL-1β、IL-6、TNF-α、丙二醛、细胞凋亡率及STAT3/GAPDH、JAK2/GAPDH显著升高(P<0.05)。结论EPO可能通过调控SOCS3/STAT3通路降低氧化应激,减轻炎性反应和神经元凋亡,对脑出血大鼠起到一定保护作用。 展开更多
关键词 红细胞生成素 脑出血 氧化性应激 细胞凋亡
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Harmonic Current′s Coupling Effect on the Main Motion of Temper Mill Set 被引量:6
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作者 HE Jian-jun YU Shou-yi zhong jue 《Journal of Central South University》 SCIE EI CAS 2000年第3期162-164,共3页
The paper probes into a probable condition that causes temper mill chatter from aspect of electromechanical coupling of complex electromechanical system, and mainly studies the effect of temper mill electrical driving... The paper probes into a probable condition that causes temper mill chatter from aspect of electromechanical coupling of complex electromechanical system, and mainly studies the effect of temper mill electrical driving system harmonic current on the main motion of temper mill set. Aiming at the electrical driving system of CM04 temper mill, the effect of harmonic current is analyzed and evaluated according to different load. Combining the features of CM04 temper mill′s structure and its working state, the paper discusses in every detail how the harmonic current in main circuit, which can be regarded as a disturbance via feedback control circuit , influences main motion of temper mill set. 展开更多
关键词 ELECTROMECHANICAL coupling TEMPER MILL HARMONIC current ROLLING MILL chatter
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OPTIMAL CONTROL OF AN ACTIVE SUSPENSION SYSTEMEMPLOYING HIGH SPEED ON/OFF SOLENOID VALVE 被引量:4
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作者 Liu Shaojun zhong jue +1 位作者 Li Qingchun (College of Mechanical and Electrical Engineering,Central South University of Technology, Changsha 410083, China)HironaoYAMADA YoshikazuSUEMATSU(NAGOYAUniversity Japan) 《Journal of Central South University》 SCIE EI CAS 1997年第2期137-140,共4页
Previous studies have confirmed that an active suspension system with high speed ON/OFF solenoid valves could provide the same vibration isolation efficiency as that of system with pressure proportional valve. In this... Previous studies have confirmed that an active suspension system with high speed ON/OFF solenoid valves could provide the same vibration isolation efficiency as that of system with pressure proportional valve. In this study, by using Linear-quadratic optimization technique and Kalman filter method, an optimal regulator controller with a state observer was designed for the proposed system. Simulation and experimental research was conducted on a quarter car model. The simulation analysis of the system frequency characteristic suggested that the peak value of magnitude response curve in the case of system with an optimal controller would be lowered significantly, and the experiment results also showed that an improvement in the vibration isolation effect was obtained in using the designed optimal controller over the sky hook damper controller. 展开更多
关键词 active SUSPENSION high SPEED ON/OFF SOLENOID VALVE optimal control
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DESCRIPTION AND PREDICTION OF CATASTROPHE OF VIBRATION STATE FOR FAULTY ROTORS 被引量:5
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作者 Chen Anhua zhong jue 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 1996年第1期130-134,共5页
A sudden increase of vibration amplitude with no foreboding often results in an abrupt breakdown of a mechanical system.The catastrophe of vibration state of a faulty rotor is a typical nonlinear phenomenon,and very d... A sudden increase of vibration amplitude with no foreboding often results in an abrupt breakdown of a mechanical system.The catastrophe of vibration state of a faulty rotor is a typical nonlinear phenomenon,and very difficult to be described and predicted with linear vibration theory.On the basis of nonlinear vibration and catastrophe theory,fhe eatastrophe of the vibration amplitude of the faulty rotor is described;a way to predict its emergence is developed. 展开更多
关键词 mechanical fault diagnosis and prediction cusp catastrophe model nonlinear vibration rotor
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Rock fragmentation under different installation polar angles of TBM disc cutters 被引量:1
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作者 CHENG Yong-liang zhong jue +1 位作者 MEI Yong-bing XIA Yi-min 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第10期2306-2313,共8页
The disc cutters of tunnel boring machine(TBM) are installed with different polar angles. This causes the cutting depth difference between adjacent disc cutters on the tunnel face. A rock-cutting model was established... The disc cutters of tunnel boring machine(TBM) are installed with different polar angles. This causes the cutting depth difference between adjacent disc cutters on the tunnel face. A rock-cutting model was established to study the rock fragmentation law between adjacent disc cutters with different polar angles based on particle flow code(PFC). The influence of polar angle of adjacent disc cutters on rock cracks and stresses under different cutter spacing and penetration was studied. Research shows that polar angle difference leads to the discontinuity of rock-fragmentation process by adjacent cutters. The effect of rock-fragmentation is influenced by the cutting depth difference between adjacent cutters. The effect of rock-fragmentation performed best, meanwhile large rock blocks were flaked when the difference of cutting depth is half of the penetration. Too large or small difference of the cutting depth will cause high specific energy consumption of rock fragmentation. The specific energy consumption is relatively small when the difference of cutting depth is half of the penetration. 展开更多
关键词 tunnel BORING machine DISC CUTTER POLAR angle particle flow code rock FRAGMENTATION
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Stress-level dependency of creep ageing behavior for friction stir welded Al-Cu alloy 被引量:1
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作者 WANG Dong-yao ZHAN Li-hua +3 位作者 zhong jue TANG Zhi-mao ZENG Quan-qing GAN Ke-fu 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第9期3030-3053,共24页
Creep ageing forming(CAF)has been widely used in the aerospace engineering,but how to optimize the processing conditions,especially under complex stress state of the CAF process for large-size components produced by f... Creep ageing forming(CAF)has been widely used in the aerospace engineering,but how to optimize the processing conditions,especially under complex stress state of the CAF process for large-size components produced by friction-stir welding is still a great challenge to now.In this work,the creep ageing behaviors and underlying microstructure evolution of a thick friction-stir welded Al-Cu alloy plate after CAF process under different stress levels are systematically investigated.The creep strain and the strength of the joint are both significantly increased when the stress is close to the average yield strength of the initial weld joint.The grain size reduces while the local strain and dislocation density increase from top to bottom of the NZ;hence,the bottom layer of the weld joint exhibits higher creep strain and steady-stage creep strain rate during the CAF process.The results reveal that the gradient microstructures sensitive to the stress level effectively govern the creep-ageing performance from the upper to the bottom layer in a thick friction stir welded Al-Cu alloy plate.Rationally increasing the initial dislocation density of the weld joint can both enhance the tensile properties and promote the creep deformation of the weld joint for CAF process. 展开更多
关键词 creep age forming friction stir welding inhomogeneous gradient microstructure thick Al-Cu alloy plate precipitation microstructure evolution mechanical property
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A NEW METHOD FOR SOLUTING TRANSIENT RESPONSE OF GENERALLY VISCOUS DAMPING MULTI-DEGREE SYSTEM
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作者 Zhang Huailiang Bu Yingyong +1 位作者 zhong jue Tan Qing 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 1996年第1期120-124,共5页
By means of the theory of composite-modality,the superposition principle of the vibra-tion mode of the linear system,and the analytical method of the original coordinate,a mathematical model of transient response to a... By means of the theory of composite-modality,the superposition principle of the vibra-tion mode of the linear system,and the analytical method of the original coordinate,a mathematical model of transient response to any stimulus for generally viscous damping multi-degree system was established.This method not only solves the problem of the transient response of displacement,but also calculates the transient response of the elastic force or the elastic couple of the system. 展开更多
关键词 DAMPING multi-degree transient response
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OPTIMIZED DESIGN OF HYDRAULIC CONTROL PATTERN OF SYNCHRONOUS SYSTEM IN LARGE SCALE DIE-FORMING HYDRAULIC PRESS
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作者 Tan Jianping zhong jue Yan Jian 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 1996年第1期125-129,140,共6页
The hydraulic control mode of the synchronous system in Chinese-built 300 MN dieforming hydraulic press was analysed comprehensively.To improve the deficiency of the existing system,a series investigations were put fo... The hydraulic control mode of the synchronous system in Chinese-built 300 MN dieforming hydraulic press was analysed comprehensively.To improve the deficiency of the existing system,a series investigations were put forward,such as the controlling of inclination angular-velocity,the pre-estimating of compensation,the synchronous cylinder's pressure signal protection,ratio pressure control and changing flow control etc,to increase the system's control accuracy and reliability greatly. 展开更多
关键词 synchronous system hydraulic control OPTIMIZATION
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SURFACE ROUGHNESS EFFECTS IN ALUMINIUM ROLLING
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作者 Tan Jianping zhong jue Yang Ping(College of Mechanical and Electrical EngineeringCentral South University of Technology, Changsha 410083) 《中国有色金属学会会刊:英文版》 CSCD 1996年第3期157-160,共4页
SURFACEROUGHNESSEFFECTSINALUMINIUMROLLING¥TanJianping;ZhongJue;YangPing(CollegeofMechanicalandElectricalEngi... SURFACEROUGHNESSEFFECTSINALUMINIUMROLLING¥TanJianping;ZhongJue;YangPing(CollegeofMechanicalandElectricalEngineeringCentralSou... 展开更多
关键词 ROLLING OIL FILM thickness SURFACE ROUGHNESS
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北京街区更新的“对话”——以北京新街口街道展示中心改造为例
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作者 王欢 钟珏 李文 《建筑与文化》 2021年第4期107-111,共5页
随着城市空间工作逐步层次化和精细化,面向社区的街区更新成为街区治理重点之一。城市工作的转型需要与之适应的信息沟通展示空间和平台,能够及时、准确且生动地将街区更新工作的规划和进度传达至市民个体、解释专业性的条文政策、鼓励... 随着城市空间工作逐步层次化和精细化,面向社区的街区更新成为街区治理重点之一。城市工作的转型需要与之适应的信息沟通展示空间和平台,能够及时、准确且生动地将街区更新工作的规划和进度传达至市民个体、解释专业性的条文政策、鼓励建言献策并参与其中,从而共同为美好街区而努力。文章立足街区更新工作,分析街道展厅文化的特点,从展示主题、展示方式、信息传递机制和展示可持续性方面,提出支持城市工作与市民沟通的展示设计策略,并结合新街口街道街区更新展厅案例具体说明。 展开更多
关键词 街区展厅 展示设计 城市更新 改造
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线粒体基因14453G>A突变所致线粒体脑肌病伴高乳酸血症和卒中样发作1例并文献复习
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作者 任艺博 龙宇 +4 位作者 周忠凯 钟珏 温世荣 潘玉君 孙若晗 《中华神经科杂志》 CAS CSCD 北大核心 2023年第10期1158-1165,共8页
目的探讨m.14453G>A突变所致线粒体脑肌病伴高乳酸血症和卒中样发作(MELAS)患者的临床及影像学特点。方法报道2021年10月12日就诊于哈尔滨医科大学附属第一医院的1例线粒体基因14453G>A(m.14453G>A)突变所致的MELAS患者,同时... 目的探讨m.14453G>A突变所致线粒体脑肌病伴高乳酸血症和卒中样发作(MELAS)患者的临床及影像学特点。方法报道2021年10月12日就诊于哈尔滨医科大学附属第一医院的1例线粒体基因14453G>A(m.14453G>A)突变所致的MELAS患者,同时系统性回顾国内外文献中所发表的m.14453G>A突变所致的MELAS及Leigh综合征(LS)的病例,对其进行总结分析和比较。结果患者女性,13岁起无明显诱因出现抽搐发作,伴有情绪障碍及记忆力下降。磁共振成像见额叶、顶叶、枕叶、颞叶及小脑病变。曾考虑为自身免疫性脑炎及可逆性后部白质脑病综合征。通过二代测序对患者行线粒体全基因组检测,在ND6基因上发现变异比率为17%的m.14453G>A突变。根据临床表现、影像学检查及基因检测结果诊断为MELAS。以“m.14453G>A”为检索词对国内外文献进行检索,筛选临床资料完整者。共检索到符合条件的国外文献5篇、国内文献3篇,共报道m.14453G>A突变11例(含本例)。诊断MELAS 5例,LS 6例。11例患者中青少年及成年发病者,MRI上多累及皮质及皮质下白质,常考虑为MELAS;婴幼儿发病者,MRI上多累及基底节区、丘脑及脑干,考虑为LS。结论m.14453G>A突变导致的临床表型存在异质性,可引起MELAS、LS。m.14453G>A突变的临床表型与发病年龄及病变部位存在一定的相关性。 展开更多
关键词 基因 线粒体 MELAS综合征 LEIGH病 突变 病例报告
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沉积气氛对电火花沉积Mo_2FeB_2基金属陶瓷涂层组织与性能的影响 被引量:17
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作者 魏祥 陈志国 +3 位作者 钟掘 黄奇胜 张怡 张雨龙 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2018年第4期1199-1204,共6页
采用电火花沉积分别在空气和氩气中制备了Mo_2FeB_2基金属陶瓷涂层,通过扫描电镜(SEM)、X射线衍射(XRD)、显微硬度计和摩擦磨损试验机研究了沉积气氛对涂层形貌、相组成、硬度和摩擦磨损性能的影响。结果表明,2种气氛中沉积所得涂层的... 采用电火花沉积分别在空气和氩气中制备了Mo_2FeB_2基金属陶瓷涂层,通过扫描电镜(SEM)、X射线衍射(XRD)、显微硬度计和摩擦磨损试验机研究了沉积气氛对涂层形貌、相组成、硬度和摩擦磨损性能的影响。结果表明,2种气氛中沉积所得涂层的组织结构都致密,涂层与基体间无分层,呈冶金结合的特征,但空气中沉积涂层的表面较粗糙,并发生了严重的氧化,涂层均匀性也较差。它们都主要由非晶相和马氏体相组成,但氩气中沉积的涂层含有更多的非晶相。氩气和空气中沉积涂层的最大显微硬度(HV_(0.05))分别为12 862和10 129 MPa,相差2733 MPa,前者涂层2 h的磨损量几乎仅为后者涂层的1/7,表现出更好的耐磨性。2种涂层的主要磨损机制都是疲劳磨损和磨粒磨损,但氩气中沉积涂层以疲劳磨损为主,空气中沉积涂层则以磨粒磨损为主。 展开更多
关键词 沉积气氛 电火花沉积 金属陶瓷 涂层 性能
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