High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillim...High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.展开更多
Electromyography(EMG)signal is the electrical potential generated by contracting muscle cells.Long-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–compute...Electromyography(EMG)signal is the electrical potential generated by contracting muscle cells.Long-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–computer interfaces.Herein,we report a skin-integrated,biocompatible,and stretchable silicon microneedle electrode(SSME)inspired by the plant thorns.The silicon microneedles are half encapsulated by the polyimide(PI)to enhance the adaptability to deformation and resistance to fatigue.Thorn-like SSME is realized by the semi-additive method with a stretchability of not less than 36%.The biocompatibility of SSME has been verified using cytotoxicity tests.EMG monitoring in motion and long-term has been conducted to demonstrate the feasibility and performance of the SSME,which is compared with a commercial wet electrode.Hopefully,the strategies reported here can lead to accurate and long-term EMG monitoring,facilitating an effective and reliable human–computer interface.展开更多
基金support of the National Natural Science Foundation of China(Nos.U20A6001,12002190,11972207,and 11921002)the Fundamental Research Funds for the Central Universities,China(No.SWUKQ22029)the Chongqing Natural Science Foundation of China(No.CSTB2022NSCQ-MSX1635).
文摘High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.
基金the financial support from the National Natural Science Foundation of China(Grant No.U20A6001,11902292)Zhejiang Province Key Research and Development Project(Grant No.2021C01183,2021C05007-4).
文摘Electromyography(EMG)signal is the electrical potential generated by contracting muscle cells.Long-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–computer interfaces.Herein,we report a skin-integrated,biocompatible,and stretchable silicon microneedle electrode(SSME)inspired by the plant thorns.The silicon microneedles are half encapsulated by the polyimide(PI)to enhance the adaptability to deformation and resistance to fatigue.Thorn-like SSME is realized by the semi-additive method with a stretchability of not less than 36%.The biocompatibility of SSME has been verified using cytotoxicity tests.EMG monitoring in motion and long-term has been conducted to demonstrate the feasibility and performance of the SSME,which is compared with a commercial wet electrode.Hopefully,the strategies reported here can lead to accurate and long-term EMG monitoring,facilitating an effective and reliable human–computer interface.
