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GmSTF accumulation mediated by DELLA protein GmRGAs contributes to coordinating light and gibberellin signaling to reduce plant height in soybean 被引量:1
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作者 zhuang li Qichao Tu +7 位作者 Xiangguang Lyu Qican Cheng Ronghuan Ji Chao Qin Jun liu Bin liu Hongyu li Tao Zhao 《The Crop Journal》 SCIE CSCD 2024年第2期432-442,共11页
Plant height influences plant architecture,lodging resistance,and yield performance.It is modulated by gibberellic acid(GA)metabolism and signaling.DELLA proteins,acting as central repressors of GA signaling,integrate... Plant height influences plant architecture,lodging resistance,and yield performance.It is modulated by gibberellic acid(GA)metabolism and signaling.DELLA proteins,acting as central repressors of GA signaling,integrate various environmental and hormonal signals to regulate plant growth and development in Arabidopsis.We examined the role of two DELLA proteins,GmRGAa and GmRGAb,in soybean plant height control.Knockout of these proteins led to longer internodes and increased plant height,primarily by increasing cell elongation.GmRGAs functioned under different light conditions,including red,blue,and far-red light,to repress plant height.Interaction studies revealed that GmRGAs interacted with the blue light receptor GmCRY1b.Consistent with this,GmCRY1b partially regulated plant height via GmRGAs.Additionally,DELLA proteins were found to stabilize the protein GmSTF1/2,a key positive regulator of photomorphogenesis.This stabilization led to increased transcription of GmGA2ox-7b and subsequent reduction in plant height.This study enhances our understanding of DELLA-mediated plant height control,offering Gmrgaab mutants for soybean structure and yield optimization. 展开更多
关键词 DELLA protein GmRGAs GmSTFs Plant height SOYBEAN
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Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring 被引量:1
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作者 Yuewei Chen Yanyan Zhou +10 位作者 Zihe Hu Weiying Lu zhuang li Ning Gao Nian liu Yuanrong li Jing He Qing Gao Zhijian Xie Jiachun li Yong He 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第2期347-364,共18页
Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant chal... Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for IHB.Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues.This study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical programmability.The regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to 0.52.The negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces.The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability.Notably,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration.The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues. 展开更多
关键词 Implantable hydrogel-based bioelectronics Conformality 3D printing Metamaterial design
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The activation of adenosine monophosphate–activated protein kinase inhibits the migration of tongue squamous cell carcinoma cells by targeting Claudin-1 via epithelial–mesenchymal transition
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作者 Xin-Yue Zhou Qiu-Ming liu +7 位作者 zhuang li Xia-Yang liu Qi-Wei Zhao Yu Wang Feng-Hua Wu Gang Zhao Rui Sun Xiao-Hong Guo 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第5期606-616,共11页
Background:The role of Claudin-1 in tongue squamous cell carcinoma(TSCC)metastasis needs further clarification,particularly its impact on cell migration.Herein,our study aims to investigate the role of Claudin-1 in TS... Background:The role of Claudin-1 in tongue squamous cell carcinoma(TSCC)metastasis needs further clarification,particularly its impact on cell migration.Herein,our study aims to investigate the role of Claudin-1 in TSCC cell migration and its underlying mechanisms.Methods:36 TSCC tissue samples underwent immunohistochemical staining for Claudin-1.Western blotting and immunofluorescence analyses were conducted to evaluate Claudin-1 expression and distribution in TSCC cells.Claudin-1 knockdown cell lines were established using short hairpin RNA transfection.Migration effects were assessed through wound healing assays.Furthermore,the expression of EMTassociated molecules was measured via western blotting.Results:Claudin-1 expression decreased as TSCC malignancy increased.Adenosine monophosphate–activated protein kinase(AMPK)activation led to increased Claudin-1 expression and membrane translocation,inhibiting TSCC cell migration and epithelial–mesenchymal transition(EMT).Conversely,Claudin-1 knockdown reversed these inhibitory effects on migration and EMT caused by AMPK activation.Conclusions:Our results indicated that AMPK activation suppresses TSCC cell migration by targeting Claudin-1 and EMT pathways. 展开更多
关键词 AMPK CLAUDIN-1 EMT MIGRATION tongue squamous cell carcinoma
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Time-dependent Vibration Frequency Reliability Analysis of Blade Vibration of Compressor Wheel of Turbocharger for Vehicle Application 被引量:10
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作者 WANG Zheng WANG Zengquan +1 位作者 zhuang li WANG A-na 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第1期205-210,共6页
Blade vibration failure is one of the main failure modes of compressor wheel of turbocharger for vehicle application. The existing models for evaluating the reliability of blade vibration of compressor wheel are stati... Blade vibration failure is one of the main failure modes of compressor wheel of turbocharger for vehicle application. The existing models for evaluating the reliability of blade vibration of compressor wheel are static, and can not reflect the relationship between the reliability of compressor wheel with blade vibration failure mode and the life parameter. For the blade vibration failure mode of compressor wheel of turbocharger, the reliability evaluation method is studied. Taking a compressor wheel of turbocharger for vehicle application as an example, the blade vibration characteristics and how they change with the operating parameters of turbocharger are analyzed. The failure criterion for blade vibration mode of compressor wheel is built with the Campbell diagram, and taking the effect of the dispersity of blade natural vibration frequency and randomness of turbocharger operating speed into account, time-dependent reliability models of compressor wheel with blade vibration failure mode are derived, which embody the parameters of blade natural vibration frequency, turbocharger operating speed, the blade number of compressor wheel, life index and minimum number of resonance, etc. Finally, the rule governing the reliability and failure rate of compressor wheel and the method for determining the reliable life of compressor with blade vibration is presented. A method is proposed to evaluate the reliability of compressor wheel with blade vibration failure mode time-dependently. 展开更多
关键词 TURBOCHARGER compressor wheel blade vibration RELIABILITY failure rate reliable life
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Method for Evaluating the Reliability of Compressor Impeller of Turbocharger for Vehicle Application in Plateau Area 被引量:2
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作者 WANG Zheng WANG Zengquan +2 位作者 WANG A-na zhuang li WANG Jinwei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第6期1218-1225,共8页
As turbocharging diesel engines for vehicle application are applied in plateau area, the environmental adaptability of engines has drawn more attention. For the environmental adaptability problem of turbocharging dies... As turbocharging diesel engines for vehicle application are applied in plateau area, the environmental adaptability of engines has drawn more attention. For the environmental adaptability problem of turbocharging diesel engines for vehicle application, the present studies almost focus on the optimization of performance match between turbocharger and engine, and the reliability problem of turbocharger is almost ignored. The reliability problem of compressor impeller of turhocharger for vehicle application when diesel engines operate in plateau area is studied. Firstly, the rule that the rotational speed of turbocharger changes with the altitude height is presented, and the potential failure modes of compressor impeller are analyzed. Then, the failure behavior models of compressor impeller are built, and the reliability models of compressor impeller operating in plateau area are developed. Finally, the rule that the reliability of compressor impeller changes with the altitude height is studied, the measurements for improving the reliability of the compressor impellers of turbocharger operating in plateau area are given. The results indicate that when the operating speed of diesel engine is certain, the rotational speed of turbocharger increases with the increase of altitude height, and the failure risk of compressor impeller with the failure modes of hub fatigue and blade resonance increases. The reliability of compressor impeller decreases with the increase of altitude height, and it also decreases as the increase of number of the mission profile cycle of engine. The method proposed can not only be used to evaluating the reliability of compressor impeller when diesel engines operate in plateau area but also be applied to direct the structural optimization of compressor impeller. 展开更多
关键词 TURBOCHARGER plateau area compressor impeller failure behavior RELIABILITY
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Application of Pyroligneous Acid in the Prevention and Control of Brown Blotch Disease in Pleurotus ostreatus 被引量:3
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作者 Yanyan XU liyan ZHENG +1 位作者 zhuang li Jie li 《Agricultural Science & Technology》 CAS 2016年第9期2103-2105,2170,共4页
In the present study, agar diffusion test and field trials were carried out using a mushroom (Pleurotus ostreatus) culti- var Shouyanping as the experimental material to determine the antibacterial activity of refin... In the present study, agar diffusion test and field trials were carried out using a mushroom (Pleurotus ostreatus) culti- var Shouyanping as the experimental material to determine the antibacterial activity of refined pyroligneous acid prepared from almond shell against Pseudomonas tolaasfi and its effects on mycelial growth of mushroom. The results revealed that 1.25%, 2.50% and 5.00% of refined pyroligneous acid obviously inhibited the occurrence of brown blotch disease in mushroom, but also greatly promoted mushroom mycelial growth. Therefore, 1.25% and 2.50% of refined pyroligneous acid can be used in fields to prevent brown blotch disease, and 5.00% refined pyroligneous acid can be used to control the incidence of brown blotch disease when it widely occurs in fields. 展开更多
关键词 Almond shell pyroligneous acid Pleurotus ostreatus Brown blotch disease Pseudomonas tolaasii
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A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting 被引量:1
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作者 Yuanrong li Mingjun Xie +4 位作者 Shang Lv Yuan Sun zhuang li Zeming Gu Yong He 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第4期486-499,共14页
Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and... Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism. 展开更多
关键词 biomimetic air-blood barrier composite material design controllable mechanical stimulus structure
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基于泄漏电流高次谐波比的电缆护层保护器老化状态评估
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作者 方春华 李放 +5 位作者 张怡琳 庄立 胡涛 孙奥琪 张瑶 吕俊杰 《高压电器》 CAS CSCD 北大核心 2024年第12期152-159,共8页
氧化锌电缆护层保护器是电力系统中保证电缆供电安全的重要设备,其运行状态将直接影响到线路安全。由于长期受到各种过电压的影响,电缆护层保护器极易发生老化,导致其性能发生明显劣化。基于泄漏电流分析的状态检测对于预测电缆护层保... 氧化锌电缆护层保护器是电力系统中保证电缆供电安全的重要设备,其运行状态将直接影响到线路安全。由于长期受到各种过电压的影响,电缆护层保护器极易发生老化,导致其性能发生明显劣化。基于泄漏电流分析的状态检测对于预测电缆护层保护器的老化状态具有重要作用。文中采用雷电冲击老化的方法,研究了电缆护层保护器冲击老化后的高频特性,提出了基于泄漏电流高次谐波比的老化状态诊断检测指标,该指标随老化程度的加深呈现逐渐增大的趋势。因此,能够用来有效评估电缆护层保护器的老化状态,为电缆护层保护器老化状态检测提供技术支撑。 展开更多
关键词 电缆护层保护器 老化状态 泄漏电流 高频特性 谐波比
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RFID电缆中间接头无线无源湿度监测
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作者 方春华 周国锐 +4 位作者 汪晋豪 柯力 陆杰炜 庄立 许瑶 《中国测试》 CAS 北大核心 2024年第2期46-53,共8页
针对电缆中间接头受潮导致的运行故障问题,提出一种基于13.56 MHz RFID技术的无源湿度监测方法。该文利用HFSS建立传感器模型,调整天线匝距使天线达到理想状态,并对天线进行谐振匹配;然后研究传感器天线在水中的传输效果及存在金属屏蔽... 针对电缆中间接头受潮导致的运行故障问题,提出一种基于13.56 MHz RFID技术的无源湿度监测方法。该文利用HFSS建立传感器模型,调整天线匝距使天线达到理想状态,并对天线进行谐振匹配;然后研究传感器天线在水中的传输效果及存在金属屏蔽层时金属对天线性能的影响;最后将所设计的传感器放置于中间接头内部进行性能测试。结果表明:天线匝距为0.6 mm时传感器性能最佳;在天线外部增加47μH电容可实现13.56 MHz谐振匹配;传感器天线在水中的传输效果良好;加装金属屏蔽层可解决路径上金属对传感器信号传输的抑制作用;实际测量距离可达到8.2 cm、相对湿度测量误差最大为0.48%,最大波动幅度仅为0.3%,传感器长期处于高湿度环境仍能准确测量。该方法可实现电缆中间接头内部湿度的直接、快速及无源测量,对防止电缆受潮具有一定的参考意义。 展开更多
关键词 中间接头 RFID 湿度监测 无线通信
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Grain size characteristics and genesis of the Muxing loess in the Muling- Xingkai Plain,Northeast China
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作者 Zhong-shuang Cheng Chen Su +3 位作者 Zhao-xian Zheng zhuang li li-kang Wang En-bao Wang 《Journal of Groundwater Science and Engineering》 2021年第2期152-160,共9页
Thick loess is deposited on the platform in the piedmont zone of Muling-Xingkai Plain(Muxing Plain),but the genesis of the Muxing loess is still unclear.The aims of this study are to analyze the grain size characteris... Thick loess is deposited on the platform in the piedmont zone of Muling-Xingkai Plain(Muxing Plain),but the genesis of the Muxing loess is still unclear.The aims of this study are to analyze the grain size characteristics of Muxing loess collected from the cores of a typical borehole(ZK1)in the piedmont zone of Muxing Plain,and to verify its genesis.The Muxing loess is mainly composed of the particles with diameter less than 50μm,with an average content of 92.48%.The coarse silt particles with diameter of 10-50μm are the basic composition of aeolian sediments,and their average content is 44.34% for the Muxing loess,which is the mode class among the particles with different diameters.The grain size parameters and frequency curves are similar to those of the typical aeolian sediments.The distribution characteristic of the Muxing loess in the C-M scatter diagram is consistent with that of the Xi Feng loess.In addition,the discriminant analysis shows the Muxing loess mostly consists of aeolian sediments.Therefore,it can be concluded that the Muxing loess mainly resulted from aeolian deposition based on the grain size characteristics.Muxing Plain is dominated by the monsoon climate,and the wind-blown dusts are gradually deposited after being transported over long distances. 展开更多
关键词 Muxing Plain LOESS Grain size Characteristics Aeolian deposition
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Adaptation Strategies to Climate Change in China- A Case Study of Heilongjiang Province
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作者 zhuang li Jia li 《Journal of Northeast Agricultural University(English Edition)》 CAS 2013年第2期89-96,共8页
Climate change is one of the most significant environment issues in the whole world today. And it is one of the most complex challenges of the humanities faced in the 21st century. Climate Change is impacted on our gl... Climate change is one of the most significant environment issues in the whole world today. And it is one of the most complex challenges of the humanities faced in the 21st century. Climate Change is impacted on our global; nobody can avoid the influence of climate change. The local adaptation strategies on climate change are very important to contribute the mitigation and poverty stricken situation, both in China and in the world. We chose a typical China's province as a case to analyze the impact of climate change on the region (such as agricultural, natural ecosystems, water resources, as well as local people healthy condition), and how the local government and local residences face the impact of the climate change influence, and summarized several strategies on climate change of the area in a sustainable development way. 展开更多
关键词 climate change ADAPTATION STRATEGY
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癌症相关性疼痛病人多维疼痛评估量表的构建及信效度检验 被引量:1
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作者 郑振东 黄明 +14 位作者 金毅 罗素霞 柳江 路平 汪子书 庄莉 余慧青 仇晓霞 刘波 褚倩 王昆 刘勇 任敬 王杰军 樊碧发 《中国疼痛医学杂志》 CAS CSCD 北大核心 2024年第3期196-204,共9页
目的:本研究旨在构建适合癌症相关性疼痛(简称癌痛)病人的疼痛评估量表,并探索评估量表用于癌痛病人的信度和效度,以期为临床癌痛病人的管理提供更加综合全面且简便易行的评估工具。方法:基于国内癌痛领域的指导性规范、临床诊疗指南、... 目的:本研究旨在构建适合癌症相关性疼痛(简称癌痛)病人的疼痛评估量表,并探索评估量表用于癌痛病人的信度和效度,以期为临床癌痛病人的管理提供更加综合全面且简便易行的评估工具。方法:基于国内癌痛领域的指导性规范、临床诊疗指南、专家共识等,本研究构建了癌痛病人评估量表初始条目池,采取德尔菲法选取我国癌痛领域的二十余名专家进行两轮咨询,统计咨询结果,确认纳入的条目,形成最终的多维疼痛评估量表(multi-dimensional brief test scale for pain,BTS)。经过两轮德尔菲法专家咨询,第一轮纳入21位专家,第二轮纳入10位专家,第一轮纳入19个评估维度,选取重要性评分≥4.5分且变异系数≤20%的7个评估维度,进行第二轮专家咨询。这7个评估维度和条目的重要性结果与第一轮一致,由此最终构建的BTS共包含7个评估维度,15个条目。选取2022年7月至2023年2月中国人民解放军北部战区总医院收治的癌痛病人,使用构建的BTS评估量表进行信效度检验。结果:共纳入166例病人,经过数据清洗,最终纳入分析的病人例数为138例。BTS的信度检测Cronbachα系数为0.78,效度检测的KMO值为0.80,具有较好的信度和效度。结论:构建的BTS条目共纳入7个评估维度,15个条目,具有较好的信度和效度,可在临床实践中推广应用于癌痛病人的疼痛评估。 展开更多
关键词 癌症相关性疼痛 疼痛评估 德尔菲法
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Special library services for regional economic development(SRED)—Practice of the NSLC
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作者 Xiwen liU Yuling SUN +8 位作者 Ping JIA Fang CHEN Hao PENG Yafei YAN Lu DONG Xiaoli CHEN Shushu CHEN Wenjiao GUO zhuang li 《Chinese Journal of Library and Information Science》 2015年第3期3-21,共19页
Purpose: By case studies of the service for regional economic development(SRED) carried out by the National Science Library of the Chinese Academy of Sciences(NSLC), this article tries to describe basic directions of ... Purpose: By case studies of the service for regional economic development(SRED) carried out by the National Science Library of the Chinese Academy of Sciences(NSLC), this article tries to describe basic directions of special libraries in the SRED.Design/methodology/approach: By comparing the aims and service forms of the SRED provided by domestic and foreign libraries and information service institutions, the authors examined the basic services provided by special libraries. Through a summary of the SRED exploration carried out by the NSLC, the authors introduce its main content, service methods, products, and service mechanisms. By analyzing the information needs of SRED users and summarizing users’ practical experiences of services, the authors propose a design for the SRED framework of the NSLC. In addition, the authors mention key points to be noticed during the process of service implementation, illustrating them with a number of selected SRED cases. The authors suggest that the SRED network and joint service mechanism are effective ways to implement SRED services. Findings: Based on information resource and expert networks, special libraries like the NSLC can carry out SRED to meet user requirements. The NSLC has not only constructed its own SRED framework, but has also expanded the patron service to the industrial intelligence service area. By setting up a nationwide S&T;(science and technology) novelty search network and a literature and information service alliance, the NSLC provides a variety of information training services. This enriches the content of the knowledge service of special libraries and enlarges the library service of the NSLC.Research limitations: The SRED of Chinese libraries is still in the exploratory stage. Questions as how to scientifically design service content and service modes, and how to establish a sustainable regional service system based on user needs are still being researchedand discussed. Furthermore, we need to pay more attention to the construction of the service network and respond more quickly to feedback while creating the SRED.Practical implications: The SRED experience of the NSLC has shown that special libraries can implement a knowledge service for economic development, and the SRED is an important direction of knowledge services for special libraries.Originality/value: Through describing a practical SRED, this paper provides a valuable reference for libraries in the transformation process from library service to knowledge service. The experimental SRED of the NSLC has verified the rationality of our service framework in support of regional economic development. 展开更多
关键词 Service for regional economic development(SRED) SE
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基于红外光谱PCA-LDA统计分析的麻纤维鉴别研究
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作者 蒋晶晶 金肖克 +3 位作者 李伟松 庄莉 袁绪政 祝成炎 《丝绸》 CAS CSCD 北大核心 2024年第7期102-108,共7页
亚麻、汉麻与苎麻纤维的成分组成和物化性质高度相似,三者间的分类鉴别是纺织品检验检测领域的难点。本文对不同种类麻纤维的傅里叶变换衰减全反射红外光谱(ATR-FTIR)作主成分分析(PCA)和线性判别分析(LDA),创建麻纤维分类判别模型以鉴... 亚麻、汉麻与苎麻纤维的成分组成和物化性质高度相似,三者间的分类鉴别是纺织品检验检测领域的难点。本文对不同种类麻纤维的傅里叶变换衰减全反射红外光谱(ATR-FTIR)作主成分分析(PCA)和线性判别分析(LDA),创建麻纤维分类判别模型以鉴别三种易混麻纤维。选取亚麻、汉麻和苎麻纤维各60组作为样品集进行脱胶清洗处理并采集ATR-FTIR光谱。光谱归一化后对800~2000 cm-1波长的光谱作主成分分析,分析结果显示:随着主成分个数增加,主成分分数依据麻纤维类别逐渐显现聚类趋势,同时前12个主成分对归一化红外光谱数据的累计贡献率超过99.5%。以训练集前12主成分数为自变量,以麻纤维种类为因变量,通过线性判别分析构建了分类判别模型(典型判别函数和分类函数)。模型验证结果显示:典型判别函数可使前12个主成分分数矩阵根据麻纤维样品类型形成良好的聚类,分类函数对训练集和测试集中所有纤维样品的分类准确率达到100%。此外,PCA-LDA分类判别模型留一交叉验证的分类准确率仍能达到99.6%。结果表明,不同类别麻纤维的ATR-FTIR光谱存在差异,基于麻纤维ATR-FTIR光谱的PCA-LDA统计分析可实现亚麻、汉麻和苎麻三种易混麻纤维的快速无损鉴别。 展开更多
关键词 亚麻 汉麻 苎麻 鉴别 红外光谱 主成分分析 线性判别分析
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基于数据挖掘探究中医治疗放射性皮炎的用药规律及作用机制
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作者 陈佳骏 孙建 +4 位作者 方庆亮 庄丽 黄星 鹿振辉 王蕾 《世界中西医结合杂志》 2024年第5期884-894,共11页
目的 探究中医处方治疗放射性皮炎(Radiodermatitis,RD)的用药规律及作用机制。方法 首先通过中英文数据库检索治疗RD的中医处方,分析处方内所含中药的使用频率和关联规则,总结治疗RD的核心处方。然后通过网络药理学方法探究核心处方的... 目的 探究中医处方治疗放射性皮炎(Radiodermatitis,RD)的用药规律及作用机制。方法 首先通过中英文数据库检索治疗RD的中医处方,分析处方内所含中药的使用频率和关联规则,总结治疗RD的核心处方。然后通过网络药理学方法探究核心处方的有效成分及治疗RD的潜在靶点与通路,并采用分子对接技术评估潜在靶点与活性成分之间的相互作用。结果 共计筛选出78篇文献,78个中药处方,累计纳入117种中草药。治疗RD的高频药物有紫草、黄柏、黄连、大黄、冰片、黄芩等,药性以寒为主,药味以苦为主,药物归经以肝经、脾经为主,药物功效以清热类为主。关联规则分析显示,“黄芩-黄柏”“黄芩-黄连-黄柏”“大黄-黄芩-黄连-黄柏”分别是二联至四联中支持度、置信度最高的组合。网络药理学分析核心处方“黄芩-黄连-黄柏-大黄”共计有效成分213个,与RD的交集靶点143个,筛选得5个关键靶点,即JUN、MAPK1、RELA、TP53和AKT1。富集分析结果显示,核心处方治疗RD的机制涉及IL-17、TNF、PI3K-Akt炎症相关信号传导和细胞凋亡途径。分子对接结果显示,槲皮素、芹菜素、汉黄芩素与筛选的潜在靶点具有较好的结合能力。结论 基于数据挖掘,总结出中药治疗RD的核心处方,并通过网络药理学和分子对接研究其治疗RD的潜在有效成分、靶点和相关信号通路,为中药治疗RD的临床应用提供理论依据。 展开更多
关键词 放射性皮炎 数据挖掘 用药规律 网络药理学 分子对接
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面向小型边缘计算的深度可分离神经网络模型与硬件加速器设计
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作者 孟群康 李强 +5 位作者 赵峰 庄莉 王秋琳 陈锴 罗军 常胜 《计算机应用研究》 CSCD 北大核心 2024年第3期861-865,879,共6页
神经网络参数量和运算量的扩大,使得在资源有限的硬件平台上流水线部署神经网络变得更加困难。基于此,提出了一种解决深度学习模型在小型边缘计算平台上部署困难的方法。该方法基于应用于自定义数据集的深度可分离网络模型,在软件端使... 神经网络参数量和运算量的扩大,使得在资源有限的硬件平台上流水线部署神经网络变得更加困难。基于此,提出了一种解决深度学习模型在小型边缘计算平台上部署困难的方法。该方法基于应用于自定义数据集的深度可分离网络模型,在软件端使用迁移学习、敏感度分析和剪枝量化的步骤进行模型压缩,在硬件端分析并设计了适用于有限资源FPGA的流水线硬件加速器。实验结果表明,经过软件端的网络压缩优化,这种量化部署模型具有94.60%的高准确率,16.64 M的较低的单次推理定点数运算量和0.079 M的参数量。此外,经过硬件资源优化后,在国产FPGA开发板上进行流水线部署,推理帧率达到了366 FPS,计算能效为8.57 GOPS/W。这一研究提供了一种在小型边缘计算平台上高性能部署深度学习模型的解决方案。 展开更多
关键词 边缘计算 深度可分离卷积 流水线部署 硬件加速器 FPGA
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舞蹈创作的“力的构造”
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作者 庄丽 张麟 《民族艺术研究》 CSSCI 2024年第4期75-81,共7页
舞蹈创作的“力的构造”是舞蹈动作内部秩序的构建,是节奏与空间的关系构建,是情感与力的关系协调,以及情感思维的运动形态。这一复杂的内部秩序运动形态蕴藏着丰富的情感表达,预示着舞蹈语言形成和表达的可能性。对于舞蹈创作的语言构... 舞蹈创作的“力的构造”是舞蹈动作内部秩序的构建,是节奏与空间的关系构建,是情感与力的关系协调,以及情感思维的运动形态。这一复杂的内部秩序运动形态蕴藏着丰富的情感表达,预示着舞蹈语言形成和表达的可能性。对于舞蹈创作的语言构建和情感表达而言,其动作内部秩序和外在表征形式所产生的复合运行,是舞蹈语言通道产生的关键所在,是构成舞蹈语言的起点。它促使形成舞蹈动作的符号化,从而产生语言的表达,实现舞蹈的表意。 展开更多
关键词 舞蹈创作 “力的构造” 内在秩序 动作形式 身心思维 舞蹈表意
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基于DSP架构的软件应用流水线开发监测技术
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作者 庄莉 陈又咏 +2 位作者 苏江文 董晓祺 王礼景 《微型电脑应用》 2024年第2期89-92,共4页
软件流水线开发过程涉及不同的开发环境和测试环境,不同环境因素的影响会导致监测指令行间出现大量延迟,严重影响了监测技术的复用性。针对这一问题,提出基于DSP架构的软件应用流水线开发监测技术。派发监测指令前,在取指站设置一个分... 软件流水线开发过程涉及不同的开发环境和测试环境,不同环境因素的影响会导致监测指令行间出现大量延迟,严重影响了监测技术的复用性。针对这一问题,提出基于DSP架构的软件应用流水线开发监测技术。派发监测指令前,在取指站设置一个分支计数器,以目的地址作为依据,启动分支计数器,完成监测指令预取。采用BWDSP100芯片搭建DSP架构,将预取内容部署到DSP架构中,同时对内部代码库进行部署,优化代码循环监测内容。设计监测引擎内部结构,建立与流水线之间的联系,设置身份权限验证功能和多个功能节点,完善监测流程,实现对软件应用流水线开发的完整监测。实验结果表明,面对开发环境的变化,所提技术在监测软件流水线开发过程中能够保证监测结果的准确和较高的监测效率,整体复用性得到了提高,具有一定的应用前景。 展开更多
关键词 DSP架构 软件应用 流水线开发 自动监测 监测指令
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一种面向工业部署的目标检测模型蒸馏技术
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作者 史星宇 李强 +5 位作者 庄莉 梁懿 王秋琳 陈锴 伍臣周 常胜 《计算机与现代化》 2024年第10期93-99,共7页
深度学习目标检测模型的应用场景相当广泛,然而,受制于部署设备的性能,部署模型的检测精度往往较低。为提高检测模型的性能,本文提出一种高效的动态蒸馏训练方法。该方法创新性地引入动态样本分配策略来筛选教师模型的高质量输出,并配... 深度学习目标检测模型的应用场景相当广泛,然而,受制于部署设备的性能,部署模型的检测精度往往较低。为提高检测模型的性能,本文提出一种高效的动态蒸馏训练方法。该方法创新性地引入动态样本分配策略来筛选教师模型的高质量输出,并配合蒸馏损失的动态权重调整,对传统的目标检测模型蒸馏算法进行改进。在电网安全施工场景数据集上的实验结果表明,相较于直接训练,该方法使YOLOv6-n模型的AP (Average Precision)值平均提高了2.63个百分点。本文提出的蒸馏方法不影响原有部署模型的推理速度,有助于提升目标检测模型在各种工业场景上的检测性能。 展开更多
关键词 深度学习 目标检测 知识蒸馏
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3D printed grafts with gradient structures for organized vascular regeneration
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作者 Yuewei Chen Zhongfei Zou +8 位作者 Tao Fu zhuang li Zhaojie Zhang Meng Zhu Qing Gao Shaofei Wu Guosheng Fu Yong He Jiayin Fu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第3期505-520,共16页
Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great need.However,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis... Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great need.However,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis and stenosis after in vivo implantation.When designing SDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(SML).To facilitate rapid SML regeneration,a high-resolution 3D printing method was used to create a novel bilayer SDVG with structures and mechanical properties mimicking natural arteries.Bioinspired by the collagen alignment of SML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate SML reconstruction for compliance restoration and spontaneous endothelialization.The outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide SDVG with sufficient mechanical strength.One month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature SML.Our study shows the importance of SML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly. 展开更多
关键词 small-diameter vascular graft smooth muscle layer 3D printing ENDOTHELIALIZATION
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