Genetic polymorphism of glutathione-S-transferase M1 and T1 in associated with carcinogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma

Objective:The aim of our study was to investigate the distribution of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) gene polymorphism in hepatocellular carcinoma (HCC) and nasopharyngeal carcinoma (NPC) patients in a high risk area in Guangxi Zhuang Autonomous Region,China.Methods:It was a case-control study.The genotypes of GSTM1 and GSTT1 in 181 HCC and 126 NPC patients were compared with 641 matched control.The GSTM1 and GSTT1 genotypes were detected using conventional multiplex PCR method.Results:The frequency of GSTM1 null genotype in HCC,NPC and control groups were 65.2%,61.9% and 47.6% respectively,significant difference between these two cancer groups and control was observed (P < 0.01).The frequency of GSTT1 null genotype in HCC,NPC and control groups were 57.5%,62.7% and 43.1% respectively,significant difference between these two cancer groups and control was observed (P < 0.01).Conclusion:The distributions of GSTM1 and T1 genes are polymorphic in HCC and NPC patients in a high risk area in Guangxi,individuals with GSTM1-null or GSTT1-null would have an increasing risk of developing HCC and NPC,especially when combination with virus infection (HBV or EBV) and absorbed chemical toxin (AFB1 or cigarette).

Wideband and high-gain BeiDou antenna with a sequential feed network for satellite tracking

BeiDou-3 navigation satellite system was officially opened in 2020.While bringing high-performance services to people around the world,the navigation system requires well-designed BeiDou antennas.In this paper,we propose a wideband circularly polarized high-performance BeiDou antenna.The antenna realizes wideband circularly polarized radiation through a four-port sequential feed network,and the phase imbalance of the feed network from 1.05 to 1.80 GHz is less than 7°.The manufactured antenna demonstrates a return loss of more than 13 dB and an axial ratio<3 dB over the entire global navigation satellite system(GNSS)frequency band.The right-handed circular polarization(RHCP)gain of the proposed antenna is greater than 4 dB in the GNSS low-frequency band and can reach more than 7.1 dB in the high-frequency band.Dimension of the proposed antenna is 120 mm×120 mm×20 mm,i.e.,0.54λo×0.54λo×0.09λo,whereλo is the wavelength of the center frequency.The proposed antenna connected to a GNSS receiver has tracked 12 BeiDou satellites with C/N0 ratios of GNSS signals greater than 30 dB.Such a high-performance antenna provides a basis for high-quality positioning services.