Investigation of Pegmatite Mineral Applicability from the Terek Ceramic Deposit in Kyrgyzstan for Production of Porcelain and Earthenware

This article is investigating analysis and chemical composition of ceramic pegmatite minerals obtained from the Terek deposit in Toktogul district of Kyrgyzstan. Several methods such as mineralogical studies, magnetic and gravitational enrichments, silicate and chemical analyses of ceramic pegmatite minerals, quartz-feldspathic concentrate and sludge removal have been performed for determination of pegmatite mineral applicability for production of porcelain and earthenware.

Thionization Method of Glycosyl Urea and Carbamide Sugars

This work is describing a thionization method for glycosyl urea and carbamide of sugars by using the Lawesson’s reagent. It is proposed the method based on the interaction of glycosyl urea and carbamide of sugars with the Lawessons reagent at a 1:1 ratio in the presence of a pyridine. As a result, sulfur-containing derivatives of sugar carbamides are obtained with the help of Lawesson’s reagent. Obtained experimental data are indicating the developed new method for thionization of sugar carbamides, which opens up broad possibilities for synthesis of various carbohydrate derivatives of thiourea. Significance of this work is that, thiourea derivatives are promising bactericidal, fungicidal and anti-inflammatory drugs. Therefore, the preparation of thiourea derivatives and the study of their properties remain topical tasks in the field of chemistry.

Synthesis, Assessment of Biological Activity and Toxicity for N-(<i>β</i>-D-Glycopyranosyl)-Thiosemicarbazides

In the modern science, priority is given for the search of biological active compounds with specific properties. As a result of experimental data, it was found that in the reaction between N-(β-D-glycopyranosyl)-semicarbazide and the Lawesson reagent (2,4-bis(p-methoxyphenyl)-1,3-dithiadiphosphetane 2,4-disulfide) at the ratio 1:1 in pyridine when boiling under reflux in a water bath for 20 - 35 minutes, a new synthetic compound N-(β-D-glycopyranosyl)-thiosemicarbazide is formed. The individuality and structure of the target products were confirmed by 13C NMR spectroscopy, 1H NMR spectroscopy, IR spectroscopy, and elemental analysis. For the synthesized new compounds of N-(β-D-glycopyranosyl)-thiosemicarbazides, the probability of pharmacological and toxic effects were predicted by the computer method in silico. From the synthesized compounds N-(β-D-galactopyranosyl)-thiosemicarbazide, the probability of antibacterial (antibacterial) activity is predicted (Pa/Pi 0.544/0.013). The antibacterial activity of the compound (4) was confirmed in a test for salmonella infection of lambs, salmonellosis of calves, and colipathogenic E. coli serotypes. An experimental study by the in vitro method made it possible to conclude that the new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effect. The synthetic new compound N-(β-D-glyco- pyranosyl)-thiosemicarbazide is a promising compound for further study.

Morphological Characteristics of Thymus in the Newborns in Different Climatic and Geographical Conditions of Kyrgyzstan

This paper is describing a detailed study of morphological structures and characteristics newborns thymus in different climatic and geographical conditions of Kara-Balta, Cholpon-Ata, and Bishkek in Kyrgyzstan. Anatomical structure research done on 26 thymuses of newborn corpses. Research results showed that a significant amount of thymuses consisted of lobes with very thin connective tissues between them. It is observed that the Hassall cells were usually located in the medulla part of the thymus after using the coloring by Van-Gieson’s stain visible clear elastic and collagen fibers. In addition, cell population dynamics in a unit of conditional area of cortical substance thymus lobes in newborns determined.

Groups of the Body Constitution and Age-Related Anthropometric Parameters in Kyrgyz Women

This article is investigating constitutional and age characteristics of the body length, body weight, body mass index (BMI), and the absolute fat mass of Kyrgyz women. The features of the BMI and fat body mass in females with different constitutional and age groups were studied. According to our study, the leptosomatic group of body constitution was determined in 20% of women, while the mesosomatic group noted in 32%, megalosomatic group recorded in 33%, and an indefinite group established in 15% among the studied women. Stenoplastic constitution was 66% - 77% in the leptosomal constitution;asthenic thin bone group was 18% - 24%;and broad bone group somatotypes were 5 - 10%. The proportion of the mesoplastic group was 31 - 66%, which is greater than picnic somatotype (34% - 69%). Results of our study revealed constitutional and age peculiarities are important for prescriptions in practical medicine.

Essential Oil from Ether-Containing Plants of Juniper (<i>Juniperus</i>) and Spruce (<i>Picea</i>) Leaves by Distillation

This article is investigating the preparation of essential oil from the ether-containing plants of Juniper (Juniperus) and spruce (Picea) leaves by using the simple water distillation equipment. This water distillation method forms an essential oil with water vapor from plants of Juniper (Juniperus) and spruce (Picea) leaves based on Dalton’s law of partial pressure, applicable for plants containing a large amount of ether oil where distillation temperature is not affecting product quality. Obtained essential oils are widely used in medicine, perfumery, cosmetics, and food industry. In addition, these essential oils possess different activities including antimicrobial, antiviral, and anti-inflammatory, which have different effects such as adaptogenic, antidepressive, disinfection, and wound healing, diuretic, and antipyretic.

Somatotypological Features of the Skin Fat Fold Thickness in Ethnic Kyrgyz Women

The purpose of this study was to determine the thickness of skin and fat folds in Kyrgyz women of various ages, taking into account their somatotypological profile. Using the method of complex anthropometry, including the determination of the values of 21 anthropometric parameters, the physical status of 1028 Kyrgyz women of different age groups was studied youth (16 - 20 years old 310 girls), mature age (1st period, 21 - 35 years old 308 women;2nd period, 36 - 55 years 410 women) living in Osh, Kyrgyzstan. For somatotyping, we used the scheme of constitutional diagnostics. Seven somatotypes distinguished within three constitutional groups. The subcutaneous fat was measured by caliperometry. Statistical processing carried out using the statistical programs Microsoft Excel and the STATISTICA package (v. 6.0). To determine the reliability of the differences between the indicators, the Student’s test was used (p < 0.05). The results demonstrate that within each somatotype there are broad changes in the studied anthropometric indicator. Thus, the thickness of the skin and fat folds is the smallest in women of asthenic, athletic and stenoplastic (p < 0.05), and the largest in representatives of the euriplastic and pycnic somatotypes (p < 0.05). Thus, indicators of physical status in adolescence and adulthood in women have a pronounced somatotypological specificity. These materials on the physical development and constitutional and typological characteristics of the studied population of women applicable for a personalized approach in the context of a relative norm.

Catamnestic Observation of Premature Newborns with Nervous System Injury in the Kyrgyz Republic

Background: Recently, among child disability disorders nervous system diseases are prevailing 19.5%, while mental disorders are 14.3% and congenital malformations 21%. In most cases, children’s neurological disability is associated with pathology during the perinatal period, while 24% of patients have a cerebral impairment. Premature newborns perished 30 to 35 times more often than in-time newborns, and perinatal mortality in case of premature pregnancies is 30 to 40 times higher than in term delivery. Aim: This article is studying catamnestic observation of premature newborns with nervous system injury and with perinatal pathology in Kyrgyzstan for the period 2020-2021. Preterm newborns’ anthropometric characteristics and main diagnoses associated with diseases in the gestational period were shown. Methods: A comprehensive clinical and laboratory examination including premature newborns health dynamic monitoring with gestational age from 28 to 36 weeks, who were treated in the neonatal pathology department of the Regional Maternity Hospital in Osh for the period from 2020-2021 were carried out. Literature review analysis from PubMed database, MEDLINE, EMBASE, Science Direct, Google Scholar, and clinical trials performed. Results: after clinical examination, it was revealed that pregnancy and childbirth in all mothers of the studied group passed with complications. In mothers of the studying group, the most common pathologies during pregnancy were chronic fetal hypoxia 49 (58.4%), acute respiratory infections 28 (33.4%), the threat of termination of pregnancy 20 (23.9%), preeclampsia 16 (19.11%), sexually transmitted infections 9 (10.8%), pyelonephritis 14 (16.7%), polyhydramnios 9 (10.8%), 71 children (84.6%) were born with asphyxiation and 25 children extracted by cesarean section with varying degrees of severity. Conclusions: Depending on the severity of the perinatal lesion of the nervous system and pathological factor effects, it is very important to start early habilitation measures with preterm newborns who are at risk of developmental delay deviations, and to exit disabling disorders.

Physiological, Anatomical, Psychological and Cultural-Ethnic Aspects of Indian Students Adaptation during Study in Kyrgyzstan Medical Universities

This article is investigating the comparative analysis of anatomical, physiological, and psycho-emotional adaptation indicators of 100 male and 100 female first-year students of the international medical faculty in Osh, Kyrgyzstan. Control groups have consisted of 100 male and 100 female local students of the same age, residing in the Osh city and region. Anthropometry is determined by 50 indicators, such as bio-impedance analysis of body composition, functional tests with exercise, and breathe holding. In addition, the girls underwent an assessment of sexual development according to Tyner. The psychological state was assessed using the Lüschers color test and Spielberger’s questionnaire. The features of anthropometric indicators for students from India are shown as a shorter length of the body, shoulder, and legs, greater waist coverage, an increase in the thickness of the skin folds of the abdomen, increased fat mass and delayed sexual development, anxiety, frequent and longer colds. Functional tests for breath holding and physical activity revealed less reserve capacity in foreign students. This requires the development of rehabilitation programs for foreign students, starting from the first year.

Microflora Formation in Newborns Depending on the Mother Microbiological Profile and Locality Altitude

Aims: This work is aimed to investigate microflora formation, quantitative and qualitative features of various bacteria colonization in the women in labor, and newborns depending on the microbiological profile and locality altitude. Rationale: Physiological and social adaptation of newborns in extreme climate of mountains, in particular the microflora formation in unusual conditions studied. Findings: In the study of nasal microflora, the C. albicans species in case of women in labor were 77.7%, while in the newborns C. albicans species were 2 times less. In lowlands, the S. aureus type was prevailed, while in case of midlands prevailed bacterium was S. epidermidis. In the newborns of highlands, E. coli was prevailed, as in the examined lowlands, it found as 75%. In the women in labor, C. albicans were detected as 56.6%, C. krusei was 36.6%, S. aureus was 23.3%, S. epidermidis was 60% and E. coli was 30%. In newborns, representatives of candida fungi found: C. albicans was 3.3%, C. krusei was 26.6%, S. aureus was 43.3%, S. epidermidis was 53.6% and E. coli was 36.6%. Conclusions: In this work, we determined bacterial microflora colonization in throat, nasal, vaginal, urinoculture and skin swab of women in labor and newborns in lowland, midland and highland conditions, respectively.

Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods

Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.

Optimization Diagnosis of Breast Cancer Vertebral Metastases

The article is describing results after analysis of research conducted in Osh Interregional Oncology Center under the Ministry of Health in the Kyrgyz Republic. X-ray computed tomography, magnetic resonance imaging analyses were made for optimization diagnosis determination in patients with breast cancer vertebral metastases. According to the obtained data, the frequency of vertebral metastases in breast cancer was observed as well as the timing of their detection depending on the detection of the primary tumor. In addition, the necessity for early screening of vertebral metastases was explained.

Development of Blood Donation Activities in Kyrgyzstan and General Implications for Blood Donation

Objectives: This article is aiming to give an essential informative principle about the development of blood donation activities in Kyrgyzstan. Background: The sequence of blood donation procedure steps before donation, during donation, and after donation was shown and discussed. Methods/Materials: Rhesus factor determination in donors was achieved by “COLICO” method which is based on the use of monoclonal antibodies solution. Results: According to the blood donation activity of donors in Osh, Kyrgyzstan for the 2018 year, it was found that gratuitous donors who donated blood in 6 months were 269, in 9 months were 366, and in 1 year were 499 people. Relative donors who donated blood in 6 months were 3480, in 9 months were 5100, and in 1 year were 6701 people. Active donors donated blood in 6 months were 12, in 9 months were 14 and in 1 year were 17 people. Conclusion: No agglutination was observed in any of the plates for the first blood group;agglutination was observed with anti-A monoclonal antibody solution for the second blood group;agglutination was observed with anti-B monoclonal antibody solution for the third blood group;agglutination was observed with both of anti-A and anti-B monoclonal antibody solutions for the fourth blood group.

Graphene Sheets with Modified Surface by Sodium Lauryl Sulfate Surfactant for Biomedical Applications

This work describes synthesis of graphene sheets with modified surface by sodium lauryl sulfate (SLS) surfactant using one-pot solvothermal reaction method. Effect of sodium lauryl sulfate surfactant amount on surface modification level of graphene sheets was investigated. Ether (-S-OR- at 762 cm-1 - 863 cm-1), thiocarbonyl (=C=S at 1050 cm-1 - 1176 cm-1) and sulfoxide (S-O, Vs and Vas at 1030 cm-1 - 1450 cm-1) functional groups released from sodium lauryl sulfate (SLS) surfactant during solvothermal reaction and attached on the surface of graphene sheets were detected by (attenuated total reflectance-fast Fourier infrared) ATR-FTIR spectroscopy. (Atomic force microscope) AFM observations revealed apparent surface of graphene sheets modified by surfactant molecules with an average multiple profile of graphene nanosheets ≈ 4.8 nm high. This synthesis way of surface modified graphene sheets can be considered as easy, one-step and cheap method for manufacturing of novel biosurface with graphene, as reinforcement for biopolymer coatings such as ultra-high molecular weight polypropylene (UHMWPE), metallic biomaterials (Ti and Ti alloys) and bioceramics as hydroxyapatite (HA).

Regularization and Choice of the Parameter for the Third Kind Nonlinear Volterra-Stieltjes Integral Equation Solutions

The article is considering the third kind of nonlinear Volterra-Stieltjes integral equations with the solution by Lavrentyev regularizing operator. A uniqueness theorem was proved, and a regularization parameter was chosen. This can be used in further development of the theory of the integral equations in non-standard problems, classes in the numerical solution of third kind Volterra-Stieltjes integral equations, and when solving specific problems that lead to equations of the third kind.

Dust Retention Ability of Plants as a Factor Improving Environment Air

It is well known that air in industrial cities contains a significant amount of dust particles, smoke, and toxic gases. The increased number of vehicles has a direct impact on air quality resulting in the emission of exhaust gases, and the increase of dust concentration in air. In this article, we are describing the dust retention ability of plants depending on their leaf structure. Plant species were classified into three groups according to their dust-holding capacities. Dust retaining ability of plant species in conditions of high, average and low dust conditions described.

Sectoral Features of the Tenir-Too Mountains

For the first time, the separating issues of the Tenir-Too mountains into sectors in contrast to the accepted schemes of physical geography as a province and sub-province were discussed. Since the term province is more acceptable in political science than in physical geography, the main factors in the process of sector formation were determined. The purpose of this article is not only to describe the high altitudes of the Tenir-Too mountains, but theoretically substantiate their formation, ecological and genetic features, and distribution patterns. Until today the Tenir-Too mountain area is not divided into sectors and subsectors with significant changes to the stencil scheme, which has been used to date in the physical geographical zoning. Research methods in this work are based on the recent study materials collected from meteorological stations of Tenir-Too region. Hypsometric and topographic maps were used to identify high altitude ranges, and climatic factors were separated by zones. Plant species and genus divisions were identified. In some areas of the Tenir-Too the range of altitudes along the routes was studied.

Joint Effects of Mexidol and Nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues

This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units;produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.

The Role of the Tenir-Too Relief Steps in the Formation of High-Altitude Belts

The article discusses regularity of the formation of high-altitude zones on the mountain territories of Tenir-Too and their relationship with geomorphological complexes and the relief steps. The main purpose was to classify geomorpho-logical complexes and to concretize their morphological characteristics. The belt structure consisting of two mixed rows is analyzed. Excess, elevated, medium-moistened, semi-moistened, semi-arid, and arid types of altitudinal belts were proposed.

Displacement of the Residual Liver Cavity in Laparoscopic Echinococcectomy

Aim: This article aimed to investigate the analysis of various methods for eliminating the residual liver cavity after laparoscopic echinococcectomy in patients. Methods: The authors used the following methods of eliminating the residual cavity: omentoplasty (36.8%), abdominalization (30%), drainage of the residual cavity (26.2%), and a combination of omentoplasty with drainage of the residual cavity (7%). Results: In the postoperative period, complications occurred in 2 (3.5%) cases in the form of bile leakage from the residual liver cavity. Conclusions: It is recommended to use abdominalization and omentoplasty when choosing a method for eliminating the residual liver cavity.