Soxllb regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish

The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye development.However,its function in retina regeneration remains elusive.Here we report that Sox11 b,a zebrafish Sox11 homolog,regulates the migration and fate determination of Müller glia-derived progenitors(MGPCs)in an adult zebrafish model of mechanical retinal injury.Following a stab injury,the expression of Sox11 b was induced in proliferating MGPCs in the retina.Sox11 b knockdown did not affect MGPC formation at 4 days post-injury,although the nuclear morphology and subsequent radial migration of MGPCs were alte red.At 7 days post-injury,Sox11 b knockdown res ulted in an increased proportion of MGPCs in the inner retina and a decreased propo rtion of MGPCs in the outer nuclear layer,compared with controls.Furthermore,Sox11 b knockdown led to reduced photoreceptor regeneration,while it increased the numbe rs of newborn amacrines and retinal ganglion cells.Finally,quantitative polymerase chain reaction analysis revealed that Sox11 b regulated the expression of Notch signaling components in the retina,and Notch inhibition partially recapitulated the Sox11 b knockdown phenotype,indicating that Notch signaling functions downstream of Sox11 b.Our findings imply that Sox11 b plays key roles in MGPC migration and fate determination during retina regeneration in zebrafish,which may have critical im plications for future explorations of retinal repair in mammals.

Community Authenticity Experience of Shared Accommodation Consumers

By constructing a research framework of theoretical concepts such as leisure involvement, authenticity experience, place attachment, and willingness to revisit, the aim is to explore the authenticity experience and its influencing mechanisms in shared accommodation consumption. Research data are collected by using questionnaire survey method, and statistical analysis of data is conducted using SPSS 21.0. Research has found that leisure involvement has a significant positive impact on authenticity experience, place attachment, and willingness to revisit;authenticity experience has a significant positive impact on place attachment and willingness to revisit;place attachment has a significant positive impact on willingness to revisit. Therefore, shared accommodation owners need to strengthen the editing and publishing of leisure strategies on we media to enhance customers sense of leisure involvement;pay attention to enhancing the local authentic cultural experience of tenants, in order to increase their sense of attachment to the place and thereby enhance their willingness to stay.

Stepwise-Nanocavity-Assisted Transmissive Color Filter Array Microprints

Visible-light color flters using patterned nanostructures have attracted much interest due to their various advantages such as compactness,enhanced stability,and environmental friendliness compared with traditional pigment or dye-based optical flters.While most existing studies are based on planar nanostructures with lateral variation in size,shape,and arrangement,the vertical dimension of structures is a long-ignored degree of freedom for the structural colors.Herein,we demonstrate a synthetic platform for transmissive color flter array by coordinated manipulations between height-varying nanocavities and their lateral flling fractions.Te thickness variation of those nanocavities has been fully deployed as an alternative degree of freedom,yielding vivid colors with wide gamut and excellent saturation.Experimental results show that the color-rendering capability of the pixelated nanocavities can be still retained as pixels are miniaturized to 500 nm.Crosstalk between closely spaced pixels of a Bayer color flter arrangement was calculated,showing minimal crosstalk for 1μm2 square subpixels.Our work provides an approach to designing and fabricating ultracompact color flter arrays for various potential applications including stained-glass microprints,microspectrometers,and high-resolution image sensing systems.

(Bi,Sb)_(2)Te_(3)/SiC nanocomposites with enhanced thermoelectric performance:Effect of SiC nanoparticle size and compositional modulation

Fabrication of nanoparticle-dispersed composites is an effective strategy for enhancing the performance of thermoelectric materials,and in particular SiC nanoparticles have been often used to create composites with Bi_(2)Te_(3)-based applied thermoelectric materials.However,the effect of particle size on the thermoelectric performance is unclear.This work systematically investigated the electrical and thermal properties of a series of(Bi,Sb)_(2)Te_(3)-based nanocomposites containing dispersed SiC nanoparticles of different sizes.It was found that particle size has a significant impact on the electrical properties with smaller SiC nanoparticles giving rise to higher electrical conductivity.Even though the dispersed SiC nanoparticles enhanced the Seebeck coefficient,no apparent dependence of the enhancement on the particle size was observed.It was also found that smaller SiC nanoparticles scatter phonons to some extent while the larger nanoparticles contribute to increased thermal conductivity.Eventually,the highest ZT value of 1.12 was obtained in 30 nm-SiC dispersed sample,corresponding to an increase by 18%from 0.95 for the matrix made from commercial scraps,and then the ZT was further boosted to 1.33 by optimizing the matrix composition and expelling excess Te during the optimized spark plasma sintering process.This work proves that the dispersion of smaller SiC nanoparticles in p-type(Bi,Sb)_(2)Te_(3) materials is more effective than the dispersion of larger nanoparticles.In addition,it is revealed that additional compositional and/or processing optimization is vital and effective for obtaining further performance enhancement for nanocomposites of SiC nanoparticles dispersed in(Bi,Sb)_(2)Te_(3).