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Ultrasound assisted multicomponent reactions:A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines usingβ-cyclodextrin as a supramolecular reusable catalyst in water 被引量:3
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作者 asha v.chate umesh b.rathod +5 位作者 jagdish s.kshirsagar pradip a.gaikwad kishor d.mane pravin s.mahajan mukesh d.nikam charansingh h.gill 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第1期146-152,共7页
We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular,biodegradable,and reusable catalyst in aqueous medium.The reaction product ... We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular,biodegradable,and reusable catalyst in aqueous medium.The reaction product is in excellent yield with moderate to excellent selectivity.The mechanistic transformation presumably proceeds via a one-pot,multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/INH,undergoing a tandem Michael addition reaction.The proposed approach in this study provides a highly efficient and environmentally benign route to N-substituted 1,8-dioxo-decahydroacridines. 展开更多
关键词 Tandem reaction N-Substituted 1 8-dioxo-decahydroacridines Β-CYCLODEXTRIN Supramolecular catalysis WATER
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β-Cyclodextrin as a supramolecular catalyst for the synthesis of 2Hindazolo[2,1-b]phthalazine-trione derivatives in water and their antimicrobial activities 被引量:2
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作者 asha v.chate Priyanka K.Bhadke +2 位作者 Manisha A.Khande Jaiprakash N.Sangshetti Charansingh H.Gill 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第7期1577-1582,共6页
An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydr... An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydrazine hydrate with succinic anhydride/phthalic anhydride in water at 80 ℃ for first time.The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains.The outcome of the screening study showed that compound 6d,6f and7 n exhibited excellent activity against E.coil.Whereas,compound 6f and 6h exhibited excellent activity against P.aeurginosa,and compound 6c,and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S.aureus and B.subtilis when compared with Ampicillin(standard control).The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs. 展开更多
关键词 Multicomponent reactions(MCRs) Pyridazino[1 2-a]indazole-triones 2H-Indazolo[2 1-b]phthalazine-trione β-Cyclodextrin Aqueous medium Green method Antimicrobial activity
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