Identification and Validation of Novel Biomarkers Related to the Calcium Metabolism Pathway in Hypertension Patients Based on Comprehensive Bioinformatics Methods

Background: Hypertension is a universal risk factor for cardiovascular diseases and is thus the leading cause of death worldwide. The identification of novel prognostic and pathogenesis biomarkers plays a key role in disease management. Methods: The GSE145854 and GSE164494 datasets were downloaded from the Gene Expression Omnibus (GEO) database and used for screening and validating hypertension signature genes, respectively. Gene Ontology (GO) enrichment analysis was performed on the differentially expressed genes (DEGs) related to calcium ion metabolism in patients with hypertension. The core genes related to immune infiltration were analyzed and screened, and the activity of the signature genes and related pathways was quantified using gene set enrichment analysis (GSEA). The infiltration of immune cells in the blood samples was analyzed, and the DEGs that were abnormally expressed in the clinical blood samples of patients with hypertension were verified via RT-qPCR. Results: A total of 176 DEGs were screened. GO showed that DEGs was involved in the regulation of calcium ion metabolism in biological processes (BP), actin mediated cell contraction, negative regulation of cell movement, and calcium ion transmembrane transport, and in the regulation of protease activity in molecular functions (MF). KEGG analysis revealed that the DEGs were involved mainly in the cGMP-PKG signaling pathway, ubiquitin-protein transferase, tight junction-associated proteins, and the regulation of myocardial cells. MF analysis revealed the immune infiltration function of the cells. RT-qPCR revealed that the expression of Cacna1d, Serpine1, Slc8a3, and Trpc4 was up regulated in hypertension, the expression of Myoz2 and Slc25a23 was down regulated. Conclusion: Cacna1d, Serpine1, Slc8a3, Trpc4, Myoz2 and Slc25a23 may be involved in the regulation of calcium metabolism pathways and play key roles in hypertension. These differentially expressed calcium metabolism-related genes may serve as prognostic markers of hypertension.

Identification and Validation of Vascular-Associated Biomarkers for the Prognosis and Potential Pathogenesis of Hypertension Using Comprehensive Bioinformatics Methods

Background: Hypertension, also known as increased blood pressure, is a phenomenon in which blood flows in blood vessels and causes persistently higher-than-normal pressure on the vessel wall. The identification of novel prognostic and pathogenesis biomarkers plays a key role in the management of hypertension. Methods: The GSE7483 and GSE75815 datasets from the gene expression omnibus (GEO) database were used to identify the genes associated with hypertension that were differentially expressed genes (DEGs). The functional role of the DEGs was elucidated by gene body (GO) enrichment analysis. In addition, we performed an immune infiltration assay and GSEA on the DEGs of hypertensive patients and verified the expression of novel DEGs in the blood of hypertensive patients by RT-qPCR. Results: A total of 267 DEGs were identified from the GEO database. GO analysis revealed that these genes were associated mainly with biological processes such as fibroblast proliferation, cell structural organization, extracellular matrix organization, vasculature development regulation, and angiogenesis. We identified five possible biomarkers, Ecm1, Sparc, Sphk1, Thbsl, and Mecp2, which correlate with vascular development and angiogenesis characteristic of hypertension by bioinformatics, and explored the clinical expression levels of these genes by RT-qPCR, and found that Sparc, Sphk1, and Thbs1 showed significant up-regulation, in agreement with the results of the bioinformatics analysis. Conclusion: Our study suggested that Sparc, Sphk1 and Thbs1 may be potential novel biomarkers for the diagnosis, treatment and prognosis of hypertension and that they are involved in the regulation of vascular development and angiogenesis in hypertension.

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in 2020.Due to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still exist.In addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor progression.The aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of immunotherapies.Therefore,personalized treatments could be developed to maximize the advantages of immunotherapy.

废旧聚氨酯泡沫醇解产物作为再生剂实现废橡胶的力化学再生

近年来,废聚氨酯和废橡胶产量呈上升趋势,其资源化循环利用成为研究热点。文中使用丙二醇作为醇解剂在不同温度下分解聚氨酯泡沫,并利用聚氨酯醇解产物作为再生剂实现了废橡胶的力化学再生。醇解产物下层液(PAPL)含有较多的胺类基团,可与橡胶再生过程中产生的自由基结合,提高橡胶的脱硫程度,从而提高再生胶(RRs)的力学性能。与只填加活化剂的RRs相比,在原有活化剂填加份数的基础上,加入PAPL可缩短RRs的最佳硫化时间,提高交联密度。使用180℃制备的聚氨酯醇解产物下层液,RRs硫化橡胶的综合性能最好,拉伸强度达到15.6MPa,断裂伸长率达到325.5%。该方法实现了废聚氨酯和废橡胶的双重高价值回收,应用前景广阔。

Recent progress on impact induced reaction mechanism of reactive alloys

In recent years,in order to improve the destructive effectiveness of munitions,the use of new types of destructive elements is an important way to improve destructive effectiveness.As a new type of reactive material,reactive alloy contains a large portion of reactive metal elements(Al,Mg,Ti,Zr,etc.),which breaks up under high-velocity impact conditions,generating a large number of high-temperature combustible fragments,which undergo a violent combustion reaction with air.Compared with traditional metal polymers(Al-PTFE)and other reactive composites,it has higher density and strength,excellent mechanical properties and broader application prospects.Currently,researchers have mainly investigated the impact energy release mechanism of reactive alloys through impact tests,and found that there are several important stages in the process of the material from fragmentation to reaction,i.e.,impact fragmentation of the material,rapid heating and combustion reaction.This paper focuses on three problems that need to be solved in the impact-induced energy release process of reactive alloys,namely:the fragmentation mechanism and size distribution law of the fragments produced by the impact of the material on the target,the relationship between the transient temperatures and the size of the fragments,and the reaction temperatures and size thresholds of the fragments to undergo the chemical reaction.The current status of the research of the above problems is reviewed,some potential directions to reveal the impact induced reaction mechanism of reactive alloy is discussed.

New process for treating boron-bearing iron ore by flash reduction coupled with magnetic separation

Boron is an important industrial raw material often sourced from minerals containing different compounds that cocrystallize,which makes it difficult to separate the mineral phases through conventional beneficiation.This study proposed a new treatment called flash reduction-melting separation(FRMS)for boron-bearing iron concentrates.In this method,the concentrates were first flash-reduced at the temperature under which the particles melt,and the slag and the reduced iron phases disengaged at the particle scale.Good reduc-tion and melting effects were achieved above 1550℃.The B_(2)O_(3) content in the separated slag was over 18wt%,and the B content in the iron was less than 0.03wt%.The proposed FRMS method was tested to investigate the effects of factors such as ore particle size and tem-perature on the reduction and melting steps with and without pre-reducing the raw concentrate.The mineral phase transformation and morphology evolution in the ore particles during FRMS were also comprehensively analyzed.

A survey on semantic communications:Technologies,solutions,applications and challenges

Semantic Communication(SC)has emerged as a novel communication paradigm that provides a receiver with meaningful information extracted from the source to maximize information transmission throughput in wireless networks,beyond the theoretical capacity limit.Despite the extensive research on SC,there is a lack of comprehensive survey on technologies,solutions,applications,and challenges for SC.In this article,the development of SC is first reviewed and its characteristics,architecture,and advantages are summarized.Next,key technologies such as semantic extraction,semantic encoding,and semantic segmentation are discussed and their corresponding solutions in terms of efficiency,robustness,adaptability,and reliability are summarized.Applications of SC to UAV communication,remote image sensing and fusion,intelligent transportation,and healthcare are also presented and their strategies are summarized.Finally,some challenges and future research directions are presented to provide guidance for further research of SC.

Rapid and real-time analysis of multi-component dissolved gas in seawater by Raman spectroscopy combined with continuous gas-liquid separator

Rapid and sensitive detection of dissolved gases in seawater is quite essential for the investigation of the global carbon cycle.Large quantities of in situ optical detection techniques showed restricted measurement efficiency,owing to the single gas sensor without the identification ability of multiple gases.In this work,a novel gas-liquid Raman detection method of monitoring the multi-component dissolved gases was proposed based on a continuous gas-liquid separator under a large difference of partial pressure.The limit of detection(LOD)of the gas Raman spectrometer could arrive at about 14 μl·L^(-1)for N_(2)gas.Moreover,based on the continuous gas-liquid separation process,the detection time of the dissolved gases could be largely decreased to about 200 s compared with that of the traditional detection method(30 min).Effect of equilibrium time on gas-liquid separation process indicated that the extracted efficiency and decay time of these dissolved gases was CO_(2)>O_(2)>N_(2).In addition,the analysis of the relationship between equilibrium time and flow speed indicated that the decay time decreased with the increase of the flow speed.The validation and application of the developed system presented its great potential for studying the components and spatiotemporal distribution of dissolved gases in seawater.

The existence of saturated vapors in the deep source region of 2017Pohang earthquake evidenced from seismic tomography

Geothermal resources are a promising approach to clean renewable energy;90%of them are deep reservoirs of hot dry rock that require hydraulic fracturing to create a network of connections among wells to enable efficient heat exchange,known as an Enhanced Geothermal System(EGS).The Pohang EGS project in south Korea led to a devasting Mw5.5 earthquake,triggered by the reservoir's EGS stimulation,the largest earthquake known to have been induced by EGS development.Detailed investigations have been conducted to understand the cause of the Pohang earthquake;the conclusion has been that overpressurized injected fluids migrated into an unknown fault triggering this large earthquake.Detailed velocity images for the source zone of the 2017 Pohang earthquake,which could be helpful for further understanding its inducing mechanism,are unavailable.However,we have assembled detailed aftershock data recorded by 41 local stations installed within about three months after the Mw5.5 Pohang earthquake,and have then applied the V_(p)/V_(s)model's consistency-constrained double-difference seismic tomography method to determine the high-resolution three-dimensional Vp(compressional wave velocity),Vs(shear wave velocity),and V_(p)/V_(s)models of the source region that we report here,as well as earthquake locations within the source region.The velocity images reveal that the deep source area of the 2017 Pohang earthquake is dominated by low Vp,high Vs,and low V_(p)/V_(s)anomalies,a pattern that can be caused by overpressurized vapors due to high temperatures at these depths.Based on aftershock locations and velocity features,our studies support the conclusion that the 2017Pohang earthquake was triggered by injected EGS fluids that migrated into a blind fault.

Calcium titanate corrosion inhibitor enabling carbon as inert anode for oxygen evolution in molten chlorides

The corrosion inhibition efficacy of titanate(CaTiO_(3))for carbon anodes in molten salts was investigated through various analytical techniques,including linear sweep voltammetry,X-ray diffraction,scanning electron microscopy,and energy dispersion spectroscopy.The results demonstrate that the addition of CaTiO_(3)corrosion inhibitor efficiently passivates the carbon anode and leads to the formation of a dense CaTiO_(3)layer during the electrolysis process in molten CaCl_(2)-CaO.Subsequently,the passivated carbon anode effectively undergoes the oxygen evolution reaction,with an optimal current density for passivation identified at 400 m A/cm^(2).Comprehensive investigations,including CaTiO_(3)solubility tests in molten CaCl_(2)-CaO and numerical modeling of the stability of complex ionic structures,provide compelling evidence supporting“complexation-precipitation”passivation mechanism.This mechanism involves the initial formation of a complex containing TiO_(2)·nCaO by CaTiO_(3)and CaO,which subsequently decomposes to yield CaTiO_(3),firmly coating the surface of the carbon anode.In practical applications,the integration of CaTiO_(3)corrosion inhibitor with the carbon anode leads to the successful preparation of the FeCoNiCrMn high-entropy alloy without carbon contamination in the molten CaCl_(2)-CaO.

Standardized ileal digestibility of amino acids in soybean meal fed to non-pregnant and pregnant sows

Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant sows.Seven solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were selected.In Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N source.Eight non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in Exp.1.Eight gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation stages.Results When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,Gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(P<0.05),whereas SID for Leu from SBM 5 was higher than in SBM 1 and 4(P<0.05).SID values for Ile,Ala,and Asp from SBM 4 were lower than in SBM 1 and 5(P<0.05).Sows had significantly greater SID values for Lys,Ala,and Asp during mid-gestation when compared with late-gestation stages(P<0.05).Mid-gestating sows had greater SID value for Val and lower SID value for Tyr when compared with non-pregnant and late-gestating sows(P<0.01),whereas non-pregnant sows had significantly greater SID value for Met when compared with gestating sows(P<0.01).Conclusions When fed to mid-gestating sows,the SID values for most AAs varied among SBM samples.The SID values for Lys,Met,Val,Ala,Asp,and Tyr in SBM were affected by sow gestation stages.Our findings provide a cornerstone for accurate SBM use in sow diets.

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be determined.Heterotopicossification(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal tissues.Hypoxia andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote HO.However,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to beelucidated.Here,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell fate.Usingsingle-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in MPCs.Zeugopod mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in vivo.ScRNA-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of HO.Importantly,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1αdeletion.From a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic metabolism.This suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC fate.These results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

Association between the frontoparietal network,clinical symptoms and treatment response in individuals with untreated anorexia nervosa

Background Anorexia nervosa(AN)has been characterised as a psychiatric disorder associated with increased control.Currently,it remains difficult to predict treatment response in patients with AN.Their cognitive abilities are known to be resistant to treatment.It has been established that the frontoparietal control network(FPCN)is the direct counterpart of the executive control network.Therefore,the resting-state brain activity of the FPCN may serve as a biomarker to predict treatment response in AN.Aims The study aimed to investigate the association between resting-state functional connectivity(RSFC)of the FPCN,clinical symptoms and treatment response in patients with AN.Methods In this case-control study,79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40 matched healthy controls(HCs)were recruited from January 2015 to March 2022.All participants completed the Questionnaire Versionof the Eating Disorder Examination(version 6.0)to assess the severity of their eating disorder symptoms.Additionally,RSFC data were obtained from all participants at baseline by functional magnetic resonance imaging.Patients with AN underwent routine outpatient treatment at the 4th and 12th week,during which time their clinical symptoms were evaluated using the same measures as at baseline.Results Among the 79 patients,40 completed the 4-week follow-up and 35 completed the 12-week follow-up.The RSFC from the right posterior parietal cortex(PPC)and dorsolateral prefrontal cortex(diPFC)increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety symptoms.By multiple linear regression,the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self-reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image,after controlling for age,age of onset and body mass index.The RSFC in the dIPFC to the middle temporal gyrus and the superior frontal gyrus may be significant factors in the treatment response to binge eating and loss of control/overeating in patients with AN.Conclusions Alterations in RSFC in the FPCN appear to affect self-reported eating disorder symptoms and treatment response in patients with AN.Our findings offer new insight into the pathogenesis of AN and could promote early prevention and treatment.

Quantifying the Microeconomic and Macroeconomic Impact of the Recent Crude Oil Price Fluctuations

This study analyzed the potential impact of the increased oil volatility on the industries and the global economy. Specifically, it separated the oil price fluctuations into positive and negative components, and modeled the return of industry portfolios with them. Next, the sensitivity of the airline industry to oil price was investigated to gauge the effectiveness of their hedging strategies, with the hope that the methodology can be extended to other industries. In addition, this paper explored the macroeconomic impact of oil price movements by examining the benchmarks such as GDP and CPI.

共同体视域下高校阅读推广策略研究

文章详细阐述了共同体视域下开展阅读推广的问题缘起及现实理路,剖析了共同体理念融入高校阅读推广的耦合逻辑。同时,从规范搭建共同体顶层架构以夯实决策根基、科学定位共同体工作计划以确定运行目标、建立健全共同体运行机制以保证发展永续以及全面优化共同体运行环境以强化支撑合力等几个方面,论述了高校依托共同体理念开展阅读推广的具体策略。

基于目标导向的高分子化学课程思政实践与探索

课程思政是专业教师在传递知识和培养能力过程中引导学生塑造正确的世界观、价值观和人生观,并与思政课程同向而行的教育新要求。本文以OBE(目标导向)的理念为指导,从课程目标、教学内容、教学方法、教学环节、教学模式和考核体系等方面实践和探索高分子化学课程思政。首先确定工程技术人才应具备的德育目标;其次挖掘出课程蕴含的思政元素;再次在实践中运用多种教学模式助力思政教学;然后构建可衡量可考核的考核体系;最后找出课程思政改进的途径。为高校教育在课程思政方面的改革提供有益的参考。

降低基本养老保险费率能促进企业年金参保和缴费吗?——基于政策体系视角的分析

"十三五"时期我国采取多种形式降低基本养老保险费率,"十四五"规划纲要则明确提出"提高企业年金覆盖率"。降低基本养老保险费率能否推动企业年金发展的问题值得研究。基于政策体系视角的分析表明,对于降低基本养老保险费率,政策制定者、执行者和目标群体利益、理念一致,制度安排保障了行动者的意愿和能力。对于企业年金,主要政策行动者利益、理念分化,制度安排无法为政策的执行和遵从提供足够的激励和约束。因此,预测仅降低基本养老保险费率无法推动企业年金发展。实证研究部分利用2016年阶段性降低企业职工基本养老保险单位缴费比例形成的准自然实验,以2013—2018年A股上市公司为样本,识别降低基本养老保险费率对企业年金参保和缴费的影响。研究发现,虽然企业基本养老保险实际缴费负担有所下降,但企业年金参保和缴费并无显著变化。建议保障目标群体能够受益或不受损,以形成共享的理念,传递政策制定者信念,赋予执行者和目标群体行动权力,以推动政策落实,三方合力推进企业年金发展。

住房公积金缴存比例的调整对谁有利?——基于社会建构理论的分析

【问题】《关于规范和阶段性适当降低住房公积金缴存比例的通知》要求企业缴存比例不得超过12%,地方政府阶段性降低缴存比例,不同企业如何反应?由此带来何种分配后果?【方法】基于社会建构理论,预测政策对缴存比例超过12%的企业无效,对缴存比例接近下限的企业有效,并以2015—2017年A股上市公司为样本,采用双重差分倾向得分匹配法检验。【发现】各利益相关者存在差别化反馈:(1)隐蔽性获益者:事前缴存比例超过12%的企业维持违规超缴,事前缴存比例低于下限的企业或维持缴存不变而转化为合规或进一步违规降低缴存,二者作为竞争者藉由可预见的执行偏差隐蔽性获益。(2)实质性获益者:事前缴存比例介于下限和12%之间的企业保持合规,缴存或不变或降低,作为优势者实质性获益,且因政策模糊避免被负面建构。(3)利益受损者:职工失去企业配款才能提高现金收入,作为依赖者支付隐蔽性成本而收益减少。【贡献】不仅直接评估政策结果,还识别出三种确保利益分配模式实现的政策设计策略:政策模糊以避免优势者被负面建构;可预见的政策执行偏差(执行不足和过度执行)使竞争者隐蔽性获益;隐蔽性成本减少依赖者净收益。

冻融作用下固化盐渍土的强度劣化及微观机理研究

为探讨固化硫酸盐渍土在冻融循环作用下的强度劣化机理,采用室内正交试验,考虑冻融循环周期、固化剂掺量、含盐量等影响因素,借助三轴试验、X射线衍射(diffraction of X-rays, XRD)衍射试验及电镜扫描试验。对粉煤灰、氯化钙固化硫酸盐渍土在不同冻融循环周期作用下的强度劣化指标及微观结构演化规律进行了研究。结果表明:冻融循环作用对固化硫酸盐渍土强度劣化影响较大,且对黏聚力影响相较内摩擦角更显著;衍射分析表明固化效果越好,固化剂反应物的低矮峰越多,同时电镜扫描分析也表明:土体结构越紧密,强度更优;在处理盐渍土地基时,从抑制盐胀及提高土体耐久性效果来看,单掺氯化钙优于单掺粉煤灰,且复掺优于单掺。不同含盐量的最佳配合比:含盐量为2%时,10%粉煤灰+4%氯化钙;含盐量为5%时,10%粉煤灰+6%氯化钙;含盐量为8%时,15%的粉煤灰+6%的氯化钙。固化后土体的强度指标劣化程度较低。从微观角度出发对冻融循环下硫酸盐渍土的强度劣化进行研究,旨在为长期冻融的硫酸盐渍土提出理论依据,以减少不必要的经济损失。

冻融干湿循环下硫酸盐渍土的微观孔隙研究

为研究冻融干湿循环对宁夏地区硫酸盐渍土微观孔隙结构的影响,在6次冻融干湿循环后,对试样进行SEM和MIP试验,借助ImageJ2X图像处理技术,从表观孔隙率、孔隙分布和孔隙分形维数3个角度分析其微观孔隙结构。结果表明:(1)经历6次冻融干湿循环后,含盐量较低(S≤1%)时,不同压实度下硫酸盐渍土的表观孔隙率随含盐量的增加均呈现先增大后减小的变化趋势,并在0.5%时达到峰值,1%时处于低谷;含盐量大于1%时,低压实度(K<95%)土体表观孔隙率随含盐量增加持续增大,而高压实度(K≥95%)土体则呈现先小幅增大后减小的变化趋势;(2)相较于未经冻融干湿循环的情况,土体最终表观孔隙率均有所增大。为提高工程的耐久性,建议硫酸盐渍土地基的压实度宜大于等于95%。(3)随含盐量的增加,孔隙孔径的变化主要集中在3~40 um区间内,孔隙分布的变化也主要体现在大孔隙、中孔隙上,且表观孔隙率与大孔隙体积百分含量变化基本一致;(4)基于MIP数据拟合得到土体孔隙分形维数随含盐量的增加呈上下波动,且其与表观孔隙率、大孔隙体积百分含量变化趋势相反。本研究有助于丰富硫酸盐渍土的微观理论,为硫酸盐渍土地区的工程建设提供理论支撑。