Under the conditions of microwave irradiation,6-indole hydrazide were obtained by hydrazinolysising 6-methyl formate indole,which then react with different aromatic aldehydes to gain corresponding hydrazones 3a^3d.Int...Under the conditions of microwave irradiation,6-indole hydrazide were obtained by hydrazinolysising 6-methyl formate indole,which then react with different aromatic aldehydes to gain corresponding hydrazones 3a^3d.Intermediates 3a^3d were treated with anhydride to afford four new 3-acetyl-2-aryl-5-(6-indole)-1,3,4-oxadiazolines by using microwave.The structures of all new compounds were characterized by 1H NMR,IR,MS spectra and elemental analysis.展开更多
Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtaine...Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtained.Subsequently,the key epoxide 5 was obtained in excellent yield via an epoxidation from the compound 4.Finally,the process of opening of epoxy ring by azole-bases resulted in the novel carbocyclic azole nucleoside compounds 6-10 in the presence of 1,8-diazabicycloundec-7-ene(DBU) as catalyst,which appeared strong regioselectivity.展开更多
From α acetylthioformanilide and thio semicarbazide eight heterocyclic compounds of substituted phenylamino 6 metyl 1,2,4 triazine 3 thiones were synthesized.Their structures were confirmed by elemental analysis, 1HN...From α acetylthioformanilide and thio semicarbazide eight heterocyclic compounds of substituted phenylamino 6 metyl 1,2,4 triazine 3 thiones were synthesized.Their structures were confirmed by elemental analysis, 1HNMR,IR and MS.展开更多
文摘Under the conditions of microwave irradiation,6-indole hydrazide were obtained by hydrazinolysising 6-methyl formate indole,which then react with different aromatic aldehydes to gain corresponding hydrazones 3a^3d.Intermediates 3a^3d were treated with anhydride to afford four new 3-acetyl-2-aryl-5-(6-indole)-1,3,4-oxadiazolines by using microwave.The structures of all new compounds were characterized by 1H NMR,IR,MS spectra and elemental analysis.
文摘Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtained.Subsequently,the key epoxide 5 was obtained in excellent yield via an epoxidation from the compound 4.Finally,the process of opening of epoxy ring by azole-bases resulted in the novel carbocyclic azole nucleoside compounds 6-10 in the presence of 1,8-diazabicycloundec-7-ene(DBU) as catalyst,which appeared strong regioselectivity.
文摘From α acetylthioformanilide and thio semicarbazide eight heterocyclic compounds of substituted phenylamino 6 metyl 1,2,4 triazine 3 thiones were synthesized.Their structures were confirmed by elemental analysis, 1HNMR,IR and MS.
