Objective Pertussis cases have increased markedly since 2018 in Guangxi.The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.Method A total of 10,215 s...Objective Pertussis cases have increased markedly since 2018 in Guangxi.The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.Method A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay(ELISA).Results Of the collected samples,1,833(17.94%)tested positive for anti-pertussis IgG,with the median concentration of 16.06 IU/mL.Antibody level<10 IU/mL accounted for more than 60%in children under 4 years of age,but declined with age,whereas the percentages of the other three levels(10-40,40-50,and≥50 IU/mL)increased almost with age(P<0.001).Moreover,7,924 samples were selected for anti-pertussis toxin IgG,of which 653(8.24%)tested positive(≥40 IU/mL)with the median concentration of 5.89 IU/mL,and 204 participants(2.56%)had recent pertussis infection(≥100 IU/mL).Among the different age groups,the highest rates of positivity and recent infection were observed at 11-20 years of age,the lowest positivity rate at 5 years of age,and the lowest recent infection rate at 4 years of age(P<0.001,P=0.005,respectively).Conclusion The survey results showed that all age groups in Guangxi lacked immunity against pertussis,which was one of the main factors contributing to the resurgence of pertussis in 2018.In addition,the prevalence of pertussis is relatively high in Guangxi,and its incidence is seriously underestimated,especially in adolescents and adults.展开更多
目的 探讨克罗恩病(Crohn’s disease, CD)患者血清25(OH)D水平与病变部位、疾病活动性、肠道炎症程度以及激素治疗等因素的相关性。方法 收集2020年1月至2022年12月在南京鼓楼医院就诊的CD患者97例,及同期在体检中心进行健康体检者79...目的 探讨克罗恩病(Crohn’s disease, CD)患者血清25(OH)D水平与病变部位、疾病活动性、肠道炎症程度以及激素治疗等因素的相关性。方法 收集2020年1月至2022年12月在南京鼓楼医院就诊的CD患者97例,及同期在体检中心进行健康体检者79例。比较两组人群25(OH)D水平的差异。记录CD患者就诊时的一般资料、临床表现、肠镜检查结果、白细胞计数(WBC)、血红蛋白(Hb)、C反应蛋白(CRP)、血沉(ESR)、血清白蛋白(ALB)水平及用药情况,并分析25(OH)D水平与其相关性。结果 CD组的25(OH)D水平显著低于健康对照组[12.87(3.00~33.84)ng/mL vs 19.97(16.28~39.61)ng/mL](Z=-8.518,P<0.001),回结肠病变的CD患者25(OH)D水平显著低于回肠病变者[11.07(3.00~33.84)ng/mL vs 14.68(3.00~27.59)ng/mL](Z=-2.081,P=0.037),回结肠病变的CD患者25(OH)D水平明显低于结肠病变者[11.07(3.00~33.84)ng/mL vs 12.63(5.29~24.54)ng/mL](Z=-0.177,P=0.860),缓解期患者25(OH)D水平明显高于轻度活动期患者[13.51(3.00~33.84)ng/mL vs 11.91(5.81~24.54)ng/mL](Z=-0.430,P=0.668),缓解期患者25(OH)D水平明显高于中度活动期患者[13.51(3.00~33.84)ng/mL vs 9.66(3.37~17.28)ng/mL](Z=-0.909,P=0.363),重度炎症组25(OH)D水平显著低于轻度炎症组[10.79(3.00~19.01)ng/mL vs 17.96(3.00~22.98)ng/mL](Z=-2.888,P<0.05),重度炎症组25(OH)D水平显著低于中度炎症组[10.79(3.00~19.01)ng/mL vs 13.39(3.37~33.84)ng/mL](Z=-2.502,P<0.05),Logistic回归回归分析显示,CRP≥8mg/L,ESR≥20mm/1h、激素治疗是VD缺乏的危险因素。结论 CD患者的VD水平降低,VD水平与病变部位、疾病活动度及炎症程度相关。感染、激素治疗是CD患者VD缺乏的危险因素,建议在CD的治疗过程中注意VD的合理补充。展开更多
基金approved by the Ethics Committee of the Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention(GXIRB 2018-0005),and the participants signed informed consent forms.
文摘Objective Pertussis cases have increased markedly since 2018 in Guangxi.The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.Method A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay(ELISA).Results Of the collected samples,1,833(17.94%)tested positive for anti-pertussis IgG,with the median concentration of 16.06 IU/mL.Antibody level<10 IU/mL accounted for more than 60%in children under 4 years of age,but declined with age,whereas the percentages of the other three levels(10-40,40-50,and≥50 IU/mL)increased almost with age(P<0.001).Moreover,7,924 samples were selected for anti-pertussis toxin IgG,of which 653(8.24%)tested positive(≥40 IU/mL)with the median concentration of 5.89 IU/mL,and 204 participants(2.56%)had recent pertussis infection(≥100 IU/mL).Among the different age groups,the highest rates of positivity and recent infection were observed at 11-20 years of age,the lowest positivity rate at 5 years of age,and the lowest recent infection rate at 4 years of age(P<0.001,P=0.005,respectively).Conclusion The survey results showed that all age groups in Guangxi lacked immunity against pertussis,which was one of the main factors contributing to the resurgence of pertussis in 2018.In addition,the prevalence of pertussis is relatively high in Guangxi,and its incidence is seriously underestimated,especially in adolescents and adults.
文摘目的 探讨克罗恩病(Crohn’s disease, CD)患者血清25(OH)D水平与病变部位、疾病活动性、肠道炎症程度以及激素治疗等因素的相关性。方法 收集2020年1月至2022年12月在南京鼓楼医院就诊的CD患者97例,及同期在体检中心进行健康体检者79例。比较两组人群25(OH)D水平的差异。记录CD患者就诊时的一般资料、临床表现、肠镜检查结果、白细胞计数(WBC)、血红蛋白(Hb)、C反应蛋白(CRP)、血沉(ESR)、血清白蛋白(ALB)水平及用药情况,并分析25(OH)D水平与其相关性。结果 CD组的25(OH)D水平显著低于健康对照组[12.87(3.00~33.84)ng/mL vs 19.97(16.28~39.61)ng/mL](Z=-8.518,P<0.001),回结肠病变的CD患者25(OH)D水平显著低于回肠病变者[11.07(3.00~33.84)ng/mL vs 14.68(3.00~27.59)ng/mL](Z=-2.081,P=0.037),回结肠病变的CD患者25(OH)D水平明显低于结肠病变者[11.07(3.00~33.84)ng/mL vs 12.63(5.29~24.54)ng/mL](Z=-0.177,P=0.860),缓解期患者25(OH)D水平明显高于轻度活动期患者[13.51(3.00~33.84)ng/mL vs 11.91(5.81~24.54)ng/mL](Z=-0.430,P=0.668),缓解期患者25(OH)D水平明显高于中度活动期患者[13.51(3.00~33.84)ng/mL vs 9.66(3.37~17.28)ng/mL](Z=-0.909,P=0.363),重度炎症组25(OH)D水平显著低于轻度炎症组[10.79(3.00~19.01)ng/mL vs 17.96(3.00~22.98)ng/mL](Z=-2.888,P<0.05),重度炎症组25(OH)D水平显著低于中度炎症组[10.79(3.00~19.01)ng/mL vs 13.39(3.37~33.84)ng/mL](Z=-2.502,P<0.05),Logistic回归回归分析显示,CRP≥8mg/L,ESR≥20mm/1h、激素治疗是VD缺乏的危险因素。结论 CD患者的VD水平降低,VD水平与病变部位、疾病活动度及炎症程度相关。感染、激素治疗是CD患者VD缺乏的危险因素,建议在CD的治疗过程中注意VD的合理补充。
