目的探讨腹腔镜胆囊切除术与经皮导管引流术治疗高危急性胆囊炎患者的疗效。方法选择2015年2月23日—2021年1月30日资阳市人民医院肝胆外科收治的134例高危急性胆囊炎患者,分为腹腔镜胆囊切除组(n=66)和经皮导管引流组(n=68)。高危被定...目的探讨腹腔镜胆囊切除术与经皮导管引流术治疗高危急性胆囊炎患者的疗效。方法选择2015年2月23日—2021年1月30日资阳市人民医院肝胆外科收治的134例高危急性胆囊炎患者,分为腹腔镜胆囊切除组(n=66)和经皮导管引流组(n=68)。高危被定义为急性生理评估和慢性健康评估Ⅱ(APACHEⅡ)评分为7分或更高。主要终点是1年内死亡和主要并发症的发生,包括1个月内感染和心肺并发症,1年内需要再次干预(必须与急性胆囊炎相关的手术、放射或内镜检查),或复发1年内胆道疾病。分析两组患者的临床资料、手术情况及治疗结果。结果①两组基线资料比较差异无统计学意义(P>0.05)。②64例接受腹腔镜胆囊切除术。1例因伴胆管炎需接受内镜逆行胰胆管造影。1例患者因低钠血症接受保守治疗,2例在出院数周后接受选择性胆囊切除术,11例(17.2%)患者腹腔镜手术转为开腹胆囊切除术。68例接受经皮导管引流,其中65例(95.6%)手术成功,其余3例患者放射科医师未能将经皮管放入胆囊腔,其中2例患者接受了保守治疗,直到症状消失,1例患者因胆囊穿孔和造影剂外渗导致严重腹痛而需要紧急胆囊切除术。③腹腔镜胆囊切除术和经皮导管引流组的病死率无统计学意义(3.0%vs.8.8%,P=0.270):分配给胆囊切除术的66例患者中有8例(12.1%)和分配到经皮导管引流组68例患者中有44例(64.7%)出现主要并发症(风险比0.2,95%置信区间0.1~0.4;P<0.001)。经皮导管引流组有45例患者(66.2%)需要再次介入治疗,而胆囊切除组有8例患者(12.1%)需要再次介入治疗(P<0.001)。经皮导管引流组胆道疾病复发率高于腹腔镜胆囊切除组(52.9%vs.4.5%,P<0.001)。中位住院时间长于腹腔镜胆囊切除组(9 d vs.5 d,P<0.001)。结论与经皮导管引流相比,腹腔镜胆囊切除术治疗高危急性胆囊炎患者的并发症发生率和胆道疾病的复发率更低、住院时间更短,有助于后期患者身体恢复。展开更多
Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity hav...Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity have various effects in several diseases.We aimed to clarify the relationship between RAC and body parameters.Methods:Patients with AC who were treated at our hospital between January 2011 and March 2022 were enrolled.The psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of AC.The areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI groups.We performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of RAC.Results:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)groups.In the propensity score-matched cohort there were 57 patients in each group.In Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),respectively.Conclusions:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.展开更多
文摘目的探讨腹腔镜胆囊切除术与经皮导管引流术治疗高危急性胆囊炎患者的疗效。方法选择2015年2月23日—2021年1月30日资阳市人民医院肝胆外科收治的134例高危急性胆囊炎患者,分为腹腔镜胆囊切除组(n=66)和经皮导管引流组(n=68)。高危被定义为急性生理评估和慢性健康评估Ⅱ(APACHEⅡ)评分为7分或更高。主要终点是1年内死亡和主要并发症的发生,包括1个月内感染和心肺并发症,1年内需要再次干预(必须与急性胆囊炎相关的手术、放射或内镜检查),或复发1年内胆道疾病。分析两组患者的临床资料、手术情况及治疗结果。结果①两组基线资料比较差异无统计学意义(P>0.05)。②64例接受腹腔镜胆囊切除术。1例因伴胆管炎需接受内镜逆行胰胆管造影。1例患者因低钠血症接受保守治疗,2例在出院数周后接受选择性胆囊切除术,11例(17.2%)患者腹腔镜手术转为开腹胆囊切除术。68例接受经皮导管引流,其中65例(95.6%)手术成功,其余3例患者放射科医师未能将经皮管放入胆囊腔,其中2例患者接受了保守治疗,直到症状消失,1例患者因胆囊穿孔和造影剂外渗导致严重腹痛而需要紧急胆囊切除术。③腹腔镜胆囊切除术和经皮导管引流组的病死率无统计学意义(3.0%vs.8.8%,P=0.270):分配给胆囊切除术的66例患者中有8例(12.1%)和分配到经皮导管引流组68例患者中有44例(64.7%)出现主要并发症(风险比0.2,95%置信区间0.1~0.4;P<0.001)。经皮导管引流组有45例患者(66.2%)需要再次介入治疗,而胆囊切除组有8例患者(12.1%)需要再次介入治疗(P<0.001)。经皮导管引流组胆道疾病复发率高于腹腔镜胆囊切除组(52.9%vs.4.5%,P<0.001)。中位住院时间长于腹腔镜胆囊切除组(9 d vs.5 d,P<0.001)。结论与经皮导管引流相比,腹腔镜胆囊切除术治疗高危急性胆囊炎患者的并发症发生率和胆道疾病的复发率更低、住院时间更短,有助于后期患者身体恢复。
基金This study was approved by the Ethics Committee of Kyushu Rosai Hospital Moji Medical Center(No:04-01,date of approval:June 2,2022).This study was conducted in compliance with the principles of the Declaration of Helsinki.
文摘Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity have various effects in several diseases.We aimed to clarify the relationship between RAC and body parameters.Methods:Patients with AC who were treated at our hospital between January 2011 and March 2022 were enrolled.The psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of AC.The areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI groups.We performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of RAC.Results:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)groups.In the propensity score-matched cohort there were 57 patients in each group.In Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),respectively.Conclusions:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.
