目的:探究腹腔镜胆囊切除术(LC)治疗老年急性结石性胆囊炎合并糖尿病的疗效及对肝功能、炎性反应的影响。方法:选取2019年4月~2022年4月福建省立医院(北院)收治的62例患有急性结石性胆囊炎合并糖尿病年长者为研究对象,分成LC组与开腹胆...目的:探究腹腔镜胆囊切除术(LC)治疗老年急性结石性胆囊炎合并糖尿病的疗效及对肝功能、炎性反应的影响。方法:选取2019年4月~2022年4月福建省立医院(北院)收治的62例患有急性结石性胆囊炎合并糖尿病年长者为研究对象,分成LC组与开腹胆囊切除术(OC)组各31例;LC组行LC治疗,OC组行OC治疗;比较两组手术指征、血糖、肝功能、炎性反应。结果:手术指征比较:LC组住院时间、手术时间、排气时间、术中出血量较OC组皆更小,差异均有统计学意义(P均<0.05);血糖比较:LC组术后糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)与OC组比较,均更低,差异有统计学意义(P均<0.05);肝功能比较:LC组白蛋白(ALB)较OC组更高,总胆红素(TBIL)、谷丙转氨酶(ALT)较OC组皆更低,差异均有统计学意义(P均<0.05);炎性反应比较:LC组内皮素(ET)、淀粉样蛋白(SAA)、肿瘤坏死因子-α(TNF)较OC组皆更低,差异均有统计学意义(P均<0.05)。结论:LC在老年急性结石性胆囊炎合并糖尿病治疗中手术效果优于OC,能有效控制血糖,降低肝功能损伤及炎性反应水平。展开更多
目的分析PTGD后择期LC治疗对GradeⅡ急性胆囊炎ACTH、MPO及Cor水平的影响。方法选取2021年12月至2023年5月安徽中科庚玖医院收治的急性胆囊炎患者121例,根据治疗方案分为三组,即甲组(急诊行LC治疗,未行PTGD)38例、乙组(PTGD引流管拔出后...目的分析PTGD后择期LC治疗对GradeⅡ急性胆囊炎ACTH、MPO及Cor水平的影响。方法选取2021年12月至2023年5月安徽中科庚玖医院收治的急性胆囊炎患者121例,根据治疗方案分为三组,即甲组(急诊行LC治疗,未行PTGD)38例、乙组(PTGD引流管拔出后72 h后行LC,早期)43例和丙组(PTGD引流管拔出后14~30 d后行LC,晚期)40例。对比三组手术情况、炎症因子、肝功能、ACTH、MP、Cor水平及并发症发生率。结果甲组LC手术时长、术后卧床时长及住院天数均长于丙组、乙组,失血量、中转开腹率高于丙组、乙组,差异有统计学意义(P<0.05);丙组LC手术时长、术后卧床时长及住院天数均长于乙组,差异具有统计学意义(P<0.05)。LC术后1 d hs-CRP、PCT、IL-6、ST、ALT、ALP、ACTH、MPO及Cor:甲组>丙组>乙组,差异有统计学意义(P<0.05)。并发症发生率:甲组>丙组>乙组,差异有统计学意义(P<0.05)。结论PTGD后择期LC治疗对GradeⅡ急性胆囊炎ACTH、MPO及Cor水平影响小,且并发症低;而PTGD后早期行LC能有效改善肝功能、炎症因子,且术后应激反应更低,值得临床推广。展开更多
Anomalies in the gallbladder can lead to misidentifying anatomical structures,heightening the risk of complications in laparoscopic and open cholecystectomy procedures.Failure to recognize these variations increases t...Anomalies in the gallbladder can lead to misidentifying anatomical structures,heightening the risk of complications in laparoscopic and open cholecystectomy procedures.Failure to recognize these variations increases the chances of iatrogenic bile duct injuries and other complications.展开更多
Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency de...Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency department(ED)experiencing severe distress,with most describing their pain level as“intolerable.”[4]Furthermore,there is usually a considerable delay before surgery,with a median time from diagnosis of AC to surgery of 28.5 h,[5]and a substantial percentage of patients wait as long as 10 d.[6]Prolonged delays before surgery lead to increased opioid use,which is associated with extended hospital stays and higher rates of readmission after cholecystectomy.[7]Furthermore,opioids can lead to vomiting,respiratory depression,delirium,and ultimately addiction.[8]We propose a novel regional anesthesia technique for managing AC:right phrenic nerve blockade.This method could offer improved pain control and a more favorable risk profile in selected patients when compared to current ED practices.展开更多
文摘目的:探究腹腔镜胆囊切除术(LC)治疗老年急性结石性胆囊炎合并糖尿病的疗效及对肝功能、炎性反应的影响。方法:选取2019年4月~2022年4月福建省立医院(北院)收治的62例患有急性结石性胆囊炎合并糖尿病年长者为研究对象,分成LC组与开腹胆囊切除术(OC)组各31例;LC组行LC治疗,OC组行OC治疗;比较两组手术指征、血糖、肝功能、炎性反应。结果:手术指征比较:LC组住院时间、手术时间、排气时间、术中出血量较OC组皆更小,差异均有统计学意义(P均<0.05);血糖比较:LC组术后糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)与OC组比较,均更低,差异有统计学意义(P均<0.05);肝功能比较:LC组白蛋白(ALB)较OC组更高,总胆红素(TBIL)、谷丙转氨酶(ALT)较OC组皆更低,差异均有统计学意义(P均<0.05);炎性反应比较:LC组内皮素(ET)、淀粉样蛋白(SAA)、肿瘤坏死因子-α(TNF)较OC组皆更低,差异均有统计学意义(P均<0.05)。结论:LC在老年急性结石性胆囊炎合并糖尿病治疗中手术效果优于OC,能有效控制血糖,降低肝功能损伤及炎性反应水平。
文摘目的分析PTGD后择期LC治疗对GradeⅡ急性胆囊炎ACTH、MPO及Cor水平的影响。方法选取2021年12月至2023年5月安徽中科庚玖医院收治的急性胆囊炎患者121例,根据治疗方案分为三组,即甲组(急诊行LC治疗,未行PTGD)38例、乙组(PTGD引流管拔出后72 h后行LC,早期)43例和丙组(PTGD引流管拔出后14~30 d后行LC,晚期)40例。对比三组手术情况、炎症因子、肝功能、ACTH、MP、Cor水平及并发症发生率。结果甲组LC手术时长、术后卧床时长及住院天数均长于丙组、乙组,失血量、中转开腹率高于丙组、乙组,差异有统计学意义(P<0.05);丙组LC手术时长、术后卧床时长及住院天数均长于乙组,差异具有统计学意义(P<0.05)。LC术后1 d hs-CRP、PCT、IL-6、ST、ALT、ALP、ACTH、MPO及Cor:甲组>丙组>乙组,差异有统计学意义(P<0.05)。并发症发生率:甲组>丙组>乙组,差异有统计学意义(P<0.05)。结论PTGD后择期LC治疗对GradeⅡ急性胆囊炎ACTH、MPO及Cor水平影响小,且并发症低;而PTGD后早期行LC能有效改善肝功能、炎症因子,且术后应激反应更低,值得临床推广。
文摘Anomalies in the gallbladder can lead to misidentifying anatomical structures,heightening the risk of complications in laparoscopic and open cholecystectomy procedures.Failure to recognize these variations increases the chances of iatrogenic bile duct injuries and other complications.
文摘Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency department(ED)experiencing severe distress,with most describing their pain level as“intolerable.”[4]Furthermore,there is usually a considerable delay before surgery,with a median time from diagnosis of AC to surgery of 28.5 h,[5]and a substantial percentage of patients wait as long as 10 d.[6]Prolonged delays before surgery lead to increased opioid use,which is associated with extended hospital stays and higher rates of readmission after cholecystectomy.[7]Furthermore,opioids can lead to vomiting,respiratory depression,delirium,and ultimately addiction.[8]We propose a novel regional anesthesia technique for managing AC:right phrenic nerve blockade.This method could offer improved pain control and a more favorable risk profile in selected patients when compared to current ED practices.
