BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare,life-threatening disorder caused by abnormal histiocytes and T cell activation.In adults,it is predominantly associated with infections,cancers,and autoimmun...BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare,life-threatening disorder caused by abnormal histiocytes and T cell activation.In adults,it is predominantly associated with infections,cancers,and autoimmune diseases.Relapsing polychondritis(RP),another rare disease,is diagnosed based on symptoms without specific tests,featuring cartilage inflammation characterized by swelling,redness,and pain,rarely inducing HLH.CASE SUMMARY A 74-year-old woman visited the emergency room with a fever of 38.6℃.Blood tests,cultures,and imaging were performed to evaluate fever.Results showed increased fluorescent antinuclear antibody levels and mild cytopenia,with no other specific findings.Imaging revealed lymph node enlargement was observed;however,biopsy results were inconclusive.Upon re-evaluation of the physical exam,inflammatory signs suggestive of RP were observed in the ears and nose,prompting a tissue biopsy for confirmation.Simultaneously,persistent fever accompanied by cytopenia prompted a bone marrow examination,revealing hemophagocytic cells.After finding no significant results in blood culture,viral markers,and tissue examination of enlarged lymph nodes,HLH was diagnosed by RP.Treatment involved methylprednisolone followed by azathioprine.After two months,bone marrow examination confirmed resolution of hemophagocytosis,with normalization of hyperferritinemia and pancytopenia.CONCLUSION Thorough physical examination enabled diagnosis and treatment of HLH trig gered by RP in patients presenting with fever of unknown origin.展开更多
目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分...目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分别采用疼痛视觉模拟评分（VAS）和美国足踝医师协会后足与踝关节评分（AOFAS HA score）对患者术前、术后12个月的疼痛情况和功能进行评价,部分患者在术后12个月随访时通过核磁共振影像对距骨软骨进行评价。结果 94例患者获得随访,随访时间（22.8±10.3）个月。VAS从术前的（4.51±0.84）分下降到术后的（0.98±0.90）分;AOFAS HA评分从术前的平均75分提高到术后的平均91分。25例患者记录了术后核磁共振影像,软骨修复情况均较术前影像有改善。结论踝关节镜下微骨折手术治疗距骨骨软骨损伤简单、安全,效果可靠、满意。展开更多
文摘BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare,life-threatening disorder caused by abnormal histiocytes and T cell activation.In adults,it is predominantly associated with infections,cancers,and autoimmune diseases.Relapsing polychondritis(RP),another rare disease,is diagnosed based on symptoms without specific tests,featuring cartilage inflammation characterized by swelling,redness,and pain,rarely inducing HLH.CASE SUMMARY A 74-year-old woman visited the emergency room with a fever of 38.6℃.Blood tests,cultures,and imaging were performed to evaluate fever.Results showed increased fluorescent antinuclear antibody levels and mild cytopenia,with no other specific findings.Imaging revealed lymph node enlargement was observed;however,biopsy results were inconclusive.Upon re-evaluation of the physical exam,inflammatory signs suggestive of RP were observed in the ears and nose,prompting a tissue biopsy for confirmation.Simultaneously,persistent fever accompanied by cytopenia prompted a bone marrow examination,revealing hemophagocytic cells.After finding no significant results in blood culture,viral markers,and tissue examination of enlarged lymph nodes,HLH was diagnosed by RP.Treatment involved methylprednisolone followed by azathioprine.After two months,bone marrow examination confirmed resolution of hemophagocytosis,with normalization of hyperferritinemia and pancytopenia.CONCLUSION Thorough physical examination enabled diagnosis and treatment of HLH trig gered by RP in patients presenting with fever of unknown origin.
文摘目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分别采用疼痛视觉模拟评分（VAS）和美国足踝医师协会后足与踝关节评分（AOFAS HA score）对患者术前、术后12个月的疼痛情况和功能进行评价,部分患者在术后12个月随访时通过核磁共振影像对距骨软骨进行评价。结果 94例患者获得随访,随访时间（22.8±10.3）个月。VAS从术前的（4.51±0.84）分下降到术后的（0.98±0.90）分;AOFAS HA评分从术前的平均75分提高到术后的平均91分。25例患者记录了术后核磁共振影像,软骨修复情况均较术前影像有改善。结论踝关节镜下微骨折手术治疗距骨骨软骨损伤简单、安全,效果可靠、满意。
