The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A si...The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.展开更多
Cardanol is a biobased raw material derived from cashew nut shell liquid. In order to extend its utility, new derivatives and additional applications are useful. In this work cardanol was first epoxidized, and a novel...Cardanol is a biobased raw material derived from cashew nut shell liquid. In order to extend its utility, new derivatives and additional applications are useful. In this work cardanol was first epoxidized, and a novel aniline derivative prepared from it under mild reaction conditions with the help of an ionic liquid catalyst. The reaction chemistry was studied by using nuclear magnetic reso- nance. The resulting aminohydrin adduct showed antiox- idant property and should also be a useful synthon for further reactions. As an example, the aminohydrin was shown to undergo a condensation reaction with formalde- hyde to form a prepolymer, which could be further reacted to form thermosetting resins.展开更多
A novel and facile method for selective ortho-C--H monofluorination of aniline derivatives was achieved using Selectfluor/Cu（OAc）JHOAc system. The reaction proceeded via electrophilic process with diverse substrates...A novel and facile method for selective ortho-C--H monofluorination of aniline derivatives was achieved using Selectfluor/Cu（OAc）JHOAc system. The reaction proceeded via electrophilic process with diverse substrates in acceptable moderate to high yields. The position selectivity was controlled by bidentate coordination of picolinic acid amides with copper.展开更多
基金Supported by the National Basic Research Program of China under Grant No 2013AA032202, and the National Natural Science Foundation of China under Grant Nos 11005019 and 11375047.
文摘The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.
文摘Cardanol is a biobased raw material derived from cashew nut shell liquid. In order to extend its utility, new derivatives and additional applications are useful. In this work cardanol was first epoxidized, and a novel aniline derivative prepared from it under mild reaction conditions with the help of an ionic liquid catalyst. The reaction chemistry was studied by using nuclear magnetic reso- nance. The resulting aminohydrin adduct showed antiox- idant property and should also be a useful synthon for further reactions. As an example, the aminohydrin was shown to undergo a condensation reaction with formalde- hyde to form a prepolymer, which could be further reacted to form thermosetting resins.
文摘A novel and facile method for selective ortho-C--H monofluorination of aniline derivatives was achieved using Selectfluor/Cu（OAc）JHOAc system. The reaction proceeded via electrophilic process with diverse substrates in acceptable moderate to high yields. The position selectivity was controlled by bidentate coordination of picolinic acid amides with copper.
