Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and deterioration of bone architecture, resulting in reduced bone strength and, consequently, increased susceptibility to fra...Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and deterioration of bone architecture, resulting in reduced bone strength and, consequently, increased susceptibility to fractures which poses a significant public health concern worldwide, particularly in aging populations [1]. The health-economic impact of vertebral and hip fractures has been extensively explored and it is well known that these fractures are associated with morbidity/disability and increased mortality;they also account for a substantial portion of the direct fracture costs. This review aims to provide a comprehensive overview of osteoporosis, including its pathophysiology, risk factors, diagnostic approaches, and management strategies. By elucidating the multifaceted nature of this condition, healthcare providers can better identify individuals at risk, implement preventive measures, and optimize treatment to reduce the burden of osteoporotic fractures.展开更多
Task-based syllabus (TBS) is organized around tasks. The basic theoretical foundation of TBS is Krashen's acquisition theory.from the L2 acquisition theory. The characteristic of TBS is focus of process of learnin...Task-based syllabus (TBS) is organized around tasks. The basic theoretical foundation of TBS is Krashen's acquisition theory.from the L2 acquisition theory. The characteristic of TBS is focus of process of learning. TBS can improve communicative competence of learners, but it ignores grammar learning and teaching. The application of TBS in China is wide and the author provides an example.展开更多
目的评价液基薄层细胞学检查(Thinprep cytologic test TCT)在妇女宫颈病变筛查中的诊断价值。方法用宫颈细胞采集刷采集宫颈细胞标本,连同采集刷放入专用的细胞保存液中,并应用液基薄层技术制片。按照Bechesda报告系统(Bethesda System...目的评价液基薄层细胞学检查(Thinprep cytologic test TCT)在妇女宫颈病变筛查中的诊断价值。方法用宫颈细胞采集刷采集宫颈细胞标本,连同采集刷放入专用的细胞保存液中,并应用液基薄层技术制片。按照Bechesda报告系统(Bethesda System for Reporting Cervical Cytology TBS)进行诊断,并对非典型鳞状细胞-意义不明确(ASC-US))以上病变行阴道镜活检,做病理对照。结果 3966例标本共检出阳性病例96例,其中非典型鳞状细胞-意义不明确(ASC-US)53例占总检查人数的1.3%、低度鳞状上皮内病变(LSIL)15例占0.7%、高度鳞状上皮内病变(HSIL)15例0.4%,非典型腺细胞(AGC)1例占0.0002%。LSIL、HSIL与病理诊断符合率占92.6%、100%。结论积极治疗宫颈炎症,可有效预防宫颈恶性病变的发生,液基薄层细胞学检查与病理活检有较高的符合率,提高了宫颈疾病的检出率。展开更多
目的评价液基薄层细胞学检查（Thinprep cytologic test TCT）在健康妇女宫颈病变筛查中的诊断价值。方法用特制宫颈刷采集宫颈细胞标本，连同宫颈刷放入专用的细胞保存液中，采用TCT技术制片。按照Bechesda报告系统（Bechesda System f...目的评价液基薄层细胞学检查（Thinprep cytologic test TCT）在健康妇女宫颈病变筛查中的诊断价值。方法用特制宫颈刷采集宫颈细胞标本，连同宫颈刷放入专用的细胞保存液中，采用TCT技术制片。按照Bechesda报告系统（Bechesda System for Reporting Cervical Cytologr TBS）进行诊断，并对低度鳞状上皮内病变（LSIL）以上病变行阴道镜活检，做病理对照。结果8487人共检出阳性病例189例，其中非典型鳞状细胞，意义不明确（ASC—US）174例占2．05％、低度鳞状上皮内病变（LSIL）13例占0．15％、高度鳞状上皮内病变（HSIL）2例0．02％。LSIL、HSIL与病理诊断符合率占84．6％、100％。结论液积薄层细胞学检查与病理活检有较高的符合率，提高了异常细胞特别是宫颈病变的检出率。展开更多
An efficient and selective method for the deprotection of primary alcoholic tert-butyl-dimethylsilyl (TBS) ethers using SnCl_2·2H_2O as catalyst is described. The reaction conditionsallow primary alcoholic TBS et...An efficient and selective method for the deprotection of primary alcoholic tert-butyl-dimethylsilyl (TBS) ethers using SnCl_2·2H_2O as catalyst is described. The reaction conditionsallow primary alcoholic TBS ethers to be desilylated chemoselectively in the presence of phenolicTBS ethers, secondary and tertiary alcolholic TBS ethers, and the extensively used TBDPS-,acetyl-, benzyloxycarbonyl-, p-toluenesulfonyl- and benzyl protective groups.展开更多
文摘Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and deterioration of bone architecture, resulting in reduced bone strength and, consequently, increased susceptibility to fractures which poses a significant public health concern worldwide, particularly in aging populations [1]. The health-economic impact of vertebral and hip fractures has been extensively explored and it is well known that these fractures are associated with morbidity/disability and increased mortality;they also account for a substantial portion of the direct fracture costs. This review aims to provide a comprehensive overview of osteoporosis, including its pathophysiology, risk factors, diagnostic approaches, and management strategies. By elucidating the multifaceted nature of this condition, healthcare providers can better identify individuals at risk, implement preventive measures, and optimize treatment to reduce the burden of osteoporotic fractures.
文摘Task-based syllabus (TBS) is organized around tasks. The basic theoretical foundation of TBS is Krashen's acquisition theory.from the L2 acquisition theory. The characteristic of TBS is focus of process of learning. TBS can improve communicative competence of learners, but it ignores grammar learning and teaching. The application of TBS in China is wide and the author provides an example.
文摘目的评价液基薄层细胞学检查(Thinprep cytologic test TCT)在妇女宫颈病变筛查中的诊断价值。方法用宫颈细胞采集刷采集宫颈细胞标本,连同采集刷放入专用的细胞保存液中,并应用液基薄层技术制片。按照Bechesda报告系统(Bethesda System for Reporting Cervical Cytology TBS)进行诊断,并对非典型鳞状细胞-意义不明确(ASC-US))以上病变行阴道镜活检,做病理对照。结果 3966例标本共检出阳性病例96例,其中非典型鳞状细胞-意义不明确(ASC-US)53例占总检查人数的1.3%、低度鳞状上皮内病变(LSIL)15例占0.7%、高度鳞状上皮内病变(HSIL)15例0.4%,非典型腺细胞(AGC)1例占0.0002%。LSIL、HSIL与病理诊断符合率占92.6%、100%。结论积极治疗宫颈炎症,可有效预防宫颈恶性病变的发生,液基薄层细胞学检查与病理活检有较高的符合率,提高了宫颈疾病的检出率。
文摘目的评价液基薄层细胞学检查（Thinprep cytologic test TCT）在健康妇女宫颈病变筛查中的诊断价值。方法用特制宫颈刷采集宫颈细胞标本，连同宫颈刷放入专用的细胞保存液中，采用TCT技术制片。按照Bechesda报告系统（Bechesda System for Reporting Cervical Cytologr TBS）进行诊断，并对低度鳞状上皮内病变（LSIL）以上病变行阴道镜活检，做病理对照。结果8487人共检出阳性病例189例，其中非典型鳞状细胞，意义不明确（ASC—US）174例占2．05％、低度鳞状上皮内病变（LSIL）13例占0．15％、高度鳞状上皮内病变（HSIL）2例0．02％。LSIL、HSIL与病理诊断符合率占84．6％、100％。结论液积薄层细胞学检查与病理活检有较高的符合率，提高了异常细胞特别是宫颈病变的检出率。
文摘An efficient and selective method for the deprotection of primary alcoholic tert-butyl-dimethylsilyl (TBS) ethers using SnCl_2·2H_2O as catalyst is described. The reaction conditionsallow primary alcoholic TBS ethers to be desilylated chemoselectively in the presence of phenolicTBS ethers, secondary and tertiary alcolholic TBS ethers, and the extensively used TBDPS-,acetyl-, benzyloxycarbonyl-, p-toluenesulfonyl- and benzyl protective groups.
