Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of R...Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.展开更多
[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury ...[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.展开更多
目的探讨桃仁承气汤化裁联合西医序贯治疗对2型糖尿病(T2DM)患者中医证候积分及血糖波动、血清白脂素(Asprosin)水平的影响。方法选取90例T2DM患者,并将其随机分成序贯组(n=45)和中医组(n=45)。序贯组44例(脱落1例)先开展胰岛素强化治疗...目的探讨桃仁承气汤化裁联合西医序贯治疗对2型糖尿病(T2DM)患者中医证候积分及血糖波动、血清白脂素(Asprosin)水平的影响。方法选取90例T2DM患者,并将其随机分成序贯组(n=45)和中医组(n=45)。序贯组44例(脱落1例)先开展胰岛素强化治疗,之后改用度拉糖肽治疗;中医组44例(脱落1例)在序贯组基础上加用桃仁承气汤化裁方治疗。比较2组治疗前、治疗8周后中医证候积分、血糖波动参数及空腹血糖(FPG)、胰岛功能指标及血清Asprosin水平。结果治疗8周后,2组中医证候积分、血糖标准差(SDBG)、平均血糖波动幅度(MAGE)及FPG、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰高血糖素、空腹和餐后2 h C肽、血清Asprosin水平与治疗前比较,差异有统计学意义(P<0.05);中医组除SDBG以外的其他指标水平与序贯组比较,差异有统计学意义(P<0.05)。结论桃仁承气汤化裁方联合西医序贯治疗可明显下调T2DM患者血清Asprosin水平及中医证候积分,有效控制血糖波动,显著改善胰岛功能。展开更多
基金National Natural Science Foundation Youth Project (81804098)Jiangsu Natural Science Foundation Youth Project (BK20180219).
文摘Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.
文摘[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.
文摘目的探讨桃仁承气汤化裁联合西医序贯治疗对2型糖尿病(T2DM)患者中医证候积分及血糖波动、血清白脂素(Asprosin)水平的影响。方法选取90例T2DM患者,并将其随机分成序贯组(n=45)和中医组(n=45)。序贯组44例(脱落1例)先开展胰岛素强化治疗,之后改用度拉糖肽治疗;中医组44例(脱落1例)在序贯组基础上加用桃仁承气汤化裁方治疗。比较2组治疗前、治疗8周后中医证候积分、血糖波动参数及空腹血糖(FPG)、胰岛功能指标及血清Asprosin水平。结果治疗8周后,2组中医证候积分、血糖标准差(SDBG)、平均血糖波动幅度(MAGE)及FPG、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰高血糖素、空腹和餐后2 h C肽、血清Asprosin水平与治疗前比较,差异有统计学意义(P<0.05);中医组除SDBG以外的其他指标水平与序贯组比较,差异有统计学意义(P<0.05)。结论桃仁承气汤化裁方联合西医序贯治疗可明显下调T2DM患者血清Asprosin水平及中医证候积分,有效控制血糖波动,显著改善胰岛功能。
