A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield...A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.展开更多
A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed.In the presence of PhI(OAc)_(2) as promoter and under ambient conditions,the reactions of...A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed.In the presence of PhI(OAc)_(2) as promoter and under ambient conditions,the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding a-iodoketones without additional photocatalyst in good yields under sunlight irradiation.Mea nwhile,the reactions of styrenes with tribromomethane and trichloromethane generate the desiredα-bromoketones and a-chloroketones in high yields by using Ru(bpy)_(3)Cl_(2) as a photocatalyst under blue LED(450-455 nm) irradiation.展开更多
When ketones were treated with ammonium chloride and Oxone in MeOH at room temperature, a direct or-chlorination of ketones was occurred and a series of the corresponding α-chloroketones were obtained in moderate to ...When ketones were treated with ammonium chloride and Oxone in MeOH at room temperature, a direct or-chlorination of ketones was occurred and a series of the corresponding α-chloroketones were obtained in moderate to good yields after 24 h. In this reaction, ammonium chloride was used as the source of chlorine and Oxone was used as an oxidant. This method was simple, convenient and providing a novel procedure for preparation of α-chloroketones.展开更多
文摘A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.
基金the National Natural Science Foundation of China(No.21772062)for financial support。
文摘A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed.In the presence of PhI(OAc)_(2) as promoter and under ambient conditions,the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding a-iodoketones without additional photocatalyst in good yields under sunlight irradiation.Mea nwhile,the reactions of styrenes with tribromomethane and trichloromethane generate the desiredα-bromoketones and a-chloroketones in high yields by using Ru(bpy)_(3)Cl_(2) as a photocatalyst under blue LED(450-455 nm) irradiation.
基金Financial support from the Zhejiang Province Natural Science Foundation of China(No.Y4100231)
文摘When ketones were treated with ammonium chloride and Oxone in MeOH at room temperature, a direct or-chlorination of ketones was occurred and a series of the corresponding α-chloroketones were obtained in moderate to good yields after 24 h. In this reaction, ammonium chloride was used as the source of chlorine and Oxone was used as an oxidant. This method was simple, convenient and providing a novel procedure for preparation of α-chloroketones.
