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Square Wave Voltammetric Behavior of N,N-DiethyI-P-Nitroso Aniline an Indirect Method for Determination of Chlorpheniramin Maleate, Application of Pharmaceutical Formulations
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作者 Saddalah Tawfeeq Sulaiman Mohammed Ameen Abdullah Al-Imam Anfal Raad Mahmood 《Journal of Chemistry and Chemical Engineering》 2013年第4期292-298,共7页
The electrochemical behavior of N,N-diethyl-p-nitroso aniline was carried out using SWV (square wave voltammetric) at HMDE. A well defined reduction peak was observed at (-0.214) volt versus the reference electro... The electrochemical behavior of N,N-diethyl-p-nitroso aniline was carried out using SWV (square wave voltammetric) at HMDE. A well defined reduction peak was observed at (-0.214) volt versus the reference electrode (Ag/AgC1/sat. KCI), calibration curve was constructed in phosphate buffer (pH = 7.0), the relationship is linear within the concentration range 1.283 × 10.5 M - 3.66 × 10.5 M with the correlation (R = 0.9923). The serial addition ofCPM (chlorpheniramine maleate) leads to the decrease in the reduction current peak (Ip), quantitatively, the plot of Alp (Ip - Ip) where, Ip: Peak current of N, N-diethyl-p-nitroso aniline alone, lp: peak current of N,N-diethyl-p-nitroso aniline in the presence of CPM, versus concentration is linear within the concentration range 0.984 × 10-6 M - 9.756 × 10-6 M, the correlation coefficient was 0.9954. The method was successfully applied to determine CPM in different types of pharmaceutical formulations, and compared with standard method from British Pharmacopeia [1]. 展开更多
关键词 VOLTAMMETRIC chlorpheniramin maleate DETERMINATION pharmaceutical formulations.
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Near-infrared chemical imaging for quantitative analysis of chlorpheniramine maleate and distribution homogeneity assessment in pharmaceutical formulations 被引量:2
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作者 Manfei Xu Luwei Zhou +3 位作者 Qiao Zhang Zhisheng Wu Xinyuan Shi Yanjiang Qiao 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2016年第6期12-20,共9页
Near infrared chemical imaging(NIR-CI)combines conventional near infrared(NIR)spectros-copy with chemical imaging,thus provides spectral and spatial information simult aneously.It could be utilized to visualize the sp... Near infrared chemical imaging(NIR-CI)combines conventional near infrared(NIR)spectros-copy with chemical imaging,thus provides spectral and spatial information simult aneously.It could be utilized to visualize the spatial distribution of the ingredients in a sample.The data acquired using NIR CI instrument are hyperspectral data cube(hypercube)containing thousands of spectra.Chemometric methodologies are necessary to transform spectral information into chemical information.Partial least squares(PLS)method was performed to extract chemical information of chlorpheniramine maleate in pharmaceutical formulations.A series of samples which consisted of different CPM concentrations(w/w)were compressed and hypercube data were measured.The spectra extracted from the hypercube were used to establish the PLS model of CPM.The results of the model were R^(2)_(val)0.981,RMSEC 0.384%,RMSECV 0.483%,RMSEP 0.631%,indicating that this model was reliable. 展开更多
关键词 Near infrared chemical imaging partial least squares regression assessment of distributional homogeneity chlorpheniramine maleate
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