Potential applications of 7 Tesla magnetic resonance imaging in paediatric neuroimaging:Feasibility and challenges

The integration of 7 Tesla magnetic resonance imaging(7 T MRI)in adult patients has marked a revolutionary stride in radiology.In this article we explore the feasibility of 7 T MRI in paediatric practice,emphasizing its feasibility,applications,challenges,and safety considerations.The heightened resolution and tissue contrast of 7 T MRI offer unprecedented diagnostic accuracy,particularly in neuroimaging.Applications range from neuro-oncology to neonatal brain imaging,showcasing its efficacy in detecting subtle structural abnormalities and providing enhanced insights into neurological conditions.Despite the promise,challenges such as high cost,discomfort,and safety concerns necessitate careful consideration.Research suggests that,with precautions,7 T MRI is feasible in paediatrics,yet ongoing studies and safety assessments are imperative.

A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions.In this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer patients.Methods:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals.The SPC test was employed to stratify patients into risk groups,and its feasibility and performance were evaluated.The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment.Furthermore,3-year disease-free survivals of risk groups were analyzed.Results:The SPC test met the primary endpoint criteria.The 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment started.In a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d.Furthermore,3-year disease-free survivals were significantly different between risk groups classified with SPC tests.Conclusions:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies.It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

Safety and feasibility of enhanced recovery after surgery-based management model for ambulatory pediatric surgical procedures

BACKGROUND There is still some room for optimizing ambulatory pediatric surgical procedures,and the preoperative and postoperative management quality for pediatric patients needs to be improved.AIM To discuss the safety and feasibility of the enhanced recovery after surgery(ERAS)-based management model for ambulatory pediatric surgical procedures.METHODS We selected 320 pediatric patients undergoing ambulatory surgery from June 2023 to January 2024 at The First People’s Hospital of Liangshan Yi Autonomous Prefecture.Of these,220 received ERAS-based management(research group)and 100 received routine management(control group).General information,postoperative ambulation activities,surgical outcomes(operation time,postoperative gastro-intestinal ventilation time,and hospital stay),postoperative pain visual analogue scale,postoperative complications(incision infection,abdominal distension,fever,nausea,and vomiting),and family satisfaction were compared.RESULTS The general information of the research group(sex,age,disease type,single parent,family history,etc.)was comparable to that of the control group(P>0.05),but the rate of postoperative(2 h,4 h,and 6 h after surgery)ambulation activities was statistically higher(P<0.01),and operation time,postoperative gastrointestinal ventilation time,and hospital stay were markedly shorter(P<0.05).The research group had lower visual analogue scale scores(P<0.01)at 12 h and 24 h after surgery and a lower incidence of total postoperative complications than the control group(P=0.001).The research group had higher family satisfaction than the control group(P=0.007).CONCLUSION The ERAS-based management model was safe and feasible in ambulatory pediatric surgical procedures and worthy of clinical promotion.

Extension of Chemoprevention of Seasonal Malaria to Five Cycles and to Children from the Age of 6 to 9 Years in Africa: Analysis of Its Acceptability, Feasibility, Cost and Impact A Systematic Review

Introduction: Seasonal Malaria Chemoprevention (SMC) aims at preventing malaria in children during the high transmission season. It has been recommended by the WHO since 2013 for children from the age of 3-59 months. However, despite the impact of this intervention, a peak in the prevalence and incidence of malaria is observed in children from the age of 5-9 years. The aim of this study is to determine from the current literature the feasibility, impact and cost-effectiveness of extending SMC to five cycles and to older children. Methods: A litterature search of PubMed/Medline, NCBI and Google scholar identified 1333 articles. After reading the titles and abstracts by two authors, 24 articles were selected and submitted for full reading. Random control studies on the extension of SMC, malaria, feasibility of SMC, impact of SMC and cost-effectiveness of SMC were selected. A total of 16 articles were included for the qualitative synthesis after excluding 8 studies. Results: Following the summary of the evidence, we conclude that the extension is feasible but will be confronted with the unavailability of older children. The intervention period coincides with field work. SMC is effective in reducing the prevalence and incidence of malaria and the parasite density in children. The financial cost of administering SMC is lower than that of treating a child suffering from malaria. Conclusion: After analysing the information, it was found that the majority of the African population supports the extension of the SMC to the number of cycles and the age group in order to alleviate the high mortality and morbidity rates among children due to malaria.

Feasibility and Path Analysis of Integrating Innovation and Entrepreneurship Education into“One-Stop”Student Communities

The“one-stop”student community provides new support for innovation and entrepreneurship education in universities.Integrating innovation and entrepreneurship education into the“one-stop”student community work enriches course materials,integrates teacher resources,improves students’participation in innovation and entrepreneurship,and solves problems such as low student participation,lack of course resources,insufficient teacher resources,and single evaluation methods in traditional classrooms.Through various means such as exploring course resources,innovating management models,and strengthening team construction,the role of“one-stop”student communities in innovation and entrepreneurship education has been fully utilized,promoting the development of innovation and entrepreneurship education.

Feasibility Analysis and Practice Research of Resource Utilization of Waste from Planting and Breeding Industry

With the extending scale of agricultural production,the treatment and utilization of waste have become increasingly serious environmental problem.Taking city garden and Zhongnan pasture in Pujiang Town of Minhang District in Shanghai for example,according to the analysis on discharge characteristic of waste and balance of resources and energy utilization,mixed anaerobic digestion was chosen to dispose waste based on government guidance and feasibility analysis of project,and the combining disposal and resource utilization of waste were realized in two enterprises,providing reference for close cases.

The Directional Breeding and Feasibility of Functional Bamboos

The functional bamboos are defined as the ones artificially selected, cultivated and produced in the special functions. Based on the principles to broaden market and maximize benefits, the directional cultivation of the functional bamboos has effectively been used bio-techniques and directionally to breed and cultivate bamboo cultivars to meet human＇s needs. The functional bamboos should feature stability, excellent quality and convenient production as well as easy duplication. The functional bamboo cultivars should also enhance the scientization, standardization industrialization and mass production. Given no negative environmental impact, ou purpose is to select, cultivate and develop one or more functional bamboos cultivars to meet the consumers＇ material and spiritual needs and bring more economic ben efits for the producers. The authors believe that directionally breeding functiona bamboo cultivars is not only feasible in techniques, resources and policies, but also in economy and market development. This implicates great significance for the green economic development given the features of China＇s natural resources.

Feasibility analysis of urban sewage source heat pump system with freezing latent heat collection

Aiming to resolve the problem that conventional sewage source heat pump systems cannot satisfy heat peak loads of buildings,a new idea that the freezing latent heat is exacted as the auxiliary heat source at the peak heat load is proposed.First,on the basis of sewage characteristics,a freezing latent heat exchanger is developed to safely eliminate ice,continuously extract heat and remove sewage soft-dirt.A reasonable form of the urban sewage source heat pump system with freezing latent heat collection is presented.Then,the feasibility of the system is theoretically analyzed.The calculation results under typical operating conditions show that the heating ability of the new system is higher than that of the conventional one and the ratio of these two highest heating rates is between 4.5 and 8.7,which proves that the new system has great application potential in cold regions.

Discussion on Feasibility of Adjustment Program for Jiangmen Chinese White Dolphin Provincial Nature Reserve

From the protection of Chinese white dolphin and living environment,and considering the industrial development in coastal areas,we put forward adjustment program for Jiangmen Chinese White Dolphin Provincial Nature Reserve. Meanwhile we analyzed the feasibility of this program by systematically focusing the effect of adjusted functional regions on Chinese white dolphin.

Study on the Feasibility of the Calculation Methods of Consolidating Rural Residential Land into Arable Land in China

Since the increasing demand for arable land and low efficient and disordered use of rural residential land,land consolidation for rural settlement has become a hot issue in China.Many Chinese scientists studied the topic from different angles.However,there is no reference systematically summarizing and discussing feasibility of consolidating rural residential land into arable land.The authors listed and analyzed the calculation methods of consolidating rural residential land into arable land,and discussed the feasibility and reasonability of those methods.Moreover,this paper put forward the study orientation in this regard for providing references for relevant researches.

Feasibility analysis of coronary angiography by transradial approach with 4F catheter

Objective:To assess the feasibility of coronary angiography by transradial approach with 4F catheter.Methods:The procedural details,picture quality,local complication were recorded for coronary by transradial approach with 4F catheter in 138 patients.Results:The success rate of angiography was 97.7%;fluoroscopy time was(5.05±3.23)minutes,total procedural time was(20.51±3.37)minutes;the incidence of dislodgement,excessive engagement of either coronary artery was 7.8%,9.4%,repectively;the angiographic scores for left anterior descending,circumflex and right coronary arteries were(2.87±0.40),(2.88±0.39),(2.90±0.35),respectively.The spasm complication occurred 4.3% in radial artery and 1.5% in coronary artery.There were no occlusion of radial artery during follow up.Conclusion:4F catheter could be the first chosen in some selecting patients for its nice maneuverability,fine images and fewer vascular complications.

The Feasibility Study of Career English Teaching Reform in Higher Vocational Colleges

It has been proved that traditional public English teaching can‘t meet the society requirements for the high skilled talent-ed,while Career English teaching can help students connect English learning with their future career,which better reflects occupa-tional and practical characteristics of higher vocational education.The paper puts forwards three feasibilities in Career Englishteaching reform in order to promote teaching quality of public English teaching in higher vocational colleges further.

The Feasibility Study on Developing General Education in Public English Courses of Higher Vocational Colleges

The implementation of general education is the only way to train higher vocational complex talents.Through analysis ofthe feasibility of developing general education in public English courses of higher vocational colleges,it is hoped that the reform ofpublic English will be promoted effectively.

The Feasibility of Strong Bilingual Education in International School

This essay discuses the feasibility of adopting strong bilingual education in some international schools in China. It will ex-plain the theory, pedagogical principles,benefits and assessment of CLIL pedagogy.

Lymph node metastasis in early gastric cancer with submucosal invasion:Feasibility of minimally invasive surgery

AIM:To explore the feasibility of pertorming minimally invasive surgery(MIS)on subsets of submucosal gastric cancers that are unlikely to have regional lymph node metastasis. METHODS:A total of 105 patients underwent radical gastrectomy with lymph node dissection for submucosal gastric cancer at our hospital from January 1995 to December 1995.Besides investigating many clinicopathological features such as tumor size,gross appearance,and differentiation, we measured the depth of invasion into submucosa minutely and analyzed the clinicopathologic features of these patients regarding lymph node metastasis. RESULTS:The rate of lymph node metastasis in cases where the depth of invasion was<500 μm,500-2 000 μm,or >2 000 μm was 9%(2/23),19%(7136),and 33%(15/46), respectively(P<0.05).In univariate analysis,no significant correlation was found between lymph node metastasis and clinicopathological characteristics such as age,sex,tumor location,gross appearance,tumor differentiation,Lauren's classification,and lymphatic invasion.In multivariate analysis, tumor size(>4 cm vs≤2 cm,odds ratio=4.80, P=0.04)and depth of invasion(>2 000 μm vs ≤500 μm, odds ratio=6.81,P=0.02)were significantly correlated with lymph node metastasis.Combining the depth and size in cases where the depth of invasion was less than 500 μm, we found that lymph node metastasis occurred where the tumor size was greater than 4 cm.In cases where the tumor size was less than 2 cm,lymph node metastasis was found only where the depth of tumor invasion was more than 2 000 μm. CONCLUSION:MIS can be applied to submucosal gastric cancer that is less than 2 cm in size and 500 μm in depth.

Feasibility and safety of single-incision laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy in an ambulatory setting

Background: Single-incision laparoscopic surgery has emerged as an alternative to conventional laparoscopic cholecystectomy(LC) in the clinical setting. Limited information is available on the possibility of performing single-incision laparoscopic surgery as an ambulatory procedure. This study aimed to determine the feasibility and safety of single-incision laparoscopic cholecystectomy(SILC) versus conventional LC in an ambulatory setting. Methods: Ninety-one patients were randomized to SILC( n = 49) or LC( n = 42). The success rate, operative duration, blood loss, hospital stay, gallbladder perforation, drainage, delayed discharge, readmission, total cost, complications, pain score, vomiting, and cosmetic satisfaction of the two groups were then compared. Results: There were significant differences in the operative time(46.89 ± 10.03 min in SILC vs. 37.24 ± 10.23 min in LC;P < 0.001). As compared with LC, SILC was associated with lower total costs(8012.28 ± 752.67 RMB vs. 10258.91 ± 1087.63 RMB;P < 0.001) and better cosmetic satisfaction(4.94 ±0.24 vs. 4.74 ± 0.54;P = 0.031). There were no significant differences between-group in terms of general data, success rate, blood loss, hospital stay, gallbladder perforation, drainage, delayed discharge, readmission, complications, pain score, and vomiting( P > 0.05). Conclusions: Ambulatory SILC is safe and feasible for selected patients. The advantages of SILC as compared with LC are improved cosmetic satisfaction and lower total costs.

Simultaneous modulated accelerated radiation therapy for esophageal cancer:A feasibility study

AIM: To establish the feasibility of simultaneous modulated accelerated radiation therapy (SMART) in esophageal cancer (EC).

China＇s nuclear power under the global 1.5℃ target： Preliminary feasibility study and prospects

This study explores the measures to achieve the global 1.5 ℃ temperature rise target （1.5 ℃ target） by analyzing the feasibility and obstacles of nuclear power in China. The 1.5 ℃target imposes stricter requirements on China＇s nuclear power. Considering the available nuclear power plant sites, nuclear power layout, equipment manufacture ＆ supply, nuclear power plant construction capacity, supportive operation ＆ management talents, investment, cost effectiveness, and public acceptance, the achievement of the development objectives of nuclear power in China considering the 1.5 ℃ Target is difficult. However, it is possible if favorable decisions and policies are made.

Feasibility of progressive strength training shortly after hip fracture surgery

AIM: To investigate the feasibility of a 6-wk progressive strength-training programme commenced shortly after hip fracture surgery in community-dwelling patients.METHODS: This prospective, single-blinded cohort study evaluated 31 community-dwelling patients from four outpatient geriatric health centres aged 60 years or older, who started a 6-wk programme at a mean of 17.5 ± 5.7 d after hip fracture surgery. The intervention consisted primarily of progressive fractured kneeextension and bilateral leg press strength training(twice weekly), with relative loads commencing at 15 and increasing to 10 repetitions maximum(RM), with three sets in each session. The main measurements included progression in weight loads, hip fracture-related pain during training, maximal isometric knee-extension strength, new mobility score, the timed up and go test, the 6-min walk test and the 10-meter fast speed walk test, assessed before and after the programme.RESULTS: Weight loads in kilograms in the fractured limb knee-extension strength training increased from 3.3 ± 1.5 to 5.7 ± 1.7 and from 6.8 ± 2.4 to 7.7 ± 2.6, respectively, in the first and last 2 wk(P < 0.001). Correspondingly, the weight loads increased from 50.3 ± 1.9 to 90.8 ± 40 kg and from 108.9 ± 47.7 to 121.9 ± 54 kg in the bilateral leg press exercise(P < 0.001). Hip fracture-related pain was reduced, and large improvements were observed in the functional outcome measurements, e.g., the 6-min walk test improved from 200.6 ± 79.5 to 322.8 ± 68.5 m(P < 0.001). The fractured limb knee-extension strength deficit was reduced from 40% to 17%, compared with the non-fractured limb. Ten patients reported knee pain as a minor restricting factor during the last 10 RM knee-extension strength-training sessions, but with no significant influences on performance. CONCLUSION: Progressive strength training, initiated shortly after hip fracture surgery, seems feasible and does not increase hip fracture-related pain. Progressive strength training resulted in improvement, although a strength deficit of 17% persisted in the fractured limb compared with the non-fractured limb.

6G Mobile Network Requirements and Technical Feasibility Study

The sixth generation(6G)mobile network is envisaged to be commercially deployed around 2030,which will profoundly change people's lifestyles and accelerate the digitalization of society.To ensure that the requirements of 6G can be achieved,it is essential to establish a set of key performance indicators(KPIs).This paper comprehensively assesses the KPIs not only from the service requirements but also from the technical feasibility points of view.Specifically,theoretical derivations of KPIs have been clarified,and numerical evaluations have been conducted with reasonable technical assumptions.Evaluation results show that some KPIs defined from the service requirements can be improved through advanced technologies while some are still challenging for practical implementations,such as Tbps-level peak data rate and 0.1 ms user plane latency.In addition,it is also necessary to comply with multiple KPIs for some cases.Furthermore,based on the technical analysis,the potential enabling technologies are outlined and foreseeable implementation challenges as well as possible solutions are presented,which promotes a more reasonable design for 6G mobile network.