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Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction
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作者 Emir Bećirović Minela Bećirović +10 位作者 SabinaŠegalo Amir Bećirović Semir Hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović Malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo Emir Begagić 《World Journal of Methodology》 2025年第2期125-136,共12页
BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derive... BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events. 展开更多
关键词 Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction
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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development
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作者 Wen-Chong Zhen Jing Sun +8 位作者 Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li 《World Journal of Gastroenterology》 SCIE CAS 2025年第2期42-51,共10页
BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality worldwide.Early detection of HCC is crucial,yet challenging.AIM To investigate the role of dyn... BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality worldwide.Early detection of HCC is crucial,yet challenging.AIM To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to HCC.METHODS Data from 4843 patients with hepatitis B(January 2015 to January 2024)were analyzed.HCC incidence rates in males and females were compared using the log-rank test.Data were evaluated using Kaplan–Meier analysis.The Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over time.Furthermore,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC risk.RESULTS The incidence of HCC was higher in males.To ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding ratio.Ratio levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR levels.Despite no baseline APR link,rising APR indicates a higher HCC risk. 展开更多
关键词 Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data
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改良Load-sharing评分对胸腰段脊柱骨折手术的指导价值 被引量:7
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作者 马辕华 《实用骨科杂志》 2016年第2期103-106,共4页
目的探讨改良Load-sharing评分对胸腰段脊柱骨折手术治疗方法选择的指导价值。方法选取2012年9月至2014年9月我院收治的69例胸腰段脊柱骨折患者为研究对象,根据改良Load-sharing评分选择不同的手术方式,对于评分为4~6分的患者应用后路手... 目的探讨改良Load-sharing评分对胸腰段脊柱骨折手术治疗方法选择的指导价值。方法选取2012年9月至2014年9月我院收治的69例胸腰段脊柱骨折患者为研究对象,根据改良Load-sharing评分选择不同的手术方式,对于评分为4~6分的患者应用后路手术;对于评分≥7分且保留完整骨折椎后方结构、不伴有脱位的患者,应用前路手术+骨折椎体次切+前路植骨术;对于评分≥7分且骨折椎后方结构破坏或伴有脱位的患者,应用前后路联合手术+骨折椎体次切+前路植骨术。观察记录临床治疗效果。结果所有患者的后凸角、椎管占位及椎体压缩于手术后均得到恢复,与手术前比较差异具有统计学意义(P〈0.05)。40例不完全性神经功能损害患者中,3级神经功能恢复者2例,2级神经功能恢复者14例,1级神经功能恢复者24例。根据Denis分级对术后腰痛评价分级,P1 49例,P2 14例,P3 6例。术后31例恢复原来从事工作或体力劳动,32例更换较轻松工作或轻体力劳动,6例生活能自理但不能参加正常工作及劳动。结论改良Load-sharing评分对胸腰段脊柱骨折手术治疗方法的选择具有重要指导价值。 展开更多
关键词 改良load-sharing评分 胸腰段脊柱骨折 治疗方法
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改良Load-sharing评分对胸腰椎脊柱骨折患者手术的指导意义 被引量:1
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作者 张燕良 姬广林 曾淑娟 《基层医学论坛》 2017年第28期3835-3836,共2页
目的分析改良Load-sharing评分对胸腰椎脊柱骨折患者手术方法选择的指导意义。方法选择2015年1月—2016年12月收治的胸腰椎脊柱骨折患者55例,采用改良Load-sharing评分帮助其选择不同手术治疗方式,而后对手术治疗效果进行评价分析。结... 目的分析改良Load-sharing评分对胸腰椎脊柱骨折患者手术方法选择的指导意义。方法选择2015年1月—2016年12月收治的胸腰椎脊柱骨折患者55例,采用改良Load-sharing评分帮助其选择不同手术治疗方式,而后对手术治疗效果进行评价分析。结果所有患者经手术治疗后,后凸角、椎管占位、椎体压缩均获得明显恢复,与术前比较存在明显差异(P<0.05)。结论在对胸腰椎脊柱骨折患者实施手术治疗时,以改良Load-sharing评分为依据,对手术方式进行选择,对于改善手术治疗效果具有重要临床价值。改良Load-sharing评分对胸腰椎脊柱骨折手术治疗具有重要的指导意义,值得关注。 展开更多
关键词 胸腰椎脊柱骨折 改良load-sharing评分 手术治疗 临床价值
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基于改进Ratio统计量的重尾AR(p)时间序列均值变点检验
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作者 张思 刘叶 金浩 《统计与决策》 CSSCI 北大核心 2024年第2期52-57,共6页
文章提出两个改进的Ratio统计量来研究重尾AR(p)时间序列均值变点检验问题,在原假设下推导了统计量的渐近分布,且在备择假设下证明了其一致性。由于重尾指数未知且难以估计,因此结合Wild Bootstrap重抽样方法来确定渐近分布的临界值;在... 文章提出两个改进的Ratio统计量来研究重尾AR(p)时间序列均值变点检验问题,在原假设下推导了统计量的渐近分布,且在备择假设下证明了其一致性。由于重尾指数未知且难以估计,因此结合Wild Bootstrap重抽样方法来确定渐近分布的临界值;在均值变点存在的情形下,给出了变点位置的一致估计量。数值模拟结果表明:统计量的临界值均不受重尾指数和自回归系数的影响,其经验水平和经验势均取得满意的效果;尤其在原假设下,积分型Ratio统计量的经验水平表现出更好的稳健性,而在备择假设下,最值型Ratio统计量则具备更好的显著性。最后,基于一组股票数据,从实际应用角度进一步阐明所提方法的有效性和可行性。 展开更多
关键词 重尾序列 ratio统计量 均值变点 Wild Bootstrap
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New model for load-sharing k-out-of-n:G system with different components 被引量:5
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作者 Tang Yinghui Zhang Jing 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第4期748-751,842,共5页
On the basis of capacity flow model, a new model is developed for a load-sharing k-out-of-n: G system consisting of different components, to describe the increase of the same component's failure rates under differen... On the basis of capacity flow model, a new model is developed for a load-sharing k-out-of-n: G system consisting of different components, to describe the increase of the same component's failure rates under different loads. All components have exponential life distributions and are nonrepairable in the system. Reliability of load- sharing 2-out- of-3: G system is calculated and some special cases for the system are discussed. The calculation and discussions show that the model is right and practical. 展开更多
关键词 load-sharing k-out-of-n: G system system reliability
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Load-sharing Characteristic of Multiple Pinions Driving in Tunneling Boring Machine 被引量:8
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作者 WEI Jing SUN Qinchao +3 位作者 SUN Wei DING Xin TU Wenping WANG Qingguo 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第3期532-540,共9页
The failure of the key parts, such as gears, in cutter head driving system of tunneling boring machine has not been properly solved under the interaction of driving motors asynchronously and wave tunneling torque load... The failure of the key parts, such as gears, in cutter head driving system of tunneling boring machine has not been properly solved under the interaction of driving motors asynchronously and wave tunneling torque load. A dynamic model of multi-gear driving system is established considering the inertia effects of driving mechanism and cutter head as well as the bending-torsional coupling. By taking into account the nonlinear coupling factors between ring gear and multiple pinions, the influence for meshing angle by bending-torsional coupling and the dynamic load-sharing characteristic of multiple pinions driving are analyzed. Load-sharing coefficients at different rotating cutter head speeds and input torques are presented. Numerical results indicate that the load-sharing coefficients can reach up to 1.2-1.3. A simulated experimental platform of the multiple pinions driving is carried out and the torque distributions under the step load in driving shaft of pinions are measured. The imbalance of torque distribution of pinions is verified and the load-sharing coefficients in each pinion can reach 1.262. The results of simulation and test are similar, which shows the correctness of theoretical model. A loop coupling control method is put forward based on current torque master slave control method. The imbalance of the multiple pinions driving in cutter head driving system of tunneling boring machine can be greatly decreased and the load-sharing coefficients can be reduced to 1.051 by using the loop coupling control method. The proposed research provides an effective solution to the imbalance of torque distribution and synchronous control method for multiple pinions driving of TBM. 展开更多
关键词 load-sharing characteristic tunneling boring machine(TBM) multiple pinions driving nonlinear dynamic characteristic
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Load-sharing评分应用于胸腰椎段脊柱骨折治疗的可行性及安全性分析 被引量:10
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作者 王恩梁 《检验医学与临床》 CAS 2017年第24期3682-3684,共3页
目的探讨Load-sharing评分应用于胸腰椎段脊柱骨折治疗的可行性及安全性。方法选取于该院诊治的胸腰椎段脊柱骨折患者80例作为研究对象,术前通过采用Load-sharing评分对患者进行评估,根据评估分值选择不同的手术入路方式,其中4分≤Load-... 目的探讨Load-sharing评分应用于胸腰椎段脊柱骨折治疗的可行性及安全性。方法选取于该院诊治的胸腰椎段脊柱骨折患者80例作为研究对象,术前通过采用Load-sharing评分对患者进行评估,根据评估分值选择不同的手术入路方式,其中4分≤Load-sharing评分≤6分的患者36例行后路短节段内固定术,作为A组;Load-sharing评分>6分且不伴脱位,骨折椎后方结构完整的16例患者行前路内固定+骨折椎体次切术+前路植骨术,作为B组;评分>6分且伴有脱位或后方结构不完整者的28例患者行前后路联合+骨折椎体次切术+前路植骨术,作为C组。对所有患者进行随访,观察手术效果及并发症发生情况。结果经手术治疗后,3种手术方案中的后凸角、椎体压缩、椎管占位改善情况明显优于手术前,差异均有统计学意义(P<0.05);日本骨科协会评估治疗分数评分较手术前均有明显改善,差异有统计学意义(P<0.05),本组患者腰背神经功能恢复均较好,仅有7.5%的患者出现轻微并发症。结论 Load-sharing评分指导胸腰椎段脊柱骨折行不同手术方案治疗效果良好,对临床手术入路的选择具有一定的参考价值。 展开更多
关键词 load-sharing评分 胸腰椎段脊柱骨折 可行性 手术入路
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Assessment of load-sharing thoracolumbar injury: A modified scoring system 被引量:2
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作者 Qi-Hang Su Yong-Chao Li +2 位作者 Yan Zhang Jun Tan Biao Cheng 《World Journal of Clinical Cases》 SCIE 2020年第21期5128-5138,共11页
BACKGROUND Many classification systems of thoracolumbar spinal fractures have been proposed to enhance treatment protocols,but none have achieved universal adoption.AIM To develop a new patient scoring system for case... BACKGROUND Many classification systems of thoracolumbar spinal fractures have been proposed to enhance treatment protocols,but none have achieved universal adoption.AIM To develop a new patient scoring system for cases with thoracolumbar injury classification and severity score(TLICS)=4,namely the load-sharing thoracolumbar injury score(LSTLIS).METHODS Based on thoracolumbar injury classification and severity score,this study proposes the use of the established load-sharing classification(LSC)to develop an improved classification system(LSTLIS).To prove the reliability and reproducibility of LSTLIS,a retrospective analysis for patients with thoracolumbar vertebral fractures has been conducted.RESULTS A total of 102 cases were enrolled in the study.The scoring trend of LSTLIS is roughly similar as the LSC scoring,however,the average deviation based on the former method is relatively smaller than that of the latter.Thus,the robustness of the LSTLIS scoring method is better than that of LSC.LSTLIS can further classify patients with TLICS=4,so as to assess more accurately this particular circumstance,and the majority of LSTLIS recommendations are consistent with actual clinical decisions.LSTLIS is a scoring system that combines LSC and TLICS to compensate for the lack of appropriate inclusion of anterior and middle column compression fractures with TLICS.Following preliminary clinical verification,LSTLIS has greater feasibility and reliability value,is more practical in comprehensively assessing certain clinical circumstances,and has better accuracy with clinically significant guidelines. 展开更多
关键词 Retrospective analysis Thoracolumbar fractures load-sharing classification Thoracolumbar injury classification and severity score Scoring system Clinical protocols
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Reliability analysis of k-out-of-n system with load-sharing and failure propagation effect
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作者 CHEN Ying MA Qichao +1 位作者 WANG Ze LI Yingyi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第5期1221-1231,共11页
In complex systems,functional dependency and physical dependency may have a coupling effect.In this paper,the reliability of a k-out-of-n system is analyzed considering load-sharing effect and failure mechanism(FM)pro... In complex systems,functional dependency and physical dependency may have a coupling effect.In this paper,the reliability of a k-out-of-n system is analyzed considering load-sharing effect and failure mechanism(FM)propagation.Three types of FMs are considered and an accumulative damage model is proposed to illustrate the system behavior of the k-out-of-n system and the coupling effect between load-sharing effect and FM propagation effect.A combinational algorithm based on Binary decision diagram(BDD)and Monte-Carlo simulation is presented to evaluate the complex system behavior and reliability of the k-out-of-n system.A current stabilizing system that consists of a 3-out-of-6 subsystem with FM propagation effect is presented as a case to illustrate the complex behavior and to verify the applicability of the proposed method.Due to the coupling effect change,the main mechanism and failure mode will be changed,and the system lifetime is shortened.Reasons are analyzed and results show that different sensitivity factors of three different FMs lead to the change of the development rate,thus changing the failure scenario.Neglecting the coupling effect may lead to an incomplete and ineffective measuring and monitoring plan.Design strategies must be adopted to make the FM propagation insensitive to load-sharing effect. 展开更多
关键词 k-out-of-n system load-sharing effect failure mechanism propagation damage factor model combinational algorithm
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Red cell distribution width-to-albumin ratio is a simple promising prognostic marker in acute cholangitis requiring biliary drainage 被引量:2
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作者 Fatih Acehan Hüseyin Camli +4 位作者 Cagdas Kalkan Mesut Tez Burak Furkan Demir Emin Altiparmak Ihsan Ates 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第5期487-494,共8页
Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investi... Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and other prognostic markers for predicting the prognosis of patients with AC. 展开更多
关键词 Acute cholangitis ALBUMIN Biliary drainage MORTALITY Red blood cell distribution width-to-albumin ratio
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Effect of Supported Bearing Clearance on Load-Sharing Characteristics of a Double-Row Planetary Gear System
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作者 WANG Linfeng LIU Jing 《Journal of Donghua University(English Edition)》 CAS 2021年第2期140-147,共8页
Few studies were focused on the load-sharing characteristics of double-row planetary gear(DRPG)systems with bearings.Meanwhile,the supported bearing has an important influence on the transmission characteristics of th... Few studies were focused on the load-sharing characteristics of double-row planetary gear(DRPG)systems with bearings.Meanwhile,the supported bearing has an important influence on the transmission characteristics of the entire system.To overcome this problem,a multi-body dynamic(MBD)model of the DRPG system fully considering the influences of bearing parameters is established.Dynamic loads among contacting gear pairs have been obtained to calculate the load-sharing coefficient(LSC)of the system.The LSC of each gear tooth pair has been compared to study the effect of the supported bearing clearance on the load-sharing characteristics.These methods are based on Hertz contact theory.The liner stiffness and damping are used in the model.The results show that the supported bearing clearance has a greatly effect on the LSC of the DRPG system.Choosing appropriate clearance parameters of supported bearing can help suppress the uneven load distribution of the DRPG system.The results can provide some guidance to find new method to study the LSC and increase the service life of planetary gear systems. 展开更多
关键词 double-row planetary gear(DRPG)system supported bearing clearance load-sharing coefficient(LSC) multi-body dynamic(MBD)
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Yields,growth and water use under chemical topping in relations to row configuration and plant density in drip-irrigated cotton 被引量:1
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作者 Wang Xuejiao Hu Yanping +10 位作者 Ji Chunrong Chen Yongfan Sun Shuai Zhang Zeshan Zhang Yutong Wang Sen Yang Mingfeng Ji Fen Guo Yanyun Li Jie Zhang Lizhen 《Journal of Cotton Research》 CAS 2024年第2期123-136,共14页
Background Water deficit is an important problem in agricultural production in arid regions.With the advent of wholly mechanized technology for cotton planting in Xinjiang,it is important to determine which planting m... Background Water deficit is an important problem in agricultural production in arid regions.With the advent of wholly mechanized technology for cotton planting in Xinjiang,it is important to determine which planting mode could achieve high yield,fiber quality and water use efficiency(WUE).This study aimed to explore if chemical topping affected cotton yield,quality and water use in relation to row configuration and plant densities.Results Experiments were carried out in Xinjiang China,in 2020 and 2021 with two topping method,manual topping and chemical topping,two plant densities,low and high,and two row configurations,i.e.,76 cm equal rows and 10+66 cm narrow-wide rows,which were commonly applied in matching harvest machine.Chemical topping increased seed cotton yield,but did not affect cotton fiber quality comparing to traditional manual topping.Under equal row spacing,the WUE in higher density was 62.4%higher than in the lower one.However,under narrow-wide row spacing,the WUE in lower density was 53.3%higher than in higher one(farmers’practice).For machine-harvest cotton in Xinjiang,the optimal row configuration and plant density for chemical topping was narrow-wide rows with 15 plants m-2 or equal rows with 18 plants m-2.Conclusion The plant density recommended in narrow-wide rows was less than farmers’practice and the density in equal rows was moderate with local practice.Our results provide new knowledge on optimizing agronomic managements of machine-harvested cotton for both high yield and water efficient. 展开更多
关键词 Yield components Fiber quality TRANSPIratioN Water use efficiency Heat ratio method(HRM)
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Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients 被引量:1
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作者 Wen Liu Hong-Yu Wu +4 位作者 Jia-Xi Lin Shu-Ting Qu Yi-Jie Gu Jin-Zhou Zhu Chun-Fang Xu 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第8期3507-3520,共14页
BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many tumors.However,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)pati... BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many tumors.However,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)patients was limited.AIM To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic models.METHODS A total of 286 patients from the Surveillance,Epidemiology,and End Results database were divided into the training set and validation set at a ratio of 8:2.92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test set.Cox regression analysis was used to explore the relationship between LNR and disease-specific survival(DSS)of gastric NEN patients.Random survival forest(RSF)algorithm and Cox proportional hazards(CoxPH)analysis were applied to develop models to predict DSS respectively,and compared with the 8th edition American Joint Committee on Cancer(AJCC)tumornode-metastasis(TNM)staging.RESULTS Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of death.The RSF model exhibited the best performance in predicting DSS,with the C-index in the test set being 0.769[95%confidence interval(CI):0.691-0.846]outperforming the CoxPH model(0.744,95%CI:0.665-0.822)and the 8th edition AJCC TNM staging(0.723,95%CI:0.613-0.833).The calibration curves and decision curve analysis(DCA)demonstrated the RSF model had good calibration and clinical benefits.Furthermore,the RSF model could perform risk stratification and individual prognosis prediction effectively.CONCLUSION A higher LNR indicated a lower DSS in postoperative gastric NEN patients.The RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set,showing potential in clinical practice. 展开更多
关键词 Gastric neuroendocrine neoplasm Lymph node ratio Disease-specific survival Random survival forest Predictive model
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A gated recurrent unit model to predict Poisson’s ratio using deep learning 被引量:1
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作者 Fahd Saeed Alakbari Mysara Eissa Mohyaldinn +4 位作者 Mohammed Abdalla Ayoub Ibnelwaleed A.Hussein Ali Samer Muhsan Syahrir Ridha Abdullah Abduljabbar Salih 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期123-135,共13页
Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to spe... Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical behaviors.In this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error an-alyses.The GRU model showed the proper trends,and the model data ranges were wider than previous ones.The GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other models.The GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,respectively.The group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs. 展开更多
关键词 Static Poisson’s ratio Deep learning Gated recurrent unit(GRU) Sand control Trend analysis Geomechanical properties
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Serum cystatin C,monocyte/high-density lipoprotein-C ratio,and uric acid for the diagnosis of coronary heart disease and heart failure 被引量:1
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作者 Ming Li Da-Hao Yuan +2 位作者 Zhi Yang Teng-Xiang Luw Xiao-Biao Zou 《World Journal of Clinical Cases》 SCIE 2024年第18期3461-3467,共7页
BACKGROUND Coronary heart disease(CHD)and heart failure(HF)are the major causes of morbidity and mortality worldwide.Early and accurate diagnoses of CHD and HF are essential for optimal management and prognosis.Howeve... BACKGROUND Coronary heart disease(CHD)and heart failure(HF)are the major causes of morbidity and mortality worldwide.Early and accurate diagnoses of CHD and HF are essential for optimal management and prognosis.However,conventional diagnostic methods such as electrocardiography,echocardiography,and cardiac biomarkers have certain limitations,such as low sensitivity,specificity,availability,and cost-effectiveness.Therefore,there is a need for simple,noninvasive,and reliable biomarkers to diagnose CHD and HF.AIM To investigate serum cystatin C(Cys-C),monocyte/high-density lipoprotein cholesterol ratio(MHR),and uric acid(UA)diagnostic values for CHD and HF.METHODS We enrolled 80 patients with suspected CHD or HF who were admitted to our hospital between July 2022 and July 2023.The patients were divided into CHD(n=20),HF(n=20),CHD+HF(n=20),and control groups(n=20).The serum levels of Cys-C,MHR,and UA were measured using immunonephelometry and an enzymatic method,respectively,and the diagnostic values for CHD and HF were evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Serum levels of Cys-C,MHR,and UA were significantly higher in the CHD,HF,and CHD+HF groups than those in the control group.The serum levels of Cys-C,MHR,and UA were significantly higher in the CHD+HF group than those in the CHD or HF group.The ROC curve analysis showed that serum Cys-C,MHR,and UA had good diagnostic performance for CHD and HF,with areas under the curve ranging from 0.78 to 0.93.The optimal cutoff values of serum Cys-C,MHR,and UA for diagnosing CHD,HF,and CHD+HF were 1.2 mg/L,0.9×10^(9),and 389μmol/L;1.4 mg/L,1.0×10^(9),and 449μmol/L;and 1.6 mg/L,1.1×10^(9),and 508μmol/L,respectively.CONCLUSION Serum Cys-C,MHR,and UA are useful biomarkers for diagnosing CHD and HF,and CHD+HF.These can provide information for decision-making and risk stratification in patients with CHD and HF. 展开更多
关键词 Serum cystatin C Monocyte/high-density lipoprotein-C ratio Uric acid Coronary heart disease Heart failure Risk stratification
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Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy
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作者 Ying Gao Rong-Xin Lu +6 位作者 Yun Tang Xin-Yi Yang Hu Meng Chang-Lin Zhao Yi-Lu Chen Feng Yan Qian Cao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第5期877-882,共6页
AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR... AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were calculated.The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)curves.The relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic regression.RESULTS:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR. 展开更多
关键词 diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index
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Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents
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作者 XIAO Tian Li YUAN Shu Qian +6 位作者 GAO Jing Yu Julien SBaker YANG Yi De WANG Xi Jie ZHENG Chan Juan DONG Yan Hui ZOU Zhi Yong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第3期233-241,共9页
Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk factors.However,it is not clear which indi... Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk factors.However,it is not clear which indicator is more suitable for children and adolescents.We aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.Methods This was a national cross-sectional study.Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China.Demographics,physical activity,dietary intake,and family history of chronic diseases were obtained through questionnaires.ANOVA,χ2 and logistic regression analysis was conducted.Results A significant sex difference was observed for HWHtR and WHR,but not for HW phenotype.The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors. 展开更多
关键词 Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors
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Load-sharing评分在胸腰椎段脊柱骨折治疗中的应用
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作者 马林 《中国伤残医学》 2021年第8期18-19,共2页
目的:探究Load-sharing评分在胸腰椎段脊柱骨折治疗中的应用效果.方法:随机选取2016年1月-2019年12月我院收治的50例胸腰椎段脊柱骨折患者.Load-sharing评分4-6分的患者为A组,Load-sharing评分>6分不伴脱位,骨折椎后方结构完整的患者... 目的:探究Load-sharing评分在胸腰椎段脊柱骨折治疗中的应用效果.方法:随机选取2016年1月-2019年12月我院收治的50例胸腰椎段脊柱骨折患者.Load-sharing评分4-6分的患者为A组,Load-sharing评分>6分不伴脱位,骨折椎后方结构完整的患者为B组,Load-sharing评分>6分且伴脱位或者骨折椎后方结构不完整的患者为C组.观察记录3组患者的手术效果.结果:手术后3组患者的后凸角、椎体压缩、椎管占位改善情况优于手术前,P<0.05,差异有统计学意义.治疗分数评分优于手术前,P<0.05,差异有统计学意义.结论:Load-sharing评分能够正确指导手术方案的选定,且指导治疗的效果良好,在胸腰椎段脊柱骨折患者的治疗方案制定中值得大力推广. 展开更多
关键词 load-sharing评分 胸腰椎段脊柱骨折 骨折椎后方结构
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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio:Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events
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作者 Qiu-Yu Jiang Ru-Yi Xue 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期577-582,共6页
We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of ne... We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting irAEs.Furthermore,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers alone.NLR and PLR are promising markers for clinical applications.Forthcoming models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite model.Furthermore,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency. 展开更多
关键词 Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Immunecheckpoint inhibitor Immune-related adverse event
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