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Comparison of Hypolipidemic Effect of Refined Konjac Meal With Several Common Dietary Fibers and Their Mechanisms of Action 被引量:5
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作者 WU JIE AND PENG +1 位作者 SHU-SHENG (Department of Nutrition and Food Hygiene, Nantong Medical College, Nantong City, 226001, Jiangsu, China Department of Nutrition and Food Hygiene, West China University of Medical Sciences,Chengdu, Sichuan, China) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第1期27-37,共11页
The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition... The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition and output of fecal bile acid were observed. All four kinds of dietary fiber were given at a level of 5% of diet to young male rats of Wistar strain fed on a lipid-rich diet contalning 5 % lard, 1% cholesteral and 0. 25 % cholate. All the dietary fibers tested have similar effects on serum lipid composition. In all groups, these substances prevent ed increases in total cholesterol in fasting serum, but the level of triglyceride was tmchangd.The concentrations of totaI cholesterol and triglyceride in the liver were lower in the RKM group than in the control group and the other three groups. Hepatic histopathological exami nation also showed the most significant lipotropic effect in the RKM group. The daily output of fecal bile acids (CDCA+GDCA) was significantly increased in the four experimental groups than in the normal group and the control group. The increase of CDCA was more significant than GDCA, suggesting that the increase of fecal bile acids, especially CDCA, may be one of the mechanisms by which RKM and the other three dietary fibers exerts a hypocholesterolemic effect 展开更多
关键词 acid Am Br Comparison of Hypolipidemic Effect of Refined Konjac Meal With Several Common Dietary Fibers and Their mechanisms of action CDCA
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Integration of multi-omics in investigations on the mechanisms of action of Chinese herbal medicine interventions in metabolic diseases
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作者 Yong-Jun Cao Han-Zhou Li +6 位作者 Yu-Meng Sun Xiao-Qian Li Le Chen Xiao-Wen Jin Shu-Quan Lyu Wei-Bo Wen Jia-Bao Liao 《Traditional Medicine Research》 2022年第4期1-7,共7页
The rapid development of bioinformatics has provided novel approaches and methods for exploring the mechanisms of disease treatment via Chinese herbal medicines.Compound Chinese herbal medicines formulas have complex ... The rapid development of bioinformatics has provided novel approaches and methods for exploring the mechanisms of disease treatment via Chinese herbal medicines.Compound Chinese herbal medicines formulas have complex compositions and are characterized by their multiple constituents and diverse array of biological targets.Therefore,the mechanisms of action of most compound Chinese herbal medicines formulas cannot be adequately explained using a single pathway.Omics technologies describe high-throughput-based analytical and detection techniques,which include transcriptomics,proteomics,and metabolomics and provide multilayer parameter information that can be integrated to characterize the overall relationships involved in the therapeutic effects of Chinese herbal medicines formulas.Through their combination with network biology and drug effect networks,omics technologies also enable investigations into the mechanisms of disease treatment in traditional Chinese medicine.The integration of multiple omics technologies is in line with the concept of holism in traditional Chinese medicine and provides an approach for combining modern science and technology with traditional Chinese medicine theories.In recent years,omics technologies have been widely used to elucidate the mechanisms of action of Chinese herbal medicines.The latest studies employing multi-omics integration for investigating the mechanisms of action of Chinese herbal medicines interventions in metabolic diseases have devoted greater attention to in-depth explorations of disease pathogenesis.This paper provides a review of the following multi-omics technologies,which are used in research on the treatment of common metabolic diseases(e.g.,type-2 diabetes mellitus,nonalcoholic fatty liver disease):network pharmacology combined with metabolomics,16S rRNA sequencing combined with transcriptomics,16S rRNA sequencing combined with metabolomics,and 16S rRNA sequencing combined with network pharmacology and metabolomics. 展开更多
关键词 omics technology Chinese herbal medicine metabolic disease mechanism of action
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Glucagon-like peptide-1 receptor agonists:Exploring the mechanisms from glycemic control to treatment of multisystemic diseases
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作者 Mo-Wei Kong Yang Yu +2 位作者 Ying Wan Yu Gao Chun-Xiang Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第36期4036-4043,共8页
This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associat... This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associated fatty liver disease.We provide supplementary insights to their research,highlighting the broader systemic implications of GLP-1RAs,synthesizing the current understanding of their mechanisms and the trajectory of research in this field.GLP-1RAs are revolutionizing the treatment of type 2 diabetes mellitus and beyond.Beyond glycemic control,GLP-1RAs demonstrate cardiovascular and renal protective effects,offering potential in managing diabetic kidney disease alongside renin–angiotensin–aldosterone system inhibitors.Their role in bone metabolism hints at benefits for diabetic osteoporosis,while the neuroprotective properties of GLP-1RAs show promise in Alzheimer's disease treatment by modulating neuronal insulin signaling.Additionally,they improve hormonal and metabolic profiles in polycystic ovary syndrome.This editorial highlights the multifaceted mechanisms of GLP-1RAs,emphasizing the need for ongoing research to fully realize their therapeutic potential across a range of multisystemic diseases. 展开更多
关键词 Glucagon-like peptide-1 receptor agonists Glycemic control Multisystem diseases Mechanism of action Cardiovascular protection Renal disease Bone metabolism Non-alcoholic fatty liver disease NEUROPROTECTION Polycystic ovary syndrome
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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus
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作者 Xin-Yue Liu Han-Wen Zheng +3 位作者 Feng-Zhong Wang Tul-Wahab Atia Bei Fan Qiong Wang 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第4期433-443,共11页
In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of e... In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of experience,has been treating diabetes for over two millennia.Different antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique advantages.As well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic drugs.Chinese herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and terpenoids.These active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free radicals.These actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood glucose.Using different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming clearer.Nonetheless,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its constituents.Further research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations. 展开更多
关键词 animal model Chinese herbal medicine diabetes mellitus evaluation index mechanism of action
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Review on dietary supplements as an effective improvement of Alzheimer's disease:focus on structures and mechanisms
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作者 Sheng Li Yinling Wei +3 位作者 Zhenzhen Liang Lingli Guo Xiaojiang Hao Yu Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期1787-1805,共19页
Alzheimer’s disease(AD),the major form of neurodegenerative diseases that can severely impede normal cognitive function,makes it one of the most common fatal diseases.There are currently over 50 million AD patients w... Alzheimer’s disease(AD),the major form of neurodegenerative diseases that can severely impede normal cognitive function,makes it one of the most common fatal diseases.There are currently over 50 million AD patients worldwide.The neuropathology of AD is perplexing and there is a scarcity of disease-modifying treatments.Currently,early diagnosis of AD has been made possible with the discovery of biological markers associated with pathology,providing strong support for the improvement of the disease status.The search for inhibitors of AD markers from dietary supplements(DSs)has become a major hot topic.Especially with the widespread use of DSs,DSs containing polyphenols,alkaloids,terpenes,polysaccharides and other bioactive components can prevent AD by reducing Aβdeposition,inhibiting tau protein hyperphosphorylation,reconstructing synaptic dysfunction,weakening cholinesterase activity,regulating mitochondrial oxidative stress,neuronal inflammation and apoptosis.This review summarizes the anti-AD effects of the main DSs and their bioactive constituents,as well as the potential molecular mechanisms covers from 2017 to 2023.Additionally,we discussed the opportunities and challenges faced by DSs in the process of AD prevention and treatment,aiming to further provide new perspectives for functional food development. 展开更多
关键词 Dietary supplements Bioactive ingredients Alzheimer’s disease Mechanism of action
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Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury
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作者 Ya-Kuan Wang Huang Lin +4 位作者 Shu-Rui Wang Ru-Tao Bian Yang Tong Wen-Tao Zhang Ying-Lin Cui 《World Journal of Clinical Cases》 SCIE 2024年第4期688-699,共12页
Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage ... Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical research.As a traditional Chinese medicinal formulation,Sanhua Decoction has gradually gained importance in the treatment of cerebrovascular diseases.Its main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate qi.In the treatment of neurological diseases,the therapeutic effects of the Sanhua Decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral edema.Among the studies conducted to date,many have found that the application of Sanhua Decoction in the treatment of neurological diseases has clear therapeutic effects.In addition,as a natural treatment,the Sanhua Decoction has received widespread attention,given that it is safer and more effective than traditional Western medicines.Consequently,research on the mechanisms of action and efficacy of the Sanhua Decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable significance.In this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.We hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice. 展开更多
关键词 Sanhua Decoction Cerebral ischemia-reperfusion Mechanism of action Application progress Traditional Chinese medical science REVIEW
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Study on the Mechanism of Action of Glyasperin A in the Treatment of Atherosclerosis Based on Network Pharmacology and Molecular Docking
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作者 Na LI Xiang PU +2 位作者 Yihui CHAI Yuqi YANG Lailai LI 《Agricultural Biotechnology》 2024年第2期53-57,共5页
[Objectives] This study was conducted to investigate the mechanism of action of glyasperin A in the treatment of atherosclerosis using a network pharmacology approach. [Methods] Targets related to atherosclerosis were... [Objectives] This study was conducted to investigate the mechanism of action of glyasperin A in the treatment of atherosclerosis using a network pharmacology approach. [Methods] Targets related to atherosclerosis were searched in GeneCards database. An active ingredient-disease-target network was constructed by Cytoscape 3.7.1. A target protein interaction network was constructed by String database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the DAVID database. [Results] Glyasperin A acted on 36 atherosclerosis-related targets, and the biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, barrier, and lipid oxidation, etc. The results showed that glyasperin A acted on 36 atherosclerosis-related targets. The biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, positive regulation of protein localization to nucleus, and hepoxilin biosynthetic process, and it played an anti-fatigue role through signal pathways such as serotonergic synapse, efferocytosis, arachidonic acid metabolism, chemical carcinogenesis-receptor activation and platelet activation. [Conclusions] Glyasperin A has multi-target and multi-pathway effects in the treatment of atherosclerosis. This study provides reference for further research on glyasperin A in the treatment of atherosclerosis. 展开更多
关键词 Glyasperin A ATHEROSCLEROSIS Network pharmacology Mechanism of action
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Study on the Therapeutic Effects and Mechanisms of Human Mesenchymal Stem Cell-Derived Exosomes Carrying NGF Gene in Treating Ischemic Stroke in Rats
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作者 Bingqian Li Xuanxuan Xu +1 位作者 Wenqin Zhou Peng Wang 《Proceedings of Anticancer Research》 2024年第4期41-47,共7页
Objective:To investigate the therapeutic effects and mechanisms of human mesenchymal stem cell-derived exosomes(hMSCs-Exo)carrying the NGF gene in treating ischemic stroke in rats,aiming to provide new insights and tr... Objective:To investigate the therapeutic effects and mechanisms of human mesenchymal stem cell-derived exosomes(hMSCs-Exo)carrying the NGF gene in treating ischemic stroke in rats,aiming to provide new insights and treatment methods for ischemic stroke therapy.Methods:After successful construction of the cerebral ischemia model in 40 male SPF-grade SD rats aged 6-8 weeks,the model rats were randomly divided into 4 groups:Sham group,PBS group,hMSCs-Exo group,and NGF-hMSCs-Exo group,with 10 rats in each group.The rat MCAO model was prepared using the classic filament method,and NGF-hMSCs-Exo were injected via the tail vein into the MCAO model rats.The expression of the NGF gene in brain ischemic tissues,neuronal regeneration,and rat neurological function recovery were observed using TTC staining,memory function evaluation,Western blot,qRT-PCR,and other methods.Results:Compared with the Sham group,neurological deficits were significant in the PBS group(P<0.01).Compared with the PBS group,neurological scores improved in the hMSCs-Exo group and NGF-hMSCs-Exo group(P<0.05).Compared with the hMSCs-Exo group,the improvement in neurological deficits was more significant in the NGF-hMSCs-Exo group(P<0.05).The infarct area after NGF-hMSCs-Exo intervention was significantly reduced(P<0.05)compared with the Sham group.Compared with the PBS group,relative expression levels of NGF mRNA and protein decreased,while Caspase-3 mRNA and protein expression significantly increased in the PBS group(P<0.01).Compared with the PBS group and hMSCs-Exo group,there were differences in NGF and Caspase-3 mRNA and protein expression in the NGF-hMSCs-Exo group rat brain tissues(P<0.05).Conclusion:Treatment with human mesenchymal stem cell-derived exosomes carrying the NGF gene improves cognitive function and exerts protective effects on SD rats while inhibiting apoptotic levels in cells. 展开更多
关键词 NGF gene Human mesenchymal stem cell-derived exosomes Ischemic stroke in rats Mechanism of action
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Clostridium perfringens epsilon toxin: Toxic effects and mechanisms of action 被引量:3
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作者 Wenwen Xin Jinglin Wang 《Biosafety and Health》 2019年第2期71-75,共5页
Clostridium perfringensε-toxin(ETX)is the main toxin resulting in enterotoxemia of sheep and goats.ETX can cause lesions of multiple organs,such as hydropericardium,pulmonary edema and focal symmetrical encephalomalc... Clostridium perfringensε-toxin(ETX)is the main toxin resulting in enterotoxemia of sheep and goats.ETX can cause lesions of multiple organs,such as hydropericardium,pulmonary edema and focal symmetrical encephalomalcia(FSE).Significant advancements have been made in studies of the cytotoxicity and neurotoxicity of ETX;however,candidates of ETX receptor still remain unconfirmed.Evidence has indicated several candidate molecules to be involved in the recognition and binding of ETX to different target cells.Myelin and lymphocyte(MAL)protein might be one of the candidate receptors for ETX,although this action needs further confirmation.Multiple signaling pathways of cell death are involved in the cytotoxicity of ETX.In Madin-Darby Canine Kidney(MDCK)cells cytotoxicity of ETX was thought to be associated with pore formation,which induces destruction of cellular ion balance.Hemolysis of human erythrocytes induced by ETX required activation of P2 receptors.Therefore,host-related factors are involved in ETX-induced cytotoxicity,which provides potential targets to block the toxic effect of ETX. 展开更多
关键词 Clostridium perfringensε-toxin Cytotoxicity mechanisms of action RECEPTOR Signal pathways
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Research progress in the study of Clinacanthus nutans and treatment of liver diseases
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作者 Qian-Jin Fu Sheng-Gang Sang 《TMR Modern Herbal Medicine》 CAS 2024年第1期26-33,共8页
Background:Based on the long history of medicinal value and modern pharmacological research,a systematic collation of the Clinacanthus nutans has been carried out with a view to providing useful references for the cli... Background:Based on the long history of medicinal value and modern pharmacological research,a systematic collation of the Clinacanthus nutans has been carried out with a view to providing useful references for the clinical application of the Clinacanthus nutans in hepatoprotection and the research and development of new drugs.Methods:The research progress of a large number of domestic and international studies on the therapeutic mechanism of the antiliver diseases of Clinacanthus nutans and its active ingredients is summarized.The aim is to explore the greater value of the herb.Results:The major chemical constituents with pharmacological activities of the Clinacanthus nutans were summarized,and a feasible mechanism of action was compiled and analyzed.Conclusion:Many studies have confirmed the great medicinal value of Clinacanthus nutans and its active monomer components,especially in the prevention and treatment of liver diseases,which is worthy of more in-depth research,development and utilization.Chinese medicine is the treasure of China,therefore,it should be used in more clinical applications. 展开更多
关键词 Clinacanthus nutans active ingredients mechanisms of action HEPATOPROTECTION
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Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives 被引量:4
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作者 Jumah Masoud Mohammad SALMANI ZHANG Xiao-Ping +1 位作者 Joe Antony JACOB CHEN Bao-An 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2017年第5期321-329,共9页
Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytoc... Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties. This review is intended to summarize the most recent advances in the anti-proliferative and chemo-preventive effects of apigenin in different cancer models. Analysis of the data from the studied cancer models has revealed that apigenin exerts its anti-proliferative effects through multiple and complex pathways. This guided us to discover some controversial results about the exact role of certain molecular pathways such as autophagy in the anticancer effects of apigenin. Further, there were cumulative positive evidences supporting the involvement of certain pathways such as apoptosis, ROS and DNA damage and repair. Apigenin possesses a high potential to be used as a chemosensitizing agent through the up-regulation of DR5 pathway. According to these preclinical findings we recommend that further robust unbiased studies should consider the possible interactions between different molecular pathways. 展开更多
关键词 APIGENIN ANTICANCER Flavonoid Mechanism of action
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Effects and Mechanisms of Actions of Chinese Herbal Medicines for Asthma 被引量:3
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作者 洪敏俐 宋英 李秀敏 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第7期483-491,共9页
Asthma is a chronic inflammatory disorder of airways that affects approximately 300 million adults and children worldwide.Most therapy currently uses bronchodilators and corticosteroids.Systemic side effects from chro... Asthma is a chronic inflammatory disorder of airways that affects approximately 300 million adults and children worldwide.Most therapy currently uses bronchodilators and corticosteroids.Systemic side effects from chronic use of these drugs are concern.Chinese medicine(CM)has a long history of human use in China and other Asian countries and well received by the patients.But as one component of Western integrative medicine(WIM),it is required that CM use is supported by scientific evidence.On the other hand,there are also suggestions that Western standardized medicine should consider personalized practice.In recent years there have been an increasing studies to narrow the gap between CM,the personalized medicine and Western medicine,evidence based medicine.This communication reviews several CM studies published in the English language in details by reviewing the effects and mechanisms of actions on asthma from clinic and experimental studies. Chinese herbal medicines exhibit broad actions on multiple asthma pathologic mechanisms.These mechanisms may involve antiinflammatory and immunomodulatory effects,inhibiting airway remodeling and normalization of hypothalamus,pituitary and adrenal(HPA)-axis disturbances.However,the mechanisms of actions of Chinese herbal medicines for asthma are not fully understood.More controlled clinical studies are warranted and some anti-asthma CM may be proved to be effective when used as monotherapy or complementary asthma therapies. 展开更多
关键词 ASTHMA complementary and alternative medicine Chinese medicine Chinese herbal medicine mechanism of action
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Molecular targets and mechanisms of Jiawei Jiaotai Pill on diabetic cardiomyopathy based on network pharmacology
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作者 Yu-Juan Wang Yan-Li Wang +1 位作者 Xiao-Fan Jiang Juan-E Li 《World Journal of Diabetes》 SCIE 2023年第11期1659-1671,共13页
BACKGROUND Jiawei Jiaotai Pill is commonly used in clinical practice to reduce apoptosis,increase insulin secretion,and improve blood glucose tolerance.However,its mechanism of action in the treatment of diabetic card... BACKGROUND Jiawei Jiaotai Pill is commonly used in clinical practice to reduce apoptosis,increase insulin secretion,and improve blood glucose tolerance.However,its mechanism of action in the treatment of diabetic cardiomyopathy(DCM)remains unclear,hindering research efforts aimed at developing drugs specifically for the treatment of DCM.AIM To explore the pharmacodynamic basis and molecular mechanism of Jiawei Jiaotai Pill in DCM treatment.METHODS We explored various databases and software,including the Traditional Chinese Medicine Systems Pharmacology Database,Uniport,PubChem,GenCards,String,and Cytoscape,to identify the active components and targets of Jiawei Jiaotai Pill,and the disease targets in DCM.Protein-protein interaction network,gene ontology,and Kyoto Encyclopedia of Genes and Genomes analyses were used to determine the mechanism of action of Jiawei Jiaotai Pill in treating DCM.Molecular docking of key active components and core targets was verified using AutoDock software.RESULTS Total 42 active ingredients and 142 potential targets of Jiawei Jiaotai Pill were identified.There were 100 common targets between the DCM and Jiawei Jiaotai Pills.Through this screening process,TNF,IL6,TP53,EGFR,INS,and other important targets were identified.These targets are mainly involved in the positive regulation of the mitogen-activated protein kinase(MAPK)MAPK cascade,response to xenobiotic stimuli,response to hypoxia,positive regulation of gene expression,positive regulation of cell proliferation,negative regulation of the apoptotic process,and other biological processes.It was mainly enriched in the AGE-RAGE signaling pathway in diabetic complications,DCM,PI3K-Akt,interleukin-17,and MAPK signaling pathways.Molecular docking results showed that Jiawei Jiaotai Pill's active ingredients had good docking activity with DCM's core target.CONCLUSION The active components of Jiawei Jiaotai Pill may play a role in the treatment of DCM by reducing oxidative stress,cardiomyocyte apoptosis and fibrosis,and maintaining metabolic homeostasis. 展开更多
关键词 Jiawei Jiaotai pill Diabetic cardiomyopathy Mechanism of action Enrichment analysis Network pharmacology Molecular docking
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Study on the mechanism of action of Lizhong Tang in ameliorating non-alcoholic fatty liver disease by regulating mitochondrial autophagy
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作者 SUN Dong-qi ZHOU Xiao-ling +7 位作者 WU Teng LI Ling-chang LI Ze-peng SUN Su-hong WANG Yue-ming LIU Lin MO Yi-ling YU Jing-fang 《Journal of Hainan Medical University》 CAS 2023年第21期14-14,共1页
Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and l... Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and liver samples were collected to facilitate a comparative analysis of rat body mass and liver wet weight and calculate the liver index.Liver pathology was observed,while serum transaminase and blood lipid levels were measured.The protein expression levels of PINK1,Parkin,and LC-3II in rat liver were detected using Western Blot analysis.Results:Compared with the control group,the NAFLD rats exhibited a significant increase in body weight,liver wet weight,liver index,transaminase levels,and blood lipid levels.The expression levels of PINK1,Parkin,and LC3-II protein were significantly decreased(P<0.01).Following intervention with Lizhong Tang,rats in each herbal treatment group displayed a decrease in body weight,liver wet weight,liver index,se-rum transaminase,and blood lipid levels.The expression levels of PINK1,Parkin,and LC-3II rebounded(P<0.05),with the high-dose group demonstrating the most pronounced effects(P<0.01).Histopathological examination of liver tissue revealed that rats in the model group displayed disrupted hepatic lobule structure,swollen hepatocytes,disordered arrangement,and a multi-tude of varying-sized lipid vacuoles within the cytoplasm.Conversely,rats treated with different doses of the herbal remedy exhibited improvements in liver tissue pathology,with the high-dose group showing the most notable enhancement.Conclusion:Lizhong Tang can improve NAFLD disease by regulating mitochondrial autophagy. 展开更多
关键词 Mitochondrial autophagy Non-alcoholic fatty liver disease Lizhong Tang Mechanism of action
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On the Digital Transformation of the Automobile Manufacturing Industry in the Chengdu-Chongqing Economic Circle:Mechanism of Action and Feasible Paths
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作者 Chen Ying Peng Yajie 《Contemporary Social Sciences》 2023年第1期17-43,共27页
With a long industrial chain and a powerful ability to drive other industries,the automobile manufacturing industry has a prominent strategic position in the national economy.In recent years,many countries have put on... With a long industrial chain and a powerful ability to drive other industries,the automobile manufacturing industry has a prominent strategic position in the national economy.In recent years,many countries have put on their agenda the digitalization of the automobile manufacturing industry,leading to an connected,autonomous,shared,and electric(also known as CASE)①development trend in the industry.As one of the six major automobile industry clusters in China,the Chengdu-Chongqing economic circle has achieved initial results in the digital transformation of the automobile manufacturing industry.However,the region is still faced with some constraints,such as insufficient digital infrastructure,relatively slow development of new automobile products,insufficient innovation ability of the automobile industry,and complex digital transformation of small and medium-sized automobile enterprises(automobile SMEs).This paper intends to construct a framework for the mechanism of action of the digital transformation in the automobile manufacturing industry,analyze the effects of the digital transformation of the automobile manufacturing industry in the Chengdu-Chongqing economic circle,and propose feasible paths for the digital transformation of the automobile manufacturing industry in the region by drawing on domestic and international experience in this regard.The specific paths include:(a)Smoothing the“dual-core”data chain to facilitate the digital transformation of the automobile manufacturing industry;(b)Developing the new energy vehicle(NEV)industry to upgrade the quality of automobile products;(c)Achieving corner overtaking in the digital transformation of the automobile manufacturing industry with digital technology;(d)Jointly building the automobile industrial park to promote the digital transformation of the industry;(e)Addressing problems facing automobile SMEs in digital transformation via targeted policy tools. 展开更多
关键词 Chengdu-Chongqing economic circle automobile manufacturing industry digital transformation mechanism of action
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Mechanism of Action and Therapeutic Effect of Modified Qiwei Baishu Powder in Diabetes
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作者 Jinyan Sun Kaiwen Li +1 位作者 Chunyan Sun Shichao Dong 《Journal of Clinical and Nursing Research》 2023年第3期118-123,共6页
Objective:To study the mechanism of action and therapeutic effect of modified Qiwei Baishu powder in diabetic patients.Methods:From January 2021 to January 2022,80 diabetic patients were recruited in our study and div... Objective:To study the mechanism of action and therapeutic effect of modified Qiwei Baishu powder in diabetic patients.Methods:From January 2021 to January 2022,80 diabetic patients were recruited in our study and divided into two groups by the random number table method.Group A was treated with modified Qiwei Baishu powder,whereas group B was treated with western medicine.The therapeutic effect,traditional Chinese medicine(TCM)syndrome score,blood sugar level,and incidence of adverse reaction were compared between the two groups.Result:The therapeutic effect in group A was significantly higher than that in group B(P<0.05);the TCM syndrome scores of group A were significantly lower than those of group B(P<0.05);the fasting blood glucose(FBG),2 hour-postprandial blood glucose(PBG),and glycosylated hemoglobin(HbA1c)levels of group A were significantly lower than those of group B(P<0.05);the incidence of adverse reaction in group A was significantly lower than that in group B(P<0.05).Conclusion:On the basis of western medicine,the addition of modified Qiwei Baishu powder can maintain stable blood sugar levels in patients and alleviate diabetic symptoms;thus,it is not only effective,but also safe for clinical use in diabetes. 展开更多
关键词 DIABETES Modified Qiwei Baishu powder Therapeutic effect Mechanism of action
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Mechanism of traditional Chinese medicine in the treatment of psoriasis with depression:A review
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作者 ZHANG Ning YANG Su-qing YUAN Rui 《Journal of Hainan Medical University》 CAS 2024年第1期76-82,共7页
Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psorias... Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment. 展开更多
关键词 PSORIASIS DEPRESSION Mechanism of action Chinese medicinal compound Characteristic therapy of traditional Chinese medicine
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Based on network pharmacology,molecular docking and experimental validation to reveal the potential molecular mechanism of quercetin for the treatment of diarrheal irritable bowel syndrome
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作者 FENG Min-chao LUO Fang +5 位作者 XIE Sheng CHEN Zu-min TAN Jin-xuan LI Kai CHEN Guo-zhong WANG Dao-gang 《Journal of Hainan Medical University》 CAS 2024年第3期42-52,共11页
Objective:To explore the potential mechanism of action of quercetin in the treatment of diarrhea irritable bowel syndrome(IBS-D).Methods:The potential targets of quercetin were obtained from the TCMSP,SwissTar-getPred... Objective:To explore the potential mechanism of action of quercetin in the treatment of diarrhea irritable bowel syndrome(IBS-D).Methods:The potential targets of quercetin were obtained from the TCMSP,SwissTar-getPrediction,and BATMAN-TCM databases.The targets of IBS-D were obtained by searching the GeneCards database with"diarrhea irritable bowel syndrome"as the keyword,and the targets of quercetin and IBS-D were intersected.The PPI network was constructed by Cytoscape 3.7.1 software.The intersected targets were imported into the DAVID database for GO functional analysis and KEGG pathway enrichment analysis.The binding ability of quercetin to the core targets was observed using molecular docking.Based on this,we established an IBS-D rat model,administered quercetin for intervention,and experimentally validated the network pharmacology prediction results by HE staining and ELISA assay.Results:Network pharmacology analysis showed that TP53,TNF-α,AKT1,VEGF-A,IL-6 factors and MAPK,PI3K-Akt signaling pathway as the core targets and pathways of quercetin for the treatment of IBS-D.The results of animal experiments revealed that quercetin could inhibit the secretion of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,reduce the inflammatory response and improve IBS-D.Conclusion:Quercetin could protect colon tissue by regulating the expression of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,thereby treating IBS-D. 展开更多
关键词 QUERCETIN Diarrheal irritable bowel syndrome Network pharmacology Molecular docking Inflammatory re-sponse Mechanism of action
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Research Progress on Modern Biological Mechanism of Chinese Medicine in Prevention and Treatment of Gouty Nephropathy
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作者 Feifan LIU Shifang LUO +4 位作者 Yan WAN Linao ZHANG Xue WU Yuhuan XIE Peixin GUO 《Medicinal Plant》 2024年第4期129-132,共4页
Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinic... Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinical symptoms.In conclusion,the mechanism of action of Chinese medicine against gouty nephropathy mainly involves oxidative stress,inflammatory response,etc.,with a view to providing new ideas and methods for the prevention and treatment of gouty nephropathy by Chinese medicine. 展开更多
关键词 Chinese medicine Gouty nephropathy Mechanism of action Research progress
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Anti-cancer mechanisms of action of therapeutic alternating electric fields(tumor treating fields[TTFields])
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作者 Shadi Shams Chirag B.Patel 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2022年第8期1-16,共16页
Despite improved survival outcomes across many cancer types,the prognosis remains grim for certain solid organ cancers including glioblastoma and pancreatic cancer.Invariably in these cancers,the control achieved by t... Despite improved survival outcomes across many cancer types,the prognosis remains grim for certain solid organ cancers including glioblastoma and pancreatic cancer.Invariably in these cancers,the control achieved by time-limited interventions such as traditional surgical resection,radiation therapy,and chemotherapy is short-lived.A new form of anti-cancer therapy called therapeutic alternating electric fields(AEFs)or tumor treating fields(TTFields)has been shown,either by itself or in combination with chemotherapy,to have anti-cancer effects that translate to improved survival outcomes in patients.Although the pre-clinical and clinical data are promising,the mechanisms of TTFields are not fully elucidated.Many investigations are underway to better understand how and why TTFields is able to selectively kill cancer cells and impede their proliferation.The purpose of this review is to summarize and discuss the reported mechanisms of action of TTFields from pre-clinical studies(both in vitro and in vivo).An improved understanding of how TTFields works will guide strategies focused on the timing and combination of TTFields with other therapies,to further improve survival outcomes in patients with solid organ cancers. 展开更多
关键词 alternating electric fields(AEFs) cancer mechanism of action PRE-CLINICAL tumor treating fields(TTFields)
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