Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput s...Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.展开更多
Some 1-（6-chloroquinoxalin-2-yl）-2-[4-（trifluoromethyl）-2,6-dinitrophenyl] hydrazine derivatives have been synthesized via both conventional and microwave assisted organic synthesis（MAOS） methods. The MAOS metho...Some 1-（6-chloroquinoxalin-2-yl）-2-[4-（trifluoromethyl）-2,6-dinitrophenyl] hydrazine derivatives have been synthesized via both conventional and microwave assisted organic synthesis（MAOS） methods. The MAOS method is more effective on synthesizing these compounds than the conventional method in regard to the higher chemical yields of products（76%-98%） and the shorter reaction time（1-15 min）.展开更多
A novel channel-wall engineering strategy of the porous materials cationic covalent organic frameworks(COFs)is established based on rapid microwave-assisted anion exchange reaction and utilized to prepare a set of new...A novel channel-wall engineering strategy of the porous materials cationic covalent organic frameworks(COFs)is established based on rapid microwave-assisted anion exchange reaction and utilized to prepare a set of new COFs.Due to the interaction between the carbon dioxide(C02)and the acetate anion,the resulting SJTU-COF-AcO shows greatly enhanced carbon dioxide capacity up to 1.7 times of the pristine COF.The effect of the counteranions to CO2 capacity in the cationic COFs is investigated for the first time,which demonstrates that our channel-wall engineering strategy is a promising way to tailor the property of COFs for high CO2 capacity.展开更多
微波辅助水相有机合成结合了水为溶剂和微波加热的特点,具有反应速率快、产率高、绿色环保等优点。本文介绍了近几年来微波辅助水相(过热水,T≥100℃)有机合成的研究进展,主要包括过碳—碳键形成反应、碳—杂键形成反应、环加成反应、M ...微波辅助水相有机合成结合了水为溶剂和微波加热的特点,具有反应速率快、产率高、绿色环保等优点。本文介绍了近几年来微波辅助水相(过热水,T≥100℃)有机合成的研究进展,主要包括过碳—碳键形成反应、碳—杂键形成反应、环加成反应、M ann ich反应、脱保护反应等。并展望了该领域今后的发展方向。展开更多
文摘Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.
文摘Some 1-（6-chloroquinoxalin-2-yl）-2-[4-（trifluoromethyl）-2,6-dinitrophenyl] hydrazine derivatives have been synthesized via both conventional and microwave assisted organic synthesis（MAOS） methods. The MAOS method is more effective on synthesizing these compounds than the conventional method in regard to the higher chemical yields of products（76%-98%） and the shorter reaction time（1-15 min）.
基金supported by the National Natural Science Foundation of China (Nos.61774102,81670958,81873816, 61671299)the Shanghai Science and Technology Grant (No. 16JC1402000)Program for Shanghai Eastern Scholar and the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2016MS71)
文摘A novel channel-wall engineering strategy of the porous materials cationic covalent organic frameworks(COFs)is established based on rapid microwave-assisted anion exchange reaction and utilized to prepare a set of new COFs.Due to the interaction between the carbon dioxide(C02)and the acetate anion,the resulting SJTU-COF-AcO shows greatly enhanced carbon dioxide capacity up to 1.7 times of the pristine COF.The effect of the counteranions to CO2 capacity in the cationic COFs is investigated for the first time,which demonstrates that our channel-wall engineering strategy is a promising way to tailor the property of COFs for high CO2 capacity.
