目的:分析早发型子痫前期患者发生胎儿脐动脉舒张末期血流缺失或反流(absent or reversed end-diastolic velocity,AREDV)的影响因素及围产儿结局。方法:回顾性分析2017年1月—2021年9月收治的416例早发型子痫前期孕妇的病例资料,根据...目的:分析早发型子痫前期患者发生胎儿脐动脉舒张末期血流缺失或反流(absent or reversed end-diastolic velocity,AREDV)的影响因素及围产儿结局。方法:回顾性分析2017年1月—2021年9月收治的416例早发型子痫前期孕妇的病例资料,根据分娩前是否发生AREDV分为AREDV组(58例)和非AREDV组(358例)。比较2组孕妇临床资料以及围产儿结局,采用二分类Logistic回归分析早发型子痫前期孕妇发生AREDV的影响因素。结果:2组孕妇子痫前期诊断孕周、血红蛋白水平、丙氨酸转氨酶和血小板分布宽度比较,差异有统计学意义(均P<0.05)。多因素Logistic回归分析显示,子痫前期诊断孕周和血红蛋白水平与AREDV的发生相关。诊断孕周<28周和28~29+6周的患者发生AREDV的风险分别是32~33+6周诊断者的8.244倍(95%CI:2.631~25.832,P<0.001)和6.532倍(95%CI:2.033~20.985,P=0.002);血红蛋白≥135 g/L的早发型子痫前期患者发生AREDV的风险是血红蛋白正常者的2.438倍(95%CI:1.173~5.065,P=0.017)。AREDV组胎死宫内发生率、引产率高于非AREDV组,新生儿1 min Apgar评分、新生儿出生体质量和孕妇终止妊娠孕周低于非AREDV组,差异均有统计学意义(均P<0.05)。结论:对于诊断孕周早、血红蛋白水平高的早发型子痫前期孕妇,需要加强对胎儿的宫内监测,警惕AREDV的发生。展开更多
Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mo...Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 months.Results Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).展开更多
Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and ...Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and Huajing town of Xuhui district, Shanghai, were recruited and interviewed by structured questionnaire to collect the information on pre-pregnancy health knowledge and service demands. Results 1） Newly-married women thought the contraceptive methods suitable for them was male condom（84.4%）, followed by oral contraceptives（54%）, emergent contraceptive（52.5%） and contraceptive suppository （48.3%）. 2） The score of pre-pregnancy health knowledge was 54.7±14.5 among the subjects. The participants with junior college or a bachelor had more knowledge than those with junior or senior high school, and those who were engaged in medicine /education/science field had higher score. 3） They had higher knowing rate on the common knowledge, and the rate was above 80%. But the knowing rate on the knowledge of birth defect was low, and all below 50%. 4）A proportion of 52. 7% of the respondents knew that there was a station for reproductive health service in their communities, but only 45.5% received the service from the station, 87.0% thought they had insufficient or scarce knowledge, 73.6% planned to consult before pregnancy training courses on preparing pregnancy. and 63.6% were willing to attend the Conclusion The participants had certain pre-pregnancy health knowledge, but still need being improved,＂ in addition, they had higher needs on knowledge and service of birth defect prevention, at the same time they can＇t make full use of the existing reproductive health institution.展开更多
Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of t...Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.展开更多
文摘目的:分析早发型子痫前期患者发生胎儿脐动脉舒张末期血流缺失或反流(absent or reversed end-diastolic velocity,AREDV)的影响因素及围产儿结局。方法:回顾性分析2017年1月—2021年9月收治的416例早发型子痫前期孕妇的病例资料,根据分娩前是否发生AREDV分为AREDV组(58例)和非AREDV组(358例)。比较2组孕妇临床资料以及围产儿结局,采用二分类Logistic回归分析早发型子痫前期孕妇发生AREDV的影响因素。结果:2组孕妇子痫前期诊断孕周、血红蛋白水平、丙氨酸转氨酶和血小板分布宽度比较,差异有统计学意义(均P<0.05)。多因素Logistic回归分析显示,子痫前期诊断孕周和血红蛋白水平与AREDV的发生相关。诊断孕周<28周和28~29+6周的患者发生AREDV的风险分别是32~33+6周诊断者的8.244倍(95%CI:2.631~25.832,P<0.001)和6.532倍(95%CI:2.033~20.985,P=0.002);血红蛋白≥135 g/L的早发型子痫前期患者发生AREDV的风险是血红蛋白正常者的2.438倍(95%CI:1.173~5.065,P=0.017)。AREDV组胎死宫内发生率、引产率高于非AREDV组,新生儿1 min Apgar评分、新生儿出生体质量和孕妇终止妊娠孕周低于非AREDV组,差异均有统计学意义(均P<0.05)。结论:对于诊断孕周早、血红蛋白水平高的早发型子痫前期孕妇,需要加强对胎儿的宫内监测,警惕AREDV的发生。
基金supported by a grant from the National Natural Science Foundation of China [No.81472967 and No.81602849]Young Elite Scientists Sponsorship Program by CAST [No.2017QNRC001]
文摘Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in China.Methods In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 months.Results Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).
文摘Objective To understand the pre-pregnancy health knowledge and service needs among un-pregnant married women in Shanghai. Methods A total of 968 newly-married un-pregnant women in Changqiao, Lingyun sub-districts and Huajing town of Xuhui district, Shanghai, were recruited and interviewed by structured questionnaire to collect the information on pre-pregnancy health knowledge and service demands. Results 1） Newly-married women thought the contraceptive methods suitable for them was male condom（84.4%）, followed by oral contraceptives（54%）, emergent contraceptive（52.5%） and contraceptive suppository （48.3%）. 2） The score of pre-pregnancy health knowledge was 54.7±14.5 among the subjects. The participants with junior college or a bachelor had more knowledge than those with junior or senior high school, and those who were engaged in medicine /education/science field had higher score. 3） They had higher knowing rate on the common knowledge, and the rate was above 80%. But the knowing rate on the knowledge of birth defect was low, and all below 50%. 4）A proportion of 52. 7% of the respondents knew that there was a station for reproductive health service in their communities, but only 45.5% received the service from the station, 87.0% thought they had insufficient or scarce knowledge, 73.6% planned to consult before pregnancy training courses on preparing pregnancy. and 63.6% were willing to attend the Conclusion The participants had certain pre-pregnancy health knowledge, but still need being improved,＂ in addition, they had higher needs on knowledge and service of birth defect prevention, at the same time they can＇t make full use of the existing reproductive health institution.
文摘Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.
