The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and...The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and mortality.The origin of the SARS-CoV-2 is still disputed.The risk of infection with SARS-CoV-2 is dependent on several risk factors as observed in many studies.The severity of the disease depends on many factors including the viral strain,host immunogenetics,environmental factors,host genetics,host nutritional status and presence of comorbidities like hypertension,diabetes,Chronic Obstructive Pulmonary Disease,cardiovascular disease,renal impairment.Diabetes is a metabolic disorder mainly characterized by hyperglycemia.Diabetic individuals are intrinsically prone to infections.SARS-CoV-2 infection in patients with diabetes result inβ-cell damage and cytokine storm.Damage to the cells impairs the equilibrium of glucose,leading to hyperglycemia.The ensuing cytokine storm causes insulin resistance,especially in the muscles and liver,which also causes a hyperglycemic state.All of these increase the severity of COVID-19.Genetics also play pivotal role in disease pathogenesis.This review article focuses from the probable sources of coronaviruses and SARS-CoV-2 to its impacts on individuals with diabetes and host genetics in pre-and post-pandemic era.展开更多
Introduction: Covid-19 is a systemic disease that can spread to all systems. Among the gastrointestinal manifestations, pancreatic involvement can have a major prognostic impact. We report 3 acute pancreatitis cases o...Introduction: Covid-19 is a systemic disease that can spread to all systems. Among the gastrointestinal manifestations, pancreatic involvement can have a major prognostic impact. We report 3 acute pancreatitis cases occurring during Covid-19, in Dakar. Case 1: 65-year-old woman who presented with intense atypical epigastric pain. Physical examination revealed obesity, high blood pressure and abdominal tenderness. Biological tests found increase CRP (134 mg/l) and lipasemia (312 UI/l). Abdominal CT scan showed findings of Balthazar grade C acute pancreatitis. RT-PCR for SARS CoV 2 RT-PCR was positive. The outcome was favorable. Case 2: 56-year-old woman patient with history of nephroangiosclerosis who presented with dyspnea, cough, fever and moderate epigastric pain. Physical examination revealed epigastric tenderness, high blood pressure, anuria. Biological testing, noted increase CRP (96 mg/l), lipasemia (793 UI/l), creatinine (227 mg/l) and urea (3.84 g/l). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Case 3: 27-year-old man who presented with physical asthenia, headache, and epigastric pain. Physical examination found epigastric tenderness. Elevated CRP level was of 102 mg/l and lipasemia level was of 427 UI/l (7N). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Conclusion: Acute pancreatitis can occur during Covid-19 infection. However, the imputability to the Covid-19 disease necessitates to rule out the most common causes.展开更多
文摘The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and mortality.The origin of the SARS-CoV-2 is still disputed.The risk of infection with SARS-CoV-2 is dependent on several risk factors as observed in many studies.The severity of the disease depends on many factors including the viral strain,host immunogenetics,environmental factors,host genetics,host nutritional status and presence of comorbidities like hypertension,diabetes,Chronic Obstructive Pulmonary Disease,cardiovascular disease,renal impairment.Diabetes is a metabolic disorder mainly characterized by hyperglycemia.Diabetic individuals are intrinsically prone to infections.SARS-CoV-2 infection in patients with diabetes result inβ-cell damage and cytokine storm.Damage to the cells impairs the equilibrium of glucose,leading to hyperglycemia.The ensuing cytokine storm causes insulin resistance,especially in the muscles and liver,which also causes a hyperglycemic state.All of these increase the severity of COVID-19.Genetics also play pivotal role in disease pathogenesis.This review article focuses from the probable sources of coronaviruses and SARS-CoV-2 to its impacts on individuals with diabetes and host genetics in pre-and post-pandemic era.
文摘Introduction: Covid-19 is a systemic disease that can spread to all systems. Among the gastrointestinal manifestations, pancreatic involvement can have a major prognostic impact. We report 3 acute pancreatitis cases occurring during Covid-19, in Dakar. Case 1: 65-year-old woman who presented with intense atypical epigastric pain. Physical examination revealed obesity, high blood pressure and abdominal tenderness. Biological tests found increase CRP (134 mg/l) and lipasemia (312 UI/l). Abdominal CT scan showed findings of Balthazar grade C acute pancreatitis. RT-PCR for SARS CoV 2 RT-PCR was positive. The outcome was favorable. Case 2: 56-year-old woman patient with history of nephroangiosclerosis who presented with dyspnea, cough, fever and moderate epigastric pain. Physical examination revealed epigastric tenderness, high blood pressure, anuria. Biological testing, noted increase CRP (96 mg/l), lipasemia (793 UI/l), creatinine (227 mg/l) and urea (3.84 g/l). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Case 3: 27-year-old man who presented with physical asthenia, headache, and epigastric pain. Physical examination found epigastric tenderness. Elevated CRP level was of 102 mg/l and lipasemia level was of 427 UI/l (7N). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Conclusion: Acute pancreatitis can occur during Covid-19 infection. However, the imputability to the Covid-19 disease necessitates to rule out the most common causes.
