Objective： To study the expressive characteristics of SKP2 protein in non-small cell lung carcinoma and it is affection to NSCLC patients＇ prognosis. Methods： The expression of SKP2 protein was detected in 89 NSCLC...Objective： To study the expressive characteristics of SKP2 protein in non-small cell lung carcinoma and it is affection to NSCLC patients＇ prognosis. Methods： The expression of SKP2 protein was detected in 89 NSCLC, 5 benign lung neoplasmas, 5 normal bronchus and lung tissues by Tissue Chip and immunohistochemistry technology. Results： The positive rate of SKP2 protein staining was （23.52±13.57）% in NSCLC tissues, significantly higher than that in benign lung neoplasmas, normal brochus and lung tissues （2.91±1.27）% （P=0.0000〈0.001）. The expressive level of SKP2 protein in NSCLC tissues was closely related to cell differentiation （PI=0.000〈0.001）, but not to age, sex, smoking history, pathological type, site, size, lymph node metastasis and TNM stage （each Pl〉0.05）. The survival analysis displayed that the NSCLC patients＇ 5 years survival rate was lower in positive expression group than that in negative expression group （P1=0.042/0.031〈0.05; r=-0.186, P2=0.000〈0.001）. Conclusion： The positive expression of SKP2 protein may play an enhancement role in the occurrence and development of NSCLC. Moreover, it may be a bad indicator to NSCLC patients＇ prognosis.展开更多
Objective： To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods： The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 sm...Objective： To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods： The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results： The positive rate of SKP2 protein staining was （23.52±13.57）% in non small cell lung carcinoma and （53.85±12.26）% in small cell lung carcinoma, which were significantly higher than （2.91±1.27）% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them （P=0.000）. The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group （P1=0.003/0.002; r=-0.275, P2=0.005）. Conclusion. The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.展开更多
目的:探讨Skp2和第10号染色体缺失的磷酸酶和张力蛋白同源物基因(Phosphatase and tensinhomologue deleted on chromosome 10,PTEN)在前列腺癌中的表达及临床意义。方法:用免疫组织化学EnVi-sionTM方法检测Skp2和PTEN蛋白在41例前列腺...目的:探讨Skp2和第10号染色体缺失的磷酸酶和张力蛋白同源物基因(Phosphatase and tensinhomologue deleted on chromosome 10,PTEN)在前列腺癌中的表达及临床意义。方法:用免疫组织化学EnVi-sionTM方法检测Skp2和PTEN蛋白在41例前列腺癌和20例BPH组织中的表达情况。结果:在前列腺癌中的Skp2蛋白染色阳性率显著高于BPH(P<0.01),Skp2蛋白表达与前列腺癌术前血清前列腺特异抗原(PSA)水平、局部浸润、肿瘤分期、病理分级呈密切正相关(P<0.05)。在前列腺癌中的PTEN蛋白染色阳性率显著低于BPH(P<0.01),PTEN蛋白表达与上述临床病理特征呈负相关(P<0.05)。前列腺癌中Skp2蛋白与PTEN蛋白表达呈负相关(P<0.01)。结论:Skp2蛋白在前列腺癌的发生发展中起重要作用,抑癌基因PTEN可能参与Skp2表达的调节。展开更多
文摘Objective： To study the expressive characteristics of SKP2 protein in non-small cell lung carcinoma and it is affection to NSCLC patients＇ prognosis. Methods： The expression of SKP2 protein was detected in 89 NSCLC, 5 benign lung neoplasmas, 5 normal bronchus and lung tissues by Tissue Chip and immunohistochemistry technology. Results： The positive rate of SKP2 protein staining was （23.52±13.57）% in NSCLC tissues, significantly higher than that in benign lung neoplasmas, normal brochus and lung tissues （2.91±1.27）% （P=0.0000〈0.001）. The expressive level of SKP2 protein in NSCLC tissues was closely related to cell differentiation （PI=0.000〈0.001）, but not to age, sex, smoking history, pathological type, site, size, lymph node metastasis and TNM stage （each Pl〉0.05）. The survival analysis displayed that the NSCLC patients＇ 5 years survival rate was lower in positive expression group than that in negative expression group （P1=0.042/0.031〈0.05; r=-0.186, P2=0.000〈0.001）. Conclusion： The positive expression of SKP2 protein may play an enhancement role in the occurrence and development of NSCLC. Moreover, it may be a bad indicator to NSCLC patients＇ prognosis.
文摘Objective： To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods： The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results： The positive rate of SKP2 protein staining was （23.52±13.57）% in non small cell lung carcinoma and （53.85±12.26）% in small cell lung carcinoma, which were significantly higher than （2.91±1.27）% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them （P=0.000）. The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group （P1=0.003/0.002; r=-0.275, P2=0.005）. Conclusion. The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
文摘目的:探讨Skp2和第10号染色体缺失的磷酸酶和张力蛋白同源物基因(Phosphatase and tensinhomologue deleted on chromosome 10,PTEN)在前列腺癌中的表达及临床意义。方法:用免疫组织化学EnVi-sionTM方法检测Skp2和PTEN蛋白在41例前列腺癌和20例BPH组织中的表达情况。结果:在前列腺癌中的Skp2蛋白染色阳性率显著高于BPH(P<0.01),Skp2蛋白表达与前列腺癌术前血清前列腺特异抗原(PSA)水平、局部浸润、肿瘤分期、病理分级呈密切正相关(P<0.05)。在前列腺癌中的PTEN蛋白染色阳性率显著低于BPH(P<0.01),PTEN蛋白表达与上述临床病理特征呈负相关(P<0.05)。前列腺癌中Skp2蛋白与PTEN蛋白表达呈负相关(P<0.01)。结论:Skp2蛋白在前列腺癌的发生发展中起重要作用,抑癌基因PTEN可能参与Skp2表达的调节。
