BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to exa...BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of AAD.METHODS:The UK Biobank study is a population-based cohort study.Weekly alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95% confidence intervals(CIs)for the associations between alcohol consumption and AAD.Several sensitivity analyses were performed to assess the robustness of the results.RESULTS:Among the 388,955 participants(mean age:57.1 years,47.4% male),2,895 incident AAD cases were documented during a median follow-up of 12.5 years.Compared with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,P<0.05)and moderate-heavy drinkers(adjusted HR:0.794,95%CI:0.635-0.992,P<0.05)were significantly associated with a decreased risk of incident AAD.Interaction-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and women.CONCLUSION:Our findings support a protective effect of moderate alcohol consumption on AAD,but are limited to participants younger than 65 years and women.展开更多
The casting production in the UK in 2004 is presented and analysed. The UK casting industry has played an important role in world casting and manufacturing production. However recent years the rapid development of som...The casting production in the UK in 2004 is presented and analysed. The UK casting industry has played an important role in world casting and manufacturing production. However recent years the rapid development of some developing countries has been shifting the casting production from the western industrialized countries including the UK. The UK casting industry and associated research and technology organizations, universities have been working together very hard to face the serious competition to make the UK casting industry have a sustainable future. The UK casting industry remains strong and plays an important role in world casting and manufacturing production.展开更多
UK Biobank是一项庞大和详细的前瞻性研究工程,由维康信托基金、英国医学研究委员会、英国卫生部、苏格兰政府和西北地区发展局发起成立。其储存着海量疾病与健康相关的研究数据和生物样本,全球的科研人员均可通过在线申请获得这些研究...UK Biobank是一项庞大和详细的前瞻性研究工程,由维康信托基金、英国医学研究委员会、英国卫生部、苏格兰政府和西北地区发展局发起成立。其储存着海量疾病与健康相关的研究数据和生物样本,全球的科研人员均可通过在线申请获得这些研究数据和生物样本并将其用于已批准的研究项目中。本文详细介绍了如何通过UK Biobank检索及申请研究数据和生物样本。展开更多
Although Theresa May the new British Prime Minister had followed Cameron to stand for staying in the EU,after taking office,she has openly stated on several occasions that she will respect the public opinions of the c...Although Theresa May the new British Prime Minister had followed Cameron to stand for staying in the EU,after taking office,she has openly stated on several occasions that she will respect the public opinions of the country and carry out a foreign policy of implementing Brexit according to the result of the referendum.In so doing,she has even made Boris Johnson,a controversy lead展开更多
基金supported by grants from the Ministry of Science and Technology of the People’s Republic of China,(No.2020AAA0109605 to XL)grants from the National Natural Science Foundation of China(No.82272246 and 82072225 to XL)+1 种基金Science and Technology Program of Guangzhou,China(No.202206010044 to XL)High-level Hospital Construction Project of Guangdong Provincial People’s Hospital(No.DFJHBF202104 to XL).
文摘BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of AAD.METHODS:The UK Biobank study is a population-based cohort study.Weekly alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95% confidence intervals(CIs)for the associations between alcohol consumption and AAD.Several sensitivity analyses were performed to assess the robustness of the results.RESULTS:Among the 388,955 participants(mean age:57.1 years,47.4% male),2,895 incident AAD cases were documented during a median follow-up of 12.5 years.Compared with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,P<0.05)and moderate-heavy drinkers(adjusted HR:0.794,95%CI:0.635-0.992,P<0.05)were significantly associated with a decreased risk of incident AAD.Interaction-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and women.CONCLUSION:Our findings support a protective effect of moderate alcohol consumption on AAD,but are limited to participants younger than 65 years and women.
文摘The casting production in the UK in 2004 is presented and analysed. The UK casting industry has played an important role in world casting and manufacturing production. However recent years the rapid development of some developing countries has been shifting the casting production from the western industrialized countries including the UK. The UK casting industry and associated research and technology organizations, universities have been working together very hard to face the serious competition to make the UK casting industry have a sustainable future. The UK casting industry remains strong and plays an important role in world casting and manufacturing production.
文摘Although Theresa May the new British Prime Minister had followed Cameron to stand for staying in the EU,after taking office,she has openly stated on several occasions that she will respect the public opinions of the country and carry out a foreign policy of implementing Brexit according to the result of the referendum.In so doing,she has even made Boris Johnson,a controversy lead
