软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于...软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于混合链路多Overlay隧道实现网络规模解耦下快速路由切换的新型设计,在广域网链路中断后提供路由收敛时间确定性上界保证,给出关键的数据结构及工作流程,对相关工程实施具备较好的指导作用。展开更多
Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this st...Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.展开更多
Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by v...Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking analysis.Methods:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their targets.Online Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of ccRCC.Cytoscape assisted in constructing herb-compound-target(H-C-T)networks.The STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential targets.Analyses of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 database.Human Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression level.Autodock Vina software validated the molecular docking regarding GQW components and pivotal targets.Results:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects ccRCC.According to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling pathways.AKT1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to reports.Molecular docking and molecular dynamics simulations showed that diosgenin has higher affinity with core targets.Conclusion:The study makes a comprehensive explanation of the biological activity,potential targets,as well as molecular mechanism regarding GQW against ccRCC,which promisingly assists in revealing the action mechanism of TCM formulae in disease treatment and the respective and scientific basis.展开更多
文章研究了软件定义广域网(Software-Defined Wide Area Networking,SD-WAN)结合边缘智能在瓦楞纸板生产车间中的应用。该研究的目标是提升瓦楞纸板生产车间的网络性能、安全性和管理效率。通过使用SD-WAN技术,该车间可以实现网络虚拟...文章研究了软件定义广域网(Software-Defined Wide Area Networking,SD-WAN)结合边缘智能在瓦楞纸板生产车间中的应用。该研究的目标是提升瓦楞纸板生产车间的网络性能、安全性和管理效率。通过使用SD-WAN技术,该车间可以实现网络虚拟化、智能路由和实时监控,从而提高网络通信的可靠性和稳定性。SD-WAN与边缘智能的结合使网络资源得以高效利用,优化路由决策,并实现主动的网络管理。该研究对于推动工业环境中的网络技术发展具有重要意义,为瓦楞纸板制造业提供了提高生产效率、降低成本以及提升运营灵活性的机遇。展开更多
SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影...SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。展开更多
文摘软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于混合链路多Overlay隧道实现网络规模解耦下快速路由切换的新型设计,在广域网链路中断后提供路由收敛时间确定性上界保证,给出关键的数据结构及工作流程,对相关工程实施具备较好的指导作用。
文摘Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.
基金supported by Weifang Health Commission Traditional Chinese Medicine Research Project Plan(WFZYY2023-1-004).
文摘Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking analysis.Methods:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their targets.Online Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of ccRCC.Cytoscape assisted in constructing herb-compound-target(H-C-T)networks.The STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential targets.Analyses of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 database.Human Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression level.Autodock Vina software validated the molecular docking regarding GQW components and pivotal targets.Results:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects ccRCC.According to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling pathways.AKT1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to reports.Molecular docking and molecular dynamics simulations showed that diosgenin has higher affinity with core targets.Conclusion:The study makes a comprehensive explanation of the biological activity,potential targets,as well as molecular mechanism regarding GQW against ccRCC,which promisingly assists in revealing the action mechanism of TCM formulae in disease treatment and the respective and scientific basis.
文摘文章研究了软件定义广域网(Software-Defined Wide Area Networking,SD-WAN)结合边缘智能在瓦楞纸板生产车间中的应用。该研究的目标是提升瓦楞纸板生产车间的网络性能、安全性和管理效率。通过使用SD-WAN技术,该车间可以实现网络虚拟化、智能路由和实时监控,从而提高网络通信的可靠性和稳定性。SD-WAN与边缘智能的结合使网络资源得以高效利用,优化路由决策,并实现主动的网络管理。该研究对于推动工业环境中的网络技术发展具有重要意义,为瓦楞纸板制造业提供了提高生产效率、降低成本以及提升运营灵活性的机遇。
文摘SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。
