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Advances in Zika virus vaccines and therapeutics:A systematic review 被引量:1
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作者 Shiza Malik Khalid Muhammad +3 位作者 Omar Ahsan Muhammad Tahir Khan Ranjit Sah Yasir Waheed 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第3期97-109,共13页
Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide.Its wide transmission route and alarming spread rates are of great concern to the sci... Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide.Its wide transmission route and alarming spread rates are of great concern to the scientific community.Numerous trials have been conducted to develop treatment options for ZIKV infection.This review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic development.The results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based vaccines.In addition,approved anti-ZIKV drugs that can reduce the global burden are discussed.Although many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to now.The issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway. 展开更多
关键词 zika virus Infection THERAPEUTICS Antiviral agents Vaccines THERAPIES Treatment Novel therapeutic Clinical management
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Characterization of the infectivity of an Indonesian Zika virus strain in mammalian cell lines
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作者 Justus Thomas Obiajulu Sievers Anom Bowolaksono R.Tedjo Sasmono 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第5期215-224,共10页
Objective:To characterize the infection patterns and growth characteristics of the Zika virus(ZIKV)strain JMB-185 from Indonesia in various mammalian cell lines.Methods:ZIKV was grown in human(A549,HEK293,HepG2,Huh7,J... Objective:To characterize the infection patterns and growth characteristics of the Zika virus(ZIKV)strain JMB-185 from Indonesia in various mammalian cell lines.Methods:ZIKV was grown in human(A549,HEK293,HepG2,Huh7,Jurkat,and THP-1)and non-human mammalian(RAW264.7,Vero,and Vero76)cell lines.Viral replication kinetics were measured using plaque assay,while intra-and extracellular viral RNA concentrations were assessed using RT-PCR.Flow cytometry was used to quantify the infected cells and cell viability was measured using an MTT assay.The ability of ZIKV to infect cell lines was visualized using a fluorescence immunostaining assay.Results:This ZIKV strain preferentially infected the lung,kidney,and liver cell lines A549,HEK293,Huh7,Vero,and Vero76,but not the immune cells Jurkat,RAW264.7,and THP-1.By contrast,the ZIKV showed no sign of infection in HepG2 cells,while maintaining viral titer over 3 days post-infection,with no infection recorded in immunostaining,no increase in viral RNA,and no indication of cell deterioration.Conclusions:The Indonesian ZIKV strain has a similar infection profile as other strains,except for its poor infectivity on HepG2 cells.Information on the growth characteristics of Indonesia ZIKV will help expand our understanding of the biology of ZIKV which will be useful for various applications including antiviral discovery. 展开更多
关键词 zika virus Infectivity REPLICATION Cell lines In vitro
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Polypyrimidine Tract-Binding Protein Enhances Zika Virus Translation by Binding to the 5'UTR of Internal Ribosomal Entry Site
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作者 Moliduer Hamiti Xin-Tian Zhang +4 位作者 Rui-Min Zhu Yun-Peng Liu Bin Yin Peng-Cheng Shu Xiao-Zhong Peng 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第3期163-172,共10页
Objectives To identify the 5'untranslated region of Zika virus(ZIKV 5'UTR)RNA-binding proteins and to investigate the impact of the binding protein on the activity of internal ribosomal entry site(IRES)located... Objectives To identify the 5'untranslated region of Zika virus(ZIKV 5'UTR)RNA-binding proteins and to investigate the impact of the binding protein on the activity of internal ribosomal entry site(IRES)located in ZIKV 5'UTR and virus production.Methods Interacting proteins in U251 cells were captured using tRSA-tagged ZIKV 5'UTR RNA and tRSA-ZIKV 5'UTR RNA-binding proteins were visualized by SDS-PAGE silver staining,Subsequently,liquid chromatographytandem mass spectrometry(LC-MS/MS),bioinformatics analysis,and Western blot were used to identify the candidate proteins binding to ZIKV 5'UTR.Dicistronic expression assay and plaque forming assay were performed to analyze the effect of the binding protein on ZIKV IRES activity and ZIKV production,respecitvely.Results tRSA RNA pull-down assay,LC-MS/MS,and Western blot analysis showed that polypyrimidine tractbinding protein(PTB)bound to the ZIKV 5'UTR.Furthermore,dual luciferase reporter assay revealed that overexpression of PTB significantly enhanced the IRES activity of ZIKV(t=10.220,P<0.001),while PTB knockdown had the opposite effect(t=4.897,P<0.01).Additionally,virus plaque forming assay demonstrated that up-regulation of PTB expression significantly enhanced viral titer(t=6.400,P<0.01),whereas reducing PTB expression level weakened virus infectivity(t=5.055,P<0.01).Conclusion PTB positively interacts with the ZIKV 5'UTR and enhances IRES activity and virus production. 展开更多
关键词 internal ribosomal entry site polypyrimidine tract-binding protein zika virus tRSA RNA pull-down dual-luciferase reporter assay
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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking
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作者 Luciene Soares Silva Tiago Soares Barbosa +8 位作者 Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão 《Journal of Biosciences and Medicines》 2024年第7期214-229,共16页
Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complica... Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation. 展开更多
关键词 zika PYRAZOLONE NS5 METHYLTRANSFERASE ANTIVIRALS
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亚洲国家Zika病毒及其感染的流行状况 被引量:1
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作者 许秀燕 王琴燕 +2 位作者 王晶 鲁晓晴 梁国栋 《中国人兽共患病学报》 CAS CSCD 北大核心 2020年第2期149-157,共9页
众所周知,2015年起南美洲地区发生Zika病毒(Zika virus)感染大流行,累积发现约200万人感染,成为近年来全世界最重要的公共卫生事件,引起世界轰动。虽然在亚洲国家未发现Zika病毒感染的大流行,但是在亚洲的印度,泰国,越南等地发现大量本... 众所周知,2015年起南美洲地区发生Zika病毒(Zika virus)感染大流行,累积发现约200万人感染,成为近年来全世界最重要的公共卫生事件,引起世界轰动。虽然在亚洲国家未发现Zika病毒感染的大流行,但是在亚洲的印度,泰国,越南等地发现大量本土Zika病毒感染病例,并且在中国自然界采集的蚊虫标本中分离到Zika病毒,可见亚洲地区存在Zika病毒感染大流行的潜在风险,而一旦Zika病毒感染在亚洲发生大流行对中国公共卫生将造成巨大危害。为此关注Zika病毒及其感染在亚洲各国的流行状况对我国医疗及公共卫生相关人员具有十分重要的意义。 展开更多
关键词 zika病毒 zika病毒感染 本地zika病毒感染病例
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Zika病毒与Zika病毒病 被引量:3
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作者 瞿涤 《微生物与感染》 2016年第3期130-136,共7页
Zika病毒(Zika virus,ZIKV)是一种新现虫媒病毒,属于黄病毒科黄病毒属。其感染后临床表现为轻症发热,因病重住院者罕见。流行病学数据显示Zika病毒病的流行与自身免疫性神经性疾病格林-巴利综合征及先天性小头畸形有关,引起了专家和公... Zika病毒(Zika virus,ZIKV)是一种新现虫媒病毒,属于黄病毒科黄病毒属。其感染后临床表现为轻症发热,因病重住院者罕见。流行病学数据显示Zika病毒病的流行与自身免疫性神经性疾病格林-巴利综合征及先天性小头畸形有关,引起了专家和公众的关注,但具体机制有待深入研究。 展开更多
关键词 zika病毒 zika病毒病 格林-巴利综合征 先天性小头畸形
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Zika病毒:虫媒病毒传染病的新挑战 被引量:3
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作者 李晓龙 严延生 +1 位作者 王环宇 梁国栋 《中国人兽共患病学报》 CAS CSCD 北大核心 2016年第9期819-824,831,共7页
Zika病毒(Zika virus,ZIKV)是一种新发的虫媒病毒,伊蚊是其主要的传播媒介。Zika病毒感染后主要引起发热,皮疹,关节痛等轻症症状。2015年起,Zika病毒在拉丁美洲及南美洲多个国家流行,并且Zika病毒感染患者不仅出现发热,皮疹和关节痛等症... Zika病毒(Zika virus,ZIKV)是一种新发的虫媒病毒,伊蚊是其主要的传播媒介。Zika病毒感染后主要引起发热,皮疹,关节痛等轻症症状。2015年起,Zika病毒在拉丁美洲及南美洲多个国家流行,并且Zika病毒感染患者不仅出现发热,皮疹和关节痛等症状,还发现Zika病毒病的流行与婴儿小头畸形,格林巴利综合征,病毒性脑膜炎病例的发生相关。不仅如此,Zika病毒感染还可以通过性途径传播。因此,从病毒感染症状的复杂性来看,目前流行的Zika病毒已经与1947年刚发现时的Zika病毒完全不同,而是成为了一种"新病毒"。本文系统地梳理总结了Zika病毒感染相关的最新研究进展,并提出Zika病毒及其感染是对虫媒病毒传染病的新挑战的概念。 展开更多
关键词 zika病毒 虫媒病毒 先天性小头畸形 格林-巴利综合征
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Zika病毒感染的实验室诊断 被引量:4
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作者 宋志刚 王蔚 胡芸文 《微生物与感染》 2016年第3期137-143,共7页
Zika病毒是一种新现虫媒黄病毒,近期在美洲暴发流行,并有向全球扩散的趋势,已成为国际关注的突发公共卫生事件。Zika病毒感染的临床诊断主要依据实验室检测结果。本文就Zika病毒的核酸检测、抗原和抗体检测、病毒分离鉴定等方面进行综述。
关键词 zika病毒 实验室检测 反转录-聚合酶链反应
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ZIKA种母兔饲粮适宜营养水平的研究 被引量:5
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作者 唐良美 谢晓红 +1 位作者 刘曼丽 兰永化 《中国养兔杂志》 1994年第3期16-19,共4页
连续三年在相同的繁殖季节,使用齐卡N系母兔148只,分别观察测定了四种不同营养水平组合日粮对不同繁殖状态母兔繁殖能力的影响。结果表明:在延期繁殖(母兔断奶后再配种)条件下,不同能量、蛋白水平对母兔繁殖性能的影响差异不... 连续三年在相同的繁殖季节,使用齐卡N系母兔148只,分别观察测定了四种不同营养水平组合日粮对不同繁殖状态母兔繁殖能力的影响。结果表明:在延期繁殖(母兔断奶后再配种)条件下,不同能量、蛋白水平对母兔繁殖性能的影响差异不显著(P>0。05),但中能高蛋白(DE10.88兆焦/公斤、CP19%)的第3组日粮略胜于其它组合。由此得出,在引延期繁殖的ZIKA能繁母兔,适宜的营养水平为:消化能(DE)10兆焦/公斤,粗蛋白(CP)19%,粗纤维(CF)10%。在母兔进行半频密繁殖(母兔产后第14天开始配种)情况下,高能高蛋白(CDE12.13兆焦/公斤、CP19%)饲粮对提高繁殖性能的效果明显优于高能低蛋(DE12.13兆焦/公斤,CP15%)和低能低蛋白(DE10.88兆焦/公斤)和CP15%)饲粮(P<0.05),尤其对提高母兔泌乳力效果明显(P<0;01),因此,实行频密(产后立即配种)或半频密繁殖的母兔,适宜营养水平为消化能12兆焦繁殖的母兔,适宜营养水平为消化能12兆焦/公斤,粗蛋白19%,粗纤维9-12%. 展开更多
关键词 zika 营养水平 繁殖性能
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ZIKA病毒及其蚊虫传播媒介 被引量:1
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作者 梁国栋 《中国人兽共患病学报》 CAS CSCD 北大核心 2018年第4期343-348,共6页
ZIKA病毒首次于1947年在非洲恒河猴标本分离到,此后于1948年在同一地区采集的非洲伊蚊(Aedes africnus)标本中分离到ZIKA病毒,确定为蚊传病毒。自1948年以来全世界已经在自然界采集的20余种蚊虫(2种按蚊,15种伊蚊,3种库蚊)中分离到ZIKA... ZIKA病毒首次于1947年在非洲恒河猴标本分离到,此后于1948年在同一地区采集的非洲伊蚊(Aedes africnus)标本中分离到ZIKA病毒,确定为蚊传病毒。自1948年以来全世界已经在自然界采集的20余种蚊虫(2种按蚊,15种伊蚊,3种库蚊)中分离到ZIKA病毒,且在这些蚊虫中获得ZIKA病毒阳性分离物60余次。与此同时,已经对23种蚊虫开展过人工感染ZIKA病毒的蚊传试验研究,并证实8种(7种伊蚊,1种库蚊)为ZIKA病毒传播媒介。可见ZIKA病毒可以由多种蚊虫携带和传播。目前我国已经在自然界采集的致倦库蚊和骚扰阿蚊中分离到ZIKA病毒,但尚未有本地感染病例报告。因此了解国际上有关蚊虫与ZIKA病毒的研究进展对于我国相关研究工作和ZIKA病毒病预防控制具有重要借鉴意义。 展开更多
关键词 zika病毒 虫媒病毒 蚊虫传播媒个
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警惕Zika病毒,公众无需恐慌
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作者 许黎黎 秦川 《中国比较医学杂志》 CAS 北大核心 2016年第2期87-90,共4页
2015年底至今,Zika病毒在多国流行,关注升温。Zika病毒感染为伊蚊传播疾病,极有可能与新生儿小头畸形症有关,WHO建议孕妇要特别注意防止蚊虫叮咬。目前,除台湾省出现一例泰国籍输入病例外,我国大陆地区还没有Zika病毒感染的病例报道。... 2015年底至今,Zika病毒在多国流行,关注升温。Zika病毒感染为伊蚊传播疾病,极有可能与新生儿小头畸形症有关,WHO建议孕妇要特别注意防止蚊虫叮咬。目前,除台湾省出现一例泰国籍输入病例外,我国大陆地区还没有Zika病毒感染的病例报道。伊蚊在我国台湾、海南、广东、广西、云南、福建等地在内的北纬25度以南的亚热带地区广泛存在,这些地区具有Zika病毒感染扩散的潜在风险。我们已提前做好资源和技术储备,应对可能出现的输入性病例,公众无需过于恐慌。 展开更多
关键词 zika病毒 伊蚊 动物模型 技术储备
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Does Zika Really Have the Capacity to Affect the Nervous System and Cause Microcephaly or Intracranial Calcifications? 被引量:1
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作者 Lawrence Broxmeyer Refik Kanjhan 《Modern Research in Inflammation》 2016年第2期20-30,共11页
Although the Centers for Disease Control and Prevention (CDC) reports that brain abnormalities in infants with laboratory-confirmed Zika infection include microcephaly, disrupted brain growth, intracranial calcificati... Although the Centers for Disease Control and Prevention (CDC) reports that brain abnormalities in infants with laboratory-confirmed Zika infection include microcephaly, disrupted brain growth, intracranial calcifications, and abnormal eye findings—it is not known presently if the Zika virus itself causes any of these. In a recent 2016 review of Zika dealing with possible brain abnormalities appearing with Zika, Melo et al. mention that among the Flaviviruses, which Zika is, such brain insults and pathologic findings are practically unheard of. Melo et al. conclude that until more cases are diagnosed and more histopathological proofs are obtained, the possibility of other causes besides Zika cannot be ruled out. This paper considers just such other possible causes that have, to this point, escaped general notice. The Aedes aegypti and other Aedes species can transmit tiny viral-like, cell-wall-deficient mycobacterial forms, independent of viruses, yet prevalent in the very same Rhesus Monkey used in the original 1952 Zika communication—which spoke of “A filterable transmissible agent”. In addition, the universal fetal prenatal vaccination of Brazilian neonates is considered, strongly discouraged by The Royal Children’s Hospital in Melbourne, which forbids BCG vaccination of pregnant women and those immunosuppressed or already having tuberculosis (TB) or AIDS. And finally thought is focused on the prime candidate itself, towards explaining what an alternative cause for “Zika” might look like—an infectious agent with transmissible, filterable, viral-like forms. One which can be transmitted by the very same Aedes mosquitoes that carry Zika—one that is neurotrophic, and extremely prevalent in Brazil—and that can disrupt brain growth, cause microcephalus, cause a fever, is sexually transmissible, instigates Guillain-Barré syndrome and causes cranial calcifications—the Mycobacterium tuberculosis complex, which includes the Mycobacterium africanum prevalent, yet completely ignored, in the Rhesus monkeys used in the original Zika study. 展开更多
关键词 The zika Virus MICROCEPHALY Aedes aegypti Flaws in zika Diagnosis Mycobacterium Tuberculosis
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Healthcare workers' knowledge towards Zika virus infection in Indonesia:A survey in Aceh
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作者 Harapan Harapan Alma Aletta +7 位作者 Samsul Anwar Abdul M.Setiawan Reza Maulana Nur Wahyuniati Muhammad R.Ramadana Sotianingsih Haryanto Alfonso J.Rodriguez-Morales Kurnia F.Jamil 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2017年第2期182-186,共5页
Objective:To assess the knowledge on Zika virus(ZIKV) infection among healthcare providers(doctors) in Aceh province,Indonesia.Methods:A self-administered internet based survey was conducted from 3 May to 3 June 2016 ... Objective:To assess the knowledge on Zika virus(ZIKV) infection among healthcare providers(doctors) in Aceh province,Indonesia.Methods:A self-administered internet based survey was conducted from 3 May to 3 June 2016 among the members of doctor organizations in Aceh province.A set of validated,pre-tested questionnaire was used to measure knowledge regarding ZIKV infection and to collect a range of explanatory variables.A two-steps logistic regression analysis was employed to assess the association of participants' demographic,workplace characteristics and other explanatory variables with the knowledge.Results:A total of 442 participants included in the final analysis and 35.9% of them(159) had a good knowledge on ZIKV infection.Multivariate model revealed that type of occupation,type of workplace,availability of access to medical journals and experience made Zika disease as differential diagnose were associated with knowledge on ZIKV infection.In addition,three significant source of information regarding ZIKV were online media(60%),medical article or medical news(16.2%) and television(13.2%).Conclusion:The knowledge of the doctors in Aceh regarding ZIKV infection is relatively low.Doctors who have a good knowledge on ZIKV infection are more confident to established ZIKV disease as differential diagnosis in their clinical setting.Therefore,such program to increase healthcare providers' knowledge regarding ZIKV infection is needed to screen potential carriers of ZIKV infection. 展开更多
关键词 zika virus zika fever KNOWLEDGE ATTITUDE Health care worker Indonesia
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Zika病毒传播动力学模型及其最优控制 被引量:1
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作者 丁春晓 朱元国 《南京理工大学学报》 EI CAS CSCD 北大核心 2016年第4期423-430,共8页
为了探究Zika病毒传播规律,创建了具有Logistic增长率的Zika病毒传播动力学模型。证明了模型无病平衡点和地方病平衡点的存在性,计算了疾病爆发阈值——基本再生数。随后,提出了基于模型的最优控制问题,给出了最优解存在的必要条件并求... 为了探究Zika病毒传播规律,创建了具有Logistic增长率的Zika病毒传播动力学模型。证明了模型无病平衡点和地方病平衡点的存在性,计算了疾病爆发阈值——基本再生数。随后,提出了基于模型的最优控制问题,给出了最优解存在的必要条件并求得了最优解。最后通过数值仿真例子,对比不同控制策略,证明了模型的有效性和控制策略的合理性。 展开更多
关键词 zika病毒 模型 稳定性 最优控制 传播动力学
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The Zika epidemic and abortion in Latin America:a scoping review
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作者 Mabel Carabali Nichole Austin +1 位作者 Nicholas B.King Jay S.Kaufman 《Global Health Research and Policy》 2018年第1期272-280,共9页
Background:Latin America presently has the world’s highest burden of Zika virus,but there are unexplained differences in national rates of congenital malformations collectively referred to as Congenital Zika Syndrome... Background:Latin America presently has the world’s highest burden of Zika virus,but there are unexplained differences in national rates of congenital malformations collectively referred to as Congenital Zika Syndrome(CZS)in the region.While Zika virulence and case detection likely contribute to these differences,policy-related factors,including access to abortion,may play important roles.Our goal was to assess perspectives on,and access to,abortion in Latin America in the context of the Zika epidemic.Methods:We conducted a scoping review of peer-reviewed and gray literature published between January 2015 and December 2016,written in English,Spanish,Portuguese,or French.We searched PubMed,Scielo,and Google Scholar for literature on Zika and/or CZS and abortion,and used automated and manual review methods to synthesize the existing information.Results:36 publications met our inclusion criteria,the majority of which were qualitative.Publications were generally in favor of increased access to safe abortion as a policy-level response for mitigating the impact of CZS,but issues with implementation were cited as the main challenge.Aside from the reform of abortion regulation in Colombia,we did not find evidence that the Zika epidemic had triggered shifts in abortion policy in other countries.Conclusion:Abortion policy in the region remained largely unchanged following the Zika epidemic.Further empirical research on abortion access and differential rates of CZS across Latin American countries is required. 展开更多
关键词 zika Congenital zika syndrome Latin America ABORTION Public health practice Maternal and child health
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基于ZIKA病毒的流行性传播学分析 被引量:1
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作者 王茜 薛亚奎 《云南师范大学学报(自然科学版)》 2018年第3期42-50,共9页
为控制ZIKA病毒传染病蔓延,建立带有差别性出生率、死亡率、双线性发生率和饱和治疗率的SITRS传染病模型.证明了如果基本再生数小于1,则无病平衡点全局渐近稳定;基本再生数大于1,则无病平衡点不稳定,同时存在局部渐近稳定的地方性平衡点... 为控制ZIKA病毒传染病蔓延,建立带有差别性出生率、死亡率、双线性发生率和饱和治疗率的SITRS传染病模型.证明了如果基本再生数小于1,则无病平衡点全局渐近稳定;基本再生数大于1,则无病平衡点不稳定,同时存在局部渐近稳定的地方性平衡点,即ZIKA病毒在传播过程中,传染病是否完全爆发由此类SITRS模型的基本再生数决定,将病理学动态进程抽象化后,发现控制蚊虫和隔离治疗对控制ZIKA病毒的扩散十分重要,数值模拟出ZIKA稳定性图像,为ZIKA病毒防治提供了科学合理的理论依据. 展开更多
关键词 zika病毒 基本再生数 全局稳定性 传染病模型
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齐卡(ZIKA)配套系肉兔在四川的选育 被引量:4
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作者 刘曼丽 唐良美 +3 位作者 兰永亿 谢晓红 陈文昭 刘林 《西南农业学报》 CSCD 1994年第2期89-94,共6页
齐卡(ZIKA)兔系1988年从德国引进的高产肉兔配套系,共60只。兔群引进后由德国封闭式小环境变为我国开放式饲养,经历了气候、饲料及饲养条件等的巨大变化,通过4年3个世代的扩群、选育,齐卡配套系兔由60只扩展到了年... 齐卡(ZIKA)兔系1988年从德国引进的高产肉兔配套系,共60只。兔群引进后由德国封闭式小环境变为我国开放式饲养,经历了气候、饲料及饲养条件等的巨大变化,通过4年3个世代的扩群、选育,齐卡配套系兔由60只扩展到了年龄一致的二世代种用核心群330只,并向9个祖代场配套输送种兔800余只,向全国出售各代种兔6000余只。三系种兔的繁殖性能、生长发育逐代提高,二世代前三胎平均产仔数分别为:德国巨型白兔—G系6.66±2.40只;德国大型新西兰—N系6.79±2.07只;德国合成白兔—Z系5.81±2.63只。比1988年基础群分别提高21.1%(P<0.01)、30.6%(P<0.01)和7.6%。6月龄重分别为G系4.50±0.49kg;N系3.50±0.24kg;Z系3.35±0.23kg,比基础群分别提高12.5%(P<0.05)、3.9%和10.6%(P<0.05)。三系兔的繁殖性能分别接近和达到引进原种兔的生产水平,其中G系产活仔数超过引进原种10.9%。三系兔6月龄和成年体重也达到引进原种水平。 展开更多
关键词 肉兔 齐卡配套系 引种 育种
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Immunological evidence of Zika virus transmission in Thailand 被引量:6
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作者 Nitwara Wikan Yupin Suputtamongkol +2 位作者 Sutee Yoksan Duncan R.Smith Prasert Auewarakul 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第2期136-139,共4页
Objective: To identify immunological evidence of Zika virus transmission in Thailand. Methods: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferen... Objective: To identify immunological evidence of Zika virus transmission in Thailand. Methods: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated fever patients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. Results: Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. Conclusions: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation. 展开更多
关键词 EMERGING INFECTIOUS DISEASES SEROSURVEY Thailand zika VIRUS
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Afebrile, asymptomatic and non-thrombocytopenic Zika virus infection: don't miss it! 被引量:4
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作者 Somsri Wiwanitkit Viroj Wiwanitkit 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第5期499-500,共2页
Zika virus infection is the present problematic arboviral disease. Classically, this disease cause febrile illness and can result in low platelet count. However, there are some new obervations on atypical clinical pre... Zika virus infection is the present problematic arboviral disease. Classically, this disease cause febrile illness and can result in low platelet count. However, there are some new obervations on atypical clinical presentations of Zika virus infection that can make the diagnosis more difficult. The afebrile, asymptomatic and non-thrombocytopenic Zika virus infection can be seen in clinical practice and can lead to missed or delayed diagnosis. 展开更多
关键词 Afebrile ASYMPTOMATIC THROMBOCYTOPENIA zika virus Infection
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Based on the risk of dengue virus transmission via blood transfusion:What about the risk in case of Zika virus? 被引量:3
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作者 Somsri Wiwanitkit Viroj Wiwanitkit 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第11期1099-1100,共2页
The risk of dengue virus transmission via blood transfusion is confirmed.As a similar virus,the risk for the case of Zika virus should be mentioned.Here,the authors calculated for the risk of Zika virus transmission v... The risk of dengue virus transmission via blood transfusion is confirmed.As a similar virus,the risk for the case of Zika virus should be mentioned.Here,the authors calculated for the risk of Zika virus transmission via blood transmission referring to the previous data on the risk in case of dengue virus. 展开更多
关键词 zika virus BLOOD TRANSFUSION TRANSMISSION
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