The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo d...The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo diseases are most closely related to the liver,so the mechanism can be simply understood as liver and spleen damage.Water dampness is unfavourable for transportation and transformation as dampness gathers phlegm,and liver‘wind’carries phlegm to the ear orifice,causing dizziness,or the ear orifice can be attacked due to the deficiency of yin and hyperactivity of yang in liver and kidney,resulting in sudden dizziness.Based on the pathogenesis theory of liver and spleen damage,the treatment principles should be based on strengthening the spleen and dispelling dampness,eliminating phlegm and extinguishing‘wind’.For‘yang-type'hyperactive liver,nourishing yin and suppressing yang,and the clearing of yang in the ears should always be the standard.展开更多
belong是个不及物动词,它没有含被动意味的过去分词,也不可用于进行时,通常只用于一般态,单独使用时,常表示“处在适当位置”(be in theright place)的意思,汉译时往往需要灵活处理。例如: We all belong.我们彼此合得来。 He doesn’t ...belong是个不及物动词,它没有含被动意味的过去分词,也不可用于进行时,通常只用于一般态,单独使用时,常表示“处在适当位置”(be in theright place)的意思,汉译时往往需要灵活处理。例如: We all belong.我们彼此合得来。 He doesn’t belong.他人缘不好。 Everyone wants to belong and matter. 人人都希望成为集体一分子并起到不可或缺的作用。 The orphans are loved and feel they belong. 孤儿们受到人们的疼爱,感到自己不是外人。 After years of living here, I feel that I belong.展开更多
Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was ...Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.展开更多
The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of...The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of local Qianshan area culture, taking Hekou ancient town street of Ming and Qing Dynasty as an example, with the construction of place spirit and sense of belonging as the primary goal, and combining the history and culture of the city, the current situation of the streets and the characteristics of the buildings, this paper put forward the relevant renovation measures to provide a kind of thinking for the refined and rational renovation of the blocks in the future.展开更多
Pits are circular to elliptical,steep-sided,flat-bottomed depressions interpreted to form from collapse into a cavity.They occur on Earth,Venus and Mars and range in diameter from;00 m to several kilometres(e.g.
As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert c...As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert展开更多
A girl complained (抱怨) to her father about her hard life. She didn’t know what she had to do and wanted to 1 . She felt tired from fighting and fighting. One problem had been finished but another came. Her father, ...A girl complained (抱怨) to her father about her hard life. She didn’t know what she had to do and wanted to 1 . She felt tired from fighting and fighting. One problem had been finished but another came. Her father, a cook, took her into the kitchen. He poured water into three pans and boiled it. When the water was boiling, in the first pan he put some carrots, in the 2 he put some eggs and in the last he put some coffee. He 3 for them for a few minutes without any words. The girl closed her mouth and waited impatiently, not knowing why her father was doing that. After about 20 minutes, her father turned off the stove, took out the carrots and put them in a bowl. He took out the eggs and put them in another bowl. After that the 4 was poured into a cup. Turning back to his daughter, he asked, “What do you 5 ?” “Carrots, eggs, and coffee,” she answered.展开更多
Rural boarding schools in compulsory education in China have proliferated with school merger program.This paper analyzes the relationship between school belonging and student development and the factors that influence...Rural boarding schools in compulsory education in China have proliferated with school merger program.This paper analyzes the relationship between school belonging and student development and the factors that influence students'sense of belonging in rural boarding schools.The paper examines how principals in rural boarding schools in China can promote student development by building a sense of belonging.The paper argues that building this sense of belonging can serve as a solution to the current problems affecting rural boarding schools,improve the quality of rural primary education,and promote student development.展开更多
Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecula...Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.展开更多
Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,...Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.展开更多
Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infection...Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.展开更多
SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family...SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].展开更多
The pen shell(Atrina pectinata) is a large wedge-shaped bivalve, which belongs to family Pinnidae. Due to its large and nutritious adductor muscle, it is the popular seafood with high commercial value in Asia-Pacific ...The pen shell(Atrina pectinata) is a large wedge-shaped bivalve, which belongs to family Pinnidae. Due to its large and nutritious adductor muscle, it is the popular seafood with high commercial value in Asia-Pacific countries. However, limiting genomic and transcriptomic data have hampered its genetic investigations. In this study, the transcriptome of A. pectinata was deeply sequenced using Illumina pair-end sequencing technology. After assembling, a total of 127263 unigenes were obtained. Functional annotation indicated that the highest percentage of unigenes(18.60%) was annotated on GO database, followed by 18.44% on PFAM database and 17.04% on NR database. There were 270 biological pathways matched with those in KEGG database. Furthermore, a total of 23452 potential simple sequence repeats(SSRs) were identified, of them the most abundant type was mono-nucleotide repeats(12902, 55.01%), which was followed by di-nucleotide(8132, 34.68%), tri-nucleotide(2010, 8.57%), tetra-nucleotide(401, 1.71%), and penta-nucleotide(7, 0.03%) repeats. Sixty SSRs were selected for validating and developing genic SSR markers, of them 23 showed polymorphism in a cultured population with the average observed and expected heterozygosities of 0.412 and 0.579, respectively. In this study, we established the first comprehensive transcript dataset of A. pectinata genes. Our results demonstrated that RNA-Seq is a fast and cost-effective method for genic SSR development in non-model species.展开更多
Chronic nephritis is a frequently seen disease,but difficult to treat,from which the restora-tion of damaged renal functions is even more dif-ficult.In clinical practice,the authors
On February 14,2017 the Sinopec Corp.convened a meeting on reviewing and assessing the commercial application of the technology relating to a 200 kt/a unit for production of cyclyhexanone through esterification.The ex...On February 14,2017 the Sinopec Corp.convened a meeting on reviewing and assessing the commercial application of the technology relating to a 200 kt/a unit for production of cyclyhexanone through esterification.The expert group attending the meeting unanimously recognized that this technology is uniquely innovative around the world,and the production process。展开更多
基金Shaanxi Province Famous TCM Doctor Zhang Xiong Studio[Shaan Wei TCM Development(2018)No.95]。
文摘The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo diseases are most closely related to the liver,so the mechanism can be simply understood as liver and spleen damage.Water dampness is unfavourable for transportation and transformation as dampness gathers phlegm,and liver‘wind’carries phlegm to the ear orifice,causing dizziness,or the ear orifice can be attacked due to the deficiency of yin and hyperactivity of yang in liver and kidney,resulting in sudden dizziness.Based on the pathogenesis theory of liver and spleen damage,the treatment principles should be based on strengthening the spleen and dispelling dampness,eliminating phlegm and extinguishing‘wind’.For‘yang-type'hyperactive liver,nourishing yin and suppressing yang,and the clearing of yang in the ears should always be the standard.
文摘belong是个不及物动词,它没有含被动意味的过去分词,也不可用于进行时,通常只用于一般态,单独使用时,常表示“处在适当位置”(be in theright place)的意思,汉译时往往需要灵活处理。例如: We all belong.我们彼此合得来。 He doesn’t belong.他人缘不好。 Everyone wants to belong and matter. 人人都希望成为集体一分子并起到不可或缺的作用。 The orphans are loved and feel they belong. 孤儿们受到人们的疼爱,感到自己不是外人。 After years of living here, I feel that I belong.
文摘Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.
基金Sponsored by General Project of Humanities and Social Sciences in Colleges and Universities of Jiangxi Province(YS18126)
文摘The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of local Qianshan area culture, taking Hekou ancient town street of Ming and Qing Dynasty as an example, with the construction of place spirit and sense of belonging as the primary goal, and combining the history and culture of the city, the current situation of the streets and the characteristics of the buildings, this paper put forward the relevant renovation measures to provide a kind of thinking for the refined and rational renovation of the blocks in the future.
文摘Pits are circular to elliptical,steep-sided,flat-bottomed depressions interpreted to form from collapse into a cavity.They occur on Earth,Venus and Mars and range in diameter from;00 m to several kilometres(e.g.
文摘As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert
文摘A girl complained (抱怨) to her father about her hard life. She didn’t know what she had to do and wanted to 1 . She felt tired from fighting and fighting. One problem had been finished but another came. Her father, a cook, took her into the kitchen. He poured water into three pans and boiled it. When the water was boiling, in the first pan he put some carrots, in the 2 he put some eggs and in the last he put some coffee. He 3 for them for a few minutes without any words. The girl closed her mouth and waited impatiently, not knowing why her father was doing that. After about 20 minutes, her father turned off the stove, took out the carrots and put them in a bowl. He took out the eggs and put them in another bowl. After that the 4 was poured into a cup. Turning back to his daughter, he asked, “What do you 5 ?” “Carrots, eggs, and coffee,” she answered.
文摘Rural boarding schools in compulsory education in China have proliferated with school merger program.This paper analyzes the relationship between school belonging and student development and the factors that influence students'sense of belonging in rural boarding schools.The paper examines how principals in rural boarding schools in China can promote student development by building a sense of belonging.The paper argues that building this sense of belonging can serve as a solution to the current problems affecting rural boarding schools,improve the quality of rural primary education,and promote student development.
基金This work was supported by the National Natural Science Foundation of China(No.32030095).
文摘Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.
基金This work was sponsored by the National Natural Science Foundation of China(No.32002100,31772370,31972470).
文摘Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.
基金supported by the National Key Science and Technology Projects of China [Project Nos.2017ZX10104001,2018ZX10711001,and 2018ZX10713002]
文摘Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.
基金supported by grants from National Natural Science Foundation of China[81700920,81970894,and81870725]Natural Science Foundation of Jiangsu Province[BK20191229,BK20180048,and 17KJA180008]+3 种基金the Fifth‘333Project’Scientific Research Foundation of Jiangsu Province[BRA2019192 and BRA2019278]Medical Scientific Research Project from Health and Family Planning Commission of Jiangsu Province[H201666]Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant[20152519]Science and Technology Commission of Shanghai Municipality[14DZ2260300]。
文摘SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].
基金the grants from Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, P. R. China (No. 2016LMFS-B02)the Key Research and Development Program of Shandong Province (No. 2016GSF115012)+1 种基金Basic Scientific Research Fund of YSFRI (No. 2060302201516054)Natural Science Foundation of Shandong Province (No. ZR2016 CQ32)
文摘The pen shell(Atrina pectinata) is a large wedge-shaped bivalve, which belongs to family Pinnidae. Due to its large and nutritious adductor muscle, it is the popular seafood with high commercial value in Asia-Pacific countries. However, limiting genomic and transcriptomic data have hampered its genetic investigations. In this study, the transcriptome of A. pectinata was deeply sequenced using Illumina pair-end sequencing technology. After assembling, a total of 127263 unigenes were obtained. Functional annotation indicated that the highest percentage of unigenes(18.60%) was annotated on GO database, followed by 18.44% on PFAM database and 17.04% on NR database. There were 270 biological pathways matched with those in KEGG database. Furthermore, a total of 23452 potential simple sequence repeats(SSRs) were identified, of them the most abundant type was mono-nucleotide repeats(12902, 55.01%), which was followed by di-nucleotide(8132, 34.68%), tri-nucleotide(2010, 8.57%), tetra-nucleotide(401, 1.71%), and penta-nucleotide(7, 0.03%) repeats. Sixty SSRs were selected for validating and developing genic SSR markers, of them 23 showed polymorphism in a cultured population with the average observed and expected heterozygosities of 0.412 and 0.579, respectively. In this study, we established the first comprehensive transcript dataset of A. pectinata genes. Our results demonstrated that RNA-Seq is a fast and cost-effective method for genic SSR development in non-model species.
文摘Chronic nephritis is a frequently seen disease,but difficult to treat,from which the restora-tion of damaged renal functions is even more dif-ficult.In clinical practice,the authors
文摘On February 14,2017 the Sinopec Corp.convened a meeting on reviewing and assessing the commercial application of the technology relating to a 200 kt/a unit for production of cyclyhexanone through esterification.The expert group attending the meeting unanimously recognized that this technology is uniquely innovative around the world,and the production process。
