In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, whic...In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, which are assembled rationally to create ‘nature-like＇ and yet unnatural organic molecules with well-defined structures and useful properties. Sugar amino acids（SAAs）, the carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important ones of these multifunctional building blocks, which can be used to create novel materials with potential applications as glycomimetics and peptidomimetics. This review will focus on recent synthetic strategies of SAAs and their applications in creating large number of structurally diverse glycomimetics and peptidomimetics.展开更多
Identifying the morphology of rock blocks is vital to accurate modelling of rock mass structures. This paper applies the concepts of directed edges and vertex chain operations which are typical for block tracing appro...Identifying the morphology of rock blocks is vital to accurate modelling of rock mass structures. This paper applies the concepts of directed edges and vertex chain operations which are typical for block tracing approach to block assembling approach to construct the structure of three-dimensional fractured rock masses. Polygon subtraction and union algorithms that rely merely on vertex chain operation are proposed, which allow a fast and convenient construction of complex faces/loops. Apart from its robustness in dealing with finite discontinuities and complex geometries, the advantages of the current methodology in tackling some challenging issues associated with the morphological analysis of rock blocks are addressed. In particular, the identification of complex blocks with interior voids such as cavity, pit and toms can be readily achieved based on the number and the type of loops. The improved morphology visualization approach can benefit the pre-processing stage when analyzing the stability of rock masses subject to various engineering impacts using the block theory and the discrete element method.展开更多
We are all familiar with DNA as the substance that encodes the genomes of all living things.In addition to genetic function,DNA is one of the smartest building blocks for innovative nanostructures.DNA walker is a kind...We are all familiar with DNA as the substance that encodes the genomes of all living things.In addition to genetic function,DNA is one of the smartest building blocks for innovative nanostructures.DNA walker is a kind of self-assembled molecular machine that mimics the movement of protein motors in living systems.Usually,DNA walker consists of three parts：a single stranded DNA track,展开更多
基金supported by the National Science Foundation for Young Scientists of China(No.21302068)the Natural Science Foundation of Jiangsu Province,China(No.BK20130127)+2 种基金Jiangsu Province‘‘Six Summit Talent’’Foundation(No.2012-SWYY-009)the Specialized Research Fund for the Doctoral Program of Higher Education(No.20120093120002)the Fundamental Research Funds for the Central Universities(Nos.JUSRP51319B,JUSRP51411B)
文摘In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, which are assembled rationally to create ‘nature-like＇ and yet unnatural organic molecules with well-defined structures and useful properties. Sugar amino acids（SAAs）, the carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important ones of these multifunctional building blocks, which can be used to create novel materials with potential applications as glycomimetics and peptidomimetics. This review will focus on recent synthetic strategies of SAAs and their applications in creating large number of structurally diverse glycomimetics and peptidomimetics.
基金The research was conducted with funding provided by the National Basic Research Program of China （973 program, No.2014CB046905）, the National Science Foundation of China （Grant No. 41672262）, the State Key Laboratory for Geo mechanics and Deep Underground Engineering （No.SKLGDUEK1303）, and the Department of Communications of Guangdong Province （No.2016）.
文摘Identifying the morphology of rock blocks is vital to accurate modelling of rock mass structures. This paper applies the concepts of directed edges and vertex chain operations which are typical for block tracing approach to block assembling approach to construct the structure of three-dimensional fractured rock masses. Polygon subtraction and union algorithms that rely merely on vertex chain operation are proposed, which allow a fast and convenient construction of complex faces/loops. Apart from its robustness in dealing with finite discontinuities and complex geometries, the advantages of the current methodology in tackling some challenging issues associated with the morphological analysis of rock blocks are addressed. In particular, the identification of complex blocks with interior voids such as cavity, pit and toms can be readily achieved based on the number and the type of loops. The improved morphology visualization approach can benefit the pre-processing stage when analyzing the stability of rock masses subject to various engineering impacts using the block theory and the discrete element method.
文摘We are all familiar with DNA as the substance that encodes the genomes of all living things.In addition to genetic function,DNA is one of the smartest building blocks for innovative nanostructures.DNA walker is a kind of self-assembled molecular machine that mimics the movement of protein motors in living systems.Usually,DNA walker consists of three parts：a single stranded DNA track,
