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A study of making use of computer-aided projection fringe system to measure breast dimension
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作者 查选平 《外科研究与新技术》 2005年第3期211-211,共1页
To measure breast basic dimension by using computer-aided projection fringe system.Methods A system has been developed for measuring breast basic dimension based on computer-aided projection fringe measurement and pro... To measure breast basic dimension by using computer-aided projection fringe system.Methods A system has been developed for measuring breast basic dimension based on computer-aided projection fringe measurement and programming software.Plastic manikins breast’s SN-N (sternal notch to nipple distance),N-ML (nipple to midline distance),N-N (internipple distance),MBW (base width of breast) and N-IMF (nipple to inframammary fold distance) are measured with this system.At the same time,these items are also measured with routine ruler.Results This study indicate that the system has some merits:① non-touching measurement;② it is very rapid,the patient measured need hold his breath only 0.5 second,and all the time it takes is about 2.5 minutes;③ the measurement’s sensitivity is as high as to 0.6 mm,which meets the clinic requirement entirely;④ the measurement’s accuracy of the system is not significantly when comparing to the routine ruler’s.Conclusion Computer-adided projection fringe system for measuring breast basic dimension is feasible and advanced.14 refs,1 fig. 展开更多
关键词 A study of making use of computer-aided projection fringe system to measure breast dimension
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Optimizing Deep Learning for Computer-Aided Diagnosis of Lung Diseases: An Automated Method Combining Evolutionary Algorithm, Transfer Learning, and Model Compression
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作者 Hassen Louati Ali Louati +1 位作者 Elham Kariri Slim Bechikh 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2519-2547,共29页
Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues,particularly in the field of lung disease diagnosis.One promising avenue involves the use of chest X-Rays,w... Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues,particularly in the field of lung disease diagnosis.One promising avenue involves the use of chest X-Rays,which are commonly utilized in radiology.To fully exploit their potential,researchers have suggested utilizing deep learning methods to construct computer-aided diagnostic systems.However,constructing and compressing these systems presents a significant challenge,as it relies heavily on the expertise of data scientists.To tackle this issue,we propose an automated approach that utilizes an evolutionary algorithm(EA)to optimize the design and compression of a convolutional neural network(CNN)for X-Ray image classification.Our approach accurately classifies radiography images and detects potential chest abnormalities and infections,including COVID-19.Furthermore,our approach incorporates transfer learning,where a pre-trainedCNNmodel on a vast dataset of chest X-Ray images is fine-tuned for the specific task of detecting COVID-19.This method can help reduce the amount of labeled data required for the task and enhance the overall performance of the model.We have validated our method via a series of experiments against state-of-the-art architectures. 展开更多
关键词 computer-aided diagnosis deep learning evolutionary algorithms deep compression transfer learning
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Automatic Fetal Segmentation Designed on Computer-Aided Detection with Ultrasound Images
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作者 Mohana Priya Govindarajan Sangeetha Subramaniam Karuppaiya Bharathi 《Computers, Materials & Continua》 SCIE EI 2024年第11期2967-2986,共20页
In the present research,we describe a computer-aided detection(CAD)method aimed at automatic fetal head circumference(HC)measurement in 2D ultrasonography pictures during all trimesters of pregnancy.The HC might be ut... In the present research,we describe a computer-aided detection(CAD)method aimed at automatic fetal head circumference(HC)measurement in 2D ultrasonography pictures during all trimesters of pregnancy.The HC might be utilized toward determining gestational age and tracking fetal development.This automated approach is particularly valuable in low-resource settings where access to trained sonographers is limited.The CAD system is divided into two steps:to begin,Haar-like characteristics were extracted from ultrasound pictures in order to train a classifier using random forests to find the fetal skull.We identified the HC using dynamic programming,an elliptical fit,and a Hough transform.The computer-aided detection(CAD)program was well-trained on 999 pictures(HC18 challenge data source),and then verified on 335 photos from all trimesters in an independent test set.A skilled sonographer and an expert in medicine personally marked the test set.We used the crown-rump length(CRL)measurement to calculate the reference gestational age(GA).In the first,second,and third trimesters,the median difference between the standard GA and the GA calculated by the skilled sonographer stayed at 0.7±2.7,0.0±4.5,and 2.0±12.0 days,respectively.The regular duration variance between the baseline GA and the health investigator’s GA remained 1.5±3.0,1.9±5.0,and 4.0±14 a couple of days.The mean variance between the standard GA and the CAD system’s GA remained between 0.5 and 5.0,with an additional variation of 2.9 to 12.5 days.The outcomes reveal that the computer-aided detection(CAD)program outperforms an expert sonographer.When paired with the classifications reported in the literature,the provided system achieves results that are comparable or even better.We have assessed and scheduled this computerized approach for HC evaluation,which includes information from all trimesters of gestation. 展开更多
关键词 Fetal growth SEGMENTATION ultrasound images computer-aided detection gestational age crown-rump length head circumference
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Risk Management Techniques in Construction Projects:Development and Assessment of an Innovative
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作者 Ahmed Ali Khatatbeh 《Journal of Civil Engineering and Architecture》 2025年第1期1-8,共8页
Professional and trade skills are required for handling the construction related projects;Construction industries of the present day however lack useful information concerning different practices,patterns and trends i... Professional and trade skills are required for handling the construction related projects;Construction industries of the present day however lack useful information concerning different practices,patterns and trends involved in risk management.Considering this,the present study focuses on the aforementioned variables of risk management by quantitative analysis specifically in the domain of construction industry.This study has used IBM’s SPSS(Statistical Package for Social Sciences)version 25.0 to analyze the results.This study is an initiative to assess the impact of risk management in the construction sector of Jordan.It will assist the construction sector for exploring the limitations with respect to integrate effective risk management.A sense of competition will be developed through a comparison of risk factors of construction projects among the project stakeholders such as contractors should enhance their risk management practices. 展开更多
关键词 CONSTRUCTION Jordanian construction projects risk assessment risk treatment
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Impact of Land Use Change on Ecosystem Services Values in Danjiangkou Reservoir Area,China in the Context of National Water Network Project Construction
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作者 LIU Linghua ZHENG Liang +3 位作者 WANG Ying LIU Chongchong ZHANG Bowen BI Yuzhe 《Chinese Geographical Science》 2025年第1期111-130,共20页
Investigating the ecological impact of land use change in the context of the construction of national water network project is crucial,as it is imperative for achieving the sustainable development goals of the nationa... Investigating the ecological impact of land use change in the context of the construction of national water network project is crucial,as it is imperative for achieving the sustainable development goals of the national water network and guaranteeing regional ecological stability.Using the Danjiangkou Reservoir Area(DRA),China as the study area,this paper first examined the spatiotemporal dynamics of natural landscape patterns and ecosystem service values(ESV)in the DRA from 2000 to 2018 and then investigated the spatial clustering characteristics of the ESV using spatial statistical analysis tools.Finally,the patch-generating land use simulation(PLUS)model was used to simulate the natural landscape and future changes in the ESV of the DRA from 2018 to 2028 under four different development scenarios:business as usual(BAU),economic development(ED),ecological protection(EP),and shoreline protection(SP).The results show that:during 2000-2018,the construction of water facilities had a significant impact on regional land use/land cover(LULC)change,with a 24830 ha increase in watershed area.ESV exhibited an increasing trend,with a significant and growing spatial clustering effect.The transformation of farmland to water bodies led to accelerated ESV growth,while the transformation of forest land to farmland led to a decrease in the ESV.Normalized difference vegetation index(NDVI)had the strongest effect on the ESV.ESV exhibited a continuous increase from 2018 to 2028 under all the simulation scenarios.The EP scenario had the greatest increase in ESV,while the ED scenario had the smallest increase.The findings suggest that projected land use patterns under different scenarios have varied impacts on ecosystem services(ESs)and that the management and planning of the DRA should balance social,economic,ecological,and security benefits.nomic,ecological,and security benefits. 展开更多
关键词 ecosystem services value(ESV) national water network project of China South-to-North Water Diversion project(SNWDP)of China multi-scenario simulation Danjiangkou Reservoir Area China
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Predicting the Construction Quality of Projects by Using Hybrid Soft Computing Techniques
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作者 Ching-Lung Fan 《Computer Modeling in Engineering & Sciences》 2025年第2期1995-2017,共23页
The construction phase of a project is a critical factor that significantly impacts its overall success.The construction environment is characterized by uncertainty and dynamism,involving nonlinear relationships among... The construction phase of a project is a critical factor that significantly impacts its overall success.The construction environment is characterized by uncertainty and dynamism,involving nonlinear relationships among various factors that affect construction quality.This study utilized 987 construction inspection records from 1993 to 2022,obtained from the Taiwan residents Public Construction Management Information System(PCMIS),to determine the relationships between construction factors and quality.First,fuzzy logic was applied to calculate the weights of 499 defects,and 25 critical construction factors were selected based on these weight values.Next,a deep neural network was used to identify the relationship between the critical construction factors(input variables)and construction quality(output variable).Finally,the prediction model’s performance was evaluated to confirm the impact of these critical construction factors on project outcomes.This study employed an innovative hybrid soft computing technique,com-bining fuzzy logic and an artificial neural network,to effectively predict the relationship between critical construction factors and construction quality,achieving a model accuracy of 96.08%.Project managers can utilize the findings of this study to enhance project management practices and establish effective construction management strategies,thereby improving project construction quality. 展开更多
关键词 Fuzzy logic artificial neural network crucial construction factor project quality performance
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Computer-Aided Translation Technology and Translation Teaching 被引量:1
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作者 王红艾 《海外英语》 2011年第15期158-159,161,共3页
With the development of computer technology, Computer-Aided Translation(CAT) is widely used in the translation process, thus increasing the efficiency of the entire translation work. The purpose of this article is to ... With the development of computer technology, Computer-Aided Translation(CAT) is widely used in the translation process, thus increasing the efficiency of the entire translation work. The purpose of this article is to analyze the importance of introducing CAT technology into translation teaching and explore some ways of integrating CAT technology with translation teaching, so as to improve the quality of the translators and the translation work. 展开更多
关键词 computer-aided TRANSLATION TRANSLATION TEACHING TRANSLATION EFFICIENCY
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Computer-aided Translation Technology and Its Applications
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作者 汪美侠 何大顺 《海外英语》 2014年第5X期170-172,共3页
This article begins with a brief analysis of the significance of translation technology in different spheres of modern life,followed by a distinction between machine translation(MT)and computer-aided translation(CAT).... This article begins with a brief analysis of the significance of translation technology in different spheres of modern life,followed by a distinction between machine translation(MT)and computer-aided translation(CAT).It then describes some translation resources and tools and examines the negative and positive aspects of computer-aided translations.Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation workplace. 展开更多
关键词 MACHINE TRANSLATION computer-aided TRANSLATION APP
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The computer-aided design method of cabinet based on style imagery 被引量:2
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作者 沈张帆 薛澄岐 +3 位作者 王海燕 牛亚峰 邵将 张晶 《Journal of Southeast University(English Edition)》 EI CAS 2015年第3期369-374,共6页
Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle... Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies. 展开更多
关键词 CABINET computer-aided design style imagery component recombinant shape features
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Using shapes correlation for active contour segmentation of uterine fibroid ultrasound images in computer-aided therapy 被引量:14
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作者 NI Bo HE Fa-zhi +1 位作者 PAN Yi-teng YUAN Zhi-yong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2016年第1期37-52,共16页
Segmenting the lesion regions from the ultrasound (US) images is an important step in the intra-operative planning of some computer-aided therapies. High-Intensity Focused Ultrasound (HIFU), as a popular computer-... Segmenting the lesion regions from the ultrasound (US) images is an important step in the intra-operative planning of some computer-aided therapies. High-Intensity Focused Ultrasound (HIFU), as a popular computer-aided therapy, has been widely used in the treatment of uterine fibroids. However, such segmentation in HIFU remains challenge for two reasons: (1) the blurry or missing boundaries of lesion regions in the HIFU images and (2) the deformation of uterine fibroids caused by the patient's breathing or an external force during the US imaging process, which can lead to complex shapes of lesion regions. These factors have prevented classical active contour-based segmentation methods from yielding desired results for uterine fibroids in US images. In this paper, a novel active contour-based segmentation method is proposed, which utilizes the correlation information of target shapes among a sequence of images as prior knowledge to aid the existing active contour method. This prior knowledge can be interpreted as a unsupervised clustering of shapes prior modeling. Meanwhile, it is also proved that the shapes correlation has the low-rank property in a linear space, and the theory of matrix recovery is used as an effective tool to impose the proposed prior on an existing active contour model. Finally, an accurate method is developed to solve the proposed model by using the Augmented Lagrange Multiplier (ALM). Experimental results from both synthetic and clinical uterine fibroids US image sequences demonstrate that the proposed method can consistently improve the performance of active contour models and increase the robustness against missing or misleading boundaries, and can greatly improve the efficiency of HIFU therapy. 展开更多
关键词 Active contour shapes correlation ultrasound image segmentation matrix recovery computer-aided therapy.
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Application of computer-aided engineering optimum design method in aluminum profile extrusion mould 被引量:8
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作者 帅词俊 肖刚 +1 位作者 倪正顺 钟掘 《Journal of Central South University of Technology》 2003年第1期64-68,共5页
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine... The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces. 展开更多
关键词 EXTRUSION MOULD computer-aided ENGINEERING OPTIMUM design ANSYS
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Enhanced characterization of solid solitary pulmonary nodules with Bayesian analysis-based computer-aided diagnosis 被引量:5
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作者 Simone Perandini Gian Alberto Soardi +9 位作者 Massimiliano Motton Raffaele Augelli Chiara Dallaserra Gino Puntel Arianna Rossi Giuseppe Sala Manuel Signorini Laura Spezia Federico Zamboni Stefania Montemezzi 《World Journal of Radiology》 CAS 2016年第8期729-734,共6页
The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomogr... The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomography(CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator(BIMC) model predictions. Raters' predictions were evaluated by means of receiver operating characteristic(ROC) curve analysis and decision analysis. Overall ROC area under the curve was 0.758 before and 0.803 after the disclosure of CAD predictions(P = 0.003). A net gain in diagnostic accuracy was found in 6 out of 7 readers. Mean risk class of benign nodules dropped from 2.48 to 2.29, while mean risk class of malignancies rose from 3.66 to 3.92. Awareness of CAD predictions also determined a significant drop on mean indeterminate SPNs(15 vs 23.86 SPNs) and raised the mean number of correct and confident diagnoses(mean 39.57 vs 25.71 SPNs). This study provides evidence supporting the integration of the Bayesian analysis-based BIMC model in SPN characterization. 展开更多
关键词 SOLITARY pulmonary NODULE computer-aided diagnosis Lung NEOPLASMS MULTIDETECTOR COMPUTED tomography Bayesian prediction
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Integrated computer-aided formulation design:A case study of andrographolide/cyclodextrin ternary formulation 被引量:3
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作者 Haoshi Gao Yan Su +6 位作者 Wei Wang Wei Xiong Xiyang Sun Yuanhui Ji Hua Yu Haifeng Li Defang Ouyang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第4期494-507,共14页
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario... Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design. 展开更多
关键词 Integrated computer-aided formulation design Machine learning Molecular dynamic simulation Physiologically based absorption modeling ANDROGRAPHOLIDE Cyclodextrins
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Computer-aided diagnosis of retinopathy based on vision transformer 被引量:3
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作者 Zhencun Jiang Lingyang Wang +4 位作者 Qixin Wu Yilei Shao Meixiao Shen Wenping Jiang Cuixia Dai 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2022年第2期49-57,共9页
Age-related Macular Degeneration(AMD)and Diabetic Macular Edema(DME)are two com-mon retinal diseases for elder people that may ultimately cause irreversible blindness.Timely and accurate diagnosis is essential for the... Age-related Macular Degeneration(AMD)and Diabetic Macular Edema(DME)are two com-mon retinal diseases for elder people that may ultimately cause irreversible blindness.Timely and accurate diagnosis is essential for the treatment of these diseases.In recent years,computer-aided diagnosis(CAD)has been deeply investigated and effectively used for rapid and early diagnosis.In this paper,we proposed a method of CAD using vision transformer to analyze optical co-herence tomography(OCT)images and to automatically discriminate AMD,DME,and normal eyes.A classification accuracy of 99.69%was achieved.After the model pruning,the recognition time reached 0.010 s and the classification accuracy did not drop.Compared with the Con-volutional Neural Network(CNN)image classification models(VGG16,Resnet50,Densenet121,and EfficientNet),vision transformer after pruning exhibited better recognition ability.Results show that vision transformer is an improved alternative to diagnose retinal diseases more accurately. 展开更多
关键词 Vision transformer OCT image classi¯cation RETINOPATHY computer-aided diagnosis model pruning
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Breast Tumor Computer-Aided Detection System Based on Magnetic Resonance Imaging Using Convolutional Neural Network 被引量:3
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作者 Jing Lu Yan Wu +4 位作者 Mingyan Hu Yao Xiong Yapeng Zhou Ziliang Zhao Liutong Shang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2022年第1期365-377,共13页
Background:The main cause of breast cancer is the deterioration of malignant tumor cells in breast tissue.Early diagnosis of tumors has become the most effective way to prevent breast cancer.Method:For distinguishing ... Background:The main cause of breast cancer is the deterioration of malignant tumor cells in breast tissue.Early diagnosis of tumors has become the most effective way to prevent breast cancer.Method:For distinguishing between tumor and non-tumor in MRI,a new type of computer-aided detection CAD system for breast tumors is designed in this paper.The CAD system was constructed using three networks,namely,the VGG16,Inception V3,and ResNet50.Then,the influence of the convolutional neural network second migration on the experimental results was further explored in the VGG16 system.Result:CAD system built based on VGG16,Inception V3,and ResNet50 has higher performance than mainstream CAD systems.Among them,the system built based on VGG16 and ResNet50 has outstanding performance.We further explore the impact of the secondary migration on the experimental results in the VGG16 system,and these results show that the migration can improve system performance of the proposed framework.Conclusion:The accuracy of CNN represented by VGG16 is as high as 91.25%,which is more accurate than traditional machine learningmodels.The F1 score of the three basic networks that join the secondary migration is close to 1.0,and the performance of the VGG16-based breast tumor CAD system is higher than Inception V3,and ResNet50. 展开更多
关键词 computer-aided diagnosis breast cancer VGG16 convolutional neural network magnetic resonance imaging
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3D printed nerve guidance channels: computer-aided control of geometry, physical cues, biological supplements and gradients 被引量:3
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作者 Blake N.Johnson Xiaofeng Jia 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第10期1568-1569,共2页
Nerve guidance channels for peripheral nerve injury: Over the past decade, nerve guidance channels (NGCs) have emerged as a promising technology for regenerating gap injuries in peripheral nerves. Nerve gap injurie... Nerve guidance channels for peripheral nerve injury: Over the past decade, nerve guidance channels (NGCs) have emerged as a promising technology for regenerating gap injuries in peripheral nerves. Nerve gap injuries resulting from neurodegeneration and trauma, such as car accidents and battlefield wounds, affect hun- dreds of thousands of people annually. Motivated by suboptimal results obtained with the current gold standard of autologous grafting (i.e., autografts), various commercially available NGCs composed of synthetic and biomaterials are now alternatively available (Jia et al., 2014; Jones et al., 2016). 展开更多
关键词 NGC physical cues printed nerve guidance channels biological supplements and gradients computer-aided control of geometry
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Computer-aided texture analysis combined with experts' knowledge: Improving endoscopic celiac disease diagnosis 被引量:1
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作者 Michael Gadermayr Hubert Kogler +3 位作者 Maximilian Karla Dorit Merhof Andreas Uhl Andreas Vécsei 《World Journal of Gastroenterology》 SCIE CAS 2016年第31期7124-7134,共11页
AIM: To further improve the endoscopic detection of intestinal mucosa alterations due to celiac disease(CD).METHODS: We assessed a hybrid approach based on the integration of expert knowledge into the computerbased cl... AIM: To further improve the endoscopic detection of intestinal mucosa alterations due to celiac disease(CD).METHODS: We assessed a hybrid approach based on the integration of expert knowledge into the computerbased classification pipeline. A total of 2835 endoscopic images from the duodenum were recorded in 290 children using the modified immersion technique(MIT). These children underwent routine upper endoscopy for suspected CD or non-celiac upper abdominal symptoms between August 2008 and December 2014. Blinded to the clinical data and biopsy results, three medical experts visually classified each image as normal mucosa(Marsh-0) or villous atrophy(Marsh-3). The experts' decisions were further integrated into state-of-the-arttexture recognition systems. Using the biopsy results as the reference standard, the classification accuracies of this hybrid approach were compared to the experts' diagnoses in 27 different settings.RESULTS: Compared to the experts' diagnoses, in 24 of 27 classification settings(consisting of three imaging modalities, three endoscopists and three classification approaches), the best overall classification accuracies were obtained with the new hybrid approach. In 17 of 24 classification settings, the improvements achieved with the hybrid approach were statistically significant(P < 0.05). Using the hybrid approach classification accuracies between 94% and 100% were obtained. Whereas the improvements are only moderate in the case of the most experienced expert, the results of the less experienced expert could be improved significantly in 17 out of 18 classification settings. Furthermore, the lowest classification accuracy, based on the combination of one database and one specific expert, could be improved from 80% to 95%(P < 0.001).CONCLUSION: The overall classification performance of medical experts, especially less experienced experts, can be boosted significantly by integrating expert knowledge into computer-aided diagnosis systems. 展开更多
关键词 CELIAC disease DIAGNOSIS ENDOSCOPY computer-aided texture analysis BIOPSY Pattern recognition
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Computer-aided designing and manufacturing of advanced steels 被引量:1
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作者 LI Lin HE Yanlin +3 位作者 B.C. De Cooman P. Wollants S. G. Huang J. Vleugels 《Rare Metals》 SCIE EI CAS CSCD 2006年第5期407-411,共5页
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced... Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure. 展开更多
关键词 material science advanced steel computer-aided design REFINING THERMODYNAMICS KINETICS
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Computer-Aided Design of Some Advanced Steels and Cemented Carbides 被引量:2
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作者 LI Lin ZHANG Mei +2 位作者 HE Yan-lin De Cooman Bruno Wollants Patrick 《Journal of Iron and Steel Research International》 SCIE CAS CSCD 2005年第6期42-48,共7页
Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo... Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nh) systems and Co-V-C system were modeled. Solution parameters and thermodynamic: properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design. 展开更多
关键词 computer-aided composition design TRIP steel cemented carbide prehardened mould steel concentration profile THERMODYNAMIC KINETIC equilibrium composition
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A computer-aided chem-photodynamic drugs self-delivery system for synergistically enhanced cancer therapy 被引量:1
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作者 Qiu Wang Mengchi Sun +6 位作者 Chang Li Dan Li Zimeng Yang Qikun Jiang Zhonggui He Huaiwei Ding Jin Sun 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第2期203-212,共10页
The therapeutic strategy that gives consideration to the combination of photodynamic therapy and chemotherapy,has emerged as a potential development of effective anti-cancer medicine.Nevertheless,co-delivery of photos... The therapeutic strategy that gives consideration to the combination of photodynamic therapy and chemotherapy,has emerged as a potential development of effective anti-cancer medicine.Nevertheless,co-delivery of photosensitizers(PSs)and chemotherapeutic drugs in traditional carriers still remains great limitations due to low drug loadings and poor biocompatibility.Herein,we have utilized a computer-aided strategy to achieve a desired carrier-free self-delivery of pyropheophorbide a(PPa,a common PS)and podophyllotoxin(PPT,a classical chemotherapeutic drug)for synergistic cancer therapy.First,the computational simulation method identified the similar molecular sizes and rigid molecular structures between two drugs molecules.Based on the molecular docking,the intermolecular interactions were found to includeπ-πstackings,hydrophobic interactions and hydrogen bonds.Next,both drugs could co-assemble into nanoparticles(NPs)via one-step nanoprecipitation method.The various spectral experiments(UV,IR and FL)were conducted to evaluate the formation mechanism of spherical NPs.Moreover,in vitro and in vivo experiments systematically demonstrated that PPT/PPa NPs not only showed better cellular uptake efficiency,stronger cytotoxicity and higher accumulation in tumor sites,but also exhibited synergistic antitumor effect in female BALB/C bearing-4T1 tumor mice.Such a computer-aided design strategy of chem-photodynamic drugs self-delivery systems pave the way for efficient synergistic cancer therapy. 展开更多
关键词 Photodynamic therapy CHEMOTHERAPY Self-delivery computer-aided Synergistic cancer therapy
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