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Stem cell-based bone and dental regeneration: a view of microenvironmental modulation 被引量:23
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作者 Chenxi Zheng Ji Chen +1 位作者 Shiyu Liu Yan Jin 《International Journal of Oral Science》 SCIE CAS CSCD 2019年第3期161-175,共15页
In modern medicine,bone and dental loss and defects are common and widespread morbidities,for which regenerative therapy has shown great promise.Mesenchymal stem cells,obtained from various sources and playing an esse... In modern medicine,bone and dental loss and defects are common and widespread morbidities,for which regenerative therapy has shown great promise.Mesenchymal stem cells,obtained from various sources and playing an essential role in organ development and postnatal repair,have exhibited enormous potential for regenerating bone and dental tissue.Currently,mesenchymal stem cells (MSCs)-based bone and dental regeneration mainly includes two strategies: the rescue or mobilization of endogenous MSCs and the application of exogenous MSCs in cytotherapy or tissue engineering.Nevertheless,the efficacy of MSCbased regeneration is not always fulfilled,especially in diseased microenvironments.Specifically,the diseased microenvironment not only impairs the regenerative potential of resident MSCs but also controls the therapeutic efficacy of exogenous MSCs,both as donors and recipients.Accordingly,approaches targeting a diseased microenvironment have been established,including improving the diseased niche to restore endogenous MSCs,enhancing MSC resistance to a diseased microenvironment and renormalizing the microenvironment to guarantee MSC-mediated therapies.Moreover,the application of extracellular vesicles (EVs) as cell-free therapy has emerged as a promising therapeutic strategy.In this review,we summarize current knowledge regarding the tactics of MSC-based bone and dental regeneration and the decisive role of the microenvironment,emphasizing the therapeutic potential of microenvironment-targeting strategies in bone and dental regenerative medicine. 展开更多
关键词 stem cells cytotherapy MICROENVIRONMENT
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Mesenchymal stem cell-mediated cancer therapy: A dualtargeted strategy of personalized medicine 被引量:7
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作者 Garth L Warnock 《World Journal of Stem Cells》 SCIE CAS 2011年第11期96-103,共8页
Cancer remains one of the leading causes of mortal-ity and morbidity throughout the world. To a signifi-cant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to t... Cancer remains one of the leading causes of mortal-ity and morbidity throughout the world. To a signifi-cant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to the development of effective cancer therapy is be-lieved to be the absence of suffi cient specifi city. Since the discovery of the tumor-oriented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. The dual-targeted strategy is based on MSCs’ capacity of tumor-directed migration and incorporation and in situ expression of tumor-specifi c anticancer genes. With the aim of trans-lating bench work into meaningful clinical applications, we describe the tumor tropism of MSCs and their use as therapeutic vehicles, the dual-targeted anticancer potential of engineered MSCs and a putative personal-ized strategy with anticancer gene-engineered MSCs. 展开更多
关键词 MESENCHYMAL STEM cells Gene THERAPY Cancer THERAPY cytotherapy
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国际顶级杂志2010年6~10月发表干细胞基础研究文章对临床转化的意义
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《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2010年第40期7533-7534,共2页
○Cell Stem Cell:有助恢复脊髓功能的干细胞○Blood:可促进造血干细胞分裂的蛋白质TIMP3○PNAS:用iPS细胞进行安全治疗的方法○Cell Stem
关键词 CELL Stem CELL Blood PNAS Nature cytotherapy CELL JAMA 干细胞 IPS细胞 血液干细胞移植
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国际顶级杂志2010年1~5月发表干细胞基础研究文章对临床转化的意义
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《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2010年第45期8476-8477,共2页
转化医学将生命科学和生物技术及相关的现代科学技术整合、凝聚到4P医学,推动了医疗改革、提高了人民的健康水平和生活质量,可实现更精确的预警与诊断、更有效的干预和治疗,降低发病率、推迟发病年龄、提高治愈率、减少重症患者、降低... 转化医学将生命科学和生物技术及相关的现代科学技术整合、凝聚到4P医学,推动了医疗改革、提高了人民的健康水平和生活质量,可实现更精确的预警与诊断、更有效的干预和治疗,降低发病率、推迟发病年龄、提高治愈率、减少重症患者、降低医疗的综合成本。 展开更多
关键词 CELL Stem CELL Blood PNAS Nature cytotherapy CELL JAMA 干细胞 IPS细胞 血液干细胞移植
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Advancing application of mesenchymal stem cell-based bone tissue regeneration 被引量:30
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作者 Fengqing Shang Yang Yu +5 位作者 Shiyu Liu Leiguo Ming Yongjie Zhang Zhifei Zhou Jiayu Zhao Yan Jin 《Bioactive Materials》 SCIE 2021年第3期666-683,共18页
Reconstruction of bone defects,especially the critical-sized defects,with mechanical integrity to the skeleton is important for a patient's rehabilitation,however,it still remains challenge.Utilizing biomaterials ... Reconstruction of bone defects,especially the critical-sized defects,with mechanical integrity to the skeleton is important for a patient's rehabilitation,however,it still remains challenge.Utilizing biomaterials of human origin bone tissue for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural bone tissue with regard to its properties.However,not only efficacious and safe but also costeffective and convenient are important for regenerative biomaterials to achieve clinical translation and commercial success.Advances in our understanding of regenerative biomaterials and their roles in new bone formation potentially opened a new frontier in the fast-growing field of regenerative medicine.Taking inspiration from the role and multicomponent construction of native extracellular matrix(ECM)for cell accommodation,the ECM-mimicking biomaterials and the naturally decellularized ECM scaffolds were used to create new tissues for bone restoration.On the other hand,with the going deep in understanding of mesenchymal stem cells(MSCs),they have shown great promise to jumpstart and facilitate bone healing even in diseased microenvironments with pharmacology-based endogenous MSCs rescue/mobilization,systemic/local infusion of MSCs for cytotherapy,biomaterials-based approaches,cell-sheets/-aggregates technology and usage of subcellular vesicles of MSCs to achieve scaffolds-free or cell-free delivery system,all of them have been shown can improve MSCsmediated regeneration in preclinical studies and several clinical trials.Here,following an overview discussed autogenous/allogenic and ECM-based bone biomaterials for reconstructive surgery and applications of MSCsmediated bone healing and tissue engineering to further offer principles and effective strategies to optimize MSCs-based bone regeneration. 展开更多
关键词 Mesenchymal stem cells Bone healing Regenerative medicine BIOMATERIALS Extracellular matrix cytotherapy Cell-sheets/-aggregates EXOSOMES
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